EGFR c.2237_2255delinsT ;(p.E746_S752delinsV)

Variant ID: 7-55242467-AATTAAGAGAAGCAACATC-T

NM_005228.3(EGFR):c.2237_2255delinsT;(p.E746_S752delinsV)

This variant was identified in 26 publications

View GRCh38 version.




Publications:


Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Frontiers In Oncology
He, Ping P; Liu, Jie J; Xu, Qingyuan Q; Ma, Huaijun H; Niu, Beifang B; Huang, Gang G; Wu, Wei W
Publication Date: 2023

Variant appearance in text: EGFR: 2237_2255delinsT; rs727504258
PubMed Link: 36910641
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 8
View BVdb publication page



Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications
Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS
Publication Date: 2023-02-27

Variant appearance in text: EGFR: 2237_2255delAATTAAGAGAAGCAACATCinsT
PubMed Link: 36849494
Variant Present in the following documents:
  • 41467_2023_35961_MOESM3_ESM.xlsx, sheet 2
  • 41467_2023_35961_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



NSCLC patients with rare EGFR Ex19del/G724S mutation showed good response to afatinib combined with chemotherapy treatment: A two-case report.

Frontiers In Oncology
Wang, Huilin H; Yu, Qitao Q; Shi, Lina L; Hou, Qinhan Q; Dan, Liang L; Liang, Chuqiao C; Hong, Xiaoyu X; Zhao, Yun Y; Ning, Ruiling R
Publication Date: 2022

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 36505860
Variant Present in the following documents:
  • Main text
  • fonc-12-1054593.pdf
View BVdb publication page



Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-making.

Frontiers In Oncology
Sun, Daqiang D; Xu, Meilin M; Pan, Chaohu C; Tang, Hongzhen H; Wang, Peng P; Wu, Dongfang D; Luo, Haitao H
Publication Date: 2022

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 36425562
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
  • Table_4.xlsx, sheet 1
View BVdb publication page



PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment.

Esmo Open
Thouvenin, J J; Van Marcke, C C; Decoster, L L; Raicevic, G G; Punie, K K; Vandenbulcke, M M; Salgado, R R; Van Valckenborgh, E E; Maes, B B; Joris, S S; Steichel, D Vander DV; Vranken, K K; Jacobs, S S; Dedeurwaerdere, F F; Martens, G G; Devos, H H; Duhoux, F P FP; Rasschaert, M M; Pauwels, P P; Geboes, K K; Collignon, J J; Tejpar, S S; Canon, J-L JL; Peeters, M M; Rutten, A A; Van de Mooter, T T; Vermeij, J J; Schrijvers, D D; Demey, W W; Lybaert, W W; Van Huysse, J J; Mebis, J J; Awada, A A; Claes, K B M KBM; Hebrant, A A; Van der Meulen, J J; Delafontaine, B B; Bempt, I Vanden IV; Maetens, J J; de Hemptinne, M M; Rottey, S S; Aftimos, P P; De Grève, J J
Publication Date: 2022-08

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35970014
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Altered splicing of ATG16-L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer.

Molecular Oncology
Hatat, Anne-Sophie AS; Benoit-Pilven, Clara C; Pucciarelli, Amélie A; de Fraipont, Florence F; Lamothe, Lucie L; Perron, Pascal P; Rey, Amandine A; Levra, Matteo Giaj MG; Toffart, Anne-Claire AC; Auboeuf, Didier D; Eymin, Beatrice B; Gazzeri, Sylvie S
Publication Date: 2022-10

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35593080
Variant Present in the following documents:
  • MOL2-16-3490-s004.pdf
View BVdb publication page



PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine
Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T
Publication Date: 2022

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35308511
Variant Present in the following documents:
  • Table_7.xlsx, sheet 1
View BVdb publication page



Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology
Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X
Publication Date: 2021

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35087742
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Bmc Genomics
Chen, Sixian S; Fu, Aizhen A; Lu, Yuan Y; Lu, Wei W; Chen, Yongfeng Y; Hong, Shuiqiang S; Zhou, Suli S; Xiang, Tianmin T; Zhang, Zhenzhen Z; Cai, Yongguang Y
Publication Date: 2022-01-15

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35031014
Variant Present in the following documents:
  • Main text
  • 12864_2021_8289_MOESM1_ESM.xlsx, sheet 1
  • 12864_2021_Article_8289.pdf
View BVdb publication page



Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Bmc Genomics
Chen, Sixian S; Fu, Aizhen A; Lu, Yuan Y; Lu, Wei W; Chen, Yongfeng Y; Hong, Shuiqiang S; Zhou, Suli S; Xiang, Tianmin T; Zhang, Zhenzhen Z; Cai, Yongguang Y
Publication Date: 2022-01-15

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 35031014
Variant Present in the following documents:
  • Main text
  • 12864_2021_8289_MOESM1_ESM.xlsx, sheet 1
  • 12864_2021_Article_8289.pdf
View BVdb publication page



Intertumoural Heterogeneity and Branch Evolution of Synchronous Multiple Primary Lung Adenocarcinomas by Next-Generation Sequencing Analysis.

Frontiers In Oncology
Zhang, Qinleng Q; Jia, Hui H; Wang, Zhendan Z; Hao, Shaoyu S; Huang, Haiyan H; Yang, Airong A; Han, Lu L; Song, Pingping P
Publication Date: 2021

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 34804960
Variant Present in the following documents:
  • Table_1.xls, sheet 1
View BVdb publication page



Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers.

Scientific Reports
Gilson, Pauline P; Saurel, Chloé C; Salleron, Julia J; Husson, Marie M; Demange, Jessica J; Merlin, Jean-Louis JL; Harlé, Alexandre A
Publication Date: 2021-05-18

Variant appearance in text: EGFR: 2235_2255delinsGGT
PubMed Link: 34006948
Variant Present in the following documents:
  • 41598_2021_90091_MOESM2_ESM.pdf
View BVdb publication page



Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants.

The Journal Of Pathology. Clinical Research
Shao, Jinchen J; Yin, Jiani C JC; Bao, Hairong H; Zhao, Ruiying R; Han, Yuchen Y; Zhu, Lei L; Wu, Xue X; Shao, Yang Y; Zhang, Jie J
Publication Date: 2021-05

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 33400370
Variant Present in the following documents:
  • Main text
  • CJP2-7-287.pdf
View BVdb publication page



Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants.

The Journal Of Pathology. Clinical Research
Shao, Jinchen J; Yin, Jiani C JC; Bao, Hairong H; Zhao, Ruiying R; Han, Yuchen Y; Zhu, Lei L; Wu, Xue X; Shao, Yang Y; Zhang, Jie J
Publication Date: 2021-05

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 33400370
Variant Present in the following documents:
  • Main text
  • CJP2-7-287.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: EGFR: 2237_2255delAATTAAGAGAAGCAACATCinsT
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Clinical impact of a cancer genomic profiling test using an in-house comprehensive targeted sequencing system.

Cancer Science
Hayashi, Hideyuki H; Tanishima, Shigeki S; Fujii, Kyoko K; Mori, Ryo R; Okada, Chihiro C; Yanagita, Emmy E; Shibata, Yuka Y; Matsuoka, Ryosuke R; Amano, Toraji T; Yamada, Takahiro T; Yabe, Ichiro I; Kinoshita, Ichiro I; Komatsu, Yoshito Y; Dosaka-Akita, Hirotoshi H; Nishihara, Hiroshi H
Publication Date: 2020-10

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 32772458
Variant Present in the following documents:
  • CAS-111-3926-s001.xlsx, sheet 5
View BVdb publication page



Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge.

Practical Laboratory Medicine
Al-Turkmani, M Rabie MR; Suriawinata, Michael A MA; Deharvengt, Sophie J SJ; Green, Donald C DC; Black, Candice C CC; Shirai, Keisuke K; Dragnev, Konstantin H KH; Tsongalis, Gregory J GJ
Publication Date: 2020-05

Variant appearance in text: EGFR: 2235_2255delinsGGT
PubMed Link: 32181314
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Variation in nomenclature of somatic variants for selection of oncological therapies: Can we reach a consensus soon?

Human Mutation
Keppens, Cleo C; Tack, Véronique V; Dufraing, Kelly K; Rouleau, Etienne E; Ligtenberg, Marjolijn J L MJL; Schuuring, Ed E; Dequeker, Elisabeth M C EMC
Publication Date: 2020-01

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 31553104
Variant Present in the following documents:
  • Main text
  • HUMU-41-7-s001.pdf
  • HUMU-41-7.pdf
View BVdb publication page



Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Plos One
Grosse, Claudia C; Soltermann, Alex A; Rechsteiner, Markus M; Grosse, Alexandra A
Publication Date: 2019

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 31386689
Variant Present in the following documents:
  • Main text
  • pone.0220691.pdf
View BVdb publication page



Oncologist uptake of comprehensive genomic profile guided targeted therapy.

Oncotarget
Nesline, Mary K MK; DePietro, Paul P; Dy, Grace K GK; Early, Amy A; Papanicolau-Sengos, Antonios A; Conroy, Jeffrey M JM; Lenzo, Felicia L FL; Glenn, Sean T ST; Chen, Hongbin H; Grand'Maison, Anne A; Boland, Patrick P; Ernstoff, Marc S MS; Puzanov, Igor I; Edge, Stephen S; Akers, Stacey S; Opyrchal, Mateusz M; Chatta, Gurkamal G; Odunsi, Kunle K; Frederick, Peter P; Lele, Shashikant S; Gardner, Mark M; Morrison, Carl C
Publication Date: 2019-07-23

Variant appearance in text: EGFR: 2237_2255delAATTAAGAGAAGCAACATCinsT
PubMed Link: 31384390
Variant Present in the following documents:
  • oncotarget-10-4616-s003.xlsx, sheet 1
View BVdb publication page



Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland.

Diagnostic Pathology
Grosse, Alexandra A; Grosse, Claudia C; Rechsteiner, Markus M; Soltermann, Alex A
Publication Date: 2019-02-11

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 30744664
Variant Present in the following documents:
  • Main text
  • 13000_2019_Article_789.pdf
View BVdb publication page



Detailed overview on the mutations detected by and the sensitivity of the GeneReader NGS sequencing platform.

Data In Brief
Lüsebrink, Jessica J; Pieper, Monika M; Tillmann, Ramona-Liza RL; Brockmann, Michael M; Schildgen, Oliver O; Schildgen, Verena V
Publication Date: 2018-06

Variant appearance in text: EGFR: 2237_2255delAATTAAGAGAAGCAACATCinsT
PubMed Link: 29904702
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Optimization of EGFR mutation detection by the fully-automated qPCR-based Idylla system on tumor tissue from patients with non-small cell lung cancer.

Oncotarget
Ilie, Marius M; Butori, Catherine C; Lassalle, Sandra S; Heeke, Simon S; Piton, Nicolas N; Sabourin, Jean-Christophe JC; Tanga, Virginie V; Washetine, Kevin K; Long-Mira, Elodie E; Maitre, Priscilla P; Yazbeck, Nathalie N; Bordone, Olivier O; Lespinet, Virginie V; Leroy, Sylvie S; Cohen, Charlotte C; Mouroux, Jérôme J; Marquette, Charles Hugo CH; Hofman, Véronique V; Hofman, Paul P
Publication Date: 2017-11-28

Variant appearance in text: EGFR: 2235_2255delinsGGT
PubMed Link: 29262544
Variant Present in the following documents:
  • oncotarget-08-103055-s003.xlsx, sheet 1
View BVdb publication page



Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Oncotarget
Illei, Peter B PB; Belchis, Deborah D; Tseng, Li-Hui LH; Nguyen, Doreen D; De Marchi, Federico F; Haley, Lisa L; Riel, Stacy S; Beierl, Katie K; Zheng, Gang G; Brahmer, Julie R JR; Askin, Frederic B FB; Gocke, Christopher D CD; Eshleman, James R JR; Forde, Patrick M PM; Lin, Ming-Tseh MT
Publication Date: 2017-11-14

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 29228562
Variant Present in the following documents:
  • oncotarget-08-96684.pdf
View BVdb publication page



VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research
Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR
Publication Date: 2016-06-20

Variant appearance in text: EGFR: 2237_2255delAATTAAGAGAAGCAACATCinsT
PubMed Link: 27060149
Variant Present in the following documents:
  • supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2
View BVdb publication page



Next-Generation Sequencing Workflow for NSCLC Critical Samples Using a Targeted Sequencing Approach by Ion Torrent PGM™ Platform.

International Journal Of Molecular Sciences
Vanni, Irene I; Coco, Simona S; Truini, Anna A; Rusmini, Marta M; Dal Bello, Maria Giovanna MG; Alama, Angela A; Banelli, Barbara B; Mora, Marco M; Rijavec, Erika E; Barletta, Giulia G; Genova, Carlo C; Biello, Federica F; Maggioni, Claudia C; Grossi, Francesco F
Publication Date: 2015-12-03

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 26633390
Variant Present in the following documents:
  • Main text
  • ijms-16-26129-s001.xls, sheet 2
  • ijms-16-26129.pdf
View BVdb publication page



Complex mutations & subpopulations of deletions at exon 19 of EGFR in NSCLC revealed by next generation sequencing: potential clinical implications.

Plos One
Marchetti, Antonio A; Del Grammastro, Maela M; Filice, Giampaolo G; Felicioni, Lara L; Rossi, Giulio G; Graziano, Paolo P; Sartori, Giuliana G; Leone, Alvaro A; Malatesta, Sara S; Iacono, Michele M; Guetti, Luigi L; Viola, Patrizia P; Mucilli, Felice F; Cuccurullo, Franco F; Buttitta, Fiamma F
Publication Date: 2012

Variant appearance in text: EGFR: 2237_2255delinsT
PubMed Link: 22848739
Variant Present in the following documents:
  • Main text
  • pone.0042164.pdf
View BVdb publication page