EGFR c.2241A>C ;(p.L747F)

Variant ID: 7-55242471-A-C

NM_005228.3(EGFR):c.2241A>C;(p.L747F)

This variant was identified in 11 publications

View GRCh38 version.




Publications:


Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Sato, Hiroki H; Offin, Michael M; Kubota, Daisuke D; Yu, Helena A HA; Wilhelm, Clare C; Toyooka, Shinichi S; Somwar, Romel R; Kris, Mark G MG; Ladanyi, Marc M
Publication Date: 2021-01

Variant appearance in text: EGFR: L747F
PubMed Link: 33038514
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: EGFR: L747F
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page



Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

Cancers
Hamid, Abdulaziz B AB; Petreaca, Ruben C RC
Publication Date: 2020-04-09

Variant appearance in text: EGFR: L747F
PubMed Link: 32283832
Variant Present in the following documents:
  • cancers-12-00927-s001.pdf
View BVdb publication page



High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.

Nature Medicine
Razavi, Pedram P; Li, Bob T BT; Brown, David N DN; Jung, Byoungsok B; Hubbell, Earl E; Shen, Ronglai R; Abida, Wassim W; Juluru, Krishna K; De Bruijn, Ino I; Hou, Chenlu C; Venn, Oliver O; Lim, Raymond R; Anand, Aseem A; Maddala, Tara T; Gnerre, Sante S; Vijaya Satya, Ravi R; Liu, Qinwen Q; Shen, Ling L; Eattock, Nicholas N; Yue, Jeanne J; Blocker, Alexander W AW; Lee, Mark M; Sehnert, Amy A; Xu, Hui H; Hall, Megan P MP; Santiago-Zayas, Angie A; Novotny, William F WF; Isbell, James M JM; Rusch, Valerie W VW; Plitas, George G; Heerdt, Alexandra S AS; Ladanyi, Marc M; Hyman, David M DM; Jones, David R DR; Morrow, Monica M; Riely, Gregory J GJ; Scher, Howard I HI; Rudin, Charles M CM; Robson, Mark E ME; Diaz, Luis A LA; Solit, David B DB; Aravanis, Alexander M AM; Reis-Filho, Jorge S JS
Publication Date: 2019-12

Variant appearance in text: EGFR: 2241A>C; Leu747Phe
PubMed Link: 31768066
Variant Present in the following documents:
  • NIHMS1541314-supplement-1541314_SourceDataFig1.xlsx, sheet 3
  • NIHMS1541314-supplement-1541314_Sup_Tab.xlsx, sheet 4
  • NIHMS1541314-supplement-1541314_Sup_Tab.xlsx, sheet 6
View BVdb publication page



Targeted deep sequencing from multiple sources demonstrates increased NOTCH1 alterations in lung cancer patient plasma.

Cancer Medicine
Liao, Yuwei Y; Ma, Zhaokui Z; Zhang, Yu Y; Li, Dan D; Lv, Dekang D; Chen, Zhisheng Z; Li, Peiying P; Ai-Dherasi, Aisha A; Zheng, Feng F; Tian, Jichao J; Zou, Kun K; Wang, Yue Y; Wang, Dongxia D; Cordova, Miguel M; Zhou, Huan H; Li, Xiuhua X; Liu, Dan D; Yu, Ruofei R; Zhang, Qingzheng Q; Zhang, Xiaolong X; Zhang, Jian J; Zhang, Xuehong X; Zhang, Xia X; Li, Yulong Y; Shao, Yanyan Y; Song, Luyao L; Liu, Ruimei R; Wang, Yichen Y; Sufiyan, Sufiyan S; Liu, Quentin Q; Owen, Gareth I GI; Li, Zhiguang Z; Chen, Jun J
Publication Date: 2019-09

Variant appearance in text: EGFR: L747F
PubMed Link: 31369215
Variant Present in the following documents:
  • CAM4-8-5673-s008.xlsx, sheet 5
View BVdb publication page



Heterogeneous Responses to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) in Patients with Uncommon EGFR Mutations: New Insights and Future Perspectives in this Complex Clinical Scenario.

International Journal Of Molecular Sciences
Russo, Alessandro A; Franchina, Tindara T; Ricciardi, Giuseppina G; Battaglia, Alessandra A; Picciotto, Maria M; Adamo, Vincenzo V
Publication Date: 2019-03-21

Variant appearance in text: EGFR: L747F
PubMed Link: 30901844
Variant Present in the following documents:
  • Main text
  • ijms-20-01431.pdf
View BVdb publication page



The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma.

Plos One
de Biase, Dario D; Genestreti, Giovenzio G; Visani, Michela M; Acquaviva, Giorgia G; Di Battista, Monica M; Cavallo, Giovanna G; Paccapelo, Alexandro A; Cancellieri, Alessandra A; Trisolini, Rocco R; Degli Esposti, Roberta R; Bartolini, Stefania S; Pession, Annalisa A; Tallini, Giovanni G; Brandes, Alba A AA
Publication Date: 2017

Variant appearance in text: EGFR: L747F
PubMed Link: 28520821
Variant Present in the following documents:
  • Main text
  • pone.0177822.pdf
View BVdb publication page



Targeted sequencing identifies genetic alterations that confer primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium).

Oncotarget
Lim, Sun Min SM; Kim, Hye Ryun HR; Cho, Eun Kyung EK; Min, Young Joo YJ; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Cho, Byoung Chul BC; Lee, Ji-Hyun JH; Jeong, Hye Cheol HC; Kim, Eun Kyung EK; Kim, Joo-Hang JH
Publication Date: 2016-06-14

Variant appearance in text: EGFR: L747F
PubMed Link: 27121209
Variant Present in the following documents:
  • Main text
  • oncotarget-07-36311.pdf
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: EGFR: L747F
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 5
View BVdb publication page



Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One
Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS
Publication Date: 2008

Variant appearance in text: EGFR: L747F
PubMed Link: 19005564
Variant Present in the following documents:
  • pone.0003714.s003.xls, sheet 1
View BVdb publication page