EGFR c.2246_2248del ;(p.E749del)

Variant ID: 7-55242473-GAGA-G

NM_005228.3(EGFR):c.2246_2248del;(p.E749del)

This variant was identified in 130 publications

View GRCh38 version.




Publications:


Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications
González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR
Publication Date: 2023-06-12

Variant appearance in text: EGFR: E749del
PubMed Link: 37308482
Variant Present in the following documents:
  • 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5
View BVdb publication page



Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.

Journal Of Medicinal Chemistry
Aarhus, Thomas Ihle TI; Bjørnstad, Frithjof F; Wolowczyk, Camilla C; Larsen, Kristin Uhlving KU; Rognstad, Line L; Leithaug, Trygve T; Unger, Anke A; Habenberger, Peter P; Wolf, Alexander A; Bjørkøy, Geir G; Pridans, Clare C; Eickhoff, Jan J; Klebl, Bert B; Hoff, Bård H BH; Sundby, Eirik E
Publication Date: 2023-05-16

Variant appearance in text: EGFR: E749del
PubMed Link: 37191268
Variant Present in the following documents:
  • jm3c00428_si_001.pdf
View BVdb publication page



Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Acs Chemical Neuroscience
Ong, Han Wee HW; Liang, Yi Y; Richardson, William W; Lowry, Emily R ER; Wells, Carrow I CI; Chen, Xiangrong X; Silvestre, Margaux M; Dempster, Kelvin K; Silvaroli, Josie A JA; Smith, Jeffery L JL; Wichterle, Hynek H; Pabla, Navjot S NS; Ultanir, Sila K SK; Bullock, Alex N AN; Drewry, David H DH; Axtman, Alison D AD
Publication Date: 2023-04-21

Variant appearance in text: EGFR: E749del
PubMed Link: 37084253
Variant Present in the following documents:
  • cn3c00135_si_001.pdf
View BVdb publication page



CKAP4 is a potential exosomal biomarker and therapeutic target for lung cancer.

Translational Lung Cancer Research
Nagoya, Akihiro A; Sada, Ryota R; Kimura, Hirokazu H; Yamamoto, Hideki H; Morishita, Koichi K; Miyoshi, Eiji E; Morii, Eiichi E; Shintani, Yasushi Y; Kikuchi, Akira A
Publication Date: 2023-03-31

Variant appearance in text: EGFR: E749del
PubMed Link: 37057110
Variant Present in the following documents:
  • Main text
  • tlcr-12-03-408.pdf
  • tlcr-12-03-408-supplementary.pdf
View BVdb publication page



Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry
Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S
Publication Date: 2023-04-07

Variant appearance in text: EGFR: E749del
PubMed Link: 37026591
Variant Present in the following documents:
  • jm3c00155_si_002.xlsx, sheet 2
View BVdb publication page



Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.

Acs Chemical Biology
Tredup, Claudia C; Ndreshkjana, Benardina B; Schneider, Natalie S NS; Tjaden, Amelie A; Kemas, Aurino M AM; Youhanna, Sonia S; Lauschke, Volker M VM; Berger, Benedict-Tilman BT; Krämer, Andreas A; Berger, Lena M LM; Röhm, Sandra S; Knapp, Stefan S; Farin, Henner F HF; Müller, Susanne S
Publication Date: 2023-03-21

Variant appearance in text: EGFR: E749del
PubMed Link: 36944371
Variant Present in the following documents:
  • cb2c00877_si_004.xlsx, sheet 1
View BVdb publication page



Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.

Plos One
Kozaki, Ryohei R; Yasuhiro, Tomoko T; Kato, Hikaru H; Murai, Jun J; Hotta, Shingo S; Ariza, Yuko Y; Sakai, Shunsuke S; Fujikawa, Ryu R; Yoshida, Takao T
Publication Date: 2023

Variant appearance in text: EGFR: E749del
PubMed Link: 36897912
Variant Present in the following documents:
  • pone.0282166.s009.xlsx, sheet 1
View BVdb publication page



Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications
Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS
Publication Date: 2023-02-27

Variant appearance in text: EGFR: E749del
PubMed Link: 36849494
Variant Present in the following documents:
  • 41467_2023_35961_MOESM3_ESM.xlsx, sheet 2
View BVdb publication page



Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor.

Brazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
Machado-Rugolo, J J; Baldavira, C M CM; Prieto, T G TG; Olivieri, E H R EHR; Fabro, A T AT; Rainho, C A CA; Castelli, E C EC; Ribolla, P E M PEM; Ab'Saber, A M AM; Takagaki, T T; Nagai, M A MA; Capelozzi, V L VL
Publication Date: 2023

Variant appearance in text: EGFR: E749del
PubMed Link: 36629526
Variant Present in the following documents:
  • Main text
  • 1414-431X-bjmbr-55-e12409.pdf
View BVdb publication page



A multiple detection method for distinguishing gene mutations based on melting curves of extended quenching probes.

Heliyon
Jianping, Wang W; Zipeng, Liu L; Tengfei, Pan P; Song, Zhang Z
Publication Date: 2022-11

Variant appearance in text: EGFR: E749del
PubMed Link: 36468116
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia.

Leukemia
Sher, Steven S; Whipp, Ethan E; Walker, Janek J; Zhang, Pu P; Beaver, Larry L; Williams, Katie K; Orwick, Shelley S; Ravikrishnan, Janani J; Walker, Brandi B; Perry, Elizabeth E; Gregory, Charles C; Purcell, Matthew M; Pan, Alexander A; Yan, Pearlly P; Alinari, Lapo L; Johnson, Amy J AJ; Frigault, Melanie M MM; Greer, Joy M JM; Hamdy, Ahmed A; Izumi, Raquel R; Mo, Xiaokui X; Sampath, Deepa D; Woyach, Jennifer J; Blachly, James J; Byrd, John C JC; Lapalombella, Rosa R
Publication Date: 2022-11-14

Variant appearance in text: EGFR: E749del
PubMed Link: 36376377
Variant Present in the following documents:
  • 41375_2022_1758_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Designing Novel BCR-ABL Inhibitors for Chronic Myeloid Leukemia with Improved Cardiac Safety.

Journal Of Medicinal Chemistry
Pandrala, Mallesh M; Bruyneel, Arne Antoon N AAN; Hnatiuk, Anna P AP; Mercola, Mark M; Malhotra, Sanjay V SV
Publication Date: 2022-08-25

Variant appearance in text: EGFR: E749del
PubMed Link: 35944901
Variant Present in the following documents:
  • jm1c01853_si_003.xlsx, sheet 1
View BVdb publication page



Decoding kinase-adverse event associations for small molecule kinase inhibitors.

Nature Communications
Gong, Xiajing X; Hu, Meng M; Liu, Jinzhong J; Kim, Geoffrey G; Xu, James J; McKee, Amy A; Palmby, Todd T; de Claro, R Angelo RA; Zhao, Liang L
Publication Date: 2022-07-27

Variant appearance in text: EGFR: E749del
PubMed Link: 35896580
Variant Present in the following documents:
  • 41467_2022_Article_32033.pdf
View BVdb publication page



Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.

Acs Medicinal Chemistry Letters
Hall, Adrian A; Abendroth, Jan J; Bolejack, Madison J MJ; Ceska, Tom T; Dell'Aiera, Sylvie S; Ellis, Victoria V; Fox, David D; François, Cyril C; Muruthi, Muigai M MM; Prével, Camille C; Poullennec, Karine K; Romanov, Sergei S; Valade, Anne A; Vanbellinghen, Alain A; Yano, Jason J; Geraerts, Martine M
Publication Date: 2022-07-14

Variant appearance in text: EGFR: E749del
PubMed Link: 35859861
Variant Present in the following documents:
  • ml2c00134_si_001.pdf
View BVdb publication page



Reengineering Ponatinib to Minimize Cardiovascular Toxicity.

Cancer Research
Hnatiuk, Anna P AP; Bruyneel, Arne A N AAN; Tailor, Dhanir D; Pandrala, Mallesh M; Dheeraj, Arpit A; Li, Wenqi W; Serrano, Ricardo R; Feyen, Dries A M DAM; Vu, Michelle M MM; Amatya, Prashila P; Gupta, Saloni S; Nakauchi, Yusuke Y; Morgado, Isabel I; Wiebking, Volker V; Liao, Ronglih R; Porteus, Matthew H MH; Majeti, Ravindra R; Malhotra, Sanjay V SV; Mercola, Mark M
Publication Date: 2022-08-03

Variant appearance in text: EGFR: E749del
PubMed Link: 35763671
Variant Present in the following documents:
  • can-21-3652_supplementary_table_s1_suppst1.xls, sheet 2
View BVdb publication page



Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal Of Medicinal Chemistry
Huckvale, Rosemary R; Harnden, Alice C AC; Cheung, Kwai-Ming J KJ; Pierrat, Olivier A OA; Talbot, Rachel R; Box, Gary M GM; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Hallsworth, Albert E AE; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; Hayes, Angela A; Gunnell, Emma A EA; Brennan, Alfie A; Davis, Owen A OA; Johnson, Louise D LD; de Klerk, Selby S; McAndrew, Craig C; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S
Publication Date: 2022-06-23

Variant appearance in text: EGFR: E749del
PubMed Link: 35653645
Variant Present in the following documents:
  • jm1c02175_si_002.xlsx, sheet 2
View BVdb publication page



Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.

Elife
Wei, Tiantian T; Wang, Jue J; Liang, Ruqi R; Chen, Wendong W; Chen, Yilan Y; Ma, Mingzhe M; He, An A; Du, Yifei Y; Zhou, Wenjing W; Zhang, Zhiying Z; Zeng, Xin X; Wang, Chu C; Lu, Jin J; Guo, Xing X; Chen, Xiao-Wei XW; Wang, Youjun Y; Tian, Ruijun R; Xiao, Junyu J; Lei, Xiaoguang X
Publication Date: 2022-04-19

Variant appearance in text: EGFR: E749del
PubMed Link: 35439114
Variant Present in the following documents:
  • elife-77696.pdf
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: E749del
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Ultrasensitive analysis of genetic instability related to chemical exposure.

Journal Of Applied Genetics
Domoradzki, Tomasz T; Grochowski, Piotr P; Jaśkiewicz, Anna A; Pająk, Beata B
Publication Date: 2022-05

Variant appearance in text: EGFR: E749del
PubMed Link: 34967917
Variant Present in the following documents:
  • Main text
  • 13353_2021_Article_677.pdf
View BVdb publication page



Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Cell Death & Disease
Meng, Ya Y; Song, Chengcheng C; Ren, Zhili Z; Li, Xiaohong X; Yang, Xiangyu X; Ai, Nana N; Yang, Yang Y; Wang, Dongjin D; Zhan, Meixiao M; Wang, Jiaxian J; Lei, Chon Lok CL; Liu, Weiwei W; Ge, Wei W; Lu, Ligong L; Chen, Guokai G
Publication Date: 2021-11-29

Variant appearance in text: EGFR: E749del
PubMed Link: 34845199
Variant Present in the following documents:
  • 41419_2021_4395_MOESM9_ESM.xlsx, sheet 1
View BVdb publication page



Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology
Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K
Publication Date: 2021-07

Variant appearance in text: EGFR: E749del
PubMed Link: 34632253
Variant Present in the following documents:
  • po-5-1112.pdf
View BVdb publication page



Clinical Utility of Plasma-Based Comprehensive Molecular Profiling in Advanced Non-Small-Cell Lung Cancer.

Jco Precision Oncology
Schouten, Robert D RD; Vessies, Daan C L DCL; Bosch, Linda J W LJW; Barlo, Nicole P NP; van Lindert, Anne S R ASR; Cillessen, Saskia A G M SAGM; van den Broek, Daan D; van den Heuvel, Michel M MM; Monkhorst, Kim K
Publication Date: 2021-07

Variant appearance in text: EGFR: E749del
PubMed Link: 34632253
Variant Present in the following documents:
  • po-5-1112.pdf
View BVdb publication page



Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Publication Date: 2021-09

Variant appearance in text: EGFR: E749del
PubMed Link: 34526717
Variant Present in the following documents:
  • 41586_2021_3898_MOESM1_ESM.pdf
View BVdb publication page



Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal Of Medicinal Chemistry
Henderson, Scott H SH; Sorrell, Fiona F; Bennett, James J; Fedorov, Oleg O; Hanley, Marcus T MT; Godoi, Paulo H PH; Ruela de Sousa, Roberta R; Robinson, Sean S; Ashall-Kelly, Alexander A; Hopkins Navratilova, Iva I; Walter, Daryl S DS; Elkins, Jonathan M JM; Ward, Simon E SE
Publication Date: 2021-08-12

Variant appearance in text: EGFR: E749del
PubMed Link: 34342227
Variant Present in the following documents:
  • jm1c01115_si_002.xlsx, sheet 13
  • jm1c01115_si_002.xlsx, sheet 9
  • jm1c01115_si_002.xlsx, sheet 2
  • jm1c01115_si_002.xlsx, sheet 6
  • jm1c01115_si_002.xlsx, sheet 1
  • jm1c01115_si_002.xlsx, sheet 10
  • jm1c01115_si_002.xlsx, sheet 14
  • jm1c01115_si_002.xlsx, sheet 4
  • jm1c01115_si_002.xlsx, sheet 7
  • jm1c01115_si_002.xlsx, sheet 3
  • jm1c01115_si_002.xlsx, sheet 11
  • jm1c01115_si_002.xlsx, sheet 8
  • jm1c01115_si_002.xlsx, sheet 5
  • jm1c01115_si_002.xlsx, sheet 12
View BVdb publication page



A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers
Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC
Publication Date: 2021-07-20

Variant appearance in text: EGFR: E749del
PubMed Link: 34298851
Variant Present in the following documents:
  • Main text
  • cancers-13-03641.pdf
View BVdb publication page



Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.

Journal Of Medicinal Chemistry
Eduful, Benjamin J BJ; O'Byrne, Sean N SN; Temme, Louisa L; Asquith, Christopher R M CRM; Liang, Yi Y; Picado, Alfredo A; Pilotte, Joseph R JR; Hossain, Mohammad Anwar MA; Wells, Carrow I CI; Zuercher, William J WJ; Catta-Preta, Carolina M C CMC; Zonzini Ramos, Priscila P; Santiago, André de S AS; Couñago, Rafael M RM; Langendorf, Christopher G CG; Nay, Kévin K; Oakhill, Jonathan S JS; Pulliam, Thomas L TL; Lin, Chenchu C; Awad, Dominik D; Willson, Timothy M TM; Frigo, Daniel E DE; Scott, John W JW; Drewry, David H DH
Publication Date: 2021-08-12

Variant appearance in text: EGFR: E749del
PubMed Link: 34264658
Variant Present in the following documents:
  • jm0c02274_si_003.xlsx, sheet 1
View BVdb publication page



Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

Frontiers In Oncology
Zhang, Shirong S; Xu, Yang Y; Zhao, Pan P; Bao, Hua H; Wang, Xiyong X; Liu, Rui R; Xu, Rujun R; Xiang, Jingjing J; Jiang, Hong H; Yan, Junrong J; Wu, Xue X; Shao, Yang Y; Liang, Jiafeng J; Wu, Qiong Q; Zhang, Zhihao Z; Lu, Shun S; Ma, Shenglin S
Publication Date: 2021

Variant appearance in text: EGFR: E749del
PubMed Link: 34221970
Variant Present in the following documents:
  • Table_5.xlsx, sheet 1
View BVdb publication page



Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform.

Communications Biology
Xia, Yifeng Y; Ji, Xiaodong X; Jang, In Sock IS; Surka, Christine C; Hsu, Christy C; Wang, Kai K; Rolfe, Mark M; Bence, Neil N; Lu, Gang G
Publication Date: 2021-07-02

Variant appearance in text: EGFR: E749del
PubMed Link: 34215850
Variant Present in the following documents:
  • Main text
  • 42003_2021_Article_2352.pdf
View BVdb publication page



Visualization of Kinase Inhibition-Related Adverse Events Using the Japanese Adverse Drug Event Report Database.

Drugs - Real World Outcomes
Mizuno, Takahito T; Sakai, Takamasa T; Tanabe, Kouichi K; Umemura, Takumi T; Goto, Nobuyuki N; Ohtsu, Fumiko F
Publication Date: 2021-06

Variant appearance in text: EGFR: E749del
PubMed Link: 33686612
Variant Present in the following documents:
  • 40801_2021_235_MOESM1_ESM.pdf
View BVdb publication page



Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories.

Open Biology
Hynds, Robert E RE; Frese, Kristopher K KK; Pearce, David R DR; Grönroos, Eva E; Dive, Caroline C; Swanton, Charles C
Publication Date: 2021-01

Variant appearance in text: EGFR: Glu749del
PubMed Link: 33435818
Variant Present in the following documents:
  • Main text
  • rsob-11-200247.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: EGFR: E749del
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer.

Translational Lung Cancer Research
Ho, Gloria Y F GYF; Wang, Tao T; Kwok, Hoi-Hin HH; Rasul, Rehana R; Peila, Rita R; Guzman, Maria M; Ip, Mary S M MSM; Lam, David C L DCL
Publication Date: 2020-10

Variant appearance in text: EGFR: E749del
PubMed Link: 33209609
Variant Present in the following documents:
  • Main text
  • tlcr-09-05-1873.pdf
View BVdb publication page



Efficacy of afatinib for pulmonary adenocarcinoma with leptomeningeal metastases harboring an epidermal growth factor receptor complex mutation (exon 19del+K754E): A case report.

Medicine
Ma, Chunhua C; Liu, Mei M; Mu, Ning N; Li, Jinduo J; Li, Lin L; Jiang, Rong R
Publication Date: 2020-10-23

Variant appearance in text: EGFR: E749del
PubMed Link: 33120820
Variant Present in the following documents:
  • Main text
  • medi-99-e22851.pdf
View BVdb publication page



Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma.

Signal Transduction And Targeted Therapy
Liu, Juan J; Liang, Qianmao Q; Wang, Aoli A; Zou, Fengming F; Qi, Ziping Z; Yu, Kailin K; Liu, Qingwang Q; Chen, Cheng C; Liu, Jing J; Liu, Qingsong Q
Publication Date: 2020-09-14

Variant appearance in text: EGFR: E749del
PubMed Link: 32929063
Variant Present in the following documents:
  • 41392_2020_309_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy.

Iscience
Singh, Vibha V; Bhoir, Siddhant S; Chikhale, Rupesh V RV; Hussain, Javeena J; Dwyer, Donard D; Bryce, Richard A RA; Kirubakaran, Sivapriya S; De Benedetti, Arrigo A
Publication Date: 2020-08-20

Variant appearance in text: EGFR: E749del
PubMed Link: 32905878
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.

Ebiomedicine
de Wit, Maurice M; Gao, Ya Y; Mercieca, Darlene D; de Heer, Iris I; Valkenburg, Bart B; van Royen, Martin E ME; Aerts, Joachim J; Sillevis Smitt, Peter P; French, Pim P
Publication Date: 2020-06

Variant appearance in text: EGFR: E749del
PubMed Link: 32512509
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



EGFR mutation status in a series of Turkish non-small cell lung cancer patients.

Biomedical Reports
Calibasi-Kocal, Gizem G; Amirfallah, Arsalan A; Sever, Tolga T; Umit Unal, Olcun O; Gurel, Duygu D; Oztop, Ilhan I; Ellidokuz, Hulya H; Basbinar, Yasemin Y
Publication Date: 2020-08

Variant appearance in text: EGFR: Glu749del
PubMed Link: 32509305
Variant Present in the following documents:
  • Main text
View BVdb publication page



New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).

Molecules (Basel, Switzerland)
Asquith, Christopher R M CRM; Laitinen, Tuomo T; Wells, Carrow I CI; Tizzard, Graham J GJ; Zuercher, William J WJ
Publication Date: 2020-04-07

Variant appearance in text: EGFR: E749del
PubMed Link: 32272798
Variant Present in the following documents:
  • molecules-25-01697-s001.pdf
View BVdb publication page



Identifying a wide range of actionable variants using capture-based ultra-deep targeted sequencing in treatment-naive patients with primary lung adenocarcinoma.

International Journal Of Clinical And Experimental Pathology
Chen, Lingfeng L; Chen, Minyan M; Lin, Jie J; Chen, Xiaoyan X; Yu, Xunbin X; Chen, Zhizhong Z; Jin, Long L
Publication Date: 2020

Variant appearance in text: EGFR: E749del
PubMed Link: 32269691
Variant Present in the following documents:
  • Main text
View BVdb publication page



Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge.

Practical Laboratory Medicine
Al-Turkmani, M Rabie MR; Suriawinata, Michael A MA; Deharvengt, Sophie J SJ; Green, Donald C DC; Black, Candice C CC; Shirai, Keisuke K; Dragnev, Konstantin H KH; Tsongalis, Gregory J GJ
Publication Date: 2020-05

Variant appearance in text: EGFR: E749del
PubMed Link: 32181314
Variant Present in the following documents:
  • Main text
View BVdb publication page



Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z
Publication Date: 2020-01

Variant appearance in text: EGFR: E749del
PubMed Link: 32067422
Variant Present in the following documents:
  • Main text
  • CAC2-40-43-s001.xlsx, sheet 1
View BVdb publication page



The kinase polypharmacology landscape of clinical PARP inhibitors.

Scientific Reports
Antolin, Albert A AA; Ameratunga, Malaka M; Banerji, Udai U; Clarke, Paul A PA; Workman, Paul P; Al-Lazikani, Bissan B
Publication Date: 2020-02-17

Variant appearance in text: EGFR: E749del
PubMed Link: 32066817
Variant Present in the following documents:
  • 41598_2020_59074_MOESM1_ESM.xlsx, sheet 5
View BVdb publication page



Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations.

Bmc Cancer
Ruiz-Cordero, Roberto R; Ma, Junsheng J; Khanna, Abha A; Lyons, Genevieve G; Rinsurongkawong, Waree W; Bassett, Roland R; Guo, Ming M; Routbort, Mark J MJ; Zhang, Jianjun J; Skoulidis, Ferdinandos F; Heymach, John J; Roarty, Emily B EB; Tang, Zhenya Z; Medeiros, L Jeffrey LJ; Patel, Keyur P KP; Luthra, Rajyalakshmi R; Roy-Chowdhuri, Sinchita S
Publication Date: 2020-01-31

Variant appearance in text: EGFR: E749del
PubMed Link: 32005111
Variant Present in the following documents:
  • 12885_2020_6579_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer.

Cellular & Molecular Biology Letters
Fan, Qiang Q; Wang, Qian Q; Cai, Renjie R; Yuan, Haihua H; Xu, Ming M
Publication Date: 2020

Variant appearance in text: EGFR: E749del
PubMed Link: 31988639
Variant Present in the following documents:
  • Main text
View BVdb publication page



Results of Liquid Biopsy Studies by Next Generation Sequencing in Patients with Advanced Stage Non-small Cell Lung Cancer: Single Center Experience from Turkey.

Balkan Journal Of Medical Genetics : Bjmg
Buyuksimsek, M M; Togun, M M; Oguz, Kara I KI; Bisgin, A A; Boga, I I; Tohumcuoglu, M M; Ogul, A A; Evren, Yetisir A YA; Sahin, B B; Erdem, Sumbul H SH; Mirili, C C
Publication Date: 2019-12

Variant appearance in text: EGFR: E749del
PubMed Link: 31942412
Variant Present in the following documents:
  • Main text
  • bjmg-22-017.pdf
View BVdb publication page



High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.

International Journal Of Clinical And Experimental Pathology
Su, Fei F; Fu, Yiyun Y; Wu, Qian Q; Zheng, Ke K; Tang, Yuan Y; Su, Xueying X; Wang, Ye Y; Jiang, Lili L
Publication Date: 2018

Variant appearance in text: EGFR: E749del
PubMed Link: 31938383
Variant Present in the following documents:
  • Main text
View BVdb publication page



Potential mechanism of primary resistance to icotinib in patients with advanced non-small cell lung cancer harboring uncommon mutant epidermal growth factor receptor: A multi-center study.

Cancer Science
Lei, Lei L; Wang, Wen-Xian WX; Zhu, You-Cai YC; Li, Jin-Luan JL; Fang, Yong Y; Wang, Hong H; Zhuang, Wu W; Zhang, Yin-Bin YB; Wang, Li-Ping LP; Fang, Mei-Yu MY; Xu, Chun-Wei CW; Wang, Xiao-Jia XJ; Lv, Tang-Feng TF; Song, Yong Y
Publication Date: 2020-02

Variant appearance in text: EGFR: E749del
PubMed Link: 31828849
Variant Present in the following documents:
  • Main text
View BVdb publication page



Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Molecules (Basel, Switzerland)
Asquith, Christopher R M CRM; Bennett, James M JM; Su, Lianyong L; Laitinen, Tuomo T; Elkins, Jonathan M JM; Pickett, Julie E JE; Wells, Carrow I CI; Li, Zengbiao Z; Willson, Timothy M TM; Zuercher, William J WJ
Publication Date: 2019-11-06

Variant appearance in text: EGFR: E749del
PubMed Link: 31698822
Variant Present in the following documents:
  • molecules-24-04016-s001.pdf
View BVdb publication page



Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics.

Nature Communications
Li, Ziming Z; Wang, Zhuo Z; Tang, Yin Y; Lu, Xiang X; Chen, Jie J; Dong, Yu Y; Wu, Baojun B; Wang, Chunying C; Yang, Liu L; Guo, Zhili Z; Xue, Min M; Lu, Shun S; Wei, Wei W; Shi, Qihui Q
Publication Date: 2019-08-26

Variant appearance in text: EGFR: E749del
PubMed Link: 31451693
Variant Present in the following documents:
  • 41467_2019_11808_MOESM1_ESM.pdf
View BVdb publication page