Publications:

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Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer.

Nature Communications

Zhao, Shen S; Zhuang, Wu W; Han, Baohui B; Song, Zhengbo Z; Guo, Wei W; Luo, Feng F; Wu, Lin L; Hu, Yi Y; Wang, Huijuan H; Dong, Xiaorong X; Jiang, Da D; Wang, Mingxia M; Miao, Liyun L; Wang, Qian Q; Zhang, Junping J; Fu, Zhenming Z; Huang, Yihua Y; Xu, Chunwei C; Hu, Longyu L; Li, Lei L; Hu, Rong R; Yang, Yang Y; Li, Mengke M; Yang, Xiugao X; Zhang, Li L; Huang, Yan Y; Fang, Wenfeng W

Publication Date: 2023-06-12

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 37308490

Variant Present in the following documents:

• 41467_2023_39139_MOESM4_ESM.xlsx, sheet 3
• 41467_2023_39139_MOESM4_ESM.xlsx, sheet 23

View BVdb publication page

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Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

International Journal Of Molecular Sciences

Pretelli, Giulia G; Spagnolo, Calogera Claudia CC; Ciappina, Giuliana G; Santarpia, Mariacarmela M; Pasello, Giulia G

Publication Date: 2023-05-17

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 37240224

Variant Present in the following documents:

• Main text
• ijms-24-08878.pdf

View BVdb publication page

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[Progress in Detection of EGFR Exon 20 Insertion Mutation and Targeted Therapies 
in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Yulu Y; Chu, Tianqing T

Publication Date: 2023-02-20

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 36872052

Variant Present in the following documents:

• zgfazz-26-135.pdf

View BVdb publication page

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Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications

Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI

Publication Date: 2023-02-08

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 36755027

Variant Present in the following documents:

• 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Landscape and Predictive Significance of the Structural Classification of EGFR Mutations in Chinese NSCLCs: A Real-World Study.

Journal Of Clinical Medicine

Gu, Linping L; Huang, Huayan H; Xu, Zhangwendi Z; Niu, Xiaomin X; Li, Ziming Z; Xia, Liliang L; Yu, Yongfeng Y; Lu, Shun S

Publication Date: 2022-12-28

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 36615035

Variant Present in the following documents:

• Main text
• jcm-12-00236.pdf

View BVdb publication page

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[Consensus on Application of Third-generation EGFR-TKI in EGFR Mutated NSCLC 
(2022 Version)].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

, ; ,

Publication Date: 2022-09-20

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 36172727

Variant Present in the following documents:

• Main text
• zgfazz-25-9-627.pdf

View BVdb publication page

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Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing.

Journal Of Pathology And Translational Medicine

Lee, Jeonghyo J; Han, Yeon Bi YB; Kwon, Hyun Jung HJ; Lee, Song Kook SK; Kim, Hyojin H; Chung, Jin-Haeng JH

Publication Date: 2022-09

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 36128861

Variant Present in the following documents:

• jptm-2022-06-11.pdf

View BVdb publication page

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Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Ala763_Tyr764insPheGlnGluAla

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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EGFR Exon 20 Insertion in Metastatic Non-Small-Cell Lung Cancer: Survival and Clinical Efficacy of EGFR Tyrosine-Kinase Inhibitor and Chemotherapy.

Cancers

Chelabi, Samy S; Mignard, Xavier X; Leroy, Karen K; Monnet, Isabelle I; Brosseau, Solenn S; Theou-Anton, Nathalie N; Massiani, Marie-Ange MA; Friard, Sylvie S; Duchemann, Boris B; Fabre, Elizabeth E; Giroux-Leprieur, Etienne E; Cadranel, Jacques J; Wislez, Marie M

Publication Date: 2021-10-13

Variant appearance in text: EGFR: Ala763_Tyr764insPheGlnGluAla

PubMed Link: 34680280

Variant Present in the following documents:

• Main text
• cancers-13-05132.pdf

View BVdb publication page

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Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review).

International Journal Of Oncology

He, Jingyi J; Huang, Zhengrong Z; Han, Linzhi L; Gong, Yan Y; Xie, Conghua C

Publication Date: 2021-11

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 34558640

Variant Present in the following documents:

• Main text
• ijo-59-05-05270.pdf

View BVdb publication page

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Case Report: Afatinib Treatment in a Patient With NSCLC Harboring a Rare EGFR Exon 20 Mutation.

Frontiers In Oncology

Zöchbauer-Müller, Sabine S; Kaserer, Bettina B; Prosch, Helmut H; Cseh, Agnieszka A; Solca, Flavio F; Bauer, Markus Johann MJ; Müllauer, Leonhard L

Publication Date: 2020

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 33575211

Variant Present in the following documents:

• Main text
• fonc-10-593852.pdf

View BVdb publication page

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Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Estrada-Bernal, Adriana A; Le, Anh T AT; Doak, Andrea E AE; Tirunagaru, Vijaya G VG; Silva, Shevan S; Bull, Matthew R MR; Smaill, Jeff B JB; Patterson, Adam V AV; Kim, Chul C; Liu, Stephen V SV; Doebele, Robert C RC

Publication Date: 2021-03-01

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 33355298

Variant Present in the following documents:

• Main text

View BVdb publication page

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Impact of EGFR amplification on survival of patients with EGFR exon 20 insertion-positive non-small cell lung cancer.

Journal Of Thoracic Disease

Gao, Xin X; Wei, Xue-Wu XW; Zheng, Ming-Ying MY; Chen, Zhi-Hong ZH; Zhang, Xu-Chao XC; Zhong, Wen-Zhao WZ; Yang, Jin-Ji JJ; Wu, Yi-Long YL; Zhou, Qing Q

Publication Date: 2020-10

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 33209414

Variant Present in the following documents:

• Main text

View BVdb publication page

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Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj

Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F

Publication Date: 2020

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 33083132

Variant Present in the following documents:

• peerj-08-10069-s011.xlsx, sheet 1

View BVdb publication page

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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EGFR mutation genotypes affect efficacy and resistance mechanisms of osimertinib in T790M-positive NSCLC patients.

Translational Lung Cancer Research

Zheng, Qiufan Q; Huang, Yan Y; Zhao, Hongyun H; Yang, Yunpeng Y; Hong, Shaodong S; Hou, Xue X; Zhao, Yuanyuan Y; Ma, Yuxiang Y; Zhou, Ting T; Zhang, Yaxiong Y; Fang, Wenfeng W; Zhang, Li L

Publication Date: 2020-06

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 32676311

Variant Present in the following documents:

• Main text

View BVdb publication page

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Variability of EGFR exon 20 insertions in 24 468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors.

Molecular Oncology

Qin, YanRu Y; Jian, Hong H; Tong, Xiaoling X; Wu, Xue X; Wang, Fufeng F; Shao, Yang W YW; Zhao, Xinmin X

Publication Date: 2020-08

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 32412152

Variant Present in the following documents:

• Main text
• MOL2-14-1695.pdf

View BVdb publication page

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Oncologist uptake of comprehensive genomic profile guided targeted therapy.

Oncotarget

Nesline, Mary K MK; DePietro, Paul P; Dy, Grace K GK; Early, Amy A; Papanicolau-Sengos, Antonios A; Conroy, Jeffrey M JM; Lenzo, Felicia L FL; Glenn, Sean T ST; Chen, Hongbin H; Grand'Maison, Anne A; Boland, Patrick P; Ernstoff, Marc S MS; Puzanov, Igor I; Edge, Stephen S; Akers, Stacey S; Opyrchal, Mateusz M; Chatta, Gurkamal G; Odunsi, Kunle K; Frederick, Peter P; Lele, Shashikant S; Gardner, Mark M; Morrison, Carl C

Publication Date: 2019-07-23

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 31384390

Variant Present in the following documents:

• oncotarget-10-4616-s003.xlsx, sheet 1

View BVdb publication page

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Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Oncotarget

Illei, Peter B PB; Belchis, Deborah D; Tseng, Li-Hui LH; Nguyen, Doreen D; De Marchi, Federico F; Haley, Lisa L; Riel, Stacy S; Beierl, Katie K; Zheng, Gang G; Brahmer, Julie R JR; Askin, Frederic B FB; Gocke, Christopher D CD; Eshleman, James R JR; Forde, Patrick M PM; Lin, Ming-Tseh MT

Publication Date: 2017-11-14

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 29228562

Variant Present in the following documents:

• oncotarget-08-96684.pdf

View BVdb publication page

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Establishment of a Novel Method for Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance Mutations in Lung Cancer.

Chinese Medical Journal

Tian, Hong-Xia HX; Zhang, Xu-Chao XC; Wang, Zhen Z; Yang, Jin-Ji JJ; Guo, Wei-Bang WB; Chen, Zhi-Hong ZH; Wu, Yi-Long YL

Publication Date: 2017-06-20

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 28584208

Variant Present in the following documents:

• CMJ-130-1446.pdf

View BVdb publication page

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

View BVdb publication page

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A variant by any name: quantifying annotation discordance across tools and clinical databases.

Genome Medicine

Yen, Jennifer L JL; Garcia, Sarah S; Montana, Aldrin A; Harris, Jason J; Chervitz, Stephen S; Morra, Massimo M; West, John J; Chen, Richard R; Church, Deanna M DM

Publication Date: 2017-01-26

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 28122645

Variant Present in the following documents:

• 13073_2016_396_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma.

Oncotarget

Belchis, Deborah A DA; Tseng, Li-Hui LH; Gniadek, Thomas T; Haley, Lisa L; Lokhandwala, Parvez P; Illei, Peter P; Gocke, Christopher D CD; Forde, Patrick P; Brahmer, Julie J; Askin, Frederic B FB; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2016-07-19

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 27304188

Variant Present in the following documents:

• Main text
• oncotarget-07-45237.pdf

View BVdb publication page

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Integrated digital error suppression for improved detection of circulating tumor DNA.

Nature Biotechnology

Newman, Aaron M AM; Lovejoy, Alexander F AF; Klass, Daniel M DM; Kurtz, David M DM; Chabon, Jacob J JJ; Scherer, Florian F; Stehr, Henning H; Liu, Chih Long CL; Bratman, Scott V SV; Say, Carmen C; Zhou, Li L; Carter, Justin N JN; West, Robert B RB; Sledge, George W GW; Shrager, Joseph B JB; Loo, Billy W BW; Neal, Joel W JW; Wakelee, Heather A HA; Diehn, Maximilian M; Alizadeh, Ash A AA

Publication Date: 2016-05

Variant appearance in text: EGFR: A763_Y764insFQEA

PubMed Link: 27018799

Variant Present in the following documents:

• NIHMS764326-supplement-6.xlsx, sheet 2
• NIHMS764326-supplement-6.xlsx, sheet 1

View BVdb publication page

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