EGFR c.2303G>T ;(p.S768I)

Variant ID: 7-55249005-G-T

NM_005228.3(EGFR):c.2303G>T;(p.S768I)

This variant was identified in 963 publications

View GRCh38 version.




Publications:


Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients.

Translational Lung Cancer Research
Rehulkova, Alona A; Chudacek, Josef J; Prokopova, Andrea A; Vidlarova, Monika M; Stranska, Jana J; Drabek, Jiri J; Potockova, Jana J; Trojanec, Radek R; Vrbkova, Jana J; Skarda, Josef J; Bohanes, Tomas T; Szkorupa, Marek M; Tolmaci, Benjamin B; Klein, Jiri J; Srovnal, Josef J; Hajduch, Marian M
Publication Date: 2023-05-31

Variant appearance in text: EGFR: S768I
PubMed Link: 37323172
Variant Present in the following documents:
  • Main text
  • tlcr-12-05-1034.pdf
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Heterogeneous distribution of EGFR mutation in NSCLC: Case report.

Respiratory Medicine Case Reports
Boukansa, Sara S; Benbrahim, Zineb Z; Gamrani, Sanaa S; Mouhrach, Ismail I; El Agy, Fatima F; El Bardai, Sanae S; Bouguenouch, Laila L; Serraj, Mounia M; Amara, Bouchra B; Ouadnouni, Yassine Y; Smahi, Mohamed M; Alami, Badreeddine B; Mellas, Nawfel N; El Fatemi, Hinde H
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37251359
Variant Present in the following documents:
  • Main text
  • main.pdf
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Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

International Journal Of Molecular Sciences
Pretelli, Giulia G; Spagnolo, Calogera Claudia CC; Ciappina, Giuliana G; Santarpia, Mariacarmela M; Pasello, Giulia G
Publication Date: 2023-05-17

Variant appearance in text: EGFR: S768I
PubMed Link: 37240224
Variant Present in the following documents:
  • Main text
  • ijms-24-08878.pdf
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Advanced Non-small Cell Lung Cancer: EGFR Mutation Analysis Using Pyrosequencing and the Fully Automated qPCR-Based IdyllaTM System.

Cancer Control : Journal Of The Moffitt Cancer Center
Boustany, Youssra Y; Laraqui, Abdelilah A; El Zaitouni, Sara S; Ghaouti, Merieme M; Benzekri, Asmae A; Kettani, Fouad F; Oukabli, Mohammed M; Ennibi, Khalid K; Belkadi, Bouchra B; Sekhsokh, Yassine Y
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37196225
Variant Present in the following documents:
  • Main text
  • 10.1177_10732748231177538.pdf
View BVdb publication page



CRAC (Clinical Relevance of Alterations in Cancer): a Knowledge Base for the Selection of Molecularly Matched Therapy for Solid Tumors.

Sovremennye Tekhnologii V Meditsine
Lebedeva, A A AA; Kavun, A I AI; Veselovsky, E M EM; Mileyko, V A VA; Ivanov, M V MV
Publication Date: 2022

Variant appearance in text: EGFR: S768I
PubMed Link: 37181287
Variant Present in the following documents:
  • Main text
  • STM-14-6-02.pdf
View BVdb publication page



A real-world study of Afatinib plus ramucirumab in treatment-naïve, EGFR-mutated, non-small cell lung cancer.

Bmc Cancer
Huang, Chun-Yao CY; Huang, Hui-Li HL; Lan, Chou-Chin CC; Huang, Yi-Chih YC; Wu, Yao-Kuang YK
Publication Date: 2023-05-08

Variant appearance in text: EGFR: S768I
PubMed Link: 37158884
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10909.pdf
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Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma.

Croatian Medical Journal
Harabajsa, Suzana S; Šefčić, Hajdi H; Klasić, Marija M; Milavić, Marija M; Židovec Lepej, Snježana S; Grgić, Ivana I; Zajc Petranović, Matea M; Jakopović, Marko M; Smojver-Ježek, Silvana S; Korać, Petra P
Publication Date: 2023-04-30

Variant appearance in text: EGFR: S768I
PubMed Link: 37131310
Variant Present in the following documents:
  • Main text
  • CroatMedJ_64_0084.pdf
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Clinical Outcomes of Afatinib Versus Osimertinib in Patients With Non-Small Cell Lung Cancer With Uncommon EGFR Mutations: A Pooled Analysis.

The Oncologist
Wang, Chunsheng C; Zhao, Kewei K; Hu, Shanliang S; Dong, Wei W; Gong, Yan Y; Xie, Conghua C
Publication Date: 2023-04-28

Variant appearance in text: EGFR: S768I
PubMed Link: 37116899
Variant Present in the following documents:
  • Main text
  • oyad111.pdf
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Structure-Activity Relationship Studies Based on Quinazoline Derivatives as EGFR Kinase Inhibitors (2017-Present).

Pharmaceuticals (Basel, Switzerland)
Șandor, Alexandru A; Ionuț, Ioana I; Marc, Gabriel G; Oniga, Ilioara I; Eniu, Dan D; Oniga, Ovidiu O
Publication Date: 2023-04-03

Variant appearance in text: EGFR: S768I
PubMed Link: 37111291
Variant Present in the following documents:
  • Main text
  • pharmaceuticals-16-00534.pdf
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Challenges of EGFR-TKIs in NSCLC and the potential role of herbs and active compounds: From mechanism to clinical practice.

Frontiers In Pharmacology
Song, Xiaotong X; Cao, Luchang L; Ni, Baoyi B; Wang, Jia J; Qin, Xiaoyan X; Sun, Xiaoyue X; Xu, Bowen B; Wang, Xinmiao X; Li, Jie J
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37089959
Variant Present in the following documents:
  • Main text
  • fphar-14-1090500.pdf
View BVdb publication page



Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer.

Technology In Cancer Research & Treatment
Yu, Limeng L; Wang, Ruilin R; Zhao, Yuhua Y; Wu, Yingxi Y; Wang, Lili L; Chen, Haiyang H; He, Zhen Z; Wang, Qiming Q; Wu, Yufeng Y
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37078129
Variant Present in the following documents:
  • Main text
  • 10.1177_15330338231168466.pdf
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Guidance for clinicians and patients with non-small cell lung cancer in the time of precision medicine.

Frontiers In Oncology
Villaruz, Liza C LC; Socinski, Mark A MA; Weiss, Jared J
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37077826
Variant Present in the following documents:
  • Main text
  • fonc-13-1124167.pdf
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Ultra-rapid Idylla™ EGFR mutation screening followed by next-generation sequencing: An integrated solution to molecular diagnosis of non-small cell lung cancer.

Frontiers In Oncology
Qiu, Tian T; Zhang, Fanshuang F; Zheng, Bo B; Feng, Zitong Z; Li, Weihua W; Zeng, Hua H; Chu, Lixia L; Ying, Jianming J
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37064089
Variant Present in the following documents:
  • Main text
  • fonc-13-1064487.pdf
View BVdb publication page



Biomarker expression and survival in patients with non-small cell lung cancer receiving adjuvant chemotherapy in Denmark.

Plos One
Dalvi, Tapashi T; Nørgaard, Mette M; Fryzek, Jon P JP; Movva, Naimisha N; Pedersen, Lars L; Pham Hansen, Hanh H; Walker, Jill J; Midha, Anita A; Shire, Norah N; Boothman, Anne-Marie AM; Rigas, James J; Mellemgaard, Anders A; Rasmussen, Torben R TR; Hamilton-Dutoit, Stephen S; Cronin-Fenton, Deirdre D
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37040387
Variant Present in the following documents:
  • Main text
  • pone.0284037.pdf
View BVdb publication page



[A Real-world Study on the Expression Characteristics of PD-L1 in Patients 
with Advanced EGFR Positive NSCLC and Its Relationship with the 
Therapeutic Efficacy of EGFR-TKIs].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Chen, Ran R; Gao, Xiang X; Xu, Fudong F; Zhang, Shucai S; Ma, Li L; Hu, Bo B
Publication Date: 2023-03-20

Variant appearance in text: EGFR: S768I
PubMed Link: 37035884
Variant Present in the following documents:
  • zgfazz-26-3-217.pdf
View BVdb publication page



Immune profiles according to EGFR mutant subtypes and correlation with PD-1/PD-L1 inhibitor therapies in lung adenocarcinoma.

Frontiers In Immunology
Koh, Young Wha YW; Park, Bumhee B; Jung, Se Hee SH; Han, Jae-Ho JH; Haam, Seokjin S; Lee, Hyun Woo HW
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 37033978
Variant Present in the following documents:
  • Main text
  • fimmu-14-1137880.pdf
View BVdb publication page



T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma.

Tanaffos
Mirtavoos-Mahyari, Hanifeh H; Abbasi Dezfouli, Azizollah A; Esfahani-Monfared, Zahra Z; Khosravi, Adnan A; Seifi, Sharareh S; Sheikhy, Kambiz K
Publication Date: 2022-03

Variant appearance in text: EGFR: S768I
PubMed Link: 37025321
Variant Present in the following documents:
  • Main text
  • Tanaffos-21-376.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: EGFR: S768I
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
View BVdb publication page



Precision targeted therapy for EGFR mutation-positive NSCLC: Dilemmas and coping strategies.

Thoracic Cancer
Meng, Ying Y; Bai, Rilan R; Cui, Jiuwei J
Publication Date: 2023-04-02

Variant appearance in text: EGFR: S768I
PubMed Link: 37005552
Variant Present in the following documents:
  • Main text
  • TCA-14-1121.pdf
View BVdb publication page



Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer
Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J
Publication Date: 2023-03-31

Variant appearance in text: EGFR: Ser768Ile
PubMed Link: 37004022
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10674.pdf
View BVdb publication page



Impact of Molecular Testing Using Next-Generation Sequencing in the Clinical Management of Patients with Non-Small Cell Lung Cancer in a Public Healthcare Hospital.

Cancers
Simarro, Javier J; Pérez-Simó, Gema G; Mancheño, Nuria N; Ansotegui, Emilio E; Muñoz-Núñez, Carlos Francisco CF; Gómez-Codina, José J; Juan, Óscar Ó; Palanca, Sarai S
Publication Date: 2023-03-10

Variant appearance in text: EGFR: Ser768Ile
PubMed Link: 36980591
Variant Present in the following documents:
  • cancers-15-01705.pdf
View BVdb publication page



Trends in Survival Rates of Non-Small Cell Lung Cancer With Use of Molecular Testing and Targeted Therapy in Korea, 2010-2020.

Jama Network Open
Chi, Sang Ah SA; Yu, Hyeyeon H; Choi, Yoon-La YL; Park, Sehhoon S; Sun, Jong-Mu JM; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Choi, Dae-Ho DH; Kim, Kyunga K; Jung, Hyun Ae HA; Park, Keunchil K
Publication Date: 2023-03-01

Variant appearance in text: EGFR: S768I
PubMed Link: 36929402
Variant Present in the following documents:
  • Main text
View BVdb publication page



Monitoring of T790M in plasma ctDNA of advanced EGFR-mutant NSCLC patients on first- or second-generation tyrosine kinase inhibitors.

Bmc Cancer
Huang, Chun-Ta CT; Lin, Chih-An CA; Su, Te-Jen TJ; Yang, Ching-Yao CY; Tsai, Tzu-Hsiu TH; Hsu, Chia-Lin CL; Liao, Wei-Yu WY; Chen, Kuan-Yu KY; Ho, Chao-Chi CC; Yu, Chong-Jen CJ
Publication Date: 2023-03-13

Variant appearance in text: EGFR: S768I
PubMed Link: 36915101
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10698.pdf
View BVdb publication page



Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Frontiers In Oncology
He, Ping P; Liu, Jie J; Xu, Qingyuan Q; Ma, Huaijun H; Niu, Beifang B; Huang, Gang G; Wu, Wei W
Publication Date: 2023

Variant appearance in text: EGFR: 2303G>T; S768I; rs121913465
PubMed Link: 36910641
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 8
View BVdb publication page



A single-arm, multicenter, phase II trial of osimertinib in patients with epidermal growth factor receptor exon 18 G719X, exon 20 S768I, or exon 21 L861Q mutations.

Esmo Open
Villaruz, L C LC; Wang, X X; Bertino, E M EM; Gu, L L; Antonia, S J SJ; Burns, T F TF; Clarke, J J; Crawford, J J; Evans, T L TL; Friedland, D M DM; Otterson, G A GA; Ready, N E NE; Wozniak, A J AJ; Stinchcombe, T E TE
Publication Date: 2023-03-09

Variant appearance in text: EGFR: S768I
PubMed Link: 36905787
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Cancers
Suthapot, Praewa P; Chiangjong, Wararat W; Chaiyawat, Parunya P; Choochuen, Pongsakorn P; Pruksakorn, Dumnoensun D; Sangkhathat, Surasak S; Hongeng, Suradej S; Anurathapan, Usanarat U; Chutipongtanate, Somchai S
Publication Date: 2023-02-23

Variant appearance in text: EGFR: S768I
PubMed Link: 36900212
Variant Present in the following documents:
  • Main text
  • cancers-15-01418.pdf
View BVdb publication page



Healthcare coverage affects survival of EGFR-mutant Thai lung cancer patients.

Frontiers In Oncology
Khiewngam, Khantong K; Oranratnachai, Songporn S; Kamprerasart, Kaettipong K; Kunakorntham, Patratorn P; Sanvarinda, Pimtip P; Trachu, Narumol N; Pimsa, Pongput P; Wiwitkeyoonwong, Jirapath J; Thamrongjirapat, Thanaporn T; Dejthevaporn, Thitiya T; Sirachainan, Ekaphop E; Reungwetwattana, Thanyanan T
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 36895484
Variant Present in the following documents:
  • Main text
  • fonc-13-1047644.pdf
View BVdb publication page



Osimertinib in NSCLC With Atypical EGFR-Activating Mutations: A Retrospective Multicenter Study.

Jto Clinical And Research Reports
Ji, Jingran J; Aredo, Jacqueline V JV; Piper-Vallillo, Andrew A; Huppert, Laura L; Rotow, Julia K JK; Husain, Hatim H; Stewart, Susan S; Cobb, Rosemary R; Wakelee, Heather A HA; Blakely, Collin M CM; Wong, Melisa L ML; Gubens, Matthew A MA; Madani, Mohammad H MH; Digumarthy, Subba R SR; McCoach, Caroline C; Piotrowska, Zofia Z; Neal, Joel W JW; Riess, Jonathan W JW
Publication Date: 2023-03

Variant appearance in text: EGFR: S768I
PubMed Link: 36879929
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Organoid drug screening report for a non-small cell lung cancer patient with EGFR gene mutation negativity: A case report and review of the literature.

Frontiers In Oncology
Pan, Yuetian Y; Cui, Hongshang H; Song, Yongbin Y
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 36874139
Variant Present in the following documents:
  • Main text
  • fonc-13-1109274.pdf
View BVdb publication page



[Progress in Detection of EGFR Exon 20 Insertion Mutation and Targeted Therapies 
in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Wang, Yulu Y; Chu, Tianqing T
Publication Date: 2023-02-20

Variant appearance in text: EGFR: S768I
PubMed Link: 36872052
Variant Present in the following documents:
  • zgfazz-26-135.pdf
View BVdb publication page



Nanotechnology - a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer.

Beilstein Journal Of Nanotechnology
Gorachinov, Filip F; Mraiche, Fatima F; Moustafa, Diala Alhaj DA; Hishari, Ola O; Ismail, Yomna Y; Joseph, Jensa J; Crcarevska, Maja Simonoska MS; Dodov, Marija Glavas MG; Geskovski, Nikola N; Goracinova, Katerina K
Publication Date: 2023

Variant appearance in text: EGFR: S768I
PubMed Link: 36865093
Variant Present in the following documents:
  • Beilstein_J_Nanotechnol-14-240.pdf
View BVdb publication page



Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: a real-world study.

Bmc Cancer
Sun, Haiyan H; Ren, Peng P; Chen, Yongzi Y; Lan, Lan L; Yan, Zhuchen Z; Yang, Yinli Y; Wang, Bin B; Wang, Cong C; Li, Yanwei Y; Li, Ling L; Zhang, Yu Y; Li, Yanyang Y; Wang, Zuolin Z; Pan, Zhanyu Z; Jiang, Zhansheng Z
Publication Date: 2023-03-02

Variant appearance in text: EGFR: S768I
PubMed Link: 36864384
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10637.pdf
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: EGFR: S768I
PubMed Link: 36862804
Variant Present in the following documents:
  • 1116.pdf
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6
View BVdb publication page



Real-world clinical analysis in 190 advanced NSCLC patients with uncommon EGFR mutations: A multi-center study.

Cancer Science
Qin, Yi Y; Long, Yaling Y; Tang, Yuan Y; Tian, Yuke Y; Li, Juan J; Duan, Ping P; Luo, Jieyan J; Yu, Min M; Li, Yanying Y; Zhou, Xiaojuan X; Wang, Ke K; Gong, Youling Y; Peng, Feng F; Zhu, Jiang J; Liu, Yongmei Y; Zhou, Lin L; Lu, You Y; Huang, Meijuan M
Publication Date: 2023-02-27

Variant appearance in text: EGFR: S768I
PubMed Link: 36851884
Variant Present in the following documents:
  • Main text
  • CAS-114-2552.pdf
  • CAS-114-2552-s001.pdf
View BVdb publication page



Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications
Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS
Publication Date: 2023-02-27

Variant appearance in text: EGFR: S768I
PubMed Link: 36849494
Variant Present in the following documents:
  • 41467_2023_35961_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page