Publications:

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Identification of EGFR mutation status in male patients with non-small-cell lung cancer: role of 18F-FDG PET/CT and serum tumor markers CYFRA21-1 and SCC-Ag.

Ejnmmi Research

Jiang, Maoqing M; Chen, Ping P; Guo, Xiuyu X; Zhang, Xiaohui X; Gao, Qiaoling Q; Zhang, Jingfeng J; Zhao, Guofang G; Zheng, Jianjun J

Publication Date: 2023-04-04

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 37014455

Variant Present in the following documents:

• 13550_2023_Article_976.pdf

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[Progress in Detection of EGFR Exon 20 Insertion Mutation and Targeted Therapies 
in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Yulu Y; Chu, Tianqing T

Publication Date: 2023-02-20

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 36872052

Variant Present in the following documents:

• zgfazz-26-135.pdf

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Pan-cancer molecular analysis of EGFR large fragment deletion in the Asian population.

Cancer Medicine

Pu, Jun J; Guo, Huannan H; Yu, Ruoying R; Ou, Qiuxiang Q; Bao, Hua H; Wu, Xue X; Tang, Sanyuan S; Chang, Qingyong Q

Publication Date: 2023-01-09

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 36622089

Variant Present in the following documents:

• CAM4-12-8083-s006.xlsx, sheet 1

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EGFR exon 20 insertion variants A763_Y764insFQEA and D770delinsGY confer favorable sensitivity to currently approved EGFR-specific tyrosine kinase inhibitors.

Frontiers In Pharmacology

Yang, Guangjian G; Yang, Yaning Y; Hu, Jiaqi J; Xu, Haiyan H; Zhang, Shuyang S; Wang, Yan Y

Publication Date: 2022

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 36425568

Variant Present in the following documents:

• Main text
• fphar-13-984503.pdf

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Frequency, underdiagnosis, and heterogeneity of epidermal growth factor receptor exon 20 insertion mutations using real-world genomic datasets.

Molecular Oncology

Viteri, Santiago S; Minchom, Anna A; Bazhenova, Lyudmila L; Ou, Sai-Hong Ignatius SI; Bauml, Joshua M JM; Shell, Scott A SA; Schaffer, Michael M; Gu, Junchen J; Rose, Jennifer B JB; Curtin, Joshua C JC; Mahadevia, Parthiv P; Girard, Nicolas N

Publication Date: 2022-10-21

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 36269676

Variant Present in the following documents:

• MOL2-17-230.pdf

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Amivantamab in the Treatment of Metastatic NSCLC: Patient Selection and Special Considerations.

Oncotargets And Therapy

Petrini, Iacopo I; Giaccone, Giuseppe G

Publication Date: 2022

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 36246734

Variant Present in the following documents:

• Main text
• ott-15-1197.pdf

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First-line immunotherapy or angiogenesis inhibitor combined with chemotherapy for advanced non-small cell lung cancer with EGFR exon 20 insertions: Real-world evidence from China.

Cancer Medicine

Yang, Guangjian G; Yang, Yaning Y; Liu, Runze R; Li, Weihua W; Xu, Haiyan H; Hao, Xuezhi X; Li, Junling J; Zhang, Shuyang S; Xu, Fei F; Lei, Siyu S; Wang, Yan Y

Publication Date: 2022-05-24

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 35608132

Variant Present in the following documents:

• Main text
• CAM4-12-335.pdf

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[Advances in Treatment of Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Yang, Xue X; Zhao, Jun J

Publication Date: 2022-05-20

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 35599009

Variant Present in the following documents:

• Main text
• zgfazz-25-5-337.pdf

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EGFR exon 20 insertion mutations in non-small cell lung cancer.

Translational Cancer Research

Wang, Fenfang F; Li, Chenghui C; Wu, Qihuan Q; Lu, Hongyang H

Publication Date: 2020-04

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 35117654

Variant Present in the following documents:

• Main text

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EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma.

Cancers

Pacini, Laura L; Cabal, Virginia N VN; Hermsen, Mario A MA; Huang, Paul H PH

Publication Date: 2022-01-13

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 35053553

Variant Present in the following documents:

• Main text
• cancers-14-00394.pdf

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EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma.

Cancers

Pacini, Laura L; Cabal, Virginia N VN; Hermsen, Mario A MA; Huang, Paul H PH

Publication Date: 2022-01-13

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 35053553

Variant Present in the following documents:

• Main text
• cancers-14-00394.pdf

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Spotlight on Amivantamab (JNJ-61186372) for EGFR Exon 20 Insertions Positive Non-Small Cell Lung Cancer.

Lung Cancer (Auckland, N.Z.)

Brazel, Danielle D; Nagasaka, Misako M

Publication Date: 2021

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 34880698

Variant Present in the following documents:

• Main text
• lctt-12-133.pdf

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Treatment Outcomes and Safety of Mobocertinib in Platinum-Pretreated Patients With EGFR Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer: A Phase 1/2 Open-label Nonrandomized Clinical Trial.

Jama Oncology

Zhou, Caicun C; Ramalingam, Suresh S SS; Kim, Tae Min TM; Kim, Sang-We SW; Yang, James Chih-Hsin JC; Riely, Gregory J GJ; Mekhail, Tarek T; Nguyen, Danny D; Garcia Campelo, Maria R MR; Felip, Enriqueta E; Vincent, Sylvie S; Jin, Shu S; Griffin, Celina C; Bunn, Veronica V; Lin, Jianchang J; Lin, Huamao M HM; Mehta, Minal M; Jänne, Pasi A PA

Publication Date: 2021-12-01

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 34647988

Variant Present in the following documents:

• jamaoncol-e214761-s003.pdf

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Not All EGFR Exon 20 Insertions Are Created Equal.

Jto Clinical And Research Reports

Lin, Yen-Ting YT; Shih, Jin-Yuan JY

Publication Date: 2020-09

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 34589951

Variant Present in the following documents:

• Main text

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Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective.

Pharmaceutics

Zhu, Jing J; Yang, Qian Q; Xu, Weiguo W

Publication Date: 2021-09-18

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 34575576

Variant Present in the following documents:

• Main text
• pharmaceutics-13-01500.pdf

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

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Activity of tarloxotinib-E in cells with EGFR exon-20 insertion mutations and mechanisms of acquired resistance.

Thoracic Cancer

Nishino, Masaya M; Suda, Kenichi K; Koga, Takamasa T; Ohara, Shuta S; Fujino, Toshio T; Soh, Junichi J; Tirunagaru, Vijaya V; Vellanki, Avanish A; Doebele, Robert C RC; Mitsudomi, Tetsuya T

Publication Date: 2021-05

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 33710795

Variant Present in the following documents:

• Main text
• TCA-12-1511.pdf

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Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with EGFR exon 20 insertion mutation: a multicenter study.

Translational Lung Cancer Research

Xu, Chun-Wei CW; Wang, Wen-Xian WX; Wang, Dong D; Wang, Qi-Ming QM; Pu, Xing-Xiang XX; Zhu, You-Cai YC; Huang, Jian-Hui JH; Yu, Zong-Yang ZY; Cui, Zhao-Lei ZL; Chen, Xiao-Hui XH; Li, Jin-Luan JL; Fang, Yong Y; Wang, Hong H; Zhuang, Wu W; Lan, Shi-Jie SJ; Cai, Xin X; Zhang, Yin-Bin YB; Gao, Wen-Bin WB; Wang, Li-Ping LP; She, Ke-Lin KL; Rao, Chuang-Zhou CZ; Zhou, Yue-Fen YF; Fang, Mei-Yu MY; Miao, Li-Yun LY; Lei, Lei L; Lv, Tang-Feng TF; Song, Yong Y

Publication Date: 2020-10

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 33209607

Variant Present in the following documents:

• tlcr-09-05-1853.pdf

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Poor effect of osimertinib on EGFR exon 20 insertion-positive lung adenocarcinoma: A case report.

Medicine

Inagaki, Yuji Y; Tamiya, Akihiro A; Matsuda, Yoshinobu Y; Azuma, Kouji K; Adachi, Yuichi Y; Enomoto, Takatoshi T; Kouno, Shunichi S; Taniguchi, Yoshihiko Y; Saijo, Nobuhiko N; Okishio, Kyoichi K; Atagi, Shinji S

Publication Date: 2020-10-16

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 33080698

Variant Present in the following documents:

• Main text
• medi-99-e22628.pdf

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Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations.

Oncotargets And Therapy

Lin, Ling L; Wu, Xiaomai X; Yan, Shuangquan S; Zhu, Yefei Y; Yan, Zhengqing Z; Lv, Dongqing D; Ge, Hongfei H

Publication Date: 2020

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 33061454

Variant Present in the following documents:

• Main text
• ott-13-9753.pdf

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[Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Zhou, Wensheng W; Zhang, Wei W; Han, Baohui B

Publication Date: 2020-02-20

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 32093456

Variant Present in the following documents:

• Main text
• zgfazz-23-2-118.pdf

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Potential mechanism of primary resistance to icotinib in patients with advanced non-small cell lung cancer harboring uncommon mutant epidermal growth factor receptor: A multi-center study.

Cancer Science

Lei, Lei L; Wang, Wen-Xian WX; Zhu, You-Cai YC; Li, Jin-Luan JL; Fang, Yong Y; Wang, Hong H; Zhuang, Wu W; Zhang, Yin-Bin YB; Wang, Li-Ping LP; Fang, Mei-Yu MY; Xu, Chun-Wei CW; Wang, Xiao-Jia XJ; Lv, Tang-Feng TF; Song, Yong Y

Publication Date: 2020-02

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 31828849

Variant Present in the following documents:

• Main text
• CAS-111-679.pdf

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Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer.

Seminars In Cancer Biology

Harrison, Peter T PT; Vyse, Simon S; Huang, Paul H PH

Publication Date: 2020-04

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 31562956

Variant Present in the following documents:

• Main text
• main.pdf

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Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer.

Signal Transduction And Targeted Therapy

Vyse, Simon S; Huang, Paul H PH

Publication Date: 2019

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 30854234

Variant Present in the following documents:

• Main text
• 41392_2019_Article_38.pdf

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Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.

Nature Medicine

Robichaux, Jacqulyne P JP; Elamin, Yasir Y YY; Tan, Zhi Z; Carter, Brett W BW; Zhang, Shuxing S; Liu, Shengwu S; Li, Shuai S; Chen, Ting T; Poteete, Alissa A; Estrada-Bernal, Adriana A; Le, Anh T AT; Truini, Anna A; Nilsson, Monique B MB; Sun, Huiying H; Roarty, Emily E; Goldberg, Sarah B SB; Brahmer, Julie R JR; Altan, Mehmet M; Lu, Charles C; Papadimitrakopoulou, Vassiliki V; Politi, Katerina K; Doebele, Robert C RC; Wong, Kwok-Kin KK; Heymach, John V JV

Publication Date: 2018-05

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 29686424

Variant Present in the following documents:

• Main text

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Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors.

Cancer Research

Kosaka, Takayuki T; Tanizaki, Junko J; Paranal, Raymond M RM; Endoh, Hideki H; Lydon, Christine C; Capelletti, Marzia M; Repellin, Claire E CE; Choi, Jihyun J; Ogino, Atsuko A; Calles, Antonio A; Ercan, Dalia D; Redig, Amanda J AJ; Bahcall, Magda M; Oxnard, Geoffrey R GR; Eck, Michael J MJ; Jänne, Pasi A PA

Publication Date: 2017-05-15

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 28363995

Variant Present in the following documents:

• Main text

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Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Oxnard, Geoffrey R GR; Lo, Peter C PC; Nishino, Mizuki M; Dahlberg, Suzanne E SE; Lindeman, Neal I NI; Butaney, Mohit M; Jackman, David M DM; Johnson, Bruce E BE; Jänne, Pasi A PA

Publication Date: 2013-02

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 23328547

Variant Present in the following documents:

• Main text

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Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Jänne, Pasi A PA; Boss, David S DS; Camidge, D Ross DR; Britten, Carolyn D CD; Engelman, Jeffrey A JA; Garon, Edward B EB; Guo, Feng F; Wong, Steven S; Liang, Jane J; Letrent, Stephen S; Millham, Robert R; Taylor, Ian I; Eckhardt, S Gail SG; Schellens, Jan H M JH

Publication Date: 2011-03-01

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 21220471

Variant Present in the following documents:

• Main text

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Characterization of epidermal growth factor receptor mutations in non-small-cell lung cancer patients of African-American ancestry.

Oncogene

Harada, T T; Lopez-Chavez, A A; Xi, L L; Raffeld, M M; Wang, Y Y; Giaccone, G G

Publication Date: 2011-04-14

Variant appearance in text: EGFR: D770delinsGY

PubMed Link: 21132006

Variant Present in the following documents:

• Main text

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