Publications:

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Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

International Journal Of Molecular Sciences

Pretelli, Giulia G; Spagnolo, Calogera Claudia CC; Ciappina, Giuliana G; Santarpia, Mariacarmela M; Pasello, Giulia G

Publication Date: 2023-05-17

Variant appearance in text: EGFR: H773Y

PubMed Link: 37240224

Variant Present in the following documents:

• Main text
• ijms-24-08878.pdf

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Characterization of driver mutations in Chinese non-small cell lung cancer patients using a novel targeted sequencing panel.

Journal Of Thoracic Disease

Zhao, Jing J; Wu, Yang Y; Chen, Min-Jiang MJ; Xu, Yan Y; Zhong, Wei W; Wang, Meng-Zhao MZ

Publication Date: 2022-12

Variant appearance in text: EGFR: H773Y

PubMed Link: 36647494

Variant Present in the following documents:

• Main text
• jtd-14-12-4669.pdf

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Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene

Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S

Publication Date: 2022-04

Variant appearance in text: EGFR: H773Y

PubMed Link: 35304574

Variant Present in the following documents:

• 41388_2022_Article_2263.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: H773Y

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: His773Tyr

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

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Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine

Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z

Publication Date: 2021-10

Variant appearance in text: EGFR: His773Tyr

PubMed Link: 34599863

Variant Present in the following documents:

• CAM4-10-7360-s002.xlsx, sheet 2

View BVdb publication page

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Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature

Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV

Publication Date: 2021-09

Variant appearance in text: EGFR: 2317C>T; H773Y

PubMed Link: 34526717

Variant Present in the following documents:

• 41586_2021_3898_MOESM1_ESM.pdf

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Durable response to immunotherapy plus chemotherapy in a patient with untreated, brain-metastatic, EGFR exon 20 insertion mutation lung adenocarcinoma: A case report.

Medicine

Nong, Jingying J; Gu, Yanfei Y; Yao, Shuyang S; Zhang, Yi Y

Publication Date: 2021-07-23

Variant appearance in text: EGFR: H773Y

PubMed Link: 34398022

Variant Present in the following documents:

• Main text

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Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress.

Cancers

Napolitano, Virginia V; Russo, Daniela D; Morra, Francesco F; Merolla, Francesco F; Varricchio, Silvia S; Ilardi, Gennaro G; Di Crescenzo, Rosa Maria RM; Martino, Francesco F; Mascolo, Massimo M; Celetti, Angela A; Tamagnone, Luca L; Staibano, Stefania S

Publication Date: 2021-07-29

Variant appearance in text: EGFR: H773Y

PubMed Link: 34359721

Variant Present in the following documents:

• Main text
• cancers-13-03822.pdf

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Diving into the Pleural Fluid: Liquid Biopsy for Metastatic Malignant Pleural Effusions.

Cancers

Sorolla, Maria Alba MA; Sorolla, Anabel A; Parisi, Eva E; Salud, Antonieta A; Porcel, José M JM

Publication Date: 2021-06-04

Variant appearance in text: EGFR: H773Y

PubMed Link: 34199799

Variant Present in the following documents:

• Main text
• cancers-13-02798.pdf

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: H773Y

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Molecular features of lung adenocarcinoma in young patients.

Bmc Cancer

Chen, Zhen Z; Teng, Xiao X; Zhang, Jing J; Huang, Ke K; Shen, Qian Q; Cao, He H; Luo, Huisong H; Yuan, Yanting Y; Teng, Xiaodong X

Publication Date: 2019-08-06

Variant appearance in text: EGFR: H773Y

PubMed Link: 31387567

Variant Present in the following documents:

• Main text
• 12885_2019_Article_5978.pdf

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DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Ebiomedicine

Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P

Publication Date: 2019-01

Variant appearance in text: EGFR: His773Tyr

PubMed Link: 30578081

Variant Present in the following documents:

• mmc1.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: EGFR: H773Y

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 3

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AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors.

Oncotarget

Silva-Oliveira, Renato José RJ; Melendez, Matias M; Martinho, Olga O; Zanon, Maicon F MF; de Souza Viana, Luciano L; Carvalho, André Lopes AL; Reis, Rui Manuel RM

Publication Date: 2017-08-08

Variant appearance in text: EGFR: H773Y

PubMed Link: 28881811

Variant Present in the following documents:

• Main text
• oncotarget-08-53288.pdf

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Lung adenocarcinoma patients of young age have lower EGFR mutation rate and poorer efficacy of EGFR tyrosine kinase inhibitors.

Erj Open Research

Wu, Shang-Gin SG; Chang, Yih-Leong YL; Yu, Chong-Jen CJ; Yang, Pan-Chyr PC; Shih, Jin-Yuan JY

Publication Date: 2017-07

Variant appearance in text: EGFR: H773Y

PubMed Link: 28717642

Variant Present in the following documents:

• Main text
• 00092-2016.pdf

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Compound EGFR mutation is frequently detected with co-mutations of actionable genes and associated with poor clinical outcome in lung adenocarcinoma.

Cancer Biology & Therapy

Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS

Publication Date: 2016

Variant appearance in text: EGFR: H773Y

PubMed Link: 26785607

Variant Present in the following documents:

• Main text
• kcbt-17-03-1139235.pdf

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Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.

Bmc Cancer

Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS

Publication Date: 2016-01-18

Variant appearance in text: EGFR: 2317C>T

PubMed Link: 26782967

Variant Present in the following documents:

• 12885_2016_2049_MOESM1_ESM.xlsx, sheet 1

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Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One

Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M

Publication Date: 2015

Variant appearance in text: EGFR: H773Y

PubMed Link: 26010451

Variant Present in the following documents:

• pone.0127146.s014.xlsx, sheet 3

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A novel insertion mutation on exon 20 of epidermal growth factor receptor, conferring resistance to erlotinib.

Case Reports In Oncology

Khan, Nawazish A NA; Mirshahidi, Saied S; Mirshahidi, Hamid R HR

Publication Date: 2014-05

Variant appearance in text: EGFR: H773Y

PubMed Link: 25202264

Variant Present in the following documents:

• Main text
• cro-0007-0491.pdf

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The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma.

Yonsei Medical Journal

Kim, Hye Ryun HR; Ahn, Jung Ryun JR; Lee, Jin Gu JG; Bang, Doo Hee DH; Ha, Sang-Jun SJ; Hong, Yun Kyoung YK; Kim, Sun Mi SM; Nam, Ki Chang KC; Rha, Sun Young SY; Soo, Ross A RA; Riely, Gregory J GJ; Kim, Joo Hang JH; Cho, Byoung Chul BC

Publication Date: 2013-07

Variant appearance in text: EGFR: His773Tyr

PubMed Link: 23709419

Variant Present in the following documents:

• ymj-54-865.pdf

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EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.

Molecular Cancer Therapeutics

Arcila, Maria E ME; Nafa, Khedoudja K; Chaft, Jamie E JE; Rekhtman, Natasha N; Lau, Christopher C; Reva, Boris A BA; Zakowski, Maureen F MF; Kris, Mark G MG; Ladanyi, Marc M

Publication Date: 2013-02

Variant appearance in text: EGFR: H773Y

PubMed Link: 23371856

Variant Present in the following documents:

• Main text

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DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Yeh, Paul P; Chen, Heidi H; Andrews, Jenny J; Naser, Riyad R; Pao, William W; Horn, Leora L

Publication Date: 2013-04-01

Variant appearance in text: EGFR: H773Y

PubMed Link: 23344264

Variant Present in the following documents:

• Main text

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Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Wheler, J J JJ; Falchook, G S GS; Tsimberidou, A M AM; Hong, D S DS; Naing, A A; Piha-Paul, S A SA; Chen, S S SS; Fu, S S; Stephen, B B; Fok, J Y JY; Janku, F F; Kurzrock, R R

Publication Date: 2013-03

Variant appearance in text: EGFR: H773Y

PubMed Link: 23139256

Variant Present in the following documents:

• Main text

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