EGFR c.2320_2321insCACATG ;(p.H773_V774insAH)

Variant ID: 7-55249021-C-CGCACAT

NM_005228.3(EGFR):c.2320_2321insCACATG;(p.H773_V774insAH)

This variant was identified in 7 publications

View GRCh38 version.




Publications:


Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer.

Nature Communications
Zhao, Shen S; Zhuang, Wu W; Han, Baohui B; Song, Zhengbo Z; Guo, Wei W; Luo, Feng F; Wu, Lin L; Hu, Yi Y; Wang, Huijuan H; Dong, Xiaorong X; Jiang, Da D; Wang, Mingxia M; Miao, Liyun L; Wang, Qian Q; Zhang, Junping J; Fu, Zhenming Z; Huang, Yihua Y; Xu, Chunwei C; Hu, Longyu L; Li, Lei L; Hu, Rong R; Yang, Yang Y; Li, Mengke M; Yang, Xiugao X; Zhang, Li L; Huang, Yan Y; Fang, Wenfeng W
Publication Date: 2023-06-12

Variant appearance in text: EGFR: H773_V774insAH
PubMed Link: 37308490
Variant Present in the following documents:
  • 41467_2023_39139_MOESM4_ESM.xlsx, sheet 23
View BVdb publication page



EGFR Exon 20 Insertion in Metastatic Non-Small-Cell Lung Cancer: Survival and Clinical Efficacy of EGFR Tyrosine-Kinase Inhibitor and Chemotherapy.

Cancers
Chelabi, Samy S; Mignard, Xavier X; Leroy, Karen K; Monnet, Isabelle I; Brosseau, Solenn S; Theou-Anton, Nathalie N; Massiani, Marie-Ange MA; Friard, Sylvie S; Duchemann, Boris B; Fabre, Elizabeth E; Giroux-Leprieur, Etienne E; Cadranel, Jacques J; Wislez, Marie M
Publication Date: 2021-10-13

Variant appearance in text: EGFR: His773_Val774insAlaHis
PubMed Link: 34680280
Variant Present in the following documents:
  • Main text
  • cancers-13-05132.pdf
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: His773_Val774insAlaHis
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: His773_Val774insAlaHis
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Variability of EGFR exon 20 insertions in 24 468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors.

Molecular Oncology
Qin, YanRu Y; Jian, Hong H; Tong, Xiaoling X; Wu, Xue X; Wang, Fufeng F; Shao, Yang W YW; Zhao, Xinmin X
Publication Date: 2020-08

Variant appearance in text: EGFR: H773_V774insAH
PubMed Link: 32412152
Variant Present in the following documents:
  • Main text
  • MOL2-14-1695.pdf
View BVdb publication page



Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Plos One
Grosse, Claudia C; Soltermann, Alex A; Rechsteiner, Markus M; Grosse, Alexandra A
Publication Date: 2019

Variant appearance in text: EGFR: 2320_2321insCACATG; H773_V774insAH
PubMed Link: 31386689
Variant Present in the following documents:
  • Main text
  • pone.0220691.pdf
View BVdb publication page



Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas.

Cancers
Gao, Ya Y; Vallentgoed, Wies R WR; French, Pim J PJ
Publication Date: 2018-12-04

Variant appearance in text: EGFR: H773_V774insAH
PubMed Link: 30518123
Variant Present in the following documents:
  • Main text
  • cancers-10-00489.pdf
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: EGFR: H773_V774insAH
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page