Publications:

Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene

Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S

Publication Date: 2022-04

Variant appearance in text: EGFR: L777Q

PubMed Link: 35304574

Variant Present in the following documents:

• 41388_2022_Article_2263.pdf

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A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Cancers

Koopman, Bart B; Cajiao Garcia, Betzabel N BN; Kuijpers, Chantal C H J CCHJ; Damhuis, Ronald A M RAM; van der Wekken, Anthonie J AJ; Groen, Harry J M HJM; Schuuring, Ed E; Willems, Stefan M SM; van Kempen, Léon C LC

Publication Date: 2021-07-20

Variant appearance in text: EGFR: L777Q

PubMed Link: 34298851

Variant Present in the following documents:

• Main text
• cancers-13-03641.pdf

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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket.

Chemical Science

Kannan, Srinivasaraghavan S; Venkatachalam, Gireedhar G; Lim, Hong Hwa HH; Surana, Uttam U; Verma, Chandra C

Publication Date: 2018-06-21

Variant appearance in text: EGFR: L777Q

PubMed Link: 29997876

Variant Present in the following documents:

• Main text
• SC-009-C8SC01262H.pdf

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Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.

Scientific Reports

Kannan, Srinivasaraghavan S; Pradhan, Mohan R MR; Tiwari, Garima G; Tan, Wei-Chong WC; Chowbay, Balram B; Tan, Eng Huat EH; Tan, Daniel Shao-Weng DS; Verma, Chandra C

Publication Date: 2017-05-08

Variant appearance in text: EGFR: L777Q

PubMed Link: 28484248

Variant Present in the following documents:

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Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Biochemistry

Ruan, Zheng Z; Katiyar, Samiksha S; Kannan, Natarajan N

Publication Date: 2017-01-10

Variant appearance in text: EGFR: L777Q

PubMed Link: 27936599

Variant Present in the following documents:

• Main text

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