EGFR c.2369C>T ;(p.T790M)

Variant ID: 7-55249071-C-T

NM_005228.3(EGFR):c.2369C>T;(p.T790M)

This variant was identified in 6775 publications

View GRCh38 version.




Publications:


Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications
González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR
Publication Date: 2023-06-12

Variant appearance in text: EGFR: T790M
PubMed Link: 37308482
Variant Present in the following documents:
  • 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5
View BVdb publication page



Malignant mediastinal mesothelioma treated with anlotinib: a case report and review of the literature.

Frontiers In Oncology
Zhang, Yishi Y; He, Wan W; Zhan, Ke K; Zhang, Luobin L; Cao, Hua H; Xu, Ruilian R
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37260970
Variant Present in the following documents:
  • Main text
  • fonc-13-1153233.pdf
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Effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeted combined chemotherapy on immune function, tumor markers and oxidative stress in patients with stage IV lung adenocarcinoma.

Pakistan Journal Of Medical Sciences
Kun, Yanxiao Y; Wu, Jian J; Chen, Shaomu S
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37250563
Variant Present in the following documents:
  • PJMS-39-742.pdf
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DCLK1 Drives EGFR-TKI-Acquired Resistance in Lung Adenocarcinoma by Remodeling the Epithelial-Mesenchymal Transition Status.

Biomedicines
Yan, Rui R; Huang, Xuying X; Liu, Heshu H; Xiao, Zeru Z; Liu, Jian J; An, Guangyu G; Ge, Yang Y
Publication Date: 2023-05-22

Variant appearance in text: EGFR: T790M
PubMed Link: 37239162
Variant Present in the following documents:
  • Main text
  • biomedicines-11-01490.pdf
View BVdb publication page



Patient Characteristics, Testing and Treatment Patterns, and Outcomes in EGFR-Mutated Advanced Non-Small Cell Lung Cancer: A Multinational, Real-World Study.

Advances In Therapy
Molife, Cliff C; Winfree, Katherine B KB; Bailey, Hollie H; D'yachkova, Yulia Y; Forshaw, Cameron C; Kim, Sangmi S; Taipale, Kaisa-Leena KL; Puri, Tarun T
Publication Date: 2023-05-23

Variant appearance in text: EGFR: T790M
PubMed Link: 37221352
Variant Present in the following documents:
  • Main text
  • 12325_2023_Article_2530.pdf
View BVdb publication page



Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer.

Theranostics
Rubio, Karla K; Romero-Olmedo, Addi J AJ; Sarvari, Pouya P; Swaminathan, Guruprasadh G; Ranvir, Vikas P VP; Rogel-Ayala, Diana G DG; Cordero, Julio J; Günther, Stefan S; Mehta, Aditi A; Bassaly, Birgit B; Braubach, Peter P; Wygrecka, Malgorzata M; Gattenlöhner, Stefan S; Tresch, Achim A; Braun, Thomas T; Dobreva, Gergana G; Rivera, Miguel N MN; Singh, Indrabahadur I; Graumann, Johannes J; Barreto, Guillermo G
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37215577
Variant Present in the following documents:
  • thnov13p2384s1.pdf
  • thnov13p2384.pdf
View BVdb publication page



Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma.

Nature Communications
Potter, Danielle S DS; Du, Ruochen R; Bohl, Stephan R SR; Chow, Kin-Hoe KH; Ligon, Keith L KL; Bueno, Raphael R; Letai, Anthony A
Publication Date: 2023-05-20

Variant appearance in text: EGFR: T790M
PubMed Link: 37210412
Variant Present in the following documents:
  • 41467_2023_38552_MOESM1_ESM.pdf
View BVdb publication page



The Role of Biomarkers in Guiding Clinical Decision-Making in Oncology.

Journal Of The Advanced Practitioner In Oncology
Moore, Donald C DC; Guinigundo, Andrew S AS
Publication Date: 2023-04

Variant appearance in text: EGFR: T790M
PubMed Link: 37206905
Variant Present in the following documents:
  • Main text
  • jadpro-14-15.pdf
View BVdb publication page



Cerebrospinal fluid: A unique source of circulating tumor DNA with broad clinical applications.

Translational Oncology
Hickman, Richard A RA; Miller, Alexandra M AM; Arcila, Maria E ME
Publication Date: 2023-05-15

Variant appearance in text: EGFR: T790M
PubMed Link: 37196447
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Advanced Non-small Cell Lung Cancer: EGFR Mutation Analysis Using Pyrosequencing and the Fully Automated qPCR-Based IdyllaTM System.

Cancer Control : Journal Of The Moffitt Cancer Center
Boustany, Youssra Y; Laraqui, Abdelilah A; El Zaitouni, Sara S; Ghaouti, Merieme M; Benzekri, Asmae A; Kettani, Fouad F; Oukabli, Mohammed M; Ennibi, Khalid K; Belkadi, Bouchra B; Sekhsokh, Yassine Y
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37196225
Variant Present in the following documents:
  • Main text
  • 10.1177_10732748231177538.pdf
View BVdb publication page



Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer.

Scientific Reports
Baby, Krishnaprasad K; Maity, Swastika S; Mehta, Chetan Hasmukh CH; Nayak, Usha Y UY; Shenoy, Gautham G GG; Pai, Karkala Sreedhara Ranganath KSR; Harikumar, Kuzhuvelil B KB; Nayak, Yogendra Y
Publication Date: 2023-05-16

Variant appearance in text: EGFR: T790M
PubMed Link: 37193898
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_35122.pdf
View BVdb publication page



SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer.

Signal Transduction And Targeted Therapy
Zhou, Ji J; Zhang, Xu-Chao XC; Xue, Shan S; Dai, Mengdi M; Wang, Yueliang Y; Peng, Xia X; Chen, Jianjiao J; Wang, Xinyi X; Shen, Yanyan Y; Qin, Hui H; Chen, Bi B; Zheng, Yu Y; Gao, Xiwen X; Xie, Zuoquan Z; Ding, Jian J; Jiang, Handong H; Wu, Yi-Long YL; Geng, Meiyu M; Ai, Jing J
Publication Date: 2023-05-15

Variant appearance in text: EGFR: T790M
PubMed Link: 37183231
Variant Present in the following documents:
  • Main text
  • 41392_2023_Article_1403.pdf
View BVdb publication page



Retrospective Analysis of the Incidence of Drug-Induced Interstitial Lung Disease by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Survival in Patients Aged 75 Years or Older with Lung Cancer.

Jma Journal
Ishibashi, Masayuki M; Nakagawa, Yoshiko Y; Shimizu, Tetsuo T; Gon, Yasuhiro Y; Yamamoto, Hiroshi H
Publication Date: 2023-04-14

Variant appearance in text: EGFR: T790M
PubMed Link: 37179737
Variant Present in the following documents:
  • 2433-3298-6-2-0182.pdf
View BVdb publication page



Exploring circular MET RNA as a potential biomarker in tumors exhibiting high MET activity.

Journal Of Experimental & Clinical Cancer Research : Cr
Bersani, Francesca F; Picca, Francesca F; Morena, Deborah D; Righi, Luisella L; Napoli, Francesca F; Russo, Mariangela M; Oddo, Daniele D; Rospo, Giuseppe G; Negrino, Carola C; Castella, Barbara B; Volante, Marco M; Listì, Angela A; Zambelli, Vanessa V; Benso, Federica F; Tabbò, Fabrizio F; Bironzo, Paolo P; Monteleone, Emanuele E; Poli, Valeria V; Pietrantonio, Filippo F; Di Nicolantonio, Federica F; Bardelli, Alberto A; Ponzetto, Carola C; Novello, Silvia S; Scagliotti, Giorgio V GV; Taulli, Riccardo R
Publication Date: 2023-05-12

Variant appearance in text: EGFR: T790M
PubMed Link: 37170152
Variant Present in the following documents:
  • Main text
  • 13046_2023_Article_2690.pdf
View BVdb publication page



Pan-cancer whole-genome comparison of primary and metastatic solid tumours.

Nature
Martínez-Jiménez, Francisco F; Movasati, Ali A; Brunner, Sascha Remy SR; Nguyen, Luan L; Priestley, Peter P; Cuppen, Edwin E; Van Hoeck, Arne A
Publication Date: 2023-05-10

Variant appearance in text: EGFR: T790M
PubMed Link: 37165194
Variant Present in the following documents:
  • Main text
  • 41586_2023_6054_MOESM3_ESM.pdf
  • 41586_2023_6054_MOESM1_ESM.pdf
  • 41586_2023_Article_6054.pdf
  • 41586_2023_6054_MOESM12_ESM.xlsx, sheet 5
View BVdb publication page



Comparison of tumor-informed and tumor-naïve sequencing assays for ctDNA detection in breast cancer.

Embo Molecular Medicine
Santonja, Angela A; Cooper, Wendy N WN; Eldridge, Matthew D MD; Edwards, Paul A W PAW; Morris, James A JA; Edwards, Abigail R AR; Zhao, Hui H; Heider, Katrin K; Couturier, Dominique-Laurent DL; Vijayaraghavan, Aadhitthya A; Mennea, Paulius P; Ditter, Emma-Jane EJ; Smith, Christopher G CG; Boursnell, Chris C; Manzano García, Raquel R; Rueda, Oscar M OM; Beddowes, Emma E; Biggs, Heather H; Sammut, Stephen-John SJ; Rosenfeld, Nitzan N; Caldas, Carlos C; Abraham, Jean E JE; Gale, Davina D
Publication Date: 2023-05-10

Variant appearance in text: EGFR: T790M
PubMed Link: 37161793
Variant Present in the following documents:
  • EMMM-15-e16505-s007.pdf
  • EMMM-15-e16505.pdf
View BVdb publication page



Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer.

Molecular Cancer
Wang, Yueqin Y; Wei, Jingyao J; Feng, Luyao L; Li, Ouwen O; Huang, Lan L; Zhou, Shaoxuan S; Xu, Yingjie Y; An, Ke K; Zhang, Yu Y; Chen, Ruiying R; He, Lulu L; Wang, Qiming Q; Wang, Han H; Du, Yue Y; Liu, Ruijuan R; Huang, Chunmin C; Zhang, Xiaojian X; Yang, Yun-Gui YG; Kan, Quancheng Q; Tian, Xin X
Publication Date: 2023-05-09

Variant appearance in text: EGFR: T790M
PubMed Link: 37161388
Variant Present in the following documents:
  • Main text
  • 12943_2023_Article_1780.pdf
View BVdb publication page



EML4-ALK biology and drug resistance in Non-Small Cell Lung Cancer: a new phase of discoveries.

Molecular Oncology
Elshatlawy, Mariam M; Sampson, Josephina J; Clarke, Katy K; Bayliss, Richard R
Publication Date: 2023-05-07

Variant appearance in text: EGFR: T790M
PubMed Link: 37149843
Variant Present in the following documents:
  • Main text
  • MOL2-17-950.pdf
View BVdb publication page



The roles of EZH2 in cancer and its inhibitors.

Medical Oncology (Northwood, London, England)
Liu, Yuankai Y; Yang, Qiong Q
Publication Date: 2023-05-06

Variant appearance in text: EGFR: T790M
PubMed Link: 37148376
Variant Present in the following documents:
  • Main text
  • 12032_2023_Article_2025.pdf
View BVdb publication page



CheckMate-722: The Rise and Fall of Nivolumab with Chemotherapy in TKI-Refractory EGFR-Mutant NSCLC.

Lung Cancer (Auckland, N.Z.)
Lee, Alexandria T M ATM; Nagasaka, Misako M
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37138950
Variant Present in the following documents:
  • Main text
  • lctt-14-41.pdf
View BVdb publication page



Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma.

Croatian Medical Journal
Harabajsa, Suzana S; Šefčić, Hajdi H; Klasić, Marija M; Milavić, Marija M; Židovec Lepej, Snježana S; Grgić, Ivana I; Zajc Petranović, Matea M; Jakopović, Marko M; Smojver-Ježek, Silvana S; Korać, Petra P
Publication Date: 2023-04-30

Variant appearance in text: EGFR: T790M
PubMed Link: 37131310
Variant Present in the following documents:
  • Main text
  • CroatMedJ_64_0084.pdf
View BVdb publication page



Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies.

Bmc Medicine
Hu, Xingsheng X; Zhang, Shucai S; Ma, Zhiyong Z; Feng, Jifeng J; Wu, Lin L; Lv, Dongqing D; Zhou, Jianying J; Zhang, Xiaodong X; Liu, Li L; Yu, Qitao Q; Liao, Wangjun W; Zhang, Yiping Y; Wang, Xiang X; Cheng, Ying Y; Niu, Hongrui H; Wang, Ziping Z; Wang, Dong D; Huang, Cheng C; Liu, Chunling C; Zhao, Hui H; Feng, Jian J; Li, Jingzhang J; Ying, Kejing K; Yang, Nong N; Qin, Shukui S; Hu, Jie J; Liu, Fei F; Jiang, Yong Y; Ge, Nan N; Shi, Yuankai Y
Publication Date: 2023-04-28

Variant appearance in text: EGFR: T790M
PubMed Link: 37118803
Variant Present in the following documents:
  • Main text
  • 12916_2023_2865_MOESM3_ESM.pdf
  • 12916_2023_2865_MOESM1_ESM.pdf
  • 12916_2023_Article_2865.pdf
View BVdb publication page



Utilization of Circulating Tumor Cells in the Management of Solid Tumors.

Journal Of Personalized Medicine
Kurniali, Peter C PC; Storandt, Michael H MH; Jin, Zhaohui Z
Publication Date: 2023-04-20

Variant appearance in text: EGFR: T790M
PubMed Link: 37109080
Variant Present in the following documents:
  • Main text
  • jpm-13-00694.pdf
View BVdb publication page



Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.

Journal Of Enzyme Inhibition And Medicinal Chemistry
Son, Seohyun S; Elkamhawy, Ahmed A; Gul, Anam Rana AR; Al-Karmalawy, Ahmed A AA; Alnajjar, Radwan R; Abdeen, Ahmed A; Ibrahim, Samah F SF; Alshammari, Saud O SO; Alshammari, Qamar A QA; Choi, Won Jun WJ; Park, Tae Jung TJ; Lee, Kyeong K
Publication Date: 2023-12

Variant appearance in text: EGFR: T790M
PubMed Link: 37096560
Variant Present in the following documents:
  • IENZ_38_2202358.pdf
View BVdb publication page



Molecular Tumor Boards: The Next Step towards Precision Therapy in Cancer Care.

Hematology Reports
Liu, Angela A; Vicenzi, Paige P; Sharma, Ishna I; Orr, Kaci K; Teller, Christa C; Koentz, Micha M; Trinkman, Heidi H; Vallance, Kelly K; Ray, Anish A
Publication Date: 2023-04-04

Variant appearance in text: EGFR: T790M
PubMed Link: 37092519
Variant Present in the following documents:
  • Main text
  • hematolrep-15-00025.pdf
View BVdb publication page



Challenges of EGFR-TKIs in NSCLC and the potential role of herbs and active compounds: From mechanism to clinical practice.

Frontiers In Pharmacology
Song, Xiaotong X; Cao, Luchang L; Ni, Baoyi B; Wang, Jia J; Qin, Xiaoyan X; Sun, Xiaoyue X; Xu, Bowen B; Wang, Xinmiao X; Li, Jie J
Publication Date: 2023

Variant appearance in text: EGFR: Thr790Met
PubMed Link: 37089959
Variant Present in the following documents:
  • Main text
  • fphar-14-1090500.pdf
View BVdb publication page



Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Shie, Ming-You MY; Fang, Hsin-Yuan HY; Kan, Kai-Wen KW; Ho, Chia-Che CC; Tu, Chih-Yen CY; Lee, Pei-Chih PC; Hsueh, Po-Ren PR; Chen, Chia-Hung CH; Lee, Alvin Kai-Xing AK; Tien, Ni N; Chen, Jian-Xun JX; Shen, Yu-Cheng YC; Chang, Jan-Gowth JG; Shen, Yu-Fang YF; Lin, Ting-Ju TJ; Wang, Ben B; Hung, Mien-Chie MC; Cho, Der-Yang DY; Chen, Yi-Wen YW
Publication Date: 2023-04-21

Variant appearance in text: EGFR: T790M
PubMed Link: 37085943
Variant Present in the following documents:
  • ADVS-10-2206603-s001.pdf
View BVdb publication page



The Use of Cytotoxic Drugs as First Line Chemotherapy for EGFR (+) Nonsquamous NSCLC: A Network Meta-Analysis.

Disease Markers
Li, Duo D; Li, Meng M; Li, Hong H; Shi, Puyu P; Chen, Mingwei M; Yang, Tian T
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37077340
Variant Present in the following documents:
  • DM2023-5272125.pdf
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Metabolic adverse events of multitarget kinase inhibitors: a systematic review.

Endocrine
Acitelli, Elisa E; Maiorca, Carlo C; Grani, Giorgio G; Maranghi, Marianna M
Publication Date: 2023-04-17

Variant appearance in text: EGFR: T790M
PubMed Link: 37067769
Variant Present in the following documents:
  • 12020_2023_Article_3362.pdf
View BVdb publication page



Ramucirumab Plus Docetaxel for Patients with Non-small cell Lung Cancer with Brain Metastases: A Multicenter, Open-Label Single-Arm Phase II Trial.

The Oncologist
Tanimura, Keiko K; Uchino, Junji J; Kimura, Hideharu H; Hiranuma, Osamu O; Chihara, Yusuke Y; Tanzawa, Shigeru S; Takumi, Chieko C; Kita, Toshiyuki T; Inoue, Koji K; Minato, Koichi K; Takemoto, Shinnosuke S; Nakao, Akira A; Yoshimura, Kenichi K; Takayama, Koichi K
Publication Date: 2023-04-13

Variant appearance in text: EGFR: T790M
PubMed Link: 37053467
Variant Present in the following documents:
  • Main text
  • oyad013.pdf
View BVdb publication page



Biomarker expression and survival in patients with non-small cell lung cancer receiving adjuvant chemotherapy in Denmark.

Plos One
Dalvi, Tapashi T; Nørgaard, Mette M; Fryzek, Jon P JP; Movva, Naimisha N; Pedersen, Lars L; Pham Hansen, Hanh H; Walker, Jill J; Midha, Anita A; Shire, Norah N; Boothman, Anne-Marie AM; Rigas, James J; Mellemgaard, Anders A; Rasmussen, Torben R TR; Hamilton-Dutoit, Stephen S; Cronin-Fenton, Deirdre D
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37040387
Variant Present in the following documents:
  • Main text
  • pone.0284037.pdf
View BVdb publication page



[A Real-world Study on the Expression Characteristics of PD-L1 in Patients 
with Advanced EGFR Positive NSCLC and Its Relationship with the 
Therapeutic Efficacy of EGFR-TKIs].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Chen, Ran R; Gao, Xiang X; Xu, Fudong F; Zhang, Shucai S; Ma, Li L; Hu, Bo B
Publication Date: 2023-03-20

Variant appearance in text: EGFR: T790M
PubMed Link: 37035884
Variant Present in the following documents:
  • zgfazz-26-3-217.pdf
View BVdb publication page



LWJ-M30, a conjugate of DM1 and B6, for the targeted therapy of colorectal cancer with improved therapeutic effects.

Rsc Advances
Zhang, Qiu-Yan QY; Yu, Qing-Long QL; Luan, Wei-Jing WJ; Li, Tong-Fang TF; Xiao, Ya-Ni YN; Zhang, Li L; Li, Yi Y; Rong, Rong R; Ren, Chun-Guang CG
Publication Date: 2023-04-03

Variant appearance in text: EGFR: T790M
PubMed Link: 37033427
Variant Present in the following documents:
  • RA-013-D2RA07758B.pdf
View BVdb publication page



Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry
Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S
Publication Date: 2023-04-07

Variant appearance in text: EGFR: T790M
PubMed Link: 37026591
Variant Present in the following documents:
  • jm3c00155_si_002.xlsx, sheet 2
View BVdb publication page



Economic evaluation of five first-line PD-(L)1 inhibitors for treating non-squamous non-small cell lung cancer in China: A cost-effectiveness analysis based on network meta-analysis.

Frontiers In Pharmacology
Chen, Xi X; Zhao, Mingye M; Tian, Lei L
Publication Date: 2023

Variant appearance in text: EGFR: T790M
PubMed Link: 37021058
Variant Present in the following documents:
  • fphar-14-1119906.pdf
View BVdb publication page



Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox.

Acs Synthetic Biology
Siepe, Dirk H DH; Picton, Lora K LK; Garcia, K Christopher KC
Publication Date: 2023-04-03

Variant appearance in text: EGFR: T790M
PubMed Link: 37011906
Variant Present in the following documents:
  • sb2c00587.pdf
View BVdb publication page