EGFR c.2374_2376delinsTAA ;(p.L792*)

Variant ID: 7-55249076-CTC-TAA

NM_005228.3(EGFR):c.2374_2376delinsTAA;(p.L792*)

This variant was identified in 27 publications

View GRCh38 version.




Publications:


Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer.

Cell Communication And Signaling : Ccs
Li, Yufeng Y; Mao, Tianyu T; Wang, Jing J; Zheng, Hongrui H; Hu, Ziyi Z; Cao, Pingping P; Yang, Suisui S; Zhu, Lingyun L; Guo, Shunyao S; Zhao, Xinfei X; Tian, Yue Y; Shen, Hua H; Lin, Fan F
Publication Date: 2023-04-11

Variant appearance in text: EGFR: L792X
PubMed Link: 37041601
Variant Present in the following documents:
  • Main text
  • 12964_2023_Article_1082.pdf
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Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.

Nature Communications
Chmielecki, Juliann J; Mok, Tony T; Wu, Yi-Long YL; Han, Ji-Youn JY; Ahn, Myung-Ju MJ; Ramalingam, Suresh S SS; John, Thomas T; Okamoto, Isamu I; Yang, James Chih-Hsin JC; Shepherd, Frances A FA; Bulusu, Krishna C KC; Laus, Gianluca G; Collins, Barbara B; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Papadimitrakopoulou, Vassiliki V
Publication Date: 2023-02-27

Variant appearance in text: EGFR: L792X
PubMed Link: 36849516
Variant Present in the following documents:
  • Main text
  • 41467_2023_Article_35962.pdf
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Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer.

Genes
Nishihara, Shigetoshi S; Yamaoka, Toshimitsu T; Ishikawa, Fumihiro F; Higuchi, Kensuke K; Hasebe, Yuki Y; Manabe, Ryo R; Kishino, Yasunari Y; Kusumoto, Sojiro S; Ando, Koichi K; Kuroda, Yusuke Y; Ohmori, Tohru T; Sagara, Hironori H; Yoshida, Hitoshi H; Tsurutani, Junji J
Publication Date: 2022-11-22

Variant appearance in text: EGFR: L792X
PubMed Link: 36553449
Variant Present in the following documents:
  • Main text
  • genes-13-02183.pdf
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Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer.

Molecular Biomedicine
Wang, Zixi Z; Xing, Yurou Y; Li, Bingjie B; Li, Xiaoyu X; Liu, Bin B; Wang, Yongsheng Y
Publication Date: 2022-12-12

Variant appearance in text: EGFR: L792X
PubMed Link: 36508072
Variant Present in the following documents:
  • Main text
  • 43556_2022_Article_107.pdf
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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy
Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q
Publication Date: 2022-09-17

Variant appearance in text: EGFR: L792X
PubMed Link: 36115852
Variant Present in the following documents:
  • Main text
View BVdb publication page



Use of liquid biopsy in monitoring therapeutic resistance in EGFR oncogene addicted NSCLC.

Exploration Of Targeted Anti-Tumor Therapy
Iacovino, Marialucia M; Ciaramella, Vincenza V; Paragliola, Fernando F; Suarato, Gabriella G; Busiello, Gesualdina G; Sparano, Francesca F
Publication Date: 2020

Variant appearance in text: EGFR: L792X
PubMed Link: 36046387
Variant Present in the following documents:
  • Main text
  • etat-01-100224.pdf
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Unarranged territory in uncommon EGFR mutations.

Translational Lung Cancer Research
Fujii, Hiroyuki H; Okuma, Yusuke Y
Publication Date: 2022-07

Variant appearance in text: EGFR: L792X
PubMed Link: 35958324
Variant Present in the following documents:
  • Main text
  • tlcr-11-07-1233.pdf
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Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization.

Ebiomedicine
Sun, Yiting Y; Dong, Yiting Y; Liu, Xijuan X; Zhang, Yundi Y; Bai, Hua H; Duan, Jianchun J; Tian, Zhihua Z; Yan, Xiang X; Wang, Jie J; Wang, Zhijie Z
Publication Date: 2022-09

Variant appearance in text: EGFR: L792X
PubMed Link: 35932642
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Resistance to TKIs in EGFR-Mutated Non-Small Cell Lung Cancer: From Mechanisms to New Therapeutic Strategies.

Cancers
Koulouris, Andreas A; Tsagkaris, Christos C; Corriero, Anna Chiara AC; Metro, Giulio G; Mountzios, Giannis G
Publication Date: 2022-07-08

Variant appearance in text: EGFR: L792X
PubMed Link: 35884398
Variant Present in the following documents:
  • Main text
  • cancers-14-03337.pdf
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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology
Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J
Publication Date: 2022

Variant appearance in text: EGFR: L792X
PubMed Link: 35814426
Variant Present in the following documents:
  • Main text
  • fonc-12-889591.pdf
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Osimertinib-Centered Therapy Against Uncommon Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer- A Mini Review.

Frontiers In Oncology
Song, Chengyang C; Yang, Xueying X
Publication Date: 2022

Variant appearance in text: EGFR: L792X
PubMed Link: 35494059
Variant Present in the following documents:
  • Main text
  • fonc-12-834585.pdf
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Acquired Mechanisms of Resistance to Osimertinib-The Next Challenge.

Cancers
Ríos-Hoyo, Alejandro A; Moliner, Laura L; Arriola, Edurne E
Publication Date: 2022-04-12

Variant appearance in text: EGFR: L792X
PubMed Link: 35454838
Variant Present in the following documents:
  • Main text
  • cancers-14-01931.pdf
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[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Huang, Junxia J; Wang, Hong H
Publication Date: 2022-03-20

Variant appearance in text: EGFR: L792X
PubMed Link: 35340161
Variant Present in the following documents:
  • Main text
  • zgfazz-25-3-183.pdf
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Utility of the Ba/F3 cell system for exploring on-target mechanisms of resistance to targeted therapies for lung cancer.

Cancer Science
Koga, Takamasa T; Suda, Kenichi K; Mitsudomi, Tetsuya T
Publication Date: 2022-03

Variant appearance in text: EGFR: L792X
PubMed Link: 34997674
Variant Present in the following documents:
  • Main text
  • CAS-113-815.pdf
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Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring.

Cancers
Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M
Publication Date: 2021-09-30

Variant appearance in text: EGFR: L792X
PubMed Link: 34638411
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review).

International Journal Of Oncology
He, Jingyi J; Huang, Zhengrong Z; Han, Linzhi L; Gong, Yan Y; Xie, Conghua C
Publication Date: 2021-11

Variant appearance in text: EGFR: L792X
PubMed Link: 34558640
Variant Present in the following documents:
  • Main text
  • ijo-59-05-05270.pdf
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Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (New York, N.Y.)
Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J
Publication Date: 2021-05-28

Variant appearance in text: EGFR: L792X
PubMed Link: 34557754
Variant Present in the following documents:
  • Main text
View BVdb publication page



Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (Cambridge (Mass.))
Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J
Publication Date: 2021-05-28

Variant appearance in text: EGFR: L792X
PubMed Link: 34557754
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Publication Date: 2021-09

Variant appearance in text: EGFR: L792X
PubMed Link: 34526717
Variant Present in the following documents:
  • Main text
View BVdb publication page



A review of research progress on mechanisms and overcoming strategies of acquired osimertinib resistance.

Anti-Cancer Drugs
Qu, Fanjie F; Zhou, Yi Y; Yu, Weiwei W
Publication Date: 2021-09-13

Variant appearance in text: EGFR: L792X
PubMed Link: 34520433
Variant Present in the following documents:
  • Main text
  • acd-33-e76.pdf
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A review of research progress on mechanisms and overcoming strategies of acquired osimertinib resistance.

Anti-Cancer Drugs
Qu, Fanjie F; Zhou, Yi Y; Yu, Weiwei W
Publication Date: 2022-01-01

Variant appearance in text: EGFR: L792X
PubMed Link: 34520433
Variant Present in the following documents:
  • Main text
  • acd-33-e76.pdf
View BVdb publication page



Relationship between long non-coding RNA PCAT-1 expression and gefitinib resistance in non-small-cell lung cancer cells.

Respiratory Research
Wang, Shaojia S; Liu, Chao C; Lei, Qing Q; Wu, Zhengwei Z; Miao, Xiangshuai X; Zhu, Debing D; Yang, Xu X; Li, Na N; Tang, Mingwei M; Chen, Yan Y; Wang, Weiwei W
Publication Date: 2021-05-12

Variant appearance in text: EGFR: L792X
PubMed Link: 33980216
Variant Present in the following documents:
  • Main text
View BVdb publication page



Case Report: Dacomitinib May Not Benefit Patients Who Develop Rare Compound Mutations After Later-Line Osimertinib Treatment.

Frontiers In Oncology
Li, Hong-Shuai HS; Yang, Guang-Jian GJ; Wang, Yan Y
Publication Date: 2021

Variant appearance in text: EGFR: L792X
PubMed Link: 33937055
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Journal Of Thoracic Disease
Gini, Beatrice B; Thomas, Nicholas N; Blakely, Collin M CM
Publication Date: 2020-05

Variant appearance in text: EGFR: L792X
PubMed Link: 32642201
Variant Present in the following documents:
  • Main text
  • jtd-12-05-2883.pdf
View BVdb publication page



Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

Oncology Letters
Yamaura, Takumi T; Muto, Satoshi S; Mine, Hayato H; Takagi, Hironori H; Watanabe, Masayuki M; Ozaki, Yuki Y; Inoue, Takuya T; Fukuhara, Mitsuro M; Okabe, Naoyuki N; Matsumura, Yuki Y; Hasegawa, Takeo T; Osugi, Jun J; Hoshino, Mika M; Higuchi, Mitsunori M; Shio, Yutaka Y; Suzuki, Hiroyuki H
Publication Date: 2020-06

Variant appearance in text: EGFR: L792X
PubMed Link: 32391110
Variant Present in the following documents:
  • Main text
View BVdb publication page



Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights.

Pharmacology & Therapeutics
Meador, Catherine B CB; Hata, Aaron N AN
Publication Date: 2020-06

Variant appearance in text: EGFR: L792X
PubMed Link: 32151666
Variant Present in the following documents:
  • Main text
View BVdb publication page



Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer.

British Journal Of Cancer
Leonetti, Alessandro A; Sharma, Sugandhi S; Minari, Roberta R; Perego, Paola P; Giovannetti, Elisa E; Tiseo, Marcello M
Publication Date: 2019-10

Variant appearance in text: EGFR: L792X
PubMed Link: 31564718
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanism of Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors and a Potential Treatment Strategy.

Cells
Nagano, Tatsuya T; Tachihara, Motoko M; Nishimura, Yoshihiro Y
Publication Date: 2018-11-15

Variant appearance in text: EGFR: L792X
PubMed Link: 30445769
Variant Present in the following documents:
  • Main text
  • cells-07-00212.pdf
View BVdb publication page