Variant ID: 7-55249091-T-A

NM_005228.3(EGFR):c.2389T>A;(p.C797S)

This variant was identified in 829 publications

View GRCh38 version.




Publications:


Clinical Efficacy of Osimertinib in Patients with Advanced Non-Small Cell Lung Cancer and Its Effect on Serum CEA and VEGF Expression.

Evidence-Based Complementary And Alternative Medicine : Ecam
Wang, Huanyuan H; Zhou, Xiangwu X; Wang, Zhaozhen Z; Lu, Tianzhu T; Li, Baoliang B; Jiang, Sicong S
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35664943
Variant Present in the following documents:
View BVdb publication page



A Lung Cancer Patient Harboring a Rare Oncogenic EGFR Exon 20 V786M Mutation Responded to a Third-Generation Tyrosine Kinase Inhibitor: Case Report and Review of the Literature.

Frontiers In Oncology
Zhu, Qi Q; Jiang, Mingyun M; Li, Wenfei W; Sun, Shuangli S; Li, Jisheng J; Stebbing, Justin J; Liang, Xiaodong X; Peng, Ling L
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35664749
Variant Present in the following documents:
View BVdb publication page



Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule.

Frontiers In Immunology
Lawal, Bashir B; Wu, Alexander T H ATH; Huang, Hsu-Shan HS
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35655775
Variant Present in the following documents:
View BVdb publication page



Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy.

Acta Pharmaceutica Sinica. B
Pan, Xiaoli X; Pei, Junping J; Wang, Aoxue A; Shuai, Wen W; Feng, Lu L; Bu, Faqian F; Zhu, Yumeng Y; Zhang, Lan L; Wang, Guan G; Ouyang, Liang L
Publication Date: 2022-05

Variant appearance in text: EGFR: C797S
PubMed Link: 35646548
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Characteristics of Genomic Alterations in Pericardial Effusion of Advanced Non-small Cell Lung Cancer.

Frontiers In Genetics
He, Jiaxue J; Hu, Xintong X; Chen, Liguo L; Liu, Qiaoliang Q; Jiang, Yanfang Y
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35646096
Variant Present in the following documents:
  • Main text
  • fgene-13-850290.pdf
View BVdb publication page



Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases.

Bmc Medicine
Zheng, Mei-Mei MM; Li, Yang-Si YS; Tu, Hai-Yan HY; Sun, Hao H; Yin, Kai K; Jiang, Ben-Yuan BY; Yang, Jin-Ji JJ; Zhang, Xu-Chao XC; Zhou, Qing Q; Xu, Chong-Rui CR; Wang, Zhen Z; Chen, Hua-Jun HJ; Zhou, De-Xiang DX; Wu, Yi-Long YL
Publication Date: 2022-05-30

Variant appearance in text: EGFR: C797S
PubMed Link: 35644609
Variant Present in the following documents:
  • Main text
  • 12916_2022_Article_2387.pdf
View BVdb publication page



AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer.

Scientific Reports
Murakami, Yuichi Y; Kusakabe, Daiki D; Watari, Kosuke K; Kawahara, Akihiko A; Azuma, Koichi K; Akiba, Jun J; Taniguchi, Masahiko M; Kuwano, Michihiko M; Ono, Mayumi M
Publication Date: 2022-05-28

Variant appearance in text: EGFR: C797S
PubMed Link: 35643725
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_12995.pdf
View BVdb publication page



High-Dose Osimertinib for CNS Progression in EGFR+ NSCLC: A Multi-Institutional Experience.

Jto Clinical And Research Reports
Piper-Vallillo, A J AJ; Rotow, Julia K JK; Aredo, Jacqueline V JV; Shaverdashvili, Khvaramze K; Luo, Jia J; Carlisle, Jennifer W JW; Husain, Hatim H; Muzikansky, Alona A; Heist, Rebecca S RS; Rangachari, Deepa D; Ramalingam, Suresh S SS; Wakelee, Heather A HA; Yu, Helena A HA; Sequist, Lecia V LV; Bauml, Joshua M JM; Neal, Joel W JW; Piotrowska, Zofia Z
Publication Date: 2022-06

Variant appearance in text: EGFR: C797S
PubMed Link: 35637759
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Therapeutic Effects of Synthetic Triblock Amphiphilic Short Antimicrobial Peptides on Human Lung Adenocarcinoma.

Pharmaceutics
Yang, Danjing D; Zhu, Liang L; Lin, Xiangyu X; Zhu, Jiaming J; Qian, Yusheng Y; Liu, Wenhui W; Chen, Jianjun J; Zhou, Chuncai C; He, Jing J
Publication Date: 2022-04-24

Variant appearance in text: EGFR: C797S
PubMed Link: 35631515
Variant Present in the following documents:
  • pharmaceutics-14-00929.pdf
View BVdb publication page



Treatment Strategies for Non-Small Cell Lung Cancer Harboring Common and Uncommon EGFR Mutations: Drug Sensitivity Based on Exon Classification, and Structure-Function Analysis.

Cancers
Kitadai, Rui R; Okuma, Yusuke Y
Publication Date: 2022-05-20

Variant appearance in text: EGFR: C797S
PubMed Link: 35626123
Variant Present in the following documents:
  • Main text
  • cancers-14-02519.pdf
View BVdb publication page



Predicting EGFR mutation, ALK rearrangement, and uncommon EGFR mutation in NSCLC patients by driverless artificial intelligence: a cohort study.

Respiratory Research
Tan, Xueyun X; Li, Yuan Y; Wang, Sufei S; Xia, Hui H; Meng, Rui R; Xu, Juanjuan J; Duan, Yanran Y; Li, Yan Y; Yang, Guanghai G; Ma, Yanling Y; Jin, Yang Y
Publication Date: 2022-05-27

Variant appearance in text: EGFR: C797S
PubMed Link: 35624472
Variant Present in the following documents:
  • 12931_2022_Article_2053.pdf
View BVdb publication page



Understanding the P-Loop Conformation in the Determination of Inhibitor Selectivity Toward the Hepatocellular Carcinoma-Associated Dark Kinase STK17B.

Frontiers In Molecular Biosciences
Liu, Chang C; Li, Zhizhen Z; Liu, Zonghan Z; Yang, Shiye S; Wang, Qing Q; Chai, Zongtao Z
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35620482
Variant Present in the following documents:
View BVdb publication page



CRISPER/CAS System, a Novel Tool of Targeted Therapy of Drug-Resistant Lung Cancer.

Advanced Pharmaceutical Bulletin
Akbari Kordkheyli, Vahid V; Rashidi, Mohsen M; Shokri, Yasaman Y; Fallahpour, Samane S; Variji, Atena A; Nabipour Ghara, Ehsan E; Hosseini, Sayed Mostafa SM
Publication Date: 2022-03

Variant appearance in text: N/A
PubMed Link: 35620343
Variant Present in the following documents:
View BVdb publication page



Application and Prospect of CRISPR/Cas9 Technology in Reversing Drug Resistance of Non-Small Cell Lung Cancer.

Frontiers In Pharmacology
Huang, Lu L; Liao, Zhi Z; Liu, Zhixi Z; Chen, Yan Y; Huang, Tingwenli T; Xiao, Hongtao H
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35620280
Variant Present in the following documents:
View BVdb publication page



Genomic Alteration Spectrum of Non-Small Cell Lung Cancer Patients in East-China Characterized by Tumor Tissue DNA and Cell-Free DNA.

Oncotargets And Therapy
Li, Jie J; Chen, Siwen S; Xue, Hui H; Wang, Haoyi H; Huang, Tianwei T; Xie, Hongya H; He, Jiang J; Ke, Cai C; Yu, Zhaonan Z; Ni, Bin B
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35615557
Variant Present in the following documents:
View BVdb publication page



Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Publication Date: 2022-05-24

Variant appearance in text: EGFR: C797S
PubMed Link: 35609344
Variant Present in the following documents:
  • id2c00091_si_001.pdf
View BVdb publication page



Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China.

Genes And Environment : The Official Journal Of The Japanese Environmental Mutagen Society
Wang, Jun-Ling JL; Fu, Yu-Dong YD; Gao, Yan-Hong YH; Li, Xiu-Ping XP; Xiong, Qian Q; Li, Rui R; Hou, Bo B; Huang, Ruo-Shan RS; Wang, Jun-Feng JF; Zhang, Jian-Kun JK; Lv, Jia-Ling JL; Zhang, Chao C; Li, Hong-Wei HW
Publication Date: 2022-05-23

Variant appearance in text: EGFR: 2389T>A; Cys797Ser
PubMed Link: 35606799
Variant Present in the following documents:
  • Main text
  • 41021_2022_Article_248.pdf
  • 41021_2022_248_MOESM1_ESM.xlsx
View BVdb publication page



[Advances in Treatment of Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Yang, Xue X; Zhao, Jun J
Publication Date: 2022-05-20

Variant appearance in text: EGFR: C797S
PubMed Link: 35599009
Variant Present in the following documents:
  • Main text
  • zgfazz-25-5-337.pdf
View BVdb publication page



Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines.

Jama Network Open
Yap, Timothy A TA; Ashok, Arya A; Stoll, Jessica J; Mauer, Elizabeth E; Nepomuceno, Vanessa M VM; Blackwell, Kimberly L KL; Garber, Judy E JE; Meric-Bernstam, Funda F
Publication Date: 2022-05-02

Variant appearance in text: EGFR: C797S
PubMed Link: 35594047
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetic and pharmacogenomic discovery strategies.

Cancer Drug Resistance (Alhambra, Calif.)
Crisafulli, Concetta C; Romeo, Petronilla Daniela PD; Calabrò, Marco M; Epasto, Ludovica Martina LM; Alberti, Saverio S
Publication Date: 2019

Variant appearance in text: EGFR: C797S
PubMed Link: 35582724
Variant Present in the following documents:
  • cdr-2-225.pdf
View BVdb publication page



Non-small cell lung cancer-small cell lung cancer transformation as mechanism of resistance to tyrosine kinase inhibitors in lung cancer.

Cancer Drug Resistance (Alhambra, Calif.)
Rath, Barbara B; Plangger, Adelina A; Hamilton, Gerhard G
Publication Date: 2020

Variant appearance in text: EGFR: C797S
PubMed Link: 35582610
Variant Present in the following documents:
  • cdr-3-171.pdf
View BVdb publication page



Involvement of SNX1 in regulating EGFR endocytosis in a gefitinib-resistant NSCLC cell lines.

Cancer Drug Resistance (Alhambra, Calif.)
Nishimura, Yukio Y; Itoh, Kazuyuki K
Publication Date: 2019

Variant appearance in text: EGFR: C797S
PubMed Link: 35582586
Variant Present in the following documents:
  • cdr-2-539.pdf
View BVdb publication page



Longitudinal monitoring for the emergence of epidermal growth factor C797S resistance mutations in non-small cell lung cancer using blood-based droplet digital PCR.

Cancer Drug Resistance (Alhambra, Calif.)
Bowling, Mark M; Arastu, Hyder H; Edwards, Victoria V; Jackson, Leisa L; Thurston, Scott S; Reese, Jordan J; Mellert, Hestia H; Pestano, Gary G; Walker, Paul P
Publication Date: 2019

Variant appearance in text: EGFR: C797S
PubMed Link: 35582570
Variant Present in the following documents:
  • cdr-2-912.pdf
View BVdb publication page



RET kinase alterations in targeted cancer therapy.

Cancer Drug Resistance (Alhambra, Calif.)
Liu, Xuan X; Hu, Xueqing X; Shen, Tao T; Li, Qi Q; Mooers, Blaine H M BHM; Wu, Jie J
Publication Date: 2020

Variant appearance in text: EGFR: C797S
PubMed Link: 35582449
Variant Present in the following documents:
  • cdr-3-472.pdf
View BVdb publication page



Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics.

Cancer Drug Resistance (Alhambra, Calif.)
Ulldemolins, Anna A; Seras-Franzoso, Joaquin J; Andrade, Fernanda F; Rafael, Diana D; Abasolo, Ibane I; Gener, Petra P; Schwartz, Simo S
Publication Date: 2021

Variant appearance in text: EGFR: C797S
PubMed Link: 35582007
Variant Present in the following documents:
  • cdr-4-44.pdf
View BVdb publication page



Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer.

Biomed Research International
Li, LingJuan L; Xu, Fang F; Ye, Jun J
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35578722
Variant Present in the following documents:
  • BMRI2022-4704107.pdf
View BVdb publication page



Cerebrospinal Fluid Cell-Free DNA-Based Detection of High Level of Genomic Instability Is Associated With Poor Prognosis in NSCLC Patients With Leptomeningeal Metastases.

Frontiers In Oncology
Wu, Xi X; Xing, Puyuan P; Shi, Min M; Guo, Weihua W; Zhao, Fangping F; Zhu, Honglin H; Xiao, Jianping J; Wan, Jinghai J; Li, Junling J
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35574310
Variant Present in the following documents:
View BVdb publication page



Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report.

Frontiers In Oncology
Yang, James Chih-Hsin JC; Schuler, Martin M; Popat, Sanjay S; Miura, Satoru S; Park, Keunchil K; Passaro, Antonio A; De Marinis, Filippo F; Solca, Flavio F; Märten, Angela A; Kim, Edward S ES
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35574304
Variant Present in the following documents:
View BVdb publication page



FGFR Fusions as an Acquired Resistance Mechanism Following Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) and a Suggested Novel Target in Advanced Non-Small Cell Lung Cancer (aNSCLC).

Journal Of Clinical Medicine
Raphael, Ari A; Dudnik, Elizabeth E; Hershkovitz, Dov D; Jain, Suyog S; Olsen, Steve S; Soussan-Gutman, Lior L; Ben-Shitrit, Taly T; Dvir, Addie A; Nechushtan, Hovav H; Peled, Nir N; Onn, Amir A; Agbarya, Abed A; On Behalf Of The Israel Lung Cancer Group,
Publication Date: 2022-04-28

Variant appearance in text: N/A
PubMed Link: 35566609
Variant Present in the following documents:
View BVdb publication page



An Insight into the Medicinal Chemistry Perspective of Macrocyclic Derivatives with Antitumor Activity: A Systematic Review.

Molecules (Basel, Switzerland)
Liang, Yan Y; Fang, Ru R; Rao, Qiu Q
Publication Date: 2022-04-29

Variant appearance in text: N/A
PubMed Link: 35566196
Variant Present in the following documents:
View BVdb publication page



Overcoming Cancer Drug Resistance Utilizing PROTAC Technology.

Frontiers In Cell And Developmental Biology
Burke, Matthew R MR; Smith, Alexis R AR; Zheng, Guangrong G
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35547806
Variant Present in the following documents:
  • fcell-10-872729.pdf
View BVdb publication page



Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal Of Medicinal Chemistry
Willis, Nicky J NJ; Mahy, William W; Sipthorp, James J; Zhao, Yuguang Y; Woodward, Hannah L HL; Atkinson, Benjamin N BN; Bayle, Elliott D ED; Svensson, Fredrik F; Frew, Sarah S; Jeganathan, Fiona F; Monaghan, Amy A; Benvegnù, Stefano S; Jolly, Sarah S; Vecchia, Luca L; Ruza, Reinis R RR; Kjær, Svend S; Howell, Steven S; Snijders, Ambrosius P AP; Bictash, Magda M; Salinas, Patricia C PC; Vincent, Jean-Paul JP; Jones, E Yvonne EY; Whiting, Paul P; Fish, Paul V PV
Publication Date: 2022-05-10

Variant appearance in text: EGFR: C797S
PubMed Link: 35536179
Variant Present in the following documents:
  • jm2c00162_si_001.pdf
View BVdb publication page



Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.

Nature Communications
Beyett, Tyler S TS; To, Ciric C; Heppner, David E DE; Rana, Jaimin K JK; Schmoker, Anna M AM; Jang, Jaebong J; De Clercq, Dries J H DJH; Gomez, Gabriel G; Scott, David A DA; Gray, Nathanael S NS; Jänne, Pasi A PA; Eck, Michael J MJ
Publication Date: 2022-05-09

Variant appearance in text: N/A
PubMed Link: 35534503
Variant Present in the following documents:
View BVdb publication page



Case Report: Durable Response to the Combination of Brigatinib and Cetuximab Plus Icotinib in a NSCLC Patient Harboring EGFR L858R-T790M-cis-G796S and L718Q Resistance Mutations Following Progression With Osimertinib.

Frontiers In Oncology
Wang, Yubo Y; Han, Rui R; Zhu, Mengxiao M; He, Tingting T; He, Yong Y
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35530305
Variant Present in the following documents:
View BVdb publication page



Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer.

Frontiers In Oncology
Chen, Hui H; Jia, Bin B; Zhang, Qiang Q; Zhang, Yu Y
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35530301
Variant Present in the following documents:
View BVdb publication page



On the development of B-Raf inhibitors acting through innovative mechanisms.

F1000Research
Pinzi, Luca L
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35529278
Variant Present in the following documents:
View BVdb publication page



Overall Survival Benefits of First-Line Treatments for Asian Patients With Advanced EGFR-Mutated NSCLC Harboring L858R Mutation: A Systematic Review and Network Meta-Analysis.

Jto Clinical And Research Reports
Chan, Sik-Kwan SK; Choi, Horace Cheuk-Wai HC; Lee, Victor Ho-Fun VH
Publication Date: 2022-05

Variant appearance in text: EGFR: C797S
PubMed Link: 35516725
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review.

Frontiers In Chemistry
Zheng, Jia J; Zhang, Wei W; Li, Linfeng L; He, Yi Y; Wei, Yue Y; Dang, Yongjun Y; Nie, Shenyou S; Guo, Zufeng Z
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35494629
Variant Present in the following documents:
  • fchem-10-860985.pdf
View BVdb publication page



Osimertinib-Centered Therapy Against Uncommon Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer- A Mini Review.

Frontiers In Oncology
Song, Chengyang C; Yang, Xueying X
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35494059
Variant Present in the following documents:
  • fonc-12-834585.pdf
View BVdb publication page



Olaparib Combined With Dacomitinib in Osimertinib-Resistant Brain and Leptomeningeal Metastases From Non-Small Cell Lung Cancer: A Case Report and Systematic Review.

Frontiers In Oncology
Zhang, Hui H; Wang, Yong Y; Wu, Huaguo H; Zhou, Shizhen S; Li, Shuo S; Meng, Xiangji X; Tao, Rongjie R; Yu, Jinming J
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35494030
Variant Present in the following documents:
  • fonc-12-877279.pdf
View BVdb publication page



Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFRWT and EGFRT790M.

Journal Of Enzyme Inhibition And Medicinal Chemistry
O Aboelez, Moustafa M; Belal, Amany A; Xiang, Guangya G; Ma, Xiang X
Publication Date: 2022-12

Variant appearance in text: EGFR: C797S
PubMed Link: 35470756
Variant Present in the following documents:
  • IENZ_37_2062338.pdf
View BVdb publication page



Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.

Frontiers In Oncology
Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35463360
Variant Present in the following documents:
  • fonc-12-853501.pdf
View BVdb publication page



Combining plasma extracellular vesicle Let-7b-5p, miR-184 and circulating miR-22-3p levels for NSCLC diagnosis and drug resistance prediction.

Scientific Reports
Vadla, G P GP; Daghat, B B; Patterson, N N; Ahmad, V V; Perez, G G; Garcia, A A; Manjunath, Y Y; Kaifi, J T JT; Li, G G; Chabu, C Y CY
Publication Date: 2022-04-23

Variant appearance in text: EGFR: C797S
PubMed Link: 35461372
Variant Present in the following documents:
  • 41598_2022_Article_10598.pdf
View BVdb publication page



Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences
Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P
Publication Date: 2022-04-09

Variant appearance in text: EGFR: C797S
PubMed Link: 35456982
Variant Present in the following documents:
  • ijms-23-04164.pdf
View BVdb publication page



The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor.

Pharmaceuticals (Basel, Switzerland)
Högnäsbacka, Antonia A; Poot, Alex J AJ; Vugts, Danielle J DJ; van Dongen, Guus A M S GAMS; Windhorst, Albert D AD
Publication Date: 2022-04-05

Variant appearance in text: EGFR: C797S
PubMed Link: 35455447
Variant Present in the following documents:
  • pharmaceuticals-15-00450.pdf
View BVdb publication page



Acquired Mechanisms of Resistance to Osimertinib-The Next Challenge.

Cancers
Ríos-Hoyo, Alejandro A; Moliner, Laura L; Arriola, Edurne E
Publication Date: 2022-04-12

Variant appearance in text: EGFR: C797S
PubMed Link: 35454838
Variant Present in the following documents:
  • cancers-14-01931.pdf
View BVdb publication page



Chinese Herbal Medicine (Yiqi-Yangyin-Jiedu Decoction) Combined With Osimertinib as First-Line Treatment in EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer (CATLA-2): A Study Protocol for a Double-Blind Randomized Controlled Trial.

Frontiers In Pharmacology
Yao, Jialin J; Lu, Yan Y; Jiao, Lijing L; Bi, Ling L; Yang, Wenxiao W; Su, Lingzi L; Shi, Jun J; Wang, Zhe Z; Gong, Yabin Y; Xu, Ling L
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35431966
Variant Present in the following documents:
  • fphar-13-840889.pdf
View BVdb publication page



Proteolysis-targeting chimeras (PROTACs) in cancer therapy.

Molecular Cancer
Li, Xinyi X; Pu, Wenchen W; Zheng, Qingquan Q; Ai, Min M; Chen, Song S; Peng, Yong Y
Publication Date: 2022-04-11

Variant appearance in text: EGFR: C797S
PubMed Link: 35410300
Variant Present in the following documents:
  • 12943_2021_Article_1434.pdf
View BVdb publication page



Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution.

International Journal Of Molecular Sciences
de Pinho Pessoa, Flávia Melo Cunha FMC; Machado, Caio Bezerra CB; da Silva, Emerson Lucena EL; da Costa Pantoja, Laudreísa L; Ribeiro, Rodrigo Monteiro RM; de Moraes, Maria Elisabete Amaral MEA; de Moraes Filho, Manoel Odorico MO; Montenegro, Raquel Carvalho RC; Khayat, André Salim AS; Moreira-Nunes, Caroline Aquino CA
Publication Date: 2022-03-30

Variant appearance in text: EGFR: C797S
PubMed Link: 35409190
Variant Present in the following documents:
  • ijms-23-03830.pdf
View BVdb publication page



EGFR Mutations in Head and Neck Squamous Cell Carcinoma.

International Journal Of Molecular Sciences
Nair, Sindhu S; Bonner, James A JA; Bredel, Markus M
Publication Date: 2022-03-30

Variant appearance in text: EGFR: C797S
PubMed Link: 35409179
Variant Present in the following documents:
  • ijms-23-03818.pdf
View BVdb publication page



Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth.

International Journal Of Molecular Sciences
Weng, Chia-Wei CW; Wei, Chi-Hsuan CH; Tsai, Jeng-Yuan JY; Lai, Yi-Hua YH; Chang, Gee-Chen GC; Chen, Jeremy J W JJW
Publication Date: 2022-03-23

Variant appearance in text: EGFR: C797S
PubMed Link: 35408854
Variant Present in the following documents:
  • ijms-23-03487.pdf
View BVdb publication page



Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer.

Frontiers In Oncology
Alam, Manzar M; Alam, Shoaib S; Shamsi, Anas A; Adnan, Mohd M; Elasbali, Abdelbaset Mohamed AM; Al-Soud, Waleed Abu WA; Alreshidi, Mousa M; Hawsawi, Yousef MohammedRabaa YM; Tippana, Anitha A; Pasupuleti, Visweswara Rao VR; Hassan, Md Imtaiyaz MI
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35402265
Variant Present in the following documents:
  • fonc-12-869672.pdf
View BVdb publication page



Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling.

Nature Communications
Wu, Lucia Ruojia LR; Dai, Peng P; Wang, Michael Xiangjiang MX; Chen, Sherry Xi SX; Cohen, Evan N EN; Jayachandran, Gitanjali G; Zhang, Jinny Xuemeng JX; Serrano, Angela V AV; Xie, Nina Guanyi NG; Ueno, Naoto T NT; Reuben, James M JM; Barcenas, Carlos H CH; Zhang, David Yu DY
Publication Date: 2022-04-04

Variant appearance in text: EGFR: C797S
PubMed Link: 35379811
Variant Present in the following documents:
  • 41467_2022_Article_29487.pdf
View BVdb publication page



KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response.

Cell Death & Disease
Shen, Xiaohui X; Zhang, Yuchen Y; Xu, Zhuoqing Z; Gao, Han H; Feng, Wenqing W; Li, Wenchang W; Miao, Yiming Y; Xu, Zifeng Z; Zong, Yaping Y; Zhao, Jingkun J; Lu, Aiguo A
Publication Date: 2022-04-05

Variant appearance in text: EGFR: C797S
PubMed Link: 35379798
Variant Present in the following documents:
  • 41419_2022_4773_MOESM9_ESM.xlsx
View BVdb publication page



NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance.

Frontiers In Oncology
Liu, Fangfang F; Wei, Yuxuan Y; Zhang, Huan H; Jiang, Jizong J; Zhang, Peng P; Chu, Qian Q
Publication Date: 2022

Variant appearance in text: EGFR: C797S
PubMed Link: 35372074
Variant Present in the following documents:
  • fonc-12-864666.pdf
View BVdb publication page



Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer.

Nature Communications
Gogleva, Anna A; Polychronopoulos, Dimitris D; Pfeifer, Matthias M; Poroshin, Vladimir V; Ughetto, Michaël M; Martin, Matthew J MJ; Thorpe, Hannah H; Bornot, Aurelie A; Smith, Paul D PD; Sidders, Ben B; Dry, Jonathan R JR; Ahdesmäki, Miika M; McDermott, Ultan U; Papa, Eliseo E; Bulusu, Krishna C KC
Publication Date: 2022-03-29

Variant appearance in text: EGFR: C797S
PubMed Link: 35351890
Variant Present in the following documents:
  • 41467_2022_Article_29292.pdf
View BVdb publication page



Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans.

Cell Death & Disease
Vicencio, J M JM; Evans, R R; Green, R R; An, Z Z; Deng, J J; Treacy, C C; Mustapha, R R; Monypenny, J J; Costoya, C C; Lawler, K K; Ng, K K; De-Souza, K K; Coban, O O; Gomez, V V; Clancy, J J; Chen, S H SH; Chalk, A A; Wong, F F; Gordon, P P; Savage, C C; Gomes, C C; Pan, T T; Alfano, G G; Dolcetti, L L; Chan, J N E JNE; Flores-Borja, F F; Barber, P R PR; Weitsman, G G; Sosnowska, D D; Capone, E E; Iacobelli, S S; Hochhauser, D D; Hartley, J A JA; Parsons, M M; Arnold, J N JN; Ameer-Beg, S S; Quezada, S A SA; Yarden, Y Y; Sala, G G; Ng, T T
Publication Date: 2022-03-28

Variant appearance in text: EGFR: C797S
PubMed Link: 35347108
Variant Present in the following documents:
  • 41419_2022_Article_4701.pdf
View BVdb publication page



[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Huang, Junxia J; Wang, Hong H
Publication Date: 2022-03-20

Variant appearance in text: EGFR: C797S
PubMed Link: 35340161
Variant Present in the following documents:
  • zgfazz-25-3-183.pdf
View BVdb publication page



Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells.

Pharmaceuticals (Basel, Switzerland)
Barrios-Bernal, Pedro P; Hernandez-Pedro, Norma N; Orozco-Morales, Mario M; Viedma-Rodríguez, Rubí R; Lucio-Lozada, José J; Avila-Moreno, Federico F; Cardona, Andrés F AF; Rosell, Rafael R; Arrieta, Oscar O
Publication Date: 2022-03-21

Variant appearance in text: EGFR: C797S
PubMed Link: 35337178
Variant Present in the following documents:
  • pharmaceuticals-15-00381.pdf
View BVdb publication page



Liquid Profiling for Cancer Patient Stratification in Precision Medicine-Current Status and Challenges for Successful Implementation in Standard Care.

Diagnostics (Basel, Switzerland)
Haselmann, Verena V; Hedtke, Maren M; Neumaier, Michael M
Publication Date: 2022-03-19

Variant appearance in text: N/A
PubMed Link: 35328301
Variant Present in the following documents:
View BVdb publication page



Analytic and Clinical Validation of a Pan-Cancer NGS Liquid Biopsy Test for the Detection of Copy Number Amplifications, Fusions and Exon Skipping Variants.

Diagnostics (Basel, Switzerland)
Audetat, Audrey A; Tschida, Chérie C; Kreston, Sarah S; Stephen, Adam A; D'Alessio, Brittany B; Bondy, Madeline M; Jackson, Leisa L; Mellert, Hestia H; Givens, Niki N; Sathyanarayana, Ubaradka G UG; Pestano, Gary A GA
Publication Date: 2022-03-17

Variant appearance in text: N/A
PubMed Link: 35328282
Variant Present in the following documents:
View BVdb publication page



Effect of Osimertinib on CTCs and ctDNA in EGFR Mutant Non-Small Cell Lung Cancer Patients: The Prognostic Relevance of Liquid Biopsy.

Cancers
Kallergi, Galatea G; Kontopodis, Emmanouil E; Ntzifa, Aliki A; Jordana-Ariza, Núria N; Karachaliou, Niki N; Pantazaka, Evangelia E; Charalambous, Haris A HA; Psyrri, Amanda A; Tsaroucha, Emily E; Boukovinas, Ioannis I; Koumarianou, Anna A; Hatzidaki, Dora D; Lianidou, Evi E; Georgoulias, Vassilis V; Rosell, Rafael R; Kotsakis, Athanasios A
Publication Date: 2022-03-19

Variant appearance in text: N/A
PubMed Link: 35326725
Variant Present in the following documents:
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-03-19

Variant appearance in text: EGFR: C797S
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Synthetic developmental biology: Engineering approaches to guide multicellular organization.

Stem Cell Reports
Zarkesh, Ibrahim I; Kazemi Ashtiani, Mohammad M; Shiri, Zahra Z; Aran, Saeideh S; Braun, Thomas T; Baharvand, Hossein H
Publication Date: 2022-02-21

Variant appearance in text: N/A
PubMed Link: 35276092
Variant Present in the following documents:
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: EGFR: 2389T>A; C797S
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx
View BVdb publication page



Small Cell Lung Cancer Transformation following Treatment in EGFR-Mutated Non-Small Cell Lung Cancer.

Journal Of Clinical Medicine
Mambetsariev, Isa I; Arvanitis, Leonidas L; Fricke, Jeremy J; Pharaon, Rebecca R; Baroz, Angel R AR; Afkhami, Michelle M; Koczywas, Marianna M; Massarelli, Erminia E; Salgia, Ravi R
Publication Date: 2022-03-05

Variant appearance in text: N/A
PubMed Link: 35268520
Variant Present in the following documents:
View BVdb publication page



The Role of TP53 Mutations in EGFR-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy.

Cancers
Canale, Matteo M; Andrikou, Kalliopi K; Priano, Ilaria I; Cravero, Paola P; Pasini, Luigi L; Urbini, Milena M; Delmonte, Angelo A; Crinò, Lucio L; Bronte, Giuseppe G; Ulivi, Paola P
Publication Date: 2022-02-23

Variant appearance in text: N/A
PubMed Link: 35267450
Variant Present in the following documents:
View BVdb publication page



Efficacy of Osimertinib After Progression of First-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) in EGFR-Mutated Lung Adenocarcinoma: A Real-World Study in Chinese Patients.

Cancer Management And Research
Xu, Ziyi Z; Hao, Xuezhi X; Wang, Qi Q; Wang, Jing J; Yang, Ke K; Wang, Shouzheng S; Teng, Fei F; Li, Junling J; Xing, Puyuan P
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35256860
Variant Present in the following documents:
View BVdb publication page



Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models.

Therapeutic Advances In Medical Oncology
Lim, Sun Min SM; Yang, San-Duk SD; Lim, Sangbin S; Heo, Seong Gu SG; Daniel, Stetson S; Markovets, Aleksandra A; Minoo, Rafati R; Pyo, Kyoung-Ho KH; Yun, Mi Ran MR; Hong, Min Hee MH; Kim, Hye Ryun HR; Cho, Byoung Chul BC
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35251316
Variant Present in the following documents:
View BVdb publication page



Mechanism of Lethal Skin Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors and Related Treatment Strategies.

Frontiers In Oncology
Li, Yanping Y; Fu, Ruoqiu R; Jiang, Tingting T; Duan, Dongyu D; Wu, Yuanlin Y; Li, Chen C; Li, Ziwei Z; Ni, Rui R; Li, Li L; Liu, Yao Y
Publication Date: 2022

Variant appearance in text: N/A
PubMed Link: 35223483
Variant Present in the following documents:
View BVdb publication page



Outcomes in Patients With Lung Adenocarcinoma With Transformation to Small Cell Lung Cancer After EGFR Tyrosine Kinase Inhibitors Resistance: A Systematic Review and Pooled Analysis.

Frontiers In Oncology
Xu, Jinhe J; Xu, Lihuan L; Wang, Baoshan B; Kong, Wencui W; Chen, Ying Y; Yu, Zongyang Z
Publication Date: 2021

Variant appearance in text: N/A
PubMed Link: 35223450
Variant Present in the following documents:
View BVdb publication page



Severe stomatitis caused by osimertinib combined with gefitinib: A case report.

Clinical Case Reports
Zhu, Ya-Ning YN; Li, Li L; Zhang, Peng P; Zuo, Yan Y; Lei, Yu Y; Bai, Jun J; Cao, Lu L; Guo, Zhen-Jun ZJ
Publication Date: 2022-02

Variant appearance in text: N/A
PubMed Link: 35223006
Variant Present in the following documents:
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: N/A
PubMed Link: 35221333
Variant Present in the following documents:
View BVdb publication page



Challenges in the Use of Targeted Therapies in NSCLC.

Cancer Research And Treatment
Rivera-Concepcion, Joel J; Uprety, Dipesh D; Adjei, Alex A AA
Publication Date: 2022-02-18

Variant appearance in text: N/A
PubMed Link: 35209703
Variant Present in the following documents:
View BVdb publication page



EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones.

Molecules (Basel, Switzerland)
Musa, Arafa A; Mostafa, Ehab M EM; Bukhari, Syed Nasir Abbas SNA; Alotaibi, Nasser Hadal NH; El-Ghorab, Ahmed H AH; Farouk, Amr A; Nayl, AbdElAziz A AA; Ghoneim, Mohammed M MM; Abdelgawad, Mohamed A MA
Publication Date: 2022-02-09

Variant appearance in text: N/A
PubMed Link: 35208952
Variant Present in the following documents:
View BVdb publication page



Identification of Targetable Liabilities in the Dynamic Metabolic Profile of EGFR-Mutant Lung Adenocarcinoma: Thinking beyond Genomics for Overcoming EGFR TKI Resistance.

Biomedicines
Gkountakos, Anastasios A; Centonze, Giovanni G; Vita, Emanuele E; Belluomini, Lorenzo L; Milella, Michele M; Bria, Emilio E; Milione, Massimo M; Scarpa, Aldo A; Simbolo, Michele M
Publication Date: 2022-01-26

Variant appearance in text: N/A
PubMed Link: 35203491
Variant Present in the following documents:
View BVdb publication page



Cell-Free Tumor DNA (ctDNA) Utility in Detection of Original Sensitizing and Resistant EGFR Mutations in Non-Small Cell Lung Cancer (NSCLC).

Current Oncology (Toronto, Ont.)
Agulnik, Jason S JS; Papadakis, Andreas I AI; Pepe, Carmela C; Sakr, Lama L; Small, David D; Wang, Hangjun H; Kasymjanova, Goulnar G; Spatz, Alan A; Cohen, Victor V
Publication Date: 2022-02-14

Variant appearance in text: N/A
PubMed Link: 35200593
Variant Present in the following documents:
View BVdb publication page



Identification of Recurrent Insertions and Deletions in Exon 18 and 19 of Human Epidermal Growth Factor Receptor 2 as Potential Drivers in Non-Small-Cell Lung Cancer and Other Cancer Types.

Jco Precision Oncology
Yin, Yan Y; Song, Lijie L; Shi, Dongsheng D; Liu, Bin B; Li, Xiangke X; Yang, Minjie M; Liu, Bihao B; Wang, Dejuan D; Qin, Jianwen J
Publication Date: 2022-02

Variant appearance in text: N/A
PubMed Link: 35171661
Variant Present in the following documents:
View BVdb publication page



Exosomes derived from M2 type tumor-associated macrophages promote osimertinib resistance in non-small cell lung cancer through MSTRG.292666.16-miR-6836-5p-MAPK8IP3 axis.

Cancer Cell International
Wan, Xiaoying X; Xie, Boxiong B; Sun, Hui H; Gu, Weiqing W; Wang, Chunyan C; Deng, Qinfang Q; Zhou, Songwen S
Publication Date: 2022-02-15

Variant appearance in text: EGFR: 2389T>A; Cys797Ser
PubMed Link: 35168607
Variant Present in the following documents:
  • 12935_2022_Article_2509.pdf
View BVdb publication page



Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors.

Molecules (Basel, Switzerland)
Amelia, Tasia T; Kartasasmita, Rahmana Emran RE; Ohwada, Tomohiko T; Tjahjono, Daryono Hadi DH
Publication Date: 2022-01-26

Variant appearance in text: EGFR: C797S
PubMed Link: 35164092
Variant Present in the following documents:
  • Main text
  • molecules-27-00819.pdf
View BVdb publication page



Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma.

International Journal Of Molecular Sciences
Barzegar Behrooz, Amir A; Talaie, Zahra Z; Jusheghani, Fatemeh F; Łos, Marek J MJ; Klonisch, Thomas T; Ghavami, Saeid S
Publication Date: 2022-01-25

Variant appearance in text: N/A
PubMed Link: 35163279
Variant Present in the following documents:
View BVdb publication page



Systemic Therapy for Oligoprogression in Patients with Metastatic NSCLC Harboring Activating EGFR Mutations.

Cancers
Rossi, Antonio A; Galetta, Domenico D
Publication Date: 2022-02-06

Variant appearance in text: EGFR: C797S
PubMed Link: 35159099
Variant Present in the following documents:
  • Main text
  • cancers-14-00832.pdf
View BVdb publication page