Variant ID: 7-55259524-T-A

NM_005228.3(EGFR):c.2582T>A;(p.L861Q)

This variant was identified in 1293 publications

View GRCh38 version.




Publications:


Lung Cancer Biomarker Speak: Teach Me the Language.

Journal Of The Advanced Practitioner In Oncology
Sandy, Beth B; Morrissette, Jennifer J
Publication Date: 2022-04

Variant appearance in text: EGFR: L861Q
PubMed Link: 35663172
Variant Present in the following documents:
  • Main text
  • jadpro-13-302.pdf
View BVdb publication page



Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule.

Frontiers In Immunology
Lawal, Bashir B; Wu, Alexander T H ATH; Huang, Hsu-Shan HS
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35655775
Variant Present in the following documents:
  • Main text
  • fimmu-13-872470.pdf
View BVdb publication page



Characteristics of Genomic Alterations in Pericardial Effusion of Advanced Non-small Cell Lung Cancer.

Frontiers In Genetics
He, Jiaxue J; Hu, Xintong X; Chen, Liguo L; Liu, Qiaoliang Q; Jiang, Yanfang Y
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35646096
Variant Present in the following documents:
  • Main text
  • fgene-13-850290.pdf
View BVdb publication page



A Single-Institute Experience with C-ros Oncogene 1 Translocation in Non-Small Cell Lung Cancers in Taiwan.

International Journal Of Molecular Sciences
Wang, Hsiang-Sheng HS; Liu, Chien-Ying CY; Hsu, Sheng-Chi SC; Huang, Shih-Chiang SC; Hung, Tsai-Hsien TH; Ng, Kwai-Fong KF; Chen, Tse-Ching TC
Publication Date: 2022-05-21

Variant appearance in text: EGFR: L861Q
PubMed Link: 35628598
Variant Present in the following documents:
  • Main text
  • ijms-23-05789.pdf
View BVdb publication page



Treatment Strategies for Non-Small Cell Lung Cancer Harboring Common and Uncommon EGFR Mutations: Drug Sensitivity Based on Exon Classification, and Structure-Function Analysis.

Cancers
Kitadai, Rui R; Okuma, Yusuke Y
Publication Date: 2022-05-20

Variant appearance in text: EGFR: L861Q
PubMed Link: 35626123
Variant Present in the following documents:
  • Main text
  • cancers-14-02519.pdf
View BVdb publication page



Predicting EGFR mutation, ALK rearrangement, and uncommon EGFR mutation in NSCLC patients by driverless artificial intelligence: a cohort study.

Respiratory Research
Tan, Xueyun X; Li, Yuan Y; Wang, Sufei S; Xia, Hui H; Meng, Rui R; Xu, Juanjuan J; Duan, Yanran Y; Li, Yan Y; Yang, Guanghai G; Ma, Yanling Y; Jin, Yang Y
Publication Date: 2022-05-27

Variant appearance in text: EGFR: L861Q
PubMed Link: 35624472
Variant Present in the following documents:
  • Main text
  • 12931_2022_Article_2053.pdf
View BVdb publication page



Genomic Alteration Spectrum of Non-Small Cell Lung Cancer Patients in East-China Characterized by Tumor Tissue DNA and Cell-Free DNA.

Oncotargets And Therapy
Li, Jie J; Chen, Siwen S; Xue, Hui H; Wang, Haoyi H; Huang, Tianwei T; Xie, Hongya H; He, Jiang J; Ke, Cai C; Yu, Zhaonan Z; Ni, Bin B
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35615557
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of lung adenocarcinoma using next-generation sequencing.

Bmc Cancer
Yang, Hainan H; Wen, Lei L; Pan, Yingying Y; Shan, Changguo C; Hong, Weiping W; Wang, Hui H; Zhou, Cheng C; Cai, Linbo L; Zhou, Caicun C
Publication Date: 2022-05-25

Variant appearance in text: EGFR: L861Q
PubMed Link: 35614407
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_9597.pdf
View BVdb publication page



Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Publication Date: 2022-05-24

Variant appearance in text: EGFR: L861Q
PubMed Link: 35609344
Variant Present in the following documents:
  • id2c00091_si_001.pdf
View BVdb publication page



Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China.

Genes And Environment : The Official Journal Of The Japanese Environmental Mutagen Society
Wang, Jun-Ling JL; Fu, Yu-Dong YD; Gao, Yan-Hong YH; Li, Xiu-Ping XP; Xiong, Qian Q; Li, Rui R; Hou, Bo B; Huang, Ruo-Shan RS; Wang, Jun-Feng JF; Zhang, Jian-Kun JK; Lv, Jia-Ling JL; Zhang, Chao C; Li, Hong-Wei HW
Publication Date: 2022-05-23

Variant appearance in text: EGFR: 2582T>A; Leu861Gln
PubMed Link: 35606799
Variant Present in the following documents:
  • Main text
  • 41021_2022_Article_248.pdf
  • 41021_2022_248_MOESM1_ESM.xlsx
View BVdb publication page



Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report.

Frontiers In Oncology
Yang, James Chih-Hsin JC; Schuler, Martin M; Popat, Sanjay S; Miura, Satoru S; Park, Keunchil K; Passaro, Antonio A; De Marinis, Filippo F; Solca, Flavio F; Märten, Angela A; Kim, Edward S ES
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35574304
Variant Present in the following documents:
  • fonc-12-834704.pdf
View BVdb publication page



Osimertinib as Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer: A Case Series.

Frontiers In Pharmacology
Hu, Yan Y; Ren, Siying S; Yang, Lulu L; Tong, Zhongyi Z; Wang, Ruoyao R; Han, Wei W; Zeng, Chao C; Li, Jina J; Xiao, Peng P; Wang, Li L; Yu, Fenglei F; Liu, Wenliang W
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35571073
Variant Present in the following documents:
  • fphar-13-912153.pdf
View BVdb publication page



FGFR Fusions as an Acquired Resistance Mechanism Following Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) and a Suggested Novel Target in Advanced Non-Small Cell Lung Cancer (aNSCLC).

Journal Of Clinical Medicine
Raphael, Ari A; Dudnik, Elizabeth E; Hershkovitz, Dov D; Jain, Suyog S; Olsen, Steve S; Soussan-Gutman, Lior L; Ben-Shitrit, Taly T; Dvir, Addie A; Nechushtan, Hovav H; Peled, Nir N; Onn, Amir A; Agbarya, Abed A; On Behalf Of The Israel Lung Cancer Group,
Publication Date: 2022-04-28

Variant appearance in text: EGFR: L861Q
PubMed Link: 35566609
Variant Present in the following documents:
  • jcm-11-02475.pdf
View BVdb publication page



CancerVar: An artificial intelligence-empowered platform for clinical interpretation of somatic mutations in cancer.

Science Advances
Li, Quan Q; Ren, Zilin Z; Cao, Kajia K; Li, Marilyn M MM; Wang, Kai K; Zhou, Yunyun Y
Publication Date: 2022-05-06

Variant appearance in text: EGFR: L861Q
PubMed Link: 35544644
Variant Present in the following documents:
  • sciadv.abj1624.pdf
View BVdb publication page



Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal Of Medicinal Chemistry
Willis, Nicky J NJ; Mahy, William W; Sipthorp, James J; Zhao, Yuguang Y; Woodward, Hannah L HL; Atkinson, Benjamin N BN; Bayle, Elliott D ED; Svensson, Fredrik F; Frew, Sarah S; Jeganathan, Fiona F; Monaghan, Amy A; Benvegnù, Stefano S; Jolly, Sarah S; Vecchia, Luca L; Ruza, Reinis R RR; Kjær, Svend S; Howell, Steven S; Snijders, Ambrosius P AP; Bictash, Magda M; Salinas, Patricia C PC; Vincent, Jean-Paul JP; Jones, E Yvonne EY; Whiting, Paul P; Fish, Paul V PV
Publication Date: 2022-05-10

Variant appearance in text: EGFR: L861Q
PubMed Link: 35536179
Variant Present in the following documents:
  • jm2c00162_si_001.pdf
View BVdb publication page



The efficacy of T790M mutation testing in liquid biopsy-Real clinic data.

Plos One
Krawczyk, Paweł P; Grzycka-Kowalczyk, Luiza L; Błach, Justyna J; Reszka, Katarzyna K; Chmielewska, Izabela I; Kieszko, Robert R; Wójcik-Superczyńska, Magdalena M; Szczyrek, Michał M; Jankowski, Tomasz T; Milanowski, Janusz J
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35522668
Variant Present in the following documents:
  • pone.0267846.pdf
View BVdb publication page



Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis.

Iscience
Chava, Suresh S; Bugide, Suresh S; Zhang, Xuchen X; Gupta, Romi R; Wajapeyee, Narendra N
Publication Date: 2022-05-20

Variant appearance in text: rs121913444
PubMed Link: 35494243
Variant Present in the following documents:
  • mmc1.pdf
  • main.pdf
  • mmc2.xls
View BVdb publication page



Osimertinib-Centered Therapy Against Uncommon Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer- A Mini Review.

Frontiers In Oncology
Song, Chengyang C; Yang, Xueying X
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35494059
Variant Present in the following documents:
  • fonc-12-834585.pdf
View BVdb publication page



Efficacy of liquid biopsy for disease monitoring and early prediction of tumor progression in EGFR mutation-positive non-small cell lung cancer.

Plos One
Ho, Hsiang-Ling HL; Jiang, Yuqiu Y; Chiang, Chi-Lu CL; Karwowska, Sylwia S; Yerram, Ranga R; Sharma, Keerti K; Scudder, Sidney S; Chiu, Chao-Hua CH; Tsai, Chun-Ming CM; Palma, John F JF; Sharma, Abha A; Chou, Teh-Ying TY
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35482671
Variant Present in the following documents:
  • pone.0267362.pdf
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: EGFR: 2582T>A
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM2_ESM.xlsx
View BVdb publication page



Exceptional response to afatinib in a patient with persistent G719A EGFR-mutant NSCLC.

Lung Cancer Management
Kulkarni, Amit A AA; Fujioka, Naomi N; Reinhardt, Lucia L; Patel, Manish R MR; Kratzke, Robert A RA
Publication Date: 2022-03

Variant appearance in text: EGFR: L861Q
PubMed Link: 35463918
Variant Present in the following documents:
  • lmt-11-54.pdf
View BVdb publication page



The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor.

Pharmaceuticals (Basel, Switzerland)
Högnäsbacka, Antonia A; Poot, Alex J AJ; Vugts, Danielle J DJ; van Dongen, Guus A M S GAMS; Windhorst, Albert D AD
Publication Date: 2022-04-05

Variant appearance in text: EGFR: L861Q
PubMed Link: 35455447
Variant Present in the following documents:
  • pharmaceuticals-15-00450.pdf
View BVdb publication page



Acquired Mechanisms of Resistance to Osimertinib-The Next Challenge.

Cancers
Ríos-Hoyo, Alejandro A; Moliner, Laura L; Arriola, Edurne E
Publication Date: 2022-04-12

Variant appearance in text: EGFR: L861Q
PubMed Link: 35454838
Variant Present in the following documents:
  • cancers-14-01931.pdf
View BVdb publication page



The Clinically Actionable Molecular Profile of Early versus Late-Stage Non-Small Cell Lung Cancer, an Individual Age and Sex Propensity-Matched Pair Analysis.

Current Oncology (Toronto, Ont.)
McGuire, Anna L AL; McConechy, Melissa K MK; Melosky, Barb L BL; English, John C JC; Choi, James J JJ; Peng, Defen D; Yee, John J; Furman, Benjamin L S BLS; Aguirre Hernandez, Rosalia R; Feijao, Pedro P; Mulder, David D; Hughesman, Curtis C; Yip, Stephen S
Publication Date: 2022-04-11

Variant appearance in text: EGFR: L861Q
PubMed Link: 35448189
Variant Present in the following documents:
  • curroncol-29-00215.pdf
View BVdb publication page



Development and evaluation of ActSeq: A targeted next-generation sequencing panel for clinical oncology use.

Plos One
Shi, Zonggao Z; Lopez, Jacqueline J; Kalliney, William W; Sutton, Bobbie B; Simpson, Joyce J; Maggert, Kevin K; Liu, Sheng S; Wan, Jun J; Stack, M Sharon MS
Publication Date: 2022

Variant appearance in text: EGFR: 2582T>A; L861Q
PubMed Link: 35446881
Variant Present in the following documents:
  • pone.0266914.pdf
View BVdb publication page



TP53 Co-Mutations in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Prognosis and Therapeutic Strategy for Cancer Therapy.

Frontiers In Oncology
Liu, Surui S; Yu, Jin J; Zhang, Hui H; Liu, Jie J
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35444951
Variant Present in the following documents:
  • fonc-12-860563.pdf
View BVdb publication page



Chinese Herbal Medicine (Yiqi-Yangyin-Jiedu Decoction) Combined With Osimertinib as First-Line Treatment in EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer (CATLA-2): A Study Protocol for a Double-Blind Randomized Controlled Trial.

Frontiers In Pharmacology
Yao, Jialin J; Lu, Yan Y; Jiao, Lijing L; Bi, Ling L; Yang, Wenxiao W; Su, Lingzi L; Shi, Jun J; Wang, Zhe Z; Gong, Yabin Y; Xu, Ling L
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35431966
Variant Present in the following documents:
  • fphar-13-840889.pdf
View BVdb publication page



Observational study of rebiopsy in EGFR-TKI-resistant patients with EGFR mutation-positive advanced NSCLC.

Scientific Reports
Koyama, Kenichi K; Miura, Satoru S; Watanabe, Satoshi S; Shoji, Satoshi S; Koshio, Jun J; Hayashi, Yoshiki Y; Ishikawa, Daisuke D; Sato, Ko K; Miyabayashi, Takao T; Okajima, Masaaki M; Ota, Takeshi T; Tanaka, Tomohiro T; Matsumoto, Naoya N; Kuriyama, Hideyuki H; Abe, Tetsuya T; Nozaki, Koichiro K; Ichikawa, Kosuke K; Kondo, Rie R; Tanaka, Hiroshi H; Kikuchi, Toshiaki T
Publication Date: 2022-04-16

Variant appearance in text: EGFR: L861Q
PubMed Link: 35430596
Variant Present in the following documents:
  • 41598_2022_Article_10288.pdf
View BVdb publication page



EGFR Mutations in Head and Neck Squamous Cell Carcinoma.

International Journal Of Molecular Sciences
Nair, Sindhu S; Bonner, James A JA; Bredel, Markus M
Publication Date: 2022-03-30

Variant appearance in text: EGFR: L861Q
PubMed Link: 35409179
Variant Present in the following documents:
  • ijms-23-03818.pdf
View BVdb publication page



Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to an Old Problem.

Cancers
Falco, Michela M; Tammaro, Chiara C; Takeuchi, Takashi T; Cossu, Alessia Maria AM; Scafuro, Giuseppe G; Zappavigna, Silvia S; Itro, Annalisa A; Addeo, Raffaele R; Scrima, Marianna M; Lombardi, Angela A; Ricciardiello, Filippo F; Irace, Carlo C; Caraglia, Michele M; Misso, Gabriella G
Publication Date: 2022-03-28

Variant appearance in text: EGFR: L861Q
PubMed Link: 35406495
Variant Present in the following documents:
  • cancers-14-01716.pdf
View BVdb publication page



KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response.

Cell Death & Disease
Shen, Xiaohui X; Zhang, Yuchen Y; Xu, Zhuoqing Z; Gao, Han H; Feng, Wenqing W; Li, Wenchang W; Miao, Yiming Y; Xu, Zifeng Z; Zong, Yaping Y; Zhao, Jingkun J; Lu, Aiguo A
Publication Date: 2022-04-05

Variant appearance in text: EGFR: L861Q
PubMed Link: 35379798
Variant Present in the following documents:
  • 41419_2022_4773_MOESM10_ESM.xlsx
  • 41419_2022_4773_MOESM9_ESM.xlsx
View BVdb publication page



Prognostic Value of Albumin-to-Alkaline Phosphatase Ratio for EGFR-Mutated Advanced Non-Small-Cell Lung Cancer Patients Treated with First-Line EGFR-TKIs: A Large Population-Based Study and Literature Review.

International Journal Of General Medicine
Gan, Yuncui Y; Ren, Jing J; Xian, Jinghong J; Yu, He H; Jin, Jing J; Li, Dan D; Li, Weimin W
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35378914
Variant Present in the following documents:
  • ijgm-15-3405.pdf
View BVdb publication page



Overexpression of CEACAM6 activates Src-FAK signaling and inhibits anoikis, through homophilic interactions in lung adenocarcinomas.

Translational Oncology
Kim, Eun Young EY; Cha, Yoon Jin YJ; Jeong, Sukin S; Chang, Yoon Soo YS
Publication Date: 2022-03-28

Variant appearance in text: EGFR: L861Q
PubMed Link: 35358791
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Correlation of Epidermal Growth Factor Receptor Mutation With Major Histologic Subtype of Lung Adenocarcinoma According to IASLC/ATS/ERS Classification.

Cancer Control : Journal Of The Moffitt Cancer Center
Boukansa, Sara S; Benbrahim, Zineb Z; Gamrani, Sanaa S; Bardai, Sanae S; Bouguenouch, Laila L; Mazti, Asmae A; Boutahiri, Nadia N; Serraj, Mounia M; Amara, Bouchra B; Ouadnouni, Yassine Y; Smahi, Mohamed M; Alami, Badreeddine B; Mellas, Nawfel N; El Fatemi, Hinde H
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35348028
Variant Present in the following documents:
  • 10.1177_10732748221084930.pdf
View BVdb publication page



[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Huang, Junxia J; Wang, Hong H
Publication Date: 2022-03-20

Variant appearance in text: EGFR: L861Q
PubMed Link: 35340161
Variant Present in the following documents:
  • zgfazz-25-3-183.pdf
View BVdb publication page



[Clinical Characteristics and Prognosis of 76 Lung Adenocarcinoma Patients 
Harboring EGFR Mutations with Pleural Effusion at Initial Diagnosis: 
A Single-center Retrospective Study].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Yin, Wencheng W; Zhang, Hua H; Gu, Yangchun Y; Yi, Fumei F; Li, Qian Q; Liu, Yan'e Y; Yao, Yanhong Y; Liu, Zhentao Z; Cao, Baoshan B
Publication Date: 2022-03-20

Variant appearance in text: EGFR: L861Q
PubMed Link: 35340158
Variant Present in the following documents:
  • zgfazz-25-3-156.pdf
View BVdb publication page



Survival past five years with advanced, EGFR-mutated or ALK-rearranged non-small cell lung cancer-is there a "tail plateau" in the survival curve of these patients?

Bmc Cancer
Shimamura, Shoko Sonobe SS; Shukuya, Takehito T; Asao, Tetsuhiko T; Hayakawa, Daisuke D; Kurokawa, Kana K; Xu, Shiting S; Miura, Keita K; Mitsuishi, Yoichiro Y; Tajima, Ken K; Shibayama, Rina R; Shimada, Naoko N; Takahashi, Fumiyuki F; Takahashi, Kazuhisa K
Publication Date: 2022-03-25

Variant appearance in text: EGFR: L861Q
PubMed Link: 35337281
Variant Present in the following documents:
  • 12885_2022_Article_9421.pdf
View BVdb publication page



Prognostic Values of Inflammatory Indexes and Clinical Factors in Patients with Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma and Treated with Tyrosine Kinase Inhibitors.

Journal Of Personalized Medicine
Chang, Bee-Song BS; Peng, Tai-Chu TC; Wu, Yi-Feng YF; Hsieh, Tsung-Cheng TC; Huang, Chun-Hou CH
Publication Date: 2022-03-05

Variant appearance in text: EGFR: L861Q
PubMed Link: 35330404
Variant Present in the following documents:
  • jpm-12-00404.pdf
View BVdb publication page



Liquid Profiling for Cancer Patient Stratification in Precision Medicine-Current Status and Challenges for Successful Implementation in Standard Care.

Diagnostics (Basel, Switzerland)
Haselmann, Verena V; Hedtke, Maren M; Neumaier, Michael M
Publication Date: 2022-03-19

Variant appearance in text: EGFR: L861Q
PubMed Link: 35328301
Variant Present in the following documents:
  • diagnostics-12-00748.pdf
View BVdb publication page



Genomic Landscape of Non-Small Cell Lung Cancer (NSCLC) in East Asia Using Circulating Tumor DNA (ctDNA) in Clinical Practice.

Current Oncology (Toronto, Ont.)
Cho, Byoung Chul BC; Loong, Herbert H F HHF; Tsai, Chun-Ming CM; Teo, Man Lung P MLP; Kim, Hye Ryun HR; Lim, Sun Min SM; Jain, Suyog S; Olsen, Steve S; Park, Keunchil K
Publication Date: 2022-03-21

Variant appearance in text: EGFR: L861Q
PubMed Link: 35323374
Variant Present in the following documents:
  • curroncol-29-00174.pdf
View BVdb publication page



Two Unusual Mutations in the Epidermal Growth Factor Receptor Gene in a Patient With Lung Adenocarcinoma.

Cureus
Zapata Laguado, Martin M; Zuluaga, Andrea A; Parra Medina, Rafael R; Bruges, Ricardo R
Publication Date: 2022-02

Variant appearance in text: EGFR: L861q
PubMed Link: 35321064
Variant Present in the following documents:
  • cureus-0014-00000022372.pdf
View BVdb publication page



PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine
Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35308511
Variant Present in the following documents:
  • fmed-09-822200.pdf
View BVdb publication page



Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study).

Bmc Cancer
Zhang, Bo B; Shi, Chunlei C; Gao, Zhiqiang Z; Zhong, Hua H; Xiong, Liwen L; Gu, Aiqin A; Wang, Weimin W; Chu, Tianqing T; Zhang, Wei W; Wang, Huimin H; Zhang, Xueyan X; Zhong, Runbo R; Han, Baohui B
Publication Date: 2022-03-19

Variant appearance in text: EGFR: L861Q
PubMed Link: 35305596
Variant Present in the following documents:
  • 12885_2022_Article_9409.pdf
View BVdb publication page



Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-03-19

Variant appearance in text: EGFR: L861Q
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Efficacy of Immune Checkpoint Inhibitors in Patients With EGFR Mutated NSCLC and Potential Risk Factors Associated With Prognosis: A Single Institution Experience.

Frontiers In Immunology
Bai, Menglin M; Wang, Weiqing W; Gao, Xuetian X; Wu, Leilei L; Jin, Peng P; Wu, Hui H; Yu, Jinming J; Meng, Xue X
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35296087
Variant Present in the following documents:
  • fimmu-13-832419.pdf
View BVdb publication page



ADAURA: The Splash of Osimertinib in Adjuvant EGFR-Mutant Non-small Cell Lung Cancer.

Oncology And Therapy
Ortega-Franco, Ana A; Rafee, Shereen S
Publication Date: 2022-03-16

Variant appearance in text: EGFR: L861Q
PubMed Link: 35294773
Variant Present in the following documents:
  • 40487_2022_Article_190.pdf
View BVdb publication page



Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon EGFR Mutations: A Retrospective International Cohort Study (UpSwinG).

The Oncologist
Popat, Sanjay S; Hsia, Te-Chun TC; Hung, Jen-Yu JY; Jung, Hyun Ae HA; Shih, Jin-Yuan JY; Park, Cheol Kyu CK; Lee, Seung Hyeun SH; Okamoto, Tatsuro T; Ahn, Hee Kyung HK; Lee, Yong Chul YC; Sato, Yuki Y; Lee, Sung Sook SS; Mascaux, Celine C; Daoud, Hasan H; Märten, Angela A; Miura, Satoru S
Publication Date: 2022-03-11

Variant appearance in text: EGFR: L861Q
PubMed Link: 35274704
Variant Present in the following documents:
  • oyac022.pdf
View BVdb publication page



The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer.

Frontiers In Oncology
Cai, Jun J; Jiang, Huihui H; Li, Shuqing S; Yan, Xiaoxia X; Wang, Meng M; Li, Na N; Zhu, Cuimin C; Dong, Hui H; Wang, Dongjuan D; Xu, Yue Y; Xie, Hui H; Wu, Shouxin S; Lou, Jingwei J; Zhao, Jiangman J; Li, Qingshan Q
Publication Date: 2021

Variant appearance in text: EGFR: L861Q
PubMed Link: 35273907
Variant Present in the following documents:
  • Table_8.xlsx
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Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: EGFR: 2582T>A; L861Q
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx
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Small Cell Lung Cancer Transformation following Treatment in EGFR-Mutated Non-Small Cell Lung Cancer.

Journal Of Clinical Medicine
Mambetsariev, Isa I; Arvanitis, Leonidas L; Fricke, Jeremy J; Pharaon, Rebecca R; Baroz, Angel R AR; Afkhami, Michelle M; Koczywas, Marianna M; Massarelli, Erminia E; Salgia, Ravi R
Publication Date: 2022-03-05

Variant appearance in text: EGFR: L861Q
PubMed Link: 35268520
Variant Present in the following documents:
  • jcm-11-01429.pdf
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Review of Therapeutic Strategies for Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer.

Cancers
Fukui, Takafumi T; Tachihara, Motoko M; Nagano, Tatsuya T; Kobayashi, Kazuyuki K
Publication Date: 2022-02-24

Variant appearance in text: EGFR: L861Q
PubMed Link: 35267492
Variant Present in the following documents:
  • cancers-14-01184.pdf
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The Role of TP53 Mutations in EGFR-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy.

Cancers
Canale, Matteo M; Andrikou, Kalliopi K; Priano, Ilaria I; Cravero, Paola P; Pasini, Luigi L; Urbini, Milena M; Delmonte, Angelo A; Crinò, Lucio L; Bronte, Giuseppe G; Ulivi, Paola P
Publication Date: 2022-02-23

Variant appearance in text: EGFR: L861Q
PubMed Link: 35267450
Variant Present in the following documents:
  • cancers-14-01143.pdf
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Various Subtypes of EGFR Mutations in Patients With NSCLC Define Genetic, Immunologic Diversity and Possess Different Prognostic Biomarkers.

Frontiers In Immunology
Lei, Youming Y; Wang, Kun K; Liu, Yinqiang Y; Wang, Xuming X; Xiang, Xudong X; Ning, Xiangu X; Ding, Wanbao W; Duan, Jin J; Li, Dingbiao D; Zhao, Wei W; Li, Yi Y; Zhang, Fujun F; Luo, Xiaoyu X; Shi, Yunfei Y; Wang, Ying Y; Huang, Depei D; Bai, Yuezong Y; Zhang, Hushan H
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35265073
Variant Present in the following documents:
  • fimmu-13-811601.pdf
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Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models.

Therapeutic Advances In Medical Oncology
Lim, Sun Min SM; Yang, San-Duk SD; Lim, Sangbin S; Heo, Seong Gu SG; Daniel, Stetson S; Markovets, Aleksandra A; Minoo, Rafati R; Pyo, Kyoung-Ho KH; Yun, Mi Ran MR; Hong, Min Hee MH; Kim, Hye Ryun HR; Cho, Byoung Chul BC
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35251316
Variant Present in the following documents:
  • 10.1177_17588359221079125.pdf
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Development and Validation of a Concise Prediction Scoring System for Asian Lung Cancer Patients with EGFR Mutation Before Treatment.

Technology In Cancer Research & Treatment
An, Wenting W; Fan, Wei W; Zhong, Feiyang F; Wang, Binchen B; Wang, Shan S; Gan, Tian T; Tian, Sufang S; Liao, Meiyan M
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35234540
Variant Present in the following documents:
  • 10.1177_15330338221078732.pdf
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Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions.

The Journal Of Biological Chemistry
Aihara, Ayako A; Iwawaki, Takumi T; Abe-Fukasawa, Natsuki N; Otsuka, Keiichiro K; Saruhashi, Koichiro K; Mikashima, Takumi T; Nishino, Taito T
Publication Date: 2022-02-26

Variant appearance in text: EGFR: L861Q
PubMed Link: 35231442
Variant Present in the following documents:
  • mmc1.pdf
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Prevalence of Epidermal Growth Factor Receptor Exon 20 Insertion Mutations in Non-small-Cell Lung Cancer in Europe: A Pragmatic Literature Review and Meta-analysis.

Targeted Oncology
Van Sanden, Suzy S; Murton, Molly M; Bobrowska, Anna A; Rahhali, Nora N; Sermon, Jan J; Rodrigues, Bernardo B; Goff-Leggett, Danielle D; Chouaid, Christos C; Sebastian, Martin M; Greystoke, Alastair A
Publication Date: 2022-02-28

Variant appearance in text: EGFR: L861Q
PubMed Link: 35226283
Variant Present in the following documents:
  • 11523_2022_Article_868.pdf
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The Lifted Veil of Uncommon EGFR Mutation p.L747P in Non-Small Cell Lung Cancer: Molecular Feature and Targeting Sensitivity to Tyrosine Kinase Inhibitors.

Frontiers In Oncology
Yang, Guangjian G; Liu, Chengming C; Hu, Jiaqi J; Sun, Yang Y; Hu, Peizeng P; Liu, Liu L; Xu, Haiyan H; Li, Dazhou D; Li, Weihua W; Yang, Yaning Y; Sun, Nan N; He, Jie J; Wang, Yan Y
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35223527
Variant Present in the following documents:
  • fonc-12-843299.pdf
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Mechanism of Lethal Skin Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors and Related Treatment Strategies.

Frontiers In Oncology
Li, Yanping Y; Fu, Ruoqiu R; Jiang, Tingting T; Duan, Dongyu D; Wu, Yuanlin Y; Li, Chen C; Li, Ziwei Z; Ni, Rui R; Li, Li L; Liu, Yao Y
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35223483
Variant Present in the following documents:
  • fonc-12-804212.pdf
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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: EGFR: Leu861Gln
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx
View BVdb publication page



Clinical Utility of Plasma Cell-Free DNA EGFR Mutation Analysis in Treatment-Naïve Stage IV Non-Small Cell Lung Cancer Patients.

Journal Of Clinical Medicine
Kim, Bo-Guen BG; Jang, Ja-Hyun JH; Kim, Jong-Won JW; Shin, Sun Hye SH; Jeong, Byeong-Ho BH; Lee, Kyungjong K; Kim, Hojoong H; Kwon, O Jung OJ; Ahn, Myung-Ju MJ; Um, Sang-Won SW
Publication Date: 2022-02-21

Variant appearance in text: EGFR: L861Q
PubMed Link: 35207417
Variant Present in the following documents:
  • jcm-11-01144.pdf
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Clinical outcomes of advanced non-small cell lung cancer patients harboring distinct subtypes of EGFR mutations and receiving first-line tyrosine kinase inhibitors: brain metastasis and de novo T790M matters.

Bmc Cancer
Zeng, Ya Y; Guo, Tiantian T; Zhou, Yue Y; Zhao, Yang Y; Chu, Li L; Chu, Xiao X; Yang, Xi X; Ni, Jianjiao J; Zhu, Zhengfei Z
Publication Date: 2022-02-21

Variant appearance in text: EGFR: L861Q
PubMed Link: 35189835
Variant Present in the following documents:
  • 12885_2022_Article_9245.pdf
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Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma.

Frontiers In Oncology
Jiang, Haiping H; Wang, Yinan Y; Xu, Hanlin H; Lei, Wei W; Yu, Xiaoyun X; Tian, Haiying H; Meng, Cong C; Wang, Xueying X; Zhao, Zicheng Z; Jin, Xiangfeng X
Publication Date: 2021

Variant appearance in text: EGFR: L861Q; rs121913444
PubMed Link: 35186718
Variant Present in the following documents:
  • Table_1.xlsx
View BVdb publication page



Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT).

Therapeutic Advances In Medical Oncology
Addeo, Alfredo A; Hochmair, Maximilian M; Janzic, Urska U; Dudnik, Elizabeth E; Charpidou, Andriani A; Płużański, Adam A; Ciuleanu, Tudor T; Donev, Ivan Shterev IS; Elbaz, Judith J; Aarøe, Jørgen J; Ott, René R; Peled, Nir N
Publication Date: 2021

Variant appearance in text: EGFR: L861Q
PubMed Link: 35173817
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359211059874.pdf
View BVdb publication page



Identification of Recurrent Insertions and Deletions in Exon 18 and 19 of Human Epidermal Growth Factor Receptor 2 as Potential Drivers in Non-Small-Cell Lung Cancer and Other Cancer Types.

Jco Precision Oncology
Yin, Yan Y; Song, Lijie L; Shi, Dongsheng D; Liu, Bin B; Li, Xiangke X; Yang, Minjie M; Liu, Bihao B; Wang, Dejuan D; Qin, Jianwen J
Publication Date: 2022-02

Variant appearance in text: EGFR: L861Q
PubMed Link: 35171661
Variant Present in the following documents:
  • po-6-e2100325.pdf
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Application of CRISPR/Cas9-based mutant enrichment technique to improve the clinical sensitivity of plasma EGFR testing in patients with non-small cell lung cancer.

Cancer Cell International
Kim, Boyeon B; Kim, Yoonjung Y; Shin, Saeam S; Lee, Seung-Tae ST; Cho, Jae Yong JY; Lee, Kyung-A KA
Publication Date: 2022-02-15

Variant appearance in text: EGFR: L861Q
PubMed Link: 35168603
Variant Present in the following documents:
  • Main text
  • 12935_2022_Article_2504.pdf
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Osimertinib in advanced EGFR-mutant lung adenocarcinoma with asymptomatic brain metastases: an open-label, 3-arm, phase II pilot study.

Neuro-Oncology Advances
Peled, Nir N; Kian, Waleed W; Inbar, Edna E; Goldstein, Iris M IM; Zemel, Melanie M; Rotem, Ofer O; Rozenblum, Anna B AB; Nechushtan, Hovav H; Dudnik, Elizabeth E; Levin, Daniel D; Zer, Alona A; Keren-Rosenberg, Shoshana S; Yust-Katz, Shlomit S; Fuchs, Vered V; Remilah, Areen A AA; Shelef, Ilan I; Roisman, Laila C LC
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35156036
Variant Present in the following documents:
  • Main text
  • vdab188.pdf
View BVdb publication page



Cytology-Based Specimen Triage for Epidermal Growth Factor Receptor Mutation Testing of Malignant Pleural Effusions in Non-Small Cell Lung Cancer.

Frontiers In Oncology
Chiang, Chi-Lu CL; Shen, Chia-I CI; Huang, Hsu-Ching HC; Chang, Han-Jhih HJ; Huang, Yu-Ting YT; Chiu, Chao-Hua CH
Publication Date: 2022

Variant appearance in text: EGFR: L861Q
PubMed Link: 35141163
Variant Present in the following documents:
  • Main text
  • fonc-12-810124.pdf
View BVdb publication page



Co-occurrence CDK4/6 amplification serves as biomarkers of de novo EGFR TKI resistance in sensitizing EGFR mutation non-small cell lung cancer.

Scientific Reports
Sitthideatphaiboon, Piyada P; Teerapakpinyo, Chinachote C; Korphaisarn, Krittiya K; Leelayuwatanakul, Nophol N; Pornpatrananrak, Nopporn N; Poungvarin, Naravat N; Chantranuwat, Poonchavist P; Shuangshoti, Shanop S; Aporntewan, Chatchawit C; Chintanapakdee, Wariya W; Sriuranpong, Virote V; Vinayanuwattikun, Chanida C
Publication Date: 2022-02-09

Variant appearance in text: EGFR: L861Q
PubMed Link: 35140316
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_6239.pdf
View BVdb publication page



The Role of Circulating Biomarkers in Lung Cancer.

Frontiers In Oncology
Herath, Sayuri S; Sadeghi Rad, Habib H; Radfar, Payar P; Ladwa, Rahul R; Warkiani, Majid M; O'Byrne, Ken K; Kulasinghe, Arutha A
Publication Date: 2021

Variant appearance in text: EGFR: L861Q
PubMed Link: 35127511
Variant Present in the following documents:
  • Main text
  • fonc-11-801269.pdf
View BVdb publication page



Survival Outcomes of Patients With Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis.

Frontiers In Oncology
Li, Ning N; Bian, Zhimin Z; Cong, Minghua M; Liu, Yutao Y
Publication Date: 2021

Variant appearance in text: EGFR: L861Q
PubMed Link: 35127465
Variant Present in the following documents:
  • Main text
  • fonc-11-723562.pdf
View BVdb publication page



The clinicopathological study of lung cancer concealed in end-stage of interstitial lung disease.

Translational Cancer Research
Wang, Bei B; Zhang, Xiaoyan X; Chen, Huang H; Yang, Lei L; Li, Jie J; Xiao, Fei F; Liang, Chaoyang C; Zhong, Dingrong D
Publication Date: 2020-02

Variant appearance in text: EGFR: L861Q
PubMed Link: 35117398
Variant Present in the following documents:
  • Main text
  • tcr-09-02-536.pdf
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EGFR first- and second-generation TKIs-there is still place for them in EGFR-mutant NSCLC patients.

Translational Cancer Research
Karachaliou, Niki N; Fernandez-Bruno, Manuel M; Bracht, Jillian Wilhelmina Paulina JWP; Rosell, Rafael R
Publication Date: 2019-01

Variant appearance in text: EGFR: L861Q
PubMed Link: 35117062
Variant Present in the following documents:
  • Main text
  • tcr-08-S1-S23.pdf
View BVdb publication page



Effect of icotinib on advanced lung adenocarcinoma patients with sensitive EGFR mutation detected in ctDNA by ddPCR.

Translational Cancer Research
Chen, Hua-Fei HF; Lei, Lei L; Wu, Li-Xin LX; Li, Xiao-Feng XF; Zhang, Qu-Xia QX; Pan, Wei-Wei WW; Min, Yong-Hua YH; Zhu, You-Cai YC; Du, Kai-Qi KQ; Wang, Min M; Wang, Wen-Xian WX; Xu, Chun-Wei CW
Publication Date: 2019-12

Variant appearance in text: EGFR: L861Q
PubMed Link: 35117043
Variant Present in the following documents:
  • Main text
  • tcr-08-08-2858.pdf
View BVdb publication page



Analysis of real-word mutations of lung cancer driver genes in five regions of China.

Translational Cancer Research
Sun, Mengyao M; Guo, Ye Y; Shao, Guoguang G; Duan, Xiumei X; Yang, Zhiguang Z; Zhang, Peng P; Liu, Yunpeng Y; Dong, Yutong Y; Wang, Xu X; Xu, Yinghui Y; Sun, Chao C; Ma, Kewei K
Publication Date: 2019-11

Variant appearance in text: EGFR: L861Q
PubMed Link: 35117015
Variant Present in the following documents:
  • Main text
  • tcr-08-07-2581.pdf
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Carcinoembryonic antigen in pleural effusion of patients with lung adenocarcinoma: a predictive marker for EGFR mutation.

Translational Cancer Research
Lv, Yan-Ling YL; Liu, Hong-Bing HB; Yuan, Dong-Mei DM; Zhou, Li L; Jin, Shu-Xian SX; Song, Yong Y
Publication Date: 2019-08

Variant appearance in text: EGFR: L861Q
PubMed Link: 35116846
Variant Present in the following documents:
  • Main text
  • tcr-08-04-1027.pdf
View BVdb publication page