The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.
Oncogene
Li, Zhiping Z; Jiao, Xuanmao X; Robertson, A Gordon AG; Di Sante, Gabriele G; Ashton, Anthony W AW; DiRocco, Agnese A; Wang, Min M; Zhao, Jun J; Addya, Sankar S; Wang, Chenguang C; McCue, Peter A PA; South, Andrew P AP; Cordon-Cardo, Carlos C; Liu, Runzhi R; Patel, Kishan K; Hamid, Rasha R; Parmar, Jorim J; DuHadaway, James B JB; Jones, Steven J M SJM; Casimiro, Mathew C MC; Schultz, Nikolaus N; Kossenkov, Andrew A; Phoon, Lai Yee LY; Chen, Hao H; Lan, Li L; Sun, Yunguang Y; Iczkowski, Kenneth A KA; Rui, Hallgeir H; Pestell, Richard G RG
Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis.
Nature Communications
Angelini, Giulia G; Castagneto-Gissey, Lidia L; Salinari, Serenella S; Bertuzzi, Alessandro A; Anello, Danila D; Pradhan, Meenakshi M; Zschätzsch, Marlen M; Ritter, Paul P; Le Roux, Carel W CW; Rubino, Francesco F; Basso, Nicola N; Casella, Giovanni G; Bornstein, Stefan R SR; Tremaroli, Valentina V; Mingrone, Geltrude G
Tumor cells fail to present MHC-II restricted epitopes derived from oncogenes to CD4+ T cells.
Jci Insight
Brightman, Spencer E SE; Naradikian, Martin S MS; Thota, Rukman R RR; Becker, Angelica A; Montero, Leslie L; Bahmanof, Milad M; Premlal, Ashmitaa A; Greenbaum, Jason A JA; Peters, Bjoern B; Cohen, Ezra Ew EE; Miller, Aaron M AM; Schoenberger, Stephen P SP
Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+/K+ ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation on vital organs.
Frontiers In Pharmacology
Aslam, Huma H; Khan, Arif-Ullah AU; Qazi, Neelum Gul NG; Ali, Fawad F; Hassan, Syed Shams Ul SSU; Bungau, Simona S
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels.
Fluids And Barriers Of The Cns
Linville, Raleigh M RM; Sklar, Matthew B MB; Grifno, Gabrielle N GN; Nerenberg, Renée F RF; Zhou, Justin J; Ye, Robert R; DeStefano, Jackson G JG; Guo, Zhaobin Z; Jha, Ria R; Jamieson, John J JJ; Zhao, Nan N; Searson, Peter C PC
Keller, T C Stevenson TCS; Lechauve, Christophe C; Keller, Alexander S AS; Broseghini-Filho, Gilson Brás GB; Butcher, Joshua T JT; Askew Page, Henry R HR; Islam, Aditi A; Tan, Zhe Yin ZY; DeLalio, Leon J LJ; Brooks, Steven S; Sharma, Poonam P; Hong, Kwangseok K; Xu, Wenhao W; Padilha, Alessandra Simão AS; Ruddiman, Claire A CA; Best, Angela K AK; Macal, Edgar E; Kim-Shapiro, Daniel B DB; Christ, George G; Yan, Zhen Z; Cortese-Krott, Miriam M MM; Ricart, Karina K; Patel, Rakesh R; Bender, Timothy P TP; Sonkusare, Swapnil K SK; Weiss, Mitchell J MJ; Ackerman, Hans H; Columbus, Linda L; Isakson, Brant E BE
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition.
Cancer Discovery
Soto-Feliciano, Yadira M YM; Sanchez-Rivera, Francisco J FJ; Perner, Florian F; Barrows, Douglas W DW; Kastenhuber, Edward R ER; Ho, Yu-Jui YJ; Carroll, Thomas S TS; Xiong, Yijun Y; Anand, Disha D; Soshnev, Alexey A AA; Gates, Leah L; Beytagh, Mary Clare MC; Cheon, David D; Gu, Shengqing Stan SS; Liu, X Shirley XS; Krivtsov, Andrei V AV; Meneses, Maximiliano M; de Stanchina, Elisa E; Stone, Richard M RM; Armstrong, Scott A SA; Lowe, Scott W SW; Allis, C David CD
Developmental Deconvolution for Classification of Cancer Origin.
Cancer Discovery
Moiso, Enrico E; Farahani, Alexander A; Marble, Hetal D HD; Hendricks, Austin A; Mildrum, Samuel S; Levine, Stuart S; Lennerz, Jochen K JK; Garg, Salil S
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin.
Autophagy
Koh, Young Ik YI; Oh, Kyung Seok KS; Kim, Jung Ah JA; Noh, Byunghwa B; Choi, Hye Ji HJ; Joo, Sun Young SY; Rim, John Hoon JH; Kim, Hye-Youn HY; Kim, Dong Yun DY; Yu, Seyoung S; Kim, Da Hye DH; Lee, Sang-Guk SG; Jung, Jinsei J; Choi, Jae Young JY; Gee, Heon Yung HY
Controllable Synthesis of a Porous PEI-Functionalized Co3O4/rGO Nanocomposite as an Electrochemical Sensor for Simultaneous as Well as Individual Detection of Heavy Metal Ions.
Acs Omega
Rehman, Afrasiab Ur AU; Fayaz, Muhammad M; Lv, He H; Liu, Yang Y; Zhang, Jiawei J; Wang, Yang Y; Du, Lijuan L; Wang, Ruihong R; Shi, Keying K
3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway.
3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway.
Risk factors of nonalcoholic fatty liver disease in lean body mass population: A systematic review and meta-analysis.
Jgh Open : An Open Access Journal Of Gastroenterology And Hepatology
Alam, Shahinul S; Eslam, Mohammad M; Skm Hasan, Nazmul N; Anam, Kamrul K; Chowdhury, Mohammad Abdul Baker MAB; Khan, Md Abdullah Saeed MAS; Hasan, Mohammad J MJ; Mohamed, Rosmawati R
A Highly Sensitive and Selective Probe for the Colorimetric Detection of Mn(II) Based on the Antioxidative Selenium and Nitrogen Co-Doped Carbon Quantum Dots and ABTS•.
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
Iscience
Zee, Barry M BM; Poels, Kamrine E KE; Yao, Cong-Hui CH; Kawabata, Kimihito C KC; Wu, Gongwei G; Duy, Cihangir C; Jacobus, William D WD; Senior, Elizabeth E; Endress, Jennifer E JE; Jambhekar, Ashwini A; Lovitch, Scott B SB; Ma, Jiexian J; Dhall, Abhinav A; Harris, Isaac S IS; Blanco, M Andres MA; Sykes, David B DB; Licht, Jonathan D JD; Weinstock, David M DM; Melnick, Ari A; Haigis, Marcia C MC; Michor, Franziska F; Shi, Yang Y
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice.
Communications Biology
Voisin, Maud M; Shrestha, Elina E; Rollet, Claire C; Nikain, Cyrus A CA; Josefs, Tatjana T; Mahé, Mélanie M; Barrett, Tessa J TJ; Chang, Hye Rim HR; Ruoff, Rachel R; Schneider, Jeffrey A JA; Garabedian, Michela L ML; Zoumadakis, Chris C; Yun, Chi C; Badwan, Bara B; Brown, Emily J EJ; Mar, Adam C AC; Schneider, Robert J RJ; Goldberg, Ira J IJ; Pineda-Torra, Inés I; Fisher, Edward A EA; Garabedian, Michael J MJ
Wolska, Anna A; Lo, Larry L; Sviridov, Denis O DO; Pourmousa, Mohsen M; Pryor, Milton M; Ghosh, Soumitra S SS; Kakkar, Rahul R; Davidson, Michael M; Wilson, Sierra S; Pastor, Richard W RW; Goldberg, Ira J IJ; Basu, Debapriya D; Drake, Steven K SK; Cougnoux, Antony A; Wu, Ming Jing MJ; Neher, Saskia B SB; Freeman, Lita A LA; Tang, Jingrong J; Amar, Marcelo M; Devalaraja, Matt M; Remaley, Alan T AT
Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury.
Kidney International
Jang, Hee-Seong HS; Noh, Mi Ra MR; Jung, Eui-Man EM; Kim, Woo-Yang WY; Southekal, Siddesh S; Guda, Chittibabu C; Foster, Kirk W KW; Oupicky, David D; Ferrer, Fernando A FA; Padanilam, Babu J BJ
Radial somatic F-actin organization affects growth cone dynamics during early neuronal development.
Embo Reports
Meka, Durga Praveen DP; Scharrenberg, Robin R; Zhao, Bing B; Kobler, Oliver O; König, Theresa T; Schaefer, Irina I; Schwanke, Birgit B; Klykov, Sergei S; Richter, Melanie M; Eggert, Dennis D; Windhorst, Sabine S; Dotti, Carlos G CG; Kreutz, Michael R MR; Mikhaylova, Marina M; Calderon de Anda, Froylan F
Minimum requirements for changing and maintaining endodermis cell identity in the Arabidopsis root.
Nature Plants
Drapek, Colleen C; Sparks, Erin E EE; Marhavy, Peter P; Taylor, Isaiah I; Andersen, Tonni G TG; Hennacy, Jessica H JH; Geldner, Niko N; Benfey, Philip N PN
Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase.
Nucleic Acids Research
Morellet, Nelly N; Li, Xianghong X; Wieninger, Silke A SA; Taylor, Jennifer L JL; Bischerour, Julien J; Moriau, Séverine S; Lescop, Ewen E; Bardiaux, Benjamin B; Mathy, Nathalie N; Assrir, Nadine N; Bétermier, Mireille M; Nilges, Michael M; Hickman, Alison B AB; Dyda, Fred F; Craig, Nancy L NL; Guittet, Eric E
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum.
Oncotarget
Greenawalt, Danielle M DM; Liang, Winnie S WS; Saif, Sakina S; Johnson, Justin J; Todorov, Petar P; Dulak, Austin A; Enriquez, Daniel D; Halperin, Rebecca R; Ahmed, Ambar A; Saveliev, Vladislav V; Carpten, John J; Craig, David D; Barrett, J Carl JC; Dougherty, Brian B; Zinda, Michael M; Fawell, Stephen S; Dry, Jonathan R JR; Byth, Kate K