Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants.
Antiviral Research
Kim, Ji Woong JW; Heo, Kyun K; Kim, Hyun Jung HJ; Yoo, Youngki Y; Cho, Hyun-Soo HS; Jang, Hui Jeong HJ; Lee, Ho-Young HY; Ko, In Young IY; Woo, Ju Rang JR; Cho, Yea Bin YB; Lee, Ji Hyun JH; Yang, Ha Rim HR; Shin, Ha Gyeong HG; Choi, Hye Lim HL; Hwang, Kyusang K; Kim, Sokho S; Kim, Hanseong H; Chun, Kwangrok K; Lee, Sukmook S
Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology.
Broadly neutralizing antibodies target the coronavirus fusion peptide.
Science (New York, N.Y.)
Dacon, Cherrelle C; Tucker, Courtney C; Peng, Linghang L; Lee, Chang-Chun D CD; Lin, Ting-Hui TH; Yuan, Meng M; Cong, Yu Y; Wang, Lingshu L; Purser, Lauren L; Williams, Jazmean K JK; Pyo, Chul-Woo CW; Kosik, Ivan I; Hu, Zhe Z; Zhao, Ming M; Mohan, Divya D; Cooper, Andrew J R AJR; Peterson, Mary M; Skinner, Jeff J; Dixit, Saurabh S; Kollins, Erin E; Huzella, Louis L; Perry, Donna D; Byrum, Russell R; Lembirik, Sanae S; Drawbaugh, David D; Eaton, Brett B; Zhang, Yi Y; Yang, Eun Sung ES; Chen, Man M; Leung, Kwanyee K; Weinberg, Rona S RS; Pegu, Amarendra A; Geraghty, Daniel E DE; Davidson, Edgar E; Douagi, Iyadh I; Moir, Susan S; Yewdell, Jonathan W JW; Schmaljohn, Connie C; Crompton, Peter D PD; Holbrook, Michael R MR; Nemazee, David D; Mascola, John R JR; Wilson, Ian A IA; Tan, Joshua J