HR c.2677G>T ;(p.A893S)

Variant ID: 8-21977954-C-A

NM_005144.4(HR):c.2677G>T;(p.A893S)

This variant was identified in 17 publications

View GRCh38 version.




Publications:


The Relationship of ABCB1/MDR1 and CYP1A1 Variants with the Risk of Disease Development and Shortening of Overall Survival in Patients with Multiple Myeloma.

Journal Of Clinical Medicine
Zmorzynski, Szymon S; Wojcierowska-Litwin, Magdalena M; Popek-Marciniec, Sylwia S; Szudy-Szczyrek, Aneta A; Styk, Wojciech W; Chocholska, Sylwia S; Filip, Agata Anna AA
Publication Date: 2021-11-13

Variant appearance in text: HR: Ala893Ser
PubMed Link: 34830558
Variant Present in the following documents:
  • Main text
  • jcm-10-05276.pdf
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Outcomes of a 12-week ecologically valid observational study of first treatment with methylphenidate in a representative clinical sample of drug naïve children with ADHD.

Plos One
Kaalund-Brok, Kristine K; Houmann, Tine Bodil TB; Hebsgaard, Marie Bang MB; Lauritsen, Maj-Britt Glenn MG; Lundstrøm, Louise Hyldborg LH; Grønning, Helene H; Darling, Lise L; Reinert-Petersen, Susanna S; Petersen, Morten Aagaard MA; Jepsen, Jens Richardt Møllegaard JRM; Pagsberg, Anne Katrine AK; Plessen, Kerstin Jessica KJ; Rasmussen, Henrik Berg HB; Jeppesen, Pia P; ,
Publication Date: 2021

Variant appearance in text: HR: 2677G>T
PubMed Link: 34673771
Variant Present in the following documents:
  • Main text
  • pone.0253727.s003.pdf
  • pone.0253727.pdf
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The analysis of pharmacokinetic and pharmacogenomic impact on gefitinib efficacy in advanced non-small cell lung cancer patients: results from a prospective cohort study.

Annals Of Translational Medicine
Ma, Yuxiang Y; Xin, Shuang S; Lin, Qingguang Q; Zhuang, Wei W; Zhao, Yuanyuan Y; Zhu, Xia X; Zhao, Hongyun H; Huang, Min M; Xun, Xu X; Yang, Yunpeng Y; Fang, Wenfeng W; Zhang, Li L; Wang, Xueding X
Publication Date: 2019-12

Variant appearance in text: HR: Ala893Ser
PubMed Link: 32042822
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis.

The Lancet. Psychiatry
Cortese, Samuele S; Adamo, Nicoletta N; Del Giovane, Cinzia C; Mohr-Jensen, Christina C; Hayes, Adrian J AJ; Carucci, Sara S; Atkinson, Lauren Z LZ; Tessari, Luca L; Banaschewski, Tobias T; Coghill, David D; Hollis, Chris C; Simonoff, Emily E; Zuddas, Alessandro A; Barbui, Corrado C; Purgato, Marianna M; Steinhausen, Hans-Christoph HC; Shokraneh, Farhad F; Xia, Jun J; Cipriani, Andrea A
Publication Date: 2018-09

Variant appearance in text: HR: 2677G>T
PubMed Link: 30097390
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Pharmacogenetic study of the impact of ABCB1 single-nucleotide polymorphisms on lenalidomide treatment outcomes in patients with multiple myeloma: results from a phase IV observational study and subsequent phase II clinical trial.

Cancer Chemotherapy And Pharmacology
Jakobsen Falk, Ingrid I; Lund, Johan J; Gréen, Henrik H; Gruber, Astrid A; Alici, Evren E; Lauri, Birgitta B; Blimark, Cecilie C; Mellqvist, Ulf-Henrik UH; Swedin, Agneta A; Forsberg, Karin K; Carlsson, Conny C; Hardling, Mats M; Ahlberg, Lucia L; Lotfi, Kourosh K; Nahi, Hareth H
Publication Date: 2018-01

Variant appearance in text: HR: Ala893Ser
PubMed Link: 29177954
Variant Present in the following documents:
  • Main text
  • 280_2017_Article_3481.pdf
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Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer.

Plos One
Pascual, Tomas T; Apellániz-Ruiz, María M; Pernaut, Cristina C; Cueto-Felgueroso, Cecilia C; Villalba, Pablo P; Álvarez, Carlos C; Manso, Luis L; Inglada-Pérez, Lucia L; Robledo, Mercedes M; Rodríguez-Antona, Cristina C; Ciruelos, Eva E
Publication Date: 2017

Variant appearance in text: HR: A893S
PubMed Link: 28727815
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma.

Plos One
Chu, Ying-Hsia YH; Li, Huihua H; Tan, Hui Shan HS; Koh, Valerie V; Lai, Johnathan J; Phyo, Wai Min WM; Choudhury, Yukti Y; Kanesvaran, Ravindran R; Chau, Noan Minh NM; Toh, Chee Keong CK; Ng, Quan Sing QS; Tan, Puay Hoon PH; Chowbay, Balram B; Tan, Min-Han MH
Publication Date: 2015

Variant appearance in text: HR: A893S
PubMed Link: 26244574
Variant Present in the following documents:
  • Main text
View BVdb publication page



IL8 polymorphisms and overall survival in pazopanib- or sunitinib-treated patients with renal cell carcinoma.

British Journal Of Cancer
Xu, C-F CF; Johnson, T T; Garcia-Donas, J J; Choueiri, T K TK; Sternberg, C N CN; Davis, I D ID; Bing, N N; Deen, K C KC; Xue, Z Z; McCann, L L; Esteban, E E; Whittaker, J C JC; Spraggs, C F CF; Rodríguez-Antona, C C; Pandite, L N LN; Motzer, R J RJ
Publication Date: 2015-03-31

Variant appearance in text: HR: A893S
PubMed Link: 25695485
Variant Present in the following documents:
  • Main text
  • bjc201564a.pdf
View BVdb publication page



Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.

Journal Of Biomedical Science
Martinelli, Marcella M; Scapoli, Luca L; Cura, Francesca F; Rodia, Maria Teresa MT; Ugolini, Giampaolo G; Montroni, Isacco I; Solmi, Rossella R
Publication Date: 2014-09-04

Variant appearance in text: HR: Ala893Ser
PubMed Link: 25355168
Variant Present in the following documents:
  • 12929_2014_Article_89.pdf
View BVdb publication page



Inherited variation in the ATP-binding cassette transporter ABCB1 and survival after chemotherapy for stage III-IV lung cancer.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Weissfeld, Joel L JL; Diergaarde, Brenda B; Nukui, Tomoko T; Buch, Shama S; Pennathur, Arjun A; Socinski, Mark A MA; Siegfried, Jill M JM; Romkes, Marjorie M
Publication Date: 2014-09

Variant appearance in text: HR: Ala893Ser
PubMed Link: 25122423
Variant Present in the following documents:
  • Main text
View BVdb publication page



ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.

Gynecologic Oncology
Johnatty, Sharon E SE; Beesley, Jonathan J; Gao, Bo B; Chen, Xiaoqing X; Lu, Yi Y; Law, Matthew H MH; Henderson, Michelle J MJ; Russell, Amanda J AJ; Hedditch, Ellen L EL; Emmanuel, Catherine C; Fereday, Sian S; Webb, Penelope M PM; , ; Goode, Ellen L EL; Vierkant, Robert A RA; Fridley, Brooke L BL; Cunningham, Julie M JM; Fasching, Peter A PA; Beckmann, Matthias W MW; Ekici, Arif B AB; Hogdall, Estrid E; Kjaer, Susanne K SK; Jensen, Allan A; Hogdall, Claus C; Brown, Robert R; Paul, Jim J; Lambrechts, Sandrina S; Despierre, Evelyn E; Vergote, Ignace I; Lester, Jenny J; Karlan, Beth Y BY; Heitz, Florian F; du Bois, Andreas A; Harter, Philipp P; Schwaab, Ira I; Bean, Yukie Y; Pejovic, Tanja T; Levine, Douglas A DA; Goodman, Marc T MT; Camey, Michael E ME; Thompson, Pamela J PJ; Lurie, Galina G; Shildkraut, Joellen J; Berchuck, Andrew A; Terry, Kathryn L KL; Cramer, Daniel W DW; Norris, Murray D MD; Haber, Michelle M; MacGregor, Stuart S; deFazio, Anna A; Chenevix-Trench, Georgia G
Publication Date: 2013-10

Variant appearance in text: HR: Ala893Ser
PubMed Link: 23917080
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics, enzyme probes and therapeutic drug monitoring as potential tools for individualizing taxane therapy.

Pharmacogenomics
Krens, Stefanie D SD; McLeod, Howard L HL; Hertz, Daniel L DL
Publication Date: 2013-04

Variant appearance in text: HR: A893S
PubMed Link: 23556452
Variant Present in the following documents:
  • Main text
View BVdb publication page



Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib.

British Journal Of Cancer
Beuselinck, B B; Karadimou, A A; Lambrechts, D D; Claes, B B; Wolter, P P; Couchy, G G; Berkers, J J; Paridaens, R R; Schöffski, P P; Méjean, A A; Verkarre, V V; Lerut, E E; de la Taille, A A; Tourani, J-M JM; Bigot, P P; Linassier, C C; Négrier, S S; Berger, J J; Patard, J-J JJ; Zucman-Rossi, J J; Oudard, S S
Publication Date: 2013-03-05

Variant appearance in text: HR: A893S
PubMed Link: 23462807
Variant Present in the following documents:
  • Main text
  • bjc2012548a.pdf
View BVdb publication page



Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study.

Gynecologic Oncology
Tian, Chunqiao C; Ambrosone, Christine B CB; Darcy, Kathleen M KM; Krivak, Thomas C TC; Armstrong, Deborah K DK; Bookman, Michael A MA; Davis, Warren W; Zhao, Hua H; Moysich, Kirsten K; Gallion, Holly H; DeLoia, Julie A JA
Publication Date: 2012-03

Variant appearance in text: HR: Ala893Ser
PubMed Link: 22112610
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.

British Journal Of Clinical Pharmacology
Jensen, Berit Packert BP; Roberts, Rebecca Lee RL; Vyas, Ritva R; Bonke, Gitte G; Jardine, David L DL; Begg, Evan James EJ
Publication Date: 2012-04

Variant appearance in text: HR: A893S
PubMed Link: 21999196
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

British Journal Of Cancer
Bray, J J; Sludden, J J; Griffin, M J MJ; Cole, M M; Verrill, M M; Jamieson, D D; Boddy, A V AV
Publication Date: 2010-03-16

Variant appearance in text: HR: Ala893Ser
PubMed Link: 20179710
Variant Present in the following documents:
  • 6605587a.pdf
View BVdb publication page



Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer.

The Pharmacogenomics Journal
Glimelius, B B; Garmo, H H; Berglund, A A; Fredriksson, L A LA; Berglund, M M; Kohnke, H H; Byström, P P; Sørbye, H H; Wadelius, M M
Publication Date: 2011-02

Variant appearance in text: HR: 2677G>T
PubMed Link: 20177420
Variant Present in the following documents:
  • Main text
View BVdb publication page