Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma.
Frontiers In Endocrinology
Siebert, Claudia C; Ciato, Denis D; Murakami, Masanori M; Frei-Stuber, Ludwig L; Perez-Rivas, Luis Gustavo LG; Monteserin-Garcia, José Luis JL; Nölting, Svenja S; Maurer, Julian J; Feuchtinger, Annette A; Walch, Axel K AK; Haak, Harm R HR; Bertherat, Jérôme J; Mannelli, Massimo M; Fassnacht, Martin M; Korpershoek, Esther E; Reincke, Martin M; Stalla, Günter K GK; Hantel, Constanze C; Beuschlein, Felix F
Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo.