Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Immunity
Rajsbaum, Ricardo R; Versteeg, Gijs A GA; Schmid, Sonja S; Maestre, Ana M AM; Belicha-Villanueva, Alan A; Martínez-Romero, Carles C; Patel, Jenish R JR; Morrison, Juliet J; Pisanelli, Giuseppe G; Miorin, Lisa L; Laurent-Rolle, Maudry M; Moulton, Hong M HM; Stein, David A DA; Fernandez-Sesma, Ana A; tenOever, Benjamin R BR; García-Sastre, Adolfo A