Flow cytometric reporter assays provide robust functional analysis of signaling complexes.
The Journal Of Biological Chemistry
Muusse, Timothy W TW; Lee, Morris Y L MYL; Kim, Hyoyoung H; Parat, Marie-Odile MO; Nanson, Jeffrey D JD; Kobe, Bostjan B; Vajjhala, Parimala R PR; Stacey, Katryn J KJ
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nature Communications
Clabbers, Max T B MTB; Holmes, Susannah S; Muusse, Timothy W TW; Vajjhala, Parimala R PR; Thygesen, Sara J SJ; Malde, Alpeshkumar K AK; Hunter, Dominic J B DJB; Croll, Tristan I TI; Flueckiger, Leonie L; Nanson, Jeffrey D JD; Rahaman, Md Habibur MH; Aquila, Andrew A; Hunter, Mark S MS; Liang, Mengning M; Yoon, Chun Hong CH; Zhao, Jingjing J; Zatsepin, Nadia A NA; Abbey, Brian B; Sierecki, Emma E; Gambin, Yann Y; Stacey, Katryn J KJ; Darmanin, Connie C; Kobe, Bostjan B; Xu, Hongyi H; Ve, Thomas T
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Nature Structural & Molecular Biology
Ve, Thomas T; Vajjhala, Parimala R PR; Hedger, Andrew A; Croll, Tristan T; DiMaio, Frank F; Horsefield, Shane S; Yu, Xiong X; Lavrencic, Peter P; Hassan, Zahid Z; Morgan, Garry P GP; Mansell, Ashley A; Mobli, Mehdi M; O'Carroll, Ailis A; Chauvin, Brieuc B; Gambin, Yann Y; Sierecki, Emma E; Landsberg, Michael J MJ; Stacey, Katryn J KJ; Egelman, Edward H EH; Kobe, Bostjan B
Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage.