A novel mutation-proof, next-generation vaccine to fight against upcoming SARS-CoV-2 variants and subvariants, designed through AI enabled approaches and tools, along with the machine learning based immune simulation: A vaccine breakthrough.
International Journal Of Biological Macromolecules
Bhattacharya, Manojit M; Alshammari, Abdulrahman A; Alharbi, Metab M; Dhama, Kuldeep K; Lee, Sang-Soo SS; Chakraborty, Chiranjib C
Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients.
Journal Of Hematology & Oncology
Leyfman, Yan Y; Emmanuel, Nancy N; Menon, Gayathri P GP; Joshi, Muskan M; Wilkerson, William B WB; Cappelli, Jared J; Erick, Timothy K TK; Park, Chandler H CH; Sharma, Pushpa P
Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults.
Drug Repurposing Using Gene Co-Expression and Module Preservation Analysis in Acute Respiratory Distress Syndrome (ARDS), Systemic Inflammatory Response Syndrome (SIRS), Sepsis, and COVID-19.
Cholinergic dysfunction in COVID-19: frantic search and hoping for the best.
Naunyn-Schmiedeberg'S Archives Of Pharmacology
Nadwa, Eman Hassan EH; Al-Kuraishy, Hayder M HM; Al-Gareeb, Ali I AI; Elekhnawy, Engy E; Albogami, Sarah M SM; Alorabi, Mohammed M; Batiha, Gaber El-Saber GE; De Waard, Michel M
Recombinant proteins of spike protein of SARS-CoV-2 with the Omicron receptor-binding domain induce production of highly Omicron-specific neutralizing antibodies.
Clinical And Experimental Vaccine Research
Kang, Hyangju H; Kim, Daniel D; Min, Kyungmin K; Park, Minhee M; Kim, Seok-Hyun SH; Sohn, Eun-Ju EJ; Choi, Bo-Hwa BH; Hwang, Inhwan I
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.
Nature Communications
Ashhurst, Anneliese S AS; Johansen, Matt D MD; Maxwell, Joshua W C JWC; Stockdale, Skye S; Ashley, Caroline L CL; Aggarwal, Anupriya A; Siddiquee, Rezwan R; Miemczyk, Stefan S; Nguyen, Duc H DH; Mackay, Joel P JP; Counoupas, Claudio C; Byrne, Scott N SN; Turville, Stuart S; Steain, Megan M; Triccas, James A JA; Hansbro, Philip M PM; Payne, Richard J RJ; Britton, Warwick J WJ
Bioinformatics approach for the construction of multiple epitope vaccine against omicron variant of SARS-CoV-2.
Scientific Reports
Zaib, Sumera S; Akram, Fatima F; Liaqat, Syed Talha ST; Altaf, Muhammad Zain MZ; Khan, Imtiaz I; Dera, Ayed A AA; Uddin, Jalal J; Khan, Ajmal A; Al-Harrasi, Ahmed A
Lidocaine reinforces the anti-inflammatory action of dexamethasone on myeloid and epithelial cells activated by inflammatory cytokines or SARS-CoV-2 infection.
Biomedical Journal
Elizagaray, Maia Lina ML; Mazitelli, Ignacio I; Pontoriero, Andrea A; Baumeister, Elsa E; Docena, Guillermo G; Raimondi, Clemente C; Correger, Enrique E; Rumbo, Martin M
Using Dual Toll-like Receptor Agonism to Drive Th1-Biased Response in a Squalene- and α-Tocopherol-Containing Emulsion for a More Effective SARS-CoV-2 Vaccine.
Pharmaceutics
Short, Kristopher K KK; Lathrop, Stephanie K SK; Davison, Clara J CJ; Partlow, Haley A HA; Kaiser, Johnathan A JA; Tee, Rebekah D RD; Lorentz, Elizabeth B EB; Evans, Jay T JT; Burkhart, David J DJ
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations.
Ageing Research Reviews
Mitra, Joy J; Kodavati, Manohar M; Provasek, Vincent E VE; Rao, K S KS; Mitra, Sankar S; Hamilton, Dale J DJ; Horner, Philip J PJ; Vahidy, Farhaan S FS; Britz, Gavin W GW; Kent, Thomas A TA; Hegde, Muralidhar L ML
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges.
Human Vaccines & Immunotherapeutics
Dhama, Kuldeep K; Dhawan, Manish M; Tiwari, Ruchi R; Emran, Talha Bin TB; Mitra, Saikat S; Rabaan, Ali A AA; Alhumaid, Saad S; Alawi, Zainab Al ZA; Al Mutair, Abbas A
In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike Protein.
Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19.
Viruses
Zepeda-Cervantes, Jesús J; Martínez-Flores, Daniel D; Ramírez-Jarquín, Josué Orlando JO; Tecalco-Cruz, Ángeles C ÁC; Alavez-Pérez, Noé Santiago NS; Vaca, Luis L; Sarmiento-Silva, Rosa Elena RE
Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19.
Viruses
Zepeda-Cervantes, Jesús J; Martínez-Flores, Daniel D; Ramírez-Jarquín, Josué Orlando JO; Tecalco-Cruz, Ángeles C ÁC; Alavez-Pérez, Noé Santiago NS; Vaca, Luis L; Sarmiento-Silva, Rosa Elena RE
Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry.
Frontiers In Immunology
Palacios-Rápalo, Selvin Noé SN; De Jesús-González, Luis Adrián LA; Cordero-Rivera, Carlos Daniel CD; Farfan-Morales, Carlos Noe CN; Osuna-Ramos, Juan Fidel JF; Martínez-Mier, Gustavo G; Quistián-Galván, Judith J; Muñoz-Pérez, Armando A; Bernal-Dolores, Víctor V; Del Ángel, Rosa María RM; Reyes-Ruiz, José Manuel JM
Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines.
Frontiers In Cellular And Infection Microbiology
Tuli, Hardeep Singh HS; Sak, Katrin K; Aggarwal, Poonam P; Iqubal, Ashif A; Upadhaya, Sushil K SK; Kaur, Jagjit J; Kaur, Ginpreet G; Aggarwal, Diwakar D
Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World Population.
Vaccines
Gustiananda, Marsia M; Sulistyo, Bobby Prabowo BP; Agustriawan, David D; Andarini, Sita S
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties.
Brain, Behavior, And Immunity
Frank, Matthew G MG; Nguyen, Kathy H KH; Ball, Jayson B JB; Hopkins, Shelby S; Kelley, Tel T; Baratta, Michael V MV; Fleshner, Monika M; Maier, Steven F SF
A Next-Generation Vaccine Candidate Using Alternative Epitopes to Protect against Wuhan and All Significant Mutant Variants of SARS-CoV-2: An Immunoinformatics Approach.
Aging And Disease
Bhattacharya, Manojit M; Sharma, Ashish Ranjan AR; Ghosh, Pratik P; Lee, Sang-Soo SS; Chakraborty, Chiranjib C
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
Science Advances
Rodrigues, Kristen A KA; Rodriguez-Aponte, Sergio A SA; Dalvie, Neil C NC; Lee, Jeong Hyun JH; Abraham, Wuhbet W; Carnathan, Diane G DG; Jimenez, Luis E LE; Ngo, Julia T JT; Chang, Jason Y H JYH; Zhang, Zeli Z; Yu, Jingyou J; Chang, Aiquan A; Nakao, Catherine C; Goodwin, Benjamin B; Naranjo, Christopher A CA; Zhang, Libin L; Silva, Murillo M; Barouch, Dan H DH; Silvestri, Guido G; Crotty, Shane S; Love, J Christopher JC; Irvine, Darrell J DJ
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
Science Advances
Rodrigues, Kristen A KA; Rodriguez-Aponte, Sergio A SA; Dalvie, Neil C NC; Lee, Jeong Hyun JH; Abraham, Wuhbet W; Carnathan, Diane G DG; Jimenez, Luis E LE; Ngo, Julia T JT; Chang, Jason Y H JYH; Zhang, Zeli Z; Yu, Jingyou J; Chang, Aiquan A; Nakao, Catherine C; Goodwin, Benjamin B; Naranjo, Christopher A CA; Zhang, Libin L; Silva, Murillo M; Barouch, Dan H DH; Silvestri, Guido G; Crotty, Shane S; Love, J Christopher JC; Irvine, Darrell J DJ
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.
Immunity
Alameh, Mohamad-Gabriel MG; Tombácz, István I; Bettini, Emily E; Lederer, Katlyn K; Sittplangkoon, Chutamath C; Wilmore, Joel R JR; Gaudette, Brian T BT; Soliman, Ousamah Y OY; Pine, Matthew M; Hicks, Philip P; Manzoni, Tomaz B TB; Knox, James J JJ; Johnson, John L JL; Laczkó, Dorottya D; Muramatsu, Hiromi H; Davis, Benjamin B; Meng, Wenzhao W; Rosenfeld, Aaron M AM; Strohmeier, Shirin S; Lin, Paulo J C PJC; Mui, Barbara L BL; Tam, Ying K YK; Karikó, Katalin K; Jacquet, Alain A; Krammer, Florian F; Bates, Paul P; Cancro, Michael P MP; Weissman, Drew D; Luning Prak, Eline T ET; Allman, David D; Locci, Michela M; Pardi, Norbert N
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview.
Vaccines
Al-Karmalawy, Ahmed A AA; Soltane, Raya R; Abo Elmaaty, Ayman A; Tantawy, Mohamed A MA; Antar, Samar A SA; Yahya, Galal G; Chrouda, Amani A; Pashameah, Rami Adel RA; Mustafa, Muhamad M; Abu Mraheil, Mobarak M; Mostafa, Ahmed A