Publications:

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Cell membrane-bound toll-like receptor-1/2/4/6 monomers and -2 heterodimer inhibit enterovirus 71 replication by activating the antiviral innate response.

Frontiers In Immunology

Sun, Ping-Ping PP; Li, Dan D; Su, Meng M; Ren, Qing Q; Guo, Wen-Ping WP; Wang, Jiang-Li JL; Du, Luan-Ying LY; Xie, Guang-Cheng GC

Publication Date: 2023

Variant appearance in text: TLR4: Pro714His

PubMed Link: 37207203

Variant Present in the following documents:

• Main text
• fimmu-14-1187035.pdf

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Flow cytometric reporter assays provide robust functional analysis of signaling complexes.

The Journal Of Biological Chemistry

Muusse, Timothy W TW; Lee, Morris Y L MYL; Kim, Hyoyoung H; Parat, Marie-Odile MO; Nanson, Jeffrey D JD; Kobe, Bostjan B; Vajjhala, Parimala R PR; Stacey, Katryn J KJ

Publication Date: 2022-11-02

Variant appearance in text: TLR4: P714H

PubMed Link: 36334634

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• Main text
• main.pdf

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Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity.

The Embo Journal

Kanoh, Hirotaka H; Nitta, Takahiro T; Go, Shinji S; Inamori, Kei-Ichiro KI; Veillon, Lucas L; Nihei, Wataru W; Fujii, Mayu M; Kabayama, Kazuya K; Shimoyama, Atsushi A; Fukase, Koichi K; Ohto, Umeharu U; Shimizu, Toshiyuki T; Watanabe, Taku T; Shindo, Hiroki H; Aoki, Sorama S; Sato, Kenichi K; Nagasaki, Mika M; Yatomi, Yutaka Y; Komura, Naoko N; Ando, Hiromune H; Ishida, Hideharu H; Kiso, Makoto M; Natori, Yoshihiro Y; Yoshimura, Yuichi Y; Zonca, Asia A; Cattaneo, Anna A; Letizia, Marilena M; Ciampa, Maria M; Mauri, Laura L; Prinetti, Alessandro A; Sonnino, Sandro S; Suzuki, Akemi A; Inokuchi, Jin-Ichi JI

Publication Date: 2020-06-17

Variant appearance in text: TLR4: P714H

PubMed Link: 32378734

Variant Present in the following documents:

• Main text
• EMBJ-39-e101732.pdf

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LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.

Cell Death And Differentiation

Kuo, W-T WT; Lee, T-C TC; Yang, H-Y HY; Chen, C-Y CY; Au, Y-C YC; Lu, Y-Z YZ; Wu, L-L LL; Wei, S-C SC; Ni, Y-H YH; Lin, B-R BR; Chen, Y Y; Tsai, Y-H YH; Kung, J T JT; Sheu, F F; Lin, L-W LW; Yu, L C-H LC

Publication Date: 2015-10

Variant appearance in text: TLR4: Pro714His

PubMed Link: 25633197

Variant Present in the following documents:

• Main text

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Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling.

Cellular And Molecular Life Sciences : Cmls

Płóciennikowska, Agnieszka A; Hromada-Judycka, Aneta A; Borzęcka, Kinga K; Kwiatkowska, Katarzyna K

Publication Date: 2015-02

Variant appearance in text: TLR4: P714H

PubMed Link: 25332099

Variant Present in the following documents:

• Main text
• 18_2014_Article_1762.pdf

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Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.

The Journal Of Biological Chemistry

Stack, Julianne J; Bowie, Andrew G AG

Publication Date: 2012-06-29

Variant appearance in text: TLR4: P714H

PubMed Link: 22593572

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Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.

Plos One

Feng, Chiguang C; Stamatos, Nicholas M NM; Dragan, Anatoliy I AI; Medvedev, Andrei A; Whitford, Melissa M; Zhang, Lei L; Song, Chang C; Rallabhandi, Prasad P; Cole, Leah L; Nhu, Quan M QM; Vogel, Stefanie N SN; Geddes, Chris D CD; Cross, Alan S AS

Publication Date: 2012

Variant appearance in text: TLR4: P714H

PubMed Link: 22496731

Variant Present in the following documents:

• Main text
• pone.0032359.pdf

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Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.

The Journal Of Biological Chemistry

Bovijn, Celia C; Ulrichts, Peter P; De Smet, Anne-Sophie AS; Catteeuw, Dominiek D; Beyaert, Rudi R; Tavernier, Jan J; Peelman, Frank F

Publication Date: 2012-02-03

Variant appearance in text: TLR4: P714H

PubMed Link: 22139835

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Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories.

Clinical And Experimental Immunology

Gruenheid, S S; Gros, P P

Publication Date: 2010-12

Variant appearance in text: TLR-4: P714H

PubMed Link: 21070206

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Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model.

British Journal Of Pharmacology

Takashima, K K; Matsunaga, N N; Yoshimatsu, M M; Hazeki, K K; Kaisho, T T; Uekata, M M; Hazeki, O O; Akira, S S; Iizawa, Y Y; Ii, M M

Publication Date: 2009-08

Variant appearance in text: TLR4: P714H

PubMed Link: 19563534

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TLR4/MyD88/PI3K interactions regulate TLR4 signaling.

Journal Of Leukocyte Biology

Laird, Michelle H W MH; Rhee, Sang Hoon SH; Perkins, Darren J DJ; Medvedev, Andrei E AE; Piao, Wenji W; Fenton, Matthew J MJ; Vogel, Stefanie N SN

Publication Date: 2009-06

Variant appearance in text: TLR4: P714H

PubMed Link: 19289601

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• Main text

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Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.

The Journal Of Biological Chemistry

Rallabhandi, Prasad P; Nhu, Quan M QM; Toshchakov, Vladimir Y VY; Piao, Wenji W; Medvedev, Andrei E AE; Hollenberg, Morley D MD; Fasano, Alessio A; Vogel, Stefanie N SN

Publication Date: 2008-09-05

Variant appearance in text: TLR4: P714H

PubMed Link: 18622013

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Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.

The Journal Of Biological Chemistry

Funami, Kenji K; Sasai, Miwa M; Oshiumi, Hiroyuki H; Seya, Tsukasa T; Matsumoto, Misako M

Publication Date: 2008-06-27

Variant appearance in text: TLR4: P714H

PubMed Link: 18450748

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.

The Journal Of Biological Chemistry

Piao, Wenji W; Song, Chang C; Chen, Haiyan H; Wahl, Larry M LM; Fitzgerald, Katherine A KA; O'Neill, Luke A LA; Medvedev, Andrei E AE

Publication Date: 2008-02-08

Variant appearance in text: TLR4: P714H

PubMed Link: 18070880

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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.

Plos One

Núñez Miguel, Ricardo R; Wong, Joyce J; Westoll, Julian F JF; Brooks, Heather J HJ; O'Neill, Luke A J LA; Gay, Nicholas J NJ; Bryant, Clare E CE; Monie, Tom P TP

Publication Date: 2007-08-29

Variant appearance in text: TLR4: P714H

PubMed Link: 17726518

Variant Present in the following documents:

• Main text
• pone.0000788.pdf

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Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.

The Journal Of Biological Chemistry

Medvedev, Andrei E AE; Piao, Wenji W; Shoenfelt, Joanna J; Rhee, Sang Hoon SH; Chen, Haiyan H; Basu, Subhendu S; Wahl, Larry M LM; Fenton, Matthew J MJ; Vogel, Stefanie N SN

Publication Date: 2007-06-01

Variant appearance in text: TLR4: P714H

PubMed Link: 17392283

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Functional cell permeable motifs within medically relevant proteins.

Journal Of Biotechnology

Low, Walter W; Mortlock, Alison A; Petrovska, Liljana L; Dottorini, Tania T; Dougan, Gordon G; Crisanti, Andrea A

Publication Date: 2007-05-01

Variant appearance in text: TLR4: P714H

PubMed Link: 17331607

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Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.

The Journal Of Biological Chemistry

Gautam, Jitendra K JK; Ashish, ; Comeau, Laurey D LD; Krueger, Joanna K JK; Smith, Michael F MF

Publication Date: 2006-10-06

Variant appearance in text: TLR4: P714H

PubMed Link: 16893894

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