Publications:

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TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.

Nature Communications

Bi, Jing J; Wu, Zhihui Z; Zhang, Xin X; Zeng, Taoling T; Dai, Wanjun W; Qiu, Ningyuan N; Xu, Mingfeng M; Qiao, Yikai Y; Ke, Lang L; Zhao, Jiayi J; Cao, Xinyu X; Lin, Qi Q; Chen, Xiao Lei XL; Xie, Liping L; Ouyang, Zhong Z; Guo, Jujiang J; Zheng, Liangkai L; Ma, Chao C; Guo, Shiying S; Chen, Kangmei K; Mo, Wei W; Fu, Guo G; Zhao, Tong-Jin TJ; Wang, Hong-Rui HR

Publication Date: 2023-04-24

Variant appearance in text: JAK2: G13D

PubMed Link: 37095176

Variant Present in the following documents:

• Main text
• 41467_2023_Article_38115.pdf

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RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL).

Plos Genetics

Rehn, Jacqueline J; Mayoh, Chelsea C; Heatley, Susan L SL; McClure, Barbara J BJ; Eadie, Laura N LN; Schutz, Caitlin C; Yeung, David T DT; Cowley, Mark J MJ; Breen, James J; White, Deborah L DL

Publication Date: 2022-10

Variant appearance in text: JAK2: G13D

PubMed Link: 36251721

Variant Present in the following documents:

• pgen.1010300.pdf

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Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.

Blood Advances

Lisi, Véronique V; Blanchard, Ève È; Vladovsky, Michael M; Audemard, Éric É; Ferghaly, Albert A; Lemieux, Sébastien S; Hébert, Josée J; Sauvageau, Guy G; Lavallée, Vincent-Philippe VP

Publication Date: 2022-09-13

Variant appearance in text: JAK2: Gly13Asp

PubMed Link: 35849707

Variant Present in the following documents:

• advancesADV2022007300-suppl2.xls, sheet 4

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Clinical Features and Genomic Characterization of Post-Colonoscopy Colorectal Cancer.

Clinical And Translational Gastroenterology

Tanaka, Hidenori H; Urabe, Yuji Y; Oka, Shiro S; Shimohara, Yasutsugu Y; Nishimura, Tomoyuki T; Inagaki, Katsuaki K; Okamoto, Yuki Y; Matsumoto, Kenta K; Yamashita, Ken K; Sumimoto, Kyoku K; Ninomiya, Yuki Y; Yuge, Ryo R; Tanaka, Shinji S; Chayama, Kazuaki K

Publication Date: 2020-10

Variant appearance in text: JAK2: G13D

PubMed Link: 33031197

Variant Present in the following documents:

• ct9-11-e00246-s003.xlsx, sheet 1

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Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system.

Journal Of Cancer Research And Clinical Oncology

Hirsch, Daniela D; Gaiser, Timo T; Merx, Kirsten K; Weingaertner, Simone S; Forster, Michael M; Hendricks, Alexander A; Woenckhaus, Matthias M; Schubert, Thomas T; Hofheinz, Ralf-Dieter RD; Gencer, Deniz D

Publication Date: 2021-01

Variant appearance in text: JAK2: G13D

PubMed Link: 32776177

Variant Present in the following documents:

• Main text
• 432_2020_Article_3335.pdf

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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

Nature Communications

Dufva, Olli O; Kankainen, Matti M; Kelkka, Tiina T; Sekiguchi, Nodoka N; Awad, Shady Adnan SA; Eldfors, Samuli S; Yadav, Bhagwan B; Kuusanmäki, Heikki H; Malani, Disha D; Andersson, Emma I EI; Pietarinen, Paavo P; Saikko, Leena L; Kovanen, Panu E PE; Ojala, Teija T; Lee, Dean A DA; Loughran, Thomas P TP; Nakazawa, Hideyuki H; Suzumiya, Junji J; Suzuki, Ritsuro R; Ko, Young Hyeh YH; Kim, Won Seog WS; Chuang, Shih-Sung SS; Aittokallio, Tero T; Chan, Wing C WC; Ohshima, Koichi K; Ishida, Fumihiro F; Mustjoki, Satu S

Publication Date: 2018-04-19

Variant appearance in text: JAK2: G13D

PubMed Link: 29674644

Variant Present in the following documents:

• Main text
• 41467_2018_Article_3987.pdf

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MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells.

Oncotarget

Zeng, Zhihong Z; Wang, Rui-Yu RY; Qiu, Yi Hua YH; Mak, Duncan H DH; Coombes, Kevin K; Yoo, Suk Young SY; Zhang, Qi Q; Jessen, Katti K; Liu, Yi Y; Rommel, Christian C; Fruman, David A DA; Kantarjian, Hagop M HM; Kornblau, Steven M SM; Andreeff, Michael M; Konopleva, Marina M

Publication Date: 2016-08-23

Variant appearance in text: JAK2: G13D

PubMed Link: 27391151

Variant Present in the following documents:

• oncotarget-07-55083-s001.pdf

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Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell

Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R

Publication Date: 2015-09-24

Variant appearance in text: JAK2: G13D

PubMed Link: 26388441

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

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Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.

Oncotarget

Zhao, Chengguang C; Xiao, Hui H; Wu, Xiaojuan X; Li, Chenglong C; Liang, Guang G; Yang, Shulin S; Lin, Jiayuh J

Publication Date: 2015-06-10

Variant appearance in text: JAK2: G13D

PubMed Link: 25961376

Variant Present in the following documents:

• Main text
• oncotarget-06-14472.pdf

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Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.

The Journal Of Investigative Dermatology

Siroy, Alan E AE; Boland, Genevieve M GM; Milton, Denái R DR; Roszik, Jason J; Frankian, Silva S; Malke, Jared J; Haydu, Lauren L; Prieto, Victor G VG; Tetzlaff, Michael M; Ivan, Doina D; Wang, Wei-Lien WL; Torres-Cabala, Carlos C; Curry, Jonathan J; Roy-Chowdhuri, Sinchita S; Broaddus, Russell R; Rashid, Asif A; Stewart, John J; Gershenwald, Jeffrey E JE; Amaria, Rodabe N RN; Patel, Sapna P SP; Papadopoulos, Nicholas E NE; Bedikian, Agop A; Hwu, Wen-Jen WJ; Hwu, Patrick P; Diab, Adi A; Woodman, Scott E SE; Aldape, Kenneth D KD; Luthra, Rajyalakshmi R; Patel, Keyur P KP; Shaw, Kenna R KR; Mills, Gordon B GB; Mendelsohn, John J; Meric-Bernstam, Funda F; Kim, Kevin B KB; Routbort, Mark J MJ; Lazar, Alexander J AJ; Davies, Michael A MA

Publication Date: 2015-02

Variant appearance in text: JAK2: G13D

PubMed Link: 25148578

Variant Present in the following documents:

• NIHMS622327-supplement-supplement_1.pdf

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Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome.

Blood Cancer Journal

Tan, P P; Wei, A A; Mithraprabhu, S S; Cummings, N N; Liu, H B HB; Perugini, M M; Reed, K K; Avery, S S; Patil, S S; Walker, P P; Mollee, P P; Grigg, A A; D'Andrea, R R; Dear, A A; Spencer, A A

Publication Date: 2014-01-10

Variant appearance in text: JAK2: G13D

PubMed Link: 24413064

Variant Present in the following documents:

• bcj201368a.pdf

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Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms.

Leukemia

Tenedini, E E; Bernardis, I I; Artusi, V V; Artuso, L L; Roncaglia, E E; Guglielmelli, P P; Pieri, L L; Bogani, C C; Biamonte, F F; Rotunno, G G; Mannarelli, C C; Bianchi, E E; Pancrazzi, A A; Fanelli, T T; Malagoli Tagliazucchi, G G; Ferrari, S S; Manfredini, R R; Vannucchi, A M AM; Tagliafico, E E; ,

Publication Date: 2014-05

Variant appearance in text: JAK2: G13D

PubMed Link: 24150215

Variant Present in the following documents:

• leu2013302a.pdf

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Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.

Genes & Development

Logue, Jeremy S JS; Morrison, Deborah K DK

Publication Date: 2012-04-01

Variant appearance in text: JAK2: G13D

PubMed Link: 22474259

Variant Present in the following documents:

• Main text

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RNAi screen for rapid therapeutic target identification in leukemia patients.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Tyner, Jeffrey W JW; Deininger, Michael W MW; Loriaux, Marc M MM; Chang, Bill H BH; Gotlib, Jason R JR; Willis, Stephanie G SG; Erickson, Heidi H; Kovacsovics, Tibor T; O'Hare, Thomas T; Heinrich, Michael C MC; Druker, Brian J BJ

Publication Date: 2009-05-26

Variant appearance in text: JAK2: G13D

PubMed Link: 19433805

Variant Present in the following documents:

• Main text

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