JAK2 c.497T>C ;(p.I166T)

Variant ID: 9-5050714-T-C

NM_004972.3(JAK2):c.497T>C;(p.I166T)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors.

Plos One
Akolkar, Dadasaheb D; Patil, Darshana D; Srivastava, Navin N; Patil, Revati R; Datta, Vineet V; Apurwa, Sachin S; Yashwante, Nitin N; Dhasarathan, Raja R; Gosavi, Rahul R; John, Jinumary J; Khan, Shabishta S; Jadhav, Ninad N; Mene, Priti P; Ahire, Dhanashri D; Pawar, Sushant S; Bodke, Harshal H; Sahoo, Subhraline S; Nile, Arun A; Saindane, Dinesh D; Darokar, Harshal H; Devhare, Pradip P; Srinivasan, Ajay A; Datar, Rajan R
Publication Date: 2021

Variant appearance in text: JAK2: I166T
PubMed Link: 33556149
Variant Present in the following documents:
  • pone.0246048.s008.xlsx, sheet 1
View BVdb publication page



Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models.

Cancers
Guo, Zhanfang Z; Primeau, Tina T; Luo, Jingqin J; Zhang, Cynthia C; Sun, Hua H; Hoog, Jeremy J; Gao, Feng F; Huang, Shixia S; Edwards, Dean P DP; Davies, Sherri R SR; Aft, Rebecca R; Ding, Li L; Ellis, Matthew J MJ; Li, Shunqiang S; Ma, Cynthia X CX
Publication Date: 2020-12-21

Variant appearance in text: JAK2: I166T
PubMed Link: 33371187
Variant Present in the following documents:
  • Main text
  • cancers-12-03857.pdf
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: JAK2: 497T>C; I166T
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis.

Cell Death And Differentiation
Caffarel, M M MM; Zaragoza, R R; Pensa, S S; Li, J J; Green, A R AR; Watson, C J CJ
Publication Date: 2012-03

Variant appearance in text: JAK2: I166T
PubMed Link: 21941370
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome remodelling in a basal-like breast cancer metastasis and xenograft.

Nature
Ding, Li L; Ellis, Matthew J MJ; Li, Shunqiang S; Larson, David E DE; Chen, Ken K; Wallis, John W JW; Harris, Christopher C CC; McLellan, Michael D MD; Fulton, Robert S RS; Fulton, Lucinda L LL; Abbott, Rachel M RM; Hoog, Jeremy J; Dooling, David J DJ; Koboldt, Daniel C DC; Schmidt, Heather H; Kalicki, Joelle J; Zhang, Qunyuan Q; Chen, Lei L; Lin, Ling L; Wendl, Michael C MC; McMichael, Joshua F JF; Magrini, Vincent J VJ; Cook, Lisa L; McGrath, Sean D SD; Vickery, Tammi L TL; Appelbaum, Elizabeth E; Deschryver, Katherine K; Davies, Sherri S; Guintoli, Therese T; Lin, Li L; Crowder, Robert R; Tao, Yu Y; Snider, Jacqueline E JE; Smith, Scott M SM; Dukes, Adam F AF; Sanderson, Gabriel E GE; Pohl, Craig S CS; Delehaunty, Kim D KD; Fronick, Catrina C CC; Pape, Kimberley A KA; Reed, Jerry S JS; Robinson, Jody S JS; Hodges, Jennifer S JS; Schierding, William W; Dees, Nathan D ND; Shen, Dong D; Locke, Devin P DP; Wiechert, Madeline E ME; Eldred, James M JM; Peck, Josh B JB; Oberkfell, Benjamin J BJ; Lolofie, Justin T JT; Du, Feiyu F; Hawkins, Amy E AE; O'Laughlin, Michelle D MD; Bernard, Kelly E KE; Cunningham, Mark M; Elliott, Glendoria G; Mason, Mark D MD; Thompson, Dominic M DM; Ivanovich, Jennifer L JL; Goodfellow, Paul J PJ; Perou, Charles M CM; Weinstock, George M GM; Aft, Rebecca R; Watson, Mark M; Ley, Timothy J TJ; Wilson, Richard K RK; Mardis, Elaine R ER
Publication Date: 2010-04-15

Variant appearance in text: JAK2: I166T
PubMed Link: 20393555
Variant Present in the following documents:
  • Main text
  • nihms187230.pdf
View BVdb publication page