Publications:

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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

Nature Communications

Zehender, Ariella A; Huang, Jingang J; Györfi, Andrea-Hermina AH; Matei, Alexandru-Emil AE; Trinh-Minh, Thuong T; Xu, Xiaohan X; Li, Yi-Nan YN; Chen, Chih-Wei CW; Lin, Jianping J; Dees, Clara C; Beyer, Christian C; Gelse, Kolja K; Zhang, Zhong-Yin ZY; Bergmann, Christina C; Ramming, Andreas A; Birchmeier, Walter W; Distler, Oliver O; Schett, Georg G; Distler, Jörg H W JHW

Publication Date: 2018-08-14

Variant appearance in text: JAK2: Y570F

PubMed Link: 30108215

Variant Present in the following documents:

• Main text
• 41467_2018_Article_5768.pdf

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Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.

The Biochemical Journal

Leroy, Emilie E; Dusa, Alexandra A; Colau, Didier D; Motamedi, Amir A; Cahu, Xavier X; Mouton, Céline C; Huang, Lily J LJ; Shiau, Andrew K AK; Constantinescu, Stefan N SN

Publication Date: 2016-06-01

Variant appearance in text: JAK2: Y570F

PubMed Link: 27029346

Variant Present in the following documents:

• Main text
• bj4731579.pdf

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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hammarén, Henrik M HM; Ungureanu, Daniela D; Grisouard, Jean J; Skoda, Radek C RC; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2015-04-14

Variant appearance in text: JAK2: Y570F

PubMed Link: 25825724

Variant Present in the following documents:

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Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

The Biochemical Journal

Varghese, Leila N LN; Ungureanu, Daniela D; Liau, Nicholas P D NP; Young, Samuel N SN; Laktyushin, Artem A; Hammaren, Henrik H; Lucet, Isabelle S IS; Nicola, Nicos A NA; Silvennoinen, Olli O; Babon, Jeffrey J JJ; Murphy, James M JM

Publication Date: 2014-03-01

Variant appearance in text: JAK2: Y570F

PubMed Link: 24354892

Variant Present in the following documents:

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Nature Structural & Molecular Biology

Ungureanu, Daniela D; Wu, Jinhua J; Pekkala, Tuija T; Niranjan, Yashavanthi Y; Young, Clifford C; Jensen, Ole N ON; Xu, Chong-Feng CF; Neubert, Thomas A TA; Skoda, Radek C RC; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2011-08-14

Variant appearance in text: JAK2: Y570F

PubMed Link: 21841788

Variant Present in the following documents:

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Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.

Molecular And Cellular Biology

Funakoshi-Tago, Megumi M; Pelletier, Stéphane S; Moritake, Hiroshi H; Parganas, Evan E; Ihle, James N JN

Publication Date: 2008-03

Variant appearance in text: JAK2: Y570F

PubMed Link: 18160720

Variant Present in the following documents:

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.

Molecular And Cellular Biology

Feener, Edward P EP; Rosario, Felicia F; Dunn, Sarah L SL; Stancheva, Zlatina Z; Myers, Martin G MG

Publication Date: 2004-06

Variant appearance in text: JAK2: Y570F

PubMed Link: 15143188

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.

Molecular And Cellular Biology

Argetsinger, Lawrence S LS; Kouadio, Jean-Louis K JL; Steen, Hanno H; Stensballe, Allan A; Jensen, Ole N ON; Carter-Su, Christin C

Publication Date: 2004-06

Variant appearance in text: JAK2: Y570F

PubMed Link: 15143187

Variant Present in the following documents:

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

Molecular And Cellular Biology

Kurzer, Jason H JH; Argetsinger, Lawrence S LS; Zhou, Yong-Jie YJ; Kouadio, Jean-Louis K JL; O'Shea, John J JJ; Carter-Su, Christin C

Publication Date: 2004-05

Variant appearance in text: JAK2: Y570F

PubMed Link: 15121872

Variant Present in the following documents:

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