Publications:

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Insights into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative Neoplasms.

International Journal Of Molecular Sciences

Gou, Panhong P; Zhang, Wenchao W; Giraudier, Stephane S

Publication Date: 2022-01-18

Variant appearance in text: JAK2: F595A

PubMed Link: 35162937

Variant Present in the following documents:

• Main text
• ijms-23-01013.pdf

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Insights into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative Neoplasms.

International Journal Of Molecular Sciences

Gou, Panhong P; Zhang, Wenchao W; Giraudier, Stephane S

Publication Date: 2022-01-18

Variant appearance in text: JAK2: F595A

PubMed Link: 35162937

Variant Present in the following documents:

• Main text
• ijms-23-01013.pdf

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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.

Science (New York, N.Y.)

Wilmes, Stephan S; Hafer, Maximillian M; Vuorio, Joni J; Tucker, Julie A JA; Winkelmann, Hauke H; Löchte, Sara S; Stanly, Tess A TA; Pulgar Prieto, Katiuska D KD; Poojari, Chetan C; Sharma, Vivek V; Richter, Christian P CP; Kurre, Rainer R; Hubbard, Stevan R SR; Garcia, K Christopher KC; Moraga, Ignacio I; Vattulainen, Ilpo I; Hitchcock, Ian S IS; Piehler, Jacob J

Publication Date: 2020-02-07

Variant appearance in text: JAK2: F595A

PubMed Link: 32029621

Variant Present in the following documents:

• Main text

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Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

The Journal Of Allergy And Clinical Immunology

Hammarén, Henrik M HM; Virtanen, Anniina T AT; Abraham, Bobin George BG; Peussa, Heidi H; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2019-04

Variant appearance in text: JAK2: F595A

PubMed Link: 30092288

Variant Present in the following documents:

• Main text

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Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase.

Frontiers In Endocrinology

Hubbard, Stevan R SR

Publication Date: 2017

Variant appearance in text: JAK2: F595A

PubMed Link: 29379470

Variant Present in the following documents:

• Main text
• fendo-08-00361.pdf

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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hammarén, Henrik M HM; Ungureanu, Daniela D; Grisouard, Jean J; Skoda, Radek C RC; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2015-04-14

Variant appearance in text: JAK2: F595A

PubMed Link: 25825724

Variant Present in the following documents:

• Main text

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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Nature Structural & Molecular Biology

Shan, Yibing Y; Gnanasambandan, Kavitha K; Ungureanu, Daniela D; Kim, Eric T ET; Hammarén, Henrik H; Yamashita, Kazuo K; Silvennoinen, Olli O; Shaw, David E DE; Hubbard, Stevan R SR

Publication Date: 2014-07

Variant appearance in text: JAK2: F595A

PubMed Link: 24918548

Variant Present in the following documents:

• Main text

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Nature Structural & Molecular Biology

Bandaranayake, Rajintha M RM; Ungureanu, Daniela D; Shan, Yibing Y; Shaw, David E DE; Silvennoinen, Olli O; Hubbard, Stevan R SR

Publication Date: 2012-08

Variant appearance in text: JAK2: F595A

PubMed Link: 22820988

Variant Present in the following documents:

• Main text
• nihms389422.pdf

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JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors.

Plos One

Dusa, Alexandra A; Mouton, Céline C; Pecquet, Christian C; Herman, Murielle M; Constantinescu, Stefan N SN

Publication Date: 2010-06-16

Variant appearance in text: JAK2: F595A

PubMed Link: 20585391

Variant Present in the following documents:

• Main text
• pone.0011157.pdf

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