Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors.
Cell Reports. Medicine
Álvarez-Prado, Ángel F ÁF; Maas, Roeltje R RR; Soukup, Klara K; Klemm, Florian F; Kornete, Mara M; Krebs, Fanny S FS; Zoete, Vincent V; Berezowska, Sabina S; Brouland, Jean-Philippe JP; Hottinger, Andreas F AF; Daniel, Roy T RT; Hegi, Monika E ME; Joyce, Johanna A JA
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial.
Leukemia
Schwab, Claire C; Cranston, Ruth E RE; Ryan, Sarra L SL; Butler, Ellie E; Winterman, Emily E; Hawking, Zoe Z; Bashton, Matthew M; Enshaei, Amir A; Russell, Lisa J LJ; Kingsbury, Zoya Z; Peden, John F JF; Barretta, Emilio E; Murray, James J; Gibson, Jude J; Hinchliffe, Andrew C AC; Bain, Robert R; Vora, Ajay A; Bentley, David R DR; Ross, Mark T MT; Moorman, Anthony V AV; Harrison, Christine J CJ
RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL).
Plos Genetics
Rehn, Jacqueline J; Mayoh, Chelsea C; Heatley, Susan L SL; McClure, Barbara J BJ; Eadie, Laura N LN; Schutz, Caitlin C; Yeung, David T DT; Cowley, Mark J MJ; Breen, James J; White, Deborah L DL
JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies.
Frontiers In Cell And Developmental Biology
Downes, Charlotte Ej CE; McClure, Barbara J BJ; McDougal, Daniel P DP; Heatley, Susan L SL; Bruning, John B JB; Thomas, Daniel D; Yeung, David T DT; White, Deborah L DL
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; Saint-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallée, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer J G JJG; Schroeder, Kaitlin M KM; Koch, Victoria V; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials.
Haematologica
Creasey, Thomas T; Barretta, Emilio E; Ryan, Sarra L SL; Butler, Ellie E; Kirkwood, Amy A AA; Leongamornlert, Daniel D; Papaemmanuil, Elli E; Patrick, Pip P; Clifton-Hadley, Laura L; Patel, Bela B; Menne, Tobias T; McMillan, Andrew K AK; Harrison, Christine J CJ; Rowntree, Clare J CJ; Morley, Nick N; Marks, David I DI; Fielding, Adele K AK; Moorman, Anthony V AV
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia.
Oncotarget
Steeghs, Elisabeth M P EMP; Jerchel, Isabel S IS; de Goffau-Nobel, Willemieke W; Hoogkamer, Alex Q AQ; Boer, Judith M JM; Boeree, Aurélie A; van de Ven, Cesca C; Koudijs, Marco J MJ; Besselink, Nicolle J M NJM; de Groot-Kruseman, Hester A HA; Zwaan, Christian Michel CM; Horstmann, Martin A MA; Pieters, Rob R; den Boer, Monique L ML
Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.
Leukemia
Vesely, C C; Frech, C C; Eckert, C C; Cario, G G; Mecklenbräuker, A A; Zur Stadt, U U; Nebral, K K; Kraler, F F; Fischer, S S; Attarbaschi, A A; Schuster, M M; Bock, C C; Cavé, H H; von Stackelberg, A A; Schrappe, M M; Horstmann, M A MA; Mann, G G; Haas, O A OA; Panzer-Grümayer, R R
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.
Scientific Reports
Kesarwani, Meenu M; Huber, Erika E; Kincaid, Zachary Z; Evelyn, Chris R CR; Biesiada, Jacek J; Rance, Mark M; Thapa, Mahendra B MB; Shah, Neil P NP; Meller, Jarek J; Zheng, Yi Y; Azam, Mohammad M
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.
Blood
Loh, Mignon L ML; Zhang, Jinghui J; Harvey, Richard C RC; Roberts, Kathryn K; Payne-Turner, Debbie D; Kang, Huining H; Wu, Gang G; Chen, Xiang X; Becksfort, Jared J; Edmonson, Michael M; Buetow, Kenneth H KH; Carroll, William L WL; Chen, I-Ming IM; Wood, Brent B; Borowitz, Michael J MJ; Devidas, Meenakshi M; Gerhard, Daniela S DS; Bowman, Paul P; Larsen, Eric E; Winick, Naomi N; Raetz, Elizabeth E; Smith, Malcolm M; Downing, James R JR; Willman, Cheryl L CL; Mullighan, Charles G CG; Hunger, Stephen P SP
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Yoda, Akinori A; Yoda, Yuka Y; Chiaretti, Sabina S; Bar-Natan, Michal M; Mani, Kartik K; Rodig, Scott J SJ; West, Nathan N; Xiao, Yun Y; Brown, Jennifer R JR; Mitsiades, Constantine C; Sattler, Martin M; Kutok, Jeffrey L JL; DeAngelo, Daniel J DJ; Wadleigh, Martha M; Piciocchi, Alfonso A; Dal Cin, Paola P; Bradner, James E JE; Griffin, James D JD; Anderson, Kenneth C KC; Stone, Richard M RM; Ritz, Jerome J; Foà, Robin R; Aster, Jon C JC; Frank, David A DA; Weinstock, David M DM
Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
British Journal Of Haematology
Gaikwad, Amos A; Rye, Cassia L CL; Devidas, Meenakshi M; Heerema, Nyla A NA; Carroll, Andrew J AJ; Izraeli, Shai S; Plon, Sharon E SE; Basso, Giuseppe G; Pession, Andrea A; Rabin, Karen R KR