Publications:

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies.

Frontiers In Cell And Developmental Biology

Downes, Charlotte Ej CE; McClure, Barbara J BJ; McDougal, Daniel P DP; Heatley, Susan L SL; Bruning, John B JB; Thomas, Daniel D; Yeung, David T DT; White, Deborah L DL

Publication Date: 2022

Variant appearance in text: JAK2: F739R

PubMed Link: 35903543

Variant Present in the following documents:

• Main text
• fcell-10-942053.pdf

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Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

The Journal Of Allergy And Clinical Immunology

Hammarén, Henrik M HM; Virtanen, Anniina T AT; Abraham, Bobin George BG; Peussa, Heidi H; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2019-04

Variant appearance in text: JAK2: F739R

PubMed Link: 30092288

Variant Present in the following documents:

• Main text

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Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase.

Frontiers In Endocrinology

Hubbard, Stevan R SR

Publication Date: 2017

Variant appearance in text: JAK2: F739R

PubMed Link: 29379470

Variant Present in the following documents:

• Main text
• fendo-08-00361.pdf

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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hammarén, Henrik M HM; Ungureanu, Daniela D; Grisouard, Jean J; Skoda, Radek C RC; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2015-04-14

Variant appearance in text: JAK2: F739R

PubMed Link: 25825724

Variant Present in the following documents:

• Main text

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Nature Structural & Molecular Biology

Bandaranayake, Rajintha M RM; Ungureanu, Daniela D; Shan, Yibing Y; Shaw, David E DE; Silvennoinen, Olli O; Hubbard, Stevan R SR

Publication Date: 2012-08

Variant appearance in text: JAK2: F739R

PubMed Link: 22820988

Variant Present in the following documents:

• Main text
• nihms389422.pdf

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