JAK2 c.2380_2381delinsCA ;(p.F794H)

Variant ID: 9-5080629-TT-CA

NM_004972.3(JAK2):c.2380_2381delinsCA;(p.F794H)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.

Pharmaceuticals (Basel, Switzerland)
Virtanen, Anniina T AT; Haikarainen, Teemu T; Sampathkumar, Parthasarathy P; Palmroth, Maaria M; Liukkonen, Sanna S; Liu, Jianping J; Nekhotiaeva, Natalia N; Hubbard, Stevan R SR; Silvennoinen, Olli O
Publication Date: 2023-01-04

Variant appearance in text: JAK2: F794H
PubMed Link: 36678572
Variant Present in the following documents:
  • Main text
  • pharmaceuticals-16-00075.pdf
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Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.

Journal Of Medicinal Chemistry
Liosi, Maria-Elena ME; Krimmer, Stefan G SG; Newton, Ana S AS; Dawson, Thomas K TK; Puleo, David E DE; Cutrona, Kara J KJ; Suzuki, Yoshihisa Y; Schlessinger, Joseph J; Jorgensen, William L WL
Publication Date: 2020-05-28

Variant appearance in text: JAK2: F794H
PubMed Link: 32329617
Variant Present in the following documents:
  • Main text
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Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.

The Biochemical Journal
Leroy, Emilie E; Dusa, Alexandra A; Colau, Didier D; Motamedi, Amir A; Cahu, Xavier X; Mouton, Céline C; Huang, Lily J LJ; Shiau, Andrew K AK; Constantinescu, Stefan N SN
Publication Date: 2016-06-01

Variant appearance in text: JAK2: F794H
PubMed Link: 27029346
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nucleotide-binding mechanisms in pseudokinases.

Bioscience Reports
Hammarén, Henrik M HM; Virtanen, Anniina T AT; Silvennoinen, Olli O
Publication Date: 2015-11-20

Variant appearance in text: JAK2: F794H
PubMed Link: 26589967
Variant Present in the following documents:
  • Main text
  • bsr036e282.pdf
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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Nature Structural & Molecular Biology
Bandaranayake, Rajintha M RM; Ungureanu, Daniela D; Shan, Yibing Y; Shaw, David E DE; Silvennoinen, Olli O; Hubbard, Stevan R SR
Publication Date: 2012-08

Variant appearance in text: JAK2: F794H
PubMed Link: 22820988
Variant Present in the following documents:
  • Main text
  • nihms389422.pdf
View BVdb publication page