JAK2 c.2603A>T ;(p.Y868F)

Variant ID: 9-5089705-A-T

NM_004972.3(JAK2):c.2603A>T;(p.Y868F)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.

Scientific Reports
Shintani, Takafumi T; Higashi, Satoru S; Suzuki, Ryoko R; Takeuchi, Yasushi Y; Ikaga, Reina R; Yamazaki, Tomomi T; Kobayashi, Kenta K; Noda, Masaharu M
Publication Date: 2017-09-14

Variant appearance in text: JAK2: Y868F
PubMed Link: 28912580
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_12070.pdf
View BVdb publication page



Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.

Molecular Endocrinology (Baltimore, Md.)
Argetsinger, Lawrence S LS; Stuckey, Jeanne A JA; Robertson, Scott A SA; Koleva, Rositsa I RI; Cline, Joel M JM; Marto, Jarrod A JA; Myers, Martin G MG; Carter-Su, Christin C
Publication Date: 2010-05

Variant appearance in text: JAK2: Y868F
PubMed Link: 20304997
Variant Present in the following documents:
  • Main text
View BVdb publication page



Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.

Molecular And Cellular Biology
Funakoshi-Tago, Megumi M; Pelletier, Stéphane S; Moritake, Hiroshi H; Parganas, Evan E; Ihle, James N JN
Publication Date: 2008-03

Variant appearance in text: JAK2: Y868F
PubMed Link: 18160720
Variant Present in the following documents:
  • Main text
View BVdb publication page