Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.
Communications Biology
Cheng, Chi-Keung CK; Yung, Yuk-Lin YL; Chan, Hoi-Yun HY; Leung, Kam-Tong KT; Chan, Kathy Y Y KYY; Leung, Alex W K AWK; Cheng, Frankie W T FWT; Li, Chi-Kong CK; Wan, Thomas S K TSK; Luo, Xi X; Pitts, Herbert-Augustus HA; Cheung, Joyce S JS; Chan, Natalie P H NPH; Ng, Margaret H L MHL
Publication Date: 2023-03-31
Variant appearance in text: JAK2: 2624C>A; T875N; rs1057520016
Base editing screens map mutations affecting interferon-γ signaling in cancer.
Cancer Cell
Coelho, Matthew A MA; Cooper, Sarah S; Strauss, Magdalena E ME; Karakoc, Emre E; Bhosle, Shriram S; Gonçalves, Emanuel E; Picco, Gabriele G; Burgold, Thomas T; Cattaneo, Chiara M CM; Veninga, Vivien V; Consonni, Sarah S; Dinçer, Cansu C; Vieira, Sara F SF; Gibson, Freddy F; Barthorpe, Syd S; Hardy, Claire C; Rein, Joel J; Thomas, Mark M; Marioni, John J; Voest, Emile E EE; Bassett, Andrew A; Garnett, Mathew J MJ
RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL).
Plos Genetics
Rehn, Jacqueline J; Mayoh, Chelsea C; Heatley, Susan L SL; McClure, Barbara J BJ; Eadie, Laura N LN; Schutz, Caitlin C; Yeung, David T DT; Cowley, Mark J MJ; Breen, James J; White, Deborah L DL
Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine.
Blood Cancer Discovery
Wang, Han H; Chan, Kathy Yuen Yee KYY; Cheng, Chi Keung CK; Ng, Margaret H L MHL; Lee, Po Yi PY; Cheng, Frankie Wai Tsoi FWT; Lam, Grace Kee See GKS; Chow, Tin Wai TW; Ha, Shau Yin SY; Chiang, Alan K S AKS; Leung, Wing Hang WH; Leung, Anskar Y H AYH; Wang, Chi Chiu CC; Zhang, Tao T; Zhang, Xiao-Bing XB; So, Chi Chiu CC; Yuen, Yuet Ping YP; Sun, Qiwei Q; Zhang, Chi C; Xu, Yaqun Y; Cheung, John Tak Kit JTK; Ng, Wing Hei WH; Tang, Patrick Ming-Kuen PM; Kang, Wei W; To, Ka-Fai KF; Lee, Wayne Yuk Wai WYW; Wong, Raymond S M RSM; Poon, Ellen Ngar Yun ENY; Zhao, Qi Q; Huang, Junbin J; Chen, Chun C; Yuen, Patrick Man Pan PMP; Li, Chi-Kong CK; Leung, Alex Wing Kwan AWK; Leung, Kam Tong KT
JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies.
Frontiers In Cell And Developmental Biology
Downes, Charlotte Ej CE; McClure, Barbara J BJ; McDougal, Daniel P DP; Heatley, Susan L SL; Bruning, John B JB; Thomas, Daniel D; Yeung, David T DT; White, Deborah L DL
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; Saint-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallée, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer J G JJG; Schroeder, Kaitlin M KM; Koch, Victoria V; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Single nucleotide polymorphism array-based signature of low hypodiploidy in acute lymphoblastic leukemia.
Genes, Chromosomes & Cancer
Creasey, Thomas T; Enshaei, Amir A; Nebral, Karin K; Schwab, Claire C; Watts, Kathryn K; Cuthbert, Gavin G; Vora, Ajay A; Moppett, John J; Harrison, Christine J CJ; Fielding, Adele K AK; Haas, Oskar A OA; Moorman, Anthony V AV
Comprehensive Custom NGS Panel Validation for the Improvement of the Stratification of B-Acute Lymphoblastic Leukemia Patients.
Journal Of Personalized Medicine
Montaño, Adrián A; Hernández-Sánchez, Jesús J; Forero-Castro, Maribel M; Matorra-Miguel, María M; Lumbreras, Eva E; Miguel, Cristina C; Santos, Sandra S; Ramírez-Maldonado, Valentina V; Fuster, José Luís JL; de Las Heras, Natalia N; García-de Coca, Alfonso A; Sierra, Magdalena M; Dávila, Julio J; de la Fuente, Ignacio I; Olivier, Carmen C; Olazabal, Juan J; Martínez, Joaquín J; Vega-García, Nerea N; González, Teresa T; Hernández-Rivas, Jesús María JM; Benito, Rocío R
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Surface expression of Cytokine Receptor-Like Factor 2 increases risk of relapse in pediatric acute lymphoblastic leukemia patients harboring IKZF1 deletions.
Oncotarget
Pastorczak, Agata A; Sedek, Lukasz L; Braun, Marcin M; Madzio, Joanna J; Sonsala, Alicja A; Twardoch, Magdalena M; Fendler, Wojciech W; Nebral, Karin K; Taha, Joanna J; Bielska, Marta M; Gorniak, Patryk P; Romiszewska, Magdalena M; Matysiak, Michal M; Derwich, Katarzyna K; Lejman, Monika M; Kowalczyk, Jerzy J; Badowska, Wanda W; Niedzwiecki, Maciej M; Kazanowska, Bernarda B; Muszynska-Roslan, Katarzyna K; Sobol-Milejska, Grazyna G; Karolczyk, Grazyna G; Koltan, Andrzej A; Ociepa, Tomasz T; Szczepanski, Tomasz T; Młynarski, Wojciech W
[Spectrum of somatic mutations and their prognostic significance in adult patients with B cell acute lymphoblastic leukemia].
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
Feng, J J; Gong, X Y XY; Jia, Y J YJ; Liu, K Q KQ; Li, Y Y; Dong, X B XB; Fang, Q Y QY; Ru, K K; Li, Q H QH; Wang, H J HJ; Zhao, X L XL; Jia, Y N YN; Song, Y Y; Tian, Z Z; Wang, M M; Tang, K J KJ; Wang, J X JX; Mi, Y C YC
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.
Nature
Ma, Xiaotu X; Liu, Yu Y; Liu, Yanling Y; Alexandrov, Ludmil B LB; Edmonson, Michael N MN; Gawad, Charles C; Zhou, Xin X; Li, Yongjin Y; Rusch, Michael C MC; Easton, John J; Huether, Robert R; Gonzalez-Pena, Veronica V; Wilkinson, Mark R MR; Hermida, Leandro C LC; Davis, Sean S; Sioson, Edgar E; Pounds, Stanley S; Cao, Xueyuan X; Ries, Rhonda E RE; Wang, Zhaoming Z; Chen, Xiang X; Dong, Li L; Diskin, Sharon J SJ; Smith, Malcolm A MA; Guidry Auvil, Jaime M JM; Meltzer, Paul S PS; Lau, Ching C CC; Perlman, Elizabeth J EJ; Maris, John M JM; Meshinchi, Soheil S; Hunger, Stephen P SP; Gerhard, Daniela S DS; Zhang, Jinghui J
Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia.
Oncotarget
Zhang, Qi Q; Shi, Ce C; Han, Lina L; Jain, Nitin N; Roberts, Kathryn G KG; Ma, Helen H; Cai, Tianyu T; Cavazos, Antonio A; Tabe, Yoko Y; Jacamo, Rodrigo O RO; Mu, Hong H; Zhao, Yang Y; Wang, Jing J; Wu, Shuo-Chieh SC; Cao, Fenglin F; Zeng, Zhihong Z; Zhou, Jin J; Mi, Yingchang Y; Jabbour, Elias J EJ; Levine, Ross R; Tasian, Sarah K SK; Mullighan, Charles G CG; Weinstock, David M DM; Fruman, David A DA; Konopleva, Marina M
JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia.
Oncotarget
Steeghs, Elisabeth M P EMP; Jerchel, Isabel S IS; de Goffau-Nobel, Willemieke W; Hoogkamer, Alex Q AQ; Boer, Judith M JM; Boeree, Aurélie A; van de Ven, Cesca C; Koudijs, Marco J MJ; Besselink, Nicolle J M NJM; de Groot-Kruseman, Hester A HA; Zwaan, Christian Michel CM; Horstmann, Martin A MA; Pieters, Rob R; den Boer, Monique L ML
Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.
The Biochemical Journal
Leroy, Emilie E; Dusa, Alexandra A; Colau, Didier D; Motamedi, Amir A; Cahu, Xavier X; Mouton, Céline C; Huang, Lily J LJ; Shiau, Andrew K AK; Constantinescu, Stefan N SN
Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.
Nature Communications
Ma, Xiaotu X; Edmonson, Michael M; Yergeau, Donald D; Muzny, Donna M DM; Hampton, Oliver A OA; Rusch, Michael M; Song, Guangchun G; Easton, John J; Harvey, Richard C RC; Wheeler, David A DA; Ma, Jing J; Doddapaneni, HarshaVardhan H; Vadodaria, Bhavin B; Wu, Gang G; Nagahawatte, Panduka P; Carroll, William L WL; Chen, I-Ming IM; Gastier-Foster, Julie M JM; Relling, Mary V MV; Smith, Malcolm A MA; Devidas, Meenakshi M; Guidry Auvil, Jaime M JM; Downing, James R JR; Loh, Mignon L ML; Willman, Cheryl L CL; Gerhard, Daniela S DS; Mullighan, Charles G CG; Hunger, Stephen P SP; Zhang, Jinghui J
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Nature Structural & Molecular Biology
Shan, Yibing Y; Gnanasambandan, Kavitha K; Ungureanu, Daniela D; Kim, Eric T ET; Hammarén, Henrik H; Yamashita, Kazuo K; Silvennoinen, Olli O; Shaw, David E DE; Hubbard, Stevan R SR
Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Cell Reports
Waibel, Michaela M; Solomon, Vanessa S VS; Knight, Deborah A DA; Ralli, Rachael A RA; Kim, Sang-Kyu SK; Banks, Kellie-Marie KM; Vidacs, Eva E; Virely, Clemence C; Sia, Keith C S KC; Bracken, Lauryn S LS; Collins-Underwood, Racquel R; Drenberg, Christina C; Ramsey, Laura B LB; Meyer, Sara C SC; Takiguchi, Megumi M; Dickins, Ross A RA; Levine, Ross R; Ghysdael, Jacques J; Dawson, Mark A MA; Lock, Richard B RB; Mullighan, Charles G CG; Johnstone, Ricky W RW
Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies.
Leukemia & Lymphoma
Mughal, Tariq I TI; Girnius, Saulius S; Rosen, Steven T ST; Kumar, Shaji S; Wiestner, Adrian A; Abdel-Wahab, Omar O; Kiladjian, Jean-Jacques JJ; Wilson, Wyndham H WH; Van Etten, Richard A RA
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.
Blood
Loh, Mignon L ML; Zhang, Jinghui J; Harvey, Richard C RC; Roberts, Kathryn K; Payne-Turner, Debbie D; Kang, Huining H; Wu, Gang G; Chen, Xiang X; Becksfort, Jared J; Edmonson, Michael M; Buetow, Kenneth H KH; Carroll, William L WL; Chen, I-Ming IM; Wood, Brent B; Borowitz, Michael J MJ; Devidas, Meenakshi M; Gerhard, Daniela S DS; Bowman, Paul P; Larsen, Eric E; Winick, Naomi N; Raetz, Elizabeth E; Smith, Malcolm M; Downing, James R JR; Willman, Cheryl L CL; Mullighan, Charles G CG; Hunger, Stephen P SP