Targetability of STAT3-JAK2 fusions: implications for T-cell lymphoproliferative disorders of the gastrointestinal tract.
Leukemia
Hu, Guangzhen G; Phillips, Jessica L JL; Dasari, Surendra S; Jacobs, Hailey K HK; Luchtel, Rebecca A RA; Oishi, Naoki N; Hundal, Tanya T; Ahmed, Nada H NH; Satou, Akira A; Epstein, Alan L AL; Bennani, N Nora NN; Nowakowski, Grzegorz S GS; Murray, Joseph A JA; Feldman, Andrew L AL
Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.
Science Advances
Tvorogov, Denis D; Thomas, Daniel D; Liau, Nicholas P D NPD; Dottore, Mara M; Barry, Emma F EF; Lathi, Maya M; Kan, Winnie L WL; Hercus, Timothy R TR; Stomski, Frank F; Hughes, Timothy P TP; Tergaonkar, Vinay V; Parker, Michael W MW; Ross, David M DM; Majeti, Ravindra R; Babon, Jeffrey J JJ; Lopez, Angel F AF
CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Cancer Cell
Meyer, Sara C SC; Keller, Matthew D MD; Chiu, Sophia S; Koppikar, Priya P; Guryanova, Olga A OA; Rapaport, Franck F; Xu, Ke K; Manova, Katia K; Pankov, Dmitry D; O'Reilly, Richard J RJ; Kleppe, Maria M; McKenney, Anna Sophia AS; Shih, Alan H AH; Shank, Kaitlyn K; Ahn, Jihae J; Papalexi, Eftymia E; Spitzer, Barbara B; Socci, Nick N; Viale, Agnes A; Mandon, Emeline E; Ebel, Nicolas N; Andraos, Rita R; Rubert, Joëlle J; Dammassa, Ernesta E; Romanet, Vincent V; Dölemeyer, Arno A; Zender, Michael M; Heinlein, Melanie M; Rampal, Raajit R; Weinberg, Rona Singer RS; Hoffman, Ronald R; Sellers, William R WR; Hofmann, Francesco F; Murakami, Masato M; Baffert, Fabienne F; Gaul, Christoph C; Radimerski, Thomas T; Levine, Ross L RL
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
Molecular And Cellular Biology
Mazurkiewicz-Munoz, Anna M AM; Argetsinger, Lawrence S LS; Kouadio, Jean-Louis K JL; Stensballe, Allan A; Jensen, Ole N ON; Cline, Joel M JM; Carter-Su, Christin C
Kinase activation through dimerization by human SH2-B.
Molecular And Cellular Biology
Nishi, Masahiro M; Werner, Eric D ED; Oh, Byung-Chul BC; Frantz, J Daniel JD; Dhe-Paganon, Sirano S; Hansen, Lone L; Lee, Jongsoon J; Shoelson, Steven E SE