Publications:

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Exercise-derived peptide protects against pathological cardiac remodeling.

Ebiomedicine

Yin, Anwen A; Yuan, Ruosen R; Xiao, Qingqing Q; Zhang, Weifeng W; Xu, Ke K; Yang, Xiaoxiao X; Yang, Wentao W; Xu, Lei L; Wang, Xia X; Zhuang, Fei F; Li, Yi Y; Cai, Zhaohua Z; Sun, Zhe Z; Zhou, Bin B; He, Ben B; Shen, Linghong L

Publication Date: 2022-08

Variant appearance in text: JAK2: K882E

PubMed Link: 35843176

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• main.pdf

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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.

Plos One

Shahi, Aashirwad A; Kahle, Jacob J; Hopkins, Chandler C; Diakonova, Maria M

Publication Date: 2022

Variant appearance in text: JAK2: K882E

PubMed Link: 35089929

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• Main text
• pone.0261098.pdf

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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.

Plos One

Shahi, Aashirwad A; Kahle, Jacob J; Hopkins, Chandler C; Diakonova, Maria M

Publication Date: 2022

Variant appearance in text: JAK2: K882E

PubMed Link: 35089929

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• Main text
• pone.0261098.pdf

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IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.

Nature Communications

Hu, Fuqing F; Song, Da D; Yan, Yumeng Y; Huang, Changsheng C; Shen, Chentao C; Lan, Jingqin J; Chen, Yaqi Y; Liu, Anyi A; Wu, Qi Q; Sun, Li L; Xu, Feng F; Hu, Fayong F; Chen, Lisheng L; Luo, Xuelai X; Feng, Yongdong Y; Huang, Shengyou S; Hu, Junbo J; Wang, Guihua G

Publication Date: 2021-06-15

Variant appearance in text: JAK2: K882E

PubMed Link: 34131122

Variant Present in the following documents:

• Main text
• 41467_2021_23923_MOESM2_ESM.pdf
• 41467_2021_23923_MOESM1_ESM.pdf
• 41467_2021_Article_23923.pdf

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Targetability of STAT3-JAK2 fusions: implications for T-cell lymphoproliferative disorders of the gastrointestinal tract.

Leukemia

Hu, Guangzhen G; Phillips, Jessica L JL; Dasari, Surendra S; Jacobs, Hailey K HK; Luchtel, Rebecca A RA; Oishi, Naoki N; Hundal, Tanya T; Ahmed, Nada H NH; Satou, Akira A; Epstein, Alan L AL; Bennani, N Nora NN; Nowakowski, Grzegorz S GS; Murray, Joseph A JA; Feldman, Andrew L AL

Publication Date: 2020-05

Variant appearance in text: JAK2: K882E

PubMed Link: 31836854

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Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.

Science Immunology

Boisson-Dupuis, Stéphanie S; Ramirez-Alejo, Noe N; Li, Zhi Z; Patin, Etienne E; Rao, Geetha G; Kerner, Gaspard G; Lim, Che Kang CK; Krementsov, Dimitry N DN; Hernandez, Nicholas N; Ma, Cindy S CS; Zhang, Qian Q; Markle, Janet J; Martinez-Barricarte, Ruben R; Payne, Kathryn K; Fisch, Robert R; Deswarte, Caroline C; Halpern, Joshua J; Bouaziz, Matthieu M; Mulwa, Jeanette J; Sivanesan, Durga D; Lazarov, Tomi T; Naves, Rodrigo R; Garcia, Patricia P; Itan, Yuval Y; Boisson, Bertrand B; Checchi, Alix A; Jabot-Hanin, Fabienne F; Cobat, Aurélie A; Guennoun, Andrea A; Jackson, Carolyn C CC; Pekcan, Sevgi S; Caliskaner, Zafer Z; Inostroza, Jaime J; Costa-Carvalho, Beatriz Tavares BT; de Albuquerque, Jose Antonio Tavares JAT; Garcia-Ortiz, Humberto H; Orozco, Lorena L; Ozcelik, Tayfun T; Abid, Ahmed A; Rhorfi, Ismail Abderahmani IA; Souhi, Hicham H; Amrani, Hicham Naji HN; Zegmout, Adil A; Geissmann, Frédéric F; Michnick, Stephen W SW; Muller-Fleckenstein, Ingrid I; Fleckenstein, Bernhard B; Puel, Anne A; Ciancanelli, Michael J MJ; Marr, Nico N; Abolhassani, Hassan H; Balcells, María Elvira ME; Condino-Neto, Antonio A; Strickler, Alexis A; Abarca, Katia K; Teuscher, Cory C; Ochs, Hans D HD; Reisli, Ismail I; Sayar, Esra H EH; El-Baghdadi, Jamila J; Bustamante, Jacinta J; Hammarström, Lennart L; Tangye, Stuart G SG; Pellegrini, Sandra S; Quintana-Murci, Lluis L; Abel, Laurent L; Casanova, Jean-Laurent JL

Publication Date: 2018-12-21

Variant appearance in text: JAK2: K882E

PubMed Link: 30578352

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JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage.

Environmental And Molecular Mutagenesis

Ding, Ning N; Miller, Sam A SA; Savant, Sudha S SS; O'Hagan, Heather M HM

Publication Date: 2019-05

Variant appearance in text: JAK2: K882E

PubMed Link: 30548332

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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.

Science Advances

Tvorogov, Denis D; Thomas, Daniel D; Liau, Nicholas P D NPD; Dottore, Mara M; Barry, Emma F EF; Lathi, Maya M; Kan, Winnie L WL; Hercus, Timothy R TR; Stomski, Frank F; Hughes, Timothy P TP; Tergaonkar, Vinay V; Parker, Michael W MW; Ross, David M DM; Majeti, Ravindra R; Babon, Jeffrey J JJ; Lopez, Angel F AF

Publication Date: 2018-11

Variant appearance in text: JAK2: K882E

PubMed Link: 30498775

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• Main text
• aat3834.pdf

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CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

Cancer Cell

Meyer, Sara C SC; Keller, Matthew D MD; Chiu, Sophia S; Koppikar, Priya P; Guryanova, Olga A OA; Rapaport, Franck F; Xu, Ke K; Manova, Katia K; Pankov, Dmitry D; O'Reilly, Richard J RJ; Kleppe, Maria M; McKenney, Anna Sophia AS; Shih, Alan H AH; Shank, Kaitlyn K; Ahn, Jihae J; Papalexi, Eftymia E; Spitzer, Barbara B; Socci, Nick N; Viale, Agnes A; Mandon, Emeline E; Ebel, Nicolas N; Andraos, Rita R; Rubert, Joëlle J; Dammassa, Ernesta E; Romanet, Vincent V; Dölemeyer, Arno A; Zender, Michael M; Heinlein, Melanie M; Rampal, Raajit R; Weinberg, Rona Singer RS; Hoffman, Ronald R; Sellers, William R WR; Hofmann, Francesco F; Murakami, Masato M; Baffert, Fabienne F; Gaul, Christoph C; Radimerski, Thomas T; Levine, Ross L RL

Publication Date: 2015-07-13

Variant appearance in text: JAK2: K882E

PubMed Link: 26175413

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Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Hammer, Alan A; Oladimeji, Peter P; De Las Casas, Luis E LE; Diakonova, Maria M

Publication Date: 2015-03

Variant appearance in text: JAK2: K882E

PubMed Link: 25466889

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SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.

Molecular Endocrinology (Baltimore, Md.)

Chen, Zheng Z; Morris, David L DL; Jiang, Lin L; Liu, Yong Y; Rui, Liangyou L

Publication Date: 2014-05

Variant appearance in text: JAK2: K882E

PubMed Link: 24645678

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Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein.

Molecular Endocrinology (Baltimore, Md.)

O'Leary, Erin E EE; Mazurkiewicz-Muñoz, Anna M AM; Argetsinger, Lawrence S LS; Maures, Travis J TJ; Huynh, Hung T HT; Carter-Su, Christin C

Publication Date: 2013-04

Variant appearance in text: JAK2: K882E

PubMed Link: 23449887

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Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A.

Molecular Endocrinology (Baltimore, Md.)

Hammer, Alan A; Rider, Leah L; Oladimeji, Peter P; Cook, Leslie L; Li, Quanwen Q; Mattingly, Raymond R RR; Diakonova, Maria M

Publication Date: 2013-03

Variant appearance in text: JAK2: K882E

PubMed Link: 23340249

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The Jak/STAT signaling pathway is downregulated at febrile temperatures.

Plos One

Nespital, Tobias T; Strous, Ger J GJ

Publication Date: 2012

Variant appearance in text: JAK2: K882E

PubMed Link: 23166650

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• pone.0049374.pdf

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Identification of a redox-sensitive switch within the JAK2 catalytic domain.

Free Radical Biology & Medicine

Smith, John K JK; Patil, Chetan N CN; Patlolla, Srikant S; Gunter, Barak W BW; Booz, George W GW; Duhé, Roy J RJ

Publication Date: 2012-03-15

Variant appearance in text: JAK2: K882E

PubMed Link: 22281400

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Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways.

The Journal Of Biological Chemistry

Jiang, Lin L; Li, Zhiqin Z; Rui, Liangyou L

Publication Date: 2008-10-17

Variant appearance in text: JAK2: K882E

PubMed Link: 18718905

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Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

Molecular And Cellular Biology

Kurzer, Jason H JH; Saharinen, Pipsa P; Silvennoinen, Olli O; Carter-Su, Christin C

Publication Date: 2006-09

Variant appearance in text: JAK2: K882E

PubMed Link: 16914724

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Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.

Molecular And Cellular Biology

Mazurkiewicz-Munoz, Anna M AM; Argetsinger, Lawrence S LS; Kouadio, Jean-Louis K JL; Stensballe, Allan A; Jensen, Ole N ON; Cline, Joel M JM; Carter-Su, Christin C

Publication Date: 2006-06

Variant appearance in text: JAK2: K882E

PubMed Link: 16705159

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Kinase activation through dimerization by human SH2-B.

Molecular And Cellular Biology

Nishi, Masahiro M; Werner, Eric D ED; Oh, Byung-Chul BC; Frantz, J Daniel JD; Dhe-Paganon, Sirano S; Hansen, Lone L; Lee, Jongsoon J; Shoelson, Steven E SE

Publication Date: 2005-04

Variant appearance in text: JAK2: K882E

PubMed Link: 15767667

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.

Molecular And Cellular Biology

Argetsinger, Lawrence S LS; Kouadio, Jean-Louis K JL; Steen, Hanno H; Stensballe, Allan A; Jensen, Ole N ON; Carter-Su, Christin C

Publication Date: 2004-06

Variant appearance in text: JAK2: K882E

PubMed Link: 15143187

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

Molecular And Cellular Biology

Kurzer, Jason H JH; Argetsinger, Lawrence S LS; Zhou, Yong-Jie YJ; Kouadio, Jean-Louis K JL; O'Shea, John J JJ; Carter-Su, Christin C

Publication Date: 2004-05

Variant appearance in text: JAK2: K882E

PubMed Link: 15121872

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Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta.

Molecular And Cellular Biology

Rui, L L; Gunter, D R DR; Herrington, J J; Carter-Su, C C

Publication Date: 2000-05

Variant appearance in text: JAK2: K882E

PubMed Link: 10757801

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