JAK2 c.2753A>T ;(p.Y918F)

Variant ID: 9-5089855-A-T

NM_004972.3(JAK2):c.2753A>T;(p.Y918F)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

The Journal Of Biological Chemistry
Moretti, Sonia S; Menicali, Elisa E; Nucci, Nicole N; Voce, Pasquale P; Colella, Renato R; Melillo, Rosa Marina RM; Liotti, Federica F; Morelli, Silvia S; Fallarino, Francesca F; Macchiarulo, Antonio A; Santoro, Massimo M; Avenia, Nicola N; Puxeddu, Efisio E
Publication Date: 2017-02-03

Variant appearance in text: JAK2: Y918F
PubMed Link: 27994058
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.

Molecular Endocrinology (Baltimore, Md.)
Argetsinger, Lawrence S LS; Stuckey, Jeanne A JA; Robertson, Scott A SA; Koleva, Rositsa I RI; Cline, Joel M JM; Marto, Jarrod A JA; Myers, Martin G MG; Carter-Su, Christin C
Publication Date: 2010-05

Variant appearance in text: JAK2: Y918F
PubMed Link: 20304997
Variant Present in the following documents:
  • Main text
View BVdb publication page



Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.

Molecular And Cellular Biology
Funakoshi-Tago, Megumi M; Pelletier, Stéphane S; Moritake, Hiroshi H; Parganas, Evan E; Ihle, James N JN
Publication Date: 2008-03

Variant appearance in text: JAK2: Y918F
PubMed Link: 18160720
Variant Present in the following documents:
  • Main text
View BVdb publication page