Publications:

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Molecular dissection of Janus kinases as drug targets for inflammatory diseases.

Frontiers In Immunology

Kwon, Sunghark S

Publication Date: 2022

Variant appearance in text: JAK2: Y931C

PubMed Link: 36569926

Variant Present in the following documents:

• Main text
• fimmu-13-1075192.pdf

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JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies.

Frontiers In Cell And Developmental Biology

Downes, Charlotte Ej CE; McClure, Barbara J BJ; McDougal, Daniel P DP; Heatley, Susan L SL; Bruning, John B JB; Thomas, Daniel D; Yeung, David T DT; White, Deborah L DL

Publication Date: 2022

Variant appearance in text: JAK2: Y931C

PubMed Link: 35903543

Variant Present in the following documents:

• Main text
• fcell-10-942053.pdf

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Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.

International Journal Of Molecular Sciences

Jędraszek, Krzysztof K; Malczewska, Marta M; Parysek-Wójcik, Karolina K; Lejman, Monika M

Publication Date: 2022-03-12

Variant appearance in text: JAK2: Y931C

PubMed Link: 35328487

Variant Present in the following documents:

• Main text
• ijms-23-03067.pdf

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Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms.

Cancers

Bochicchio, Maria Teresa MT; Di Battista, Valeria V; Poggio, Pietro P; Carrà, Giovanna G; Morotti, Alessandro A; Brancaccio, Mara M; Lucchesi, Alessandro A

Publication Date: 2022-02-15

Variant appearance in text: JAK2: Y931C

PubMed Link: 35205715

Variant Present in the following documents:

• Main text
• cancers-14-00972.pdf

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Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Blood Cancer Discovery

Umeda, Masayuki M; Ma, Jing J; Huang, Benjamin J BJ; Hagiwara, Kohei K; Westover, Tamara T; Abdelhamed, Sherif S; Barajas, Juan M JM; Thomas, Melvin E ME; Walsh, Michael P MP; Song, Guangchun G; Tian, Liqing L; Liu, Yanling Y; Chen, Xiaolong X; Kolekar, Pandurang P; Tran, Quang Q; Foy, Scott G SG; Maciaszek, Jamie L JL; Kleist, Andrew B AB; Leonti, Amanda R AR; Ju, Bengsheng B; Easton, John J; Wu, Huiyun H; Valentine, Virginia V; Valentine, Marcus B MB; Liu, Yen-Chun YC; Ries, Rhonda E RE; Smith, Jenny L JL; Parganas, Evan E; Iacobucci, Ilaria I; Hiltenbrand, Ryan R; Miller, Jonathan J; Myers, Jason R JR; Rampersaud, Evadnie E; Rahbarinia, Delaram D; Rusch, Michael M; Wu, Gang G; Inaba, Hiroto H; Wang, Yi-Cheng YC; Alonzo, Todd A TA; Downing, James R JR; Mullighan, Charles G CG; Pounds, Stanley S; Babu, M Madan MM; Zhang, Jinghui J; Rubnitz, Jeffrey E JE; Meshinchi, Soheil S; Ma, Xiaotu X; Klco, Jeffery M JM

Publication Date: 2022-05-05

Variant appearance in text: JAK2: Y931C

PubMed Link: 35176137

Variant Present in the following documents:

• bcd-21-0160_supplemental_tables_supp1-32.xlsx, sheet 18

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Targeted Therapies in Cancer: To Be or Not to Be, Selective.

Biomedicines

Montoya, Skye S; Soong, Deborah D; Nguyen, Nina N; Affer, Maurizio M; Munamarty, Sailasya P SP; Taylor, Justin J

Publication Date: 2021-11-01

Variant appearance in text: JAK2: Y931C

PubMed Link: 34829820

Variant Present in the following documents:

• Main text
• biomedicines-09-01591.pdf

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Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.

Blood Cancer Discovery

Fornerod, Maarten M; Ma, Jing J; Noort, Sanne S; Liu, Yu Y; Walsh, Michael P MP; Shi, Lei L; Nance, Stephanie S; Liu, Yanling Y; Wang, Yuanyuan Y; Song, Guangchun G; Lamprecht, Tamara T; Easton, John J; Mulder, Heather L HL; Yergeau, Donald D; Myers, Jacquelyn J; Kamens, Jennifer L JL; Obeng, Esther A EA; Pigazzi, Martina M; Jarosova, Marie M; Kelaidi, Charikleia C; Polychronopoulou, Sophia S; Lamba, Jatinder K JK; Baker, Sharyn D SD; Rubnitz, Jeffrey E JE; Reinhardt, Dirk D; van den Heuvel-Eibrink, Marry M MM; Locatelli, Franco F; Hasle, Henrik H; Klco, Jeffery M JM; Downing, James R JR; Zhang, Jinghui J; Pounds, Stanley S; Zwaan, C Michel CM; Gruber, Tanja A TA; , ; , ; , ; , ; , ; ,

Publication Date: 2021-11

Variant appearance in text: JAK2: Y931C

PubMed Link: 34778799

Variant Present in the following documents:

• bloodcandisc-2-586-s001.xlsx, sheet 11

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Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia.

Npj Precision Oncology

Downes, Charlotte E J CEJ; McClure, Barbara J BJ; Bruning, John B JB; Page, Elyse E; Breen, James J; Rehn, Jacqueline J; Yeung, David T DT; White, Deborah L DL

Publication Date: 2021-08-10

Variant appearance in text: JAK2: Y931C

PubMed Link: 34376782

Variant Present in the following documents:

• Main text
• 41698_2021_Article_215.pdf
• 41698_2021_215_MOESM1_ESM.pdf

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Challenges and Perspectives for Therapeutic Targeting of Myeloproliferative Neoplasms.

Hemasphere

Brkic, Sime S; Meyer, Sara C SC

Publication Date: 2021-01

Variant appearance in text: JAK2: Y931C

PubMed Link: 33403355

Variant Present in the following documents:

• Main text
• hs9-5-e516.pdf

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Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy.

Cancers

Jego, Gaëtan G; Hermetet, François F; Girodon, François F; Garrido, Carmen C

Publication Date: 2019-12-19

Variant appearance in text: JAK2: Y931C

PubMed Link: 31861612

Variant Present in the following documents:

• Main text
• cancers-12-00021.pdf

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Structure-guided selection of specificity determining positions in the human Kinome.

Bmc Genomics

Moll, Mark M; Finn, Paul W PW; Kavraki, Lydia E LE

Publication Date: 2016-08-18

Variant appearance in text: JAK2: Y931C

PubMed Link: 27556159

Variant Present in the following documents:

• Main text
• 12864_2016_Article_2790.pdf

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: JAK2: 2792A>G; Y931C

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 2

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Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.

Scientific Reports

Kesarwani, Meenu M; Huber, Erika E; Kincaid, Zachary Z; Evelyn, Chris R CR; Biesiada, Jacek J; Rance, Mark M; Thapa, Mahendra B MB; Shah, Neil P NP; Meller, Jarek J; Zheng, Yi Y; Azam, Mohammad M

Publication Date: 2015-09-30

Variant appearance in text: JAK2: Y931C

PubMed Link: 26419724

Variant Present in the following documents:

• Main text
• srep14538.pdf

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Novel therapies for myelofibrosis.

Leukemia & Lymphoma

Stein, Brady L BL; Cervantes, Francisco F; Giles, Francis F; Harrison, Claire N CN; Verstovsek, Srdan S

Publication Date: 2015

Variant appearance in text: JAK2: Y931C

PubMed Link: 25860240

Variant Present in the following documents:

• Main text

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Tongue carcinoma infrequently harbor common actionable genetic alterations.

Bmc Cancer

Tan, Daniel S W DS; Wang, Weining W; Leong, Hui Sun HS; Sew, Pui Hoon PH; Lau, Dawn P DP; Chong, Fui Teen FT; Krisna, Sai Sakktee SS; Lim, Tony K H TK; Iyer, N Gopalakrishna NG

Publication Date: 2014-09-19

Variant appearance in text: JAK2: Y931C

PubMed Link: 25234657

Variant Present in the following documents:

• Main text

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Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.

Oncotarget

Okamoto, Isamu I; Sakai, Kazuko K; Morita, Satoshi S; Yoshioka, Hiroshige H; Kaneda, Hiroyasu H; Takeda, Koji K; Hirashima, Tomonori T; Kogure, Yoshihito Y; Kimura, Tatsuo T; Takahashi, Toshiaki T; Atagi, Shinji S; Seto, Takashi T; Sawa, Toshiyuki T; Yamamoto, Masashi M; Satouchi, Miyako M; Okuno, Motoyasu M; Nagase, Seisuke S; Takayama, Koichi K; Tomii, Keisuke K; Maeda, Tadashi T; Oizumi, Satoshi S; Fujii, Shinji S; Akashi, Yusaku Y; Nishino, Kazumi K; Ebi, Noriyuki N; Nakagawa, Kazuhiko K; Nakanishi, Yoichi Y; Nishio, Kazuto K

Publication Date: 2014-04-30

Variant appearance in text: JAK2: Y931C

PubMed Link: 24810493

Variant Present in the following documents:

• oncotarget-05-2293-s001.pdf

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Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Cancer Discovery

Zhu, Zehua Z; Aref, Amir R AR; Cohoon, Travis J TJ; Barbie, Thanh U TU; Imamura, Yu Y; Yang, Shenghong S; Moody, Susan E SE; Shen, Rhine R RR; Schinzel, Anna C AC; Thai, Tran C TC; Reibel, Jacob B JB; Tamayo, Pablo P; Godfrey, Jason T JT; Qian, Zhi Rong ZR; Page, Asher N AN; Maciag, Karolina K; Chan, Edmond M EM; Silkworth, Whitney W; Labowsky, Mary T MT; Rozhansky, Lior L; Mesirov, Jill P JP; Gillanders, William E WE; Ogino, Shuji S; Hacohen, Nir N; Gaudet, Suzanne S; Eck, Michael J MJ; Engelman, Jeffrey A JA; Corcoran, Ryan B RB; Wong, Kwok-Kin KK; Hahn, William C WC; Barbie, David A DA

Publication Date: 2014-04

Variant appearance in text: JAK2: Y931C

PubMed Link: 24444711

Variant Present in the following documents:

• Main text

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Redox regulation of Janus kinase: The elephant in the room.

Jak-Stat

Duhé, Roy J RJ

Publication Date: 2013-10-01

Variant appearance in text: JAK2: Y931C

PubMed Link: 24416654

Variant Present in the following documents:

• Main text

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A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27.

Biomarker Research

Tirado, Carlos A CA; Shabsovich, David D; DeNicola, Matthew M; Rao, Dinesh D; Yang, Lynn L; Garcia, Rolando R; Rao, Nagesh N

Publication Date: 2013-11-25

Variant appearance in text: JAK2: Y931C

PubMed Link: 24274401

Variant Present in the following documents:

• Main text
• 2050-7771-1-31.pdf

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The interplay between inhibition of JAK2 and HSP90.

Jak-Stat

Fridman, Jordan S JS; Sarlis, Nicholas J NJ

Publication Date: 2012-04-01

Variant appearance in text: JAK2: Y931C

PubMed Link: 24058754

Variant Present in the following documents:

• Main text

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Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F.

Blood Cancer Journal

Ma, L L; Clayton, J R JR; Walgren, R A RA; Zhao, B B; Evans, R J RJ; Smith, M C MC; Heinz-Taheny, K M KM; Kreklau, E L EL; Bloem, L L; Pitou, C C; Shen, W W; Strelow, J M JM; Halstead, C C; Rempala, M E ME; Parthasarathy, S S; Gillig, J R JR; Heinz, L J LJ; Pei, H H; Wang, Y Y; Stancato, L F LF; Dowless, M S MS; Iversen, P W PW; Burkholder, T P TP

Publication Date: 2013-04-12

Variant appearance in text: JAK2: Y931C

PubMed Link: 23584399

Variant Present in the following documents:

• Main text

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Therapy with JAK2 inhibitors for myeloproliferative neoplasms.

Hematology/Oncology Clinics Of North America

Santos, Fabio P S FP; Verstovsek, Srdan S

Publication Date: 2012-10

Variant appearance in text: JAK2: Y931C

PubMed Link: 23009939

Variant Present in the following documents:

• Main text

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Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor.

Plos One

Marit, Michael R MR; Chohan, Manprit M; Matthew, Natasha N; Huang, Kai K; Kuntz, Douglas A DA; Rose, David R DR; Barber, Dwayne L DL

Publication Date: 2012

Variant appearance in text: JAK2: Y931C

PubMed Link: 22916261

Variant Present in the following documents:

• Main text
• pone.0043437.pdf

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Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2.

Blood

van Bodegom, Diederik D; Zhong, Jun J; Kopp, Nadja N; Dutta, Chaitali C; Kim, Min-Sik MS; Bird, Liat L; Weigert, Oliver O; Tyner, Jeffrey J; Pandey, Akhilesh A; Yoda, Akinori A; Weinstock, David M DM

Publication Date: 2012-10-04

Variant appearance in text: JAK2: Y931C

PubMed Link: 22915648

Variant Present in the following documents:

• Main text

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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.

The Journal Of Experimental Medicine

Weigert, Oliver O; Lane, Andrew A AA; Bird, Liat L; Kopp, Nadja N; Chapuy, Bjoern B; van Bodegom, Diederik D; Toms, Angela V AV; Marubayashi, Sachie S; Christie, Amanda L AL; McKeown, Michael M; Paranal, Ronald M RM; Bradner, James E JE; Yoda, Akinori A; Gaul, Christoph C; Vangrevelinghe, Eric E; Romanet, Vincent V; Murakami, Masato M; Tiedt, Ralph R; Ebel, Nicolas N; Evrot, Emeline E; De Pover, Alain A; Régnier, Catherine H CH; Erdmann, Dirk D; Hofmann, Francesco F; Eck, Michael J MJ; Sallan, Stephen E SE; Levine, Ross L RL; Kung, Andrew L AL; Baffert, Fabienne F; Radimerski, Thomas T; Weinstock, David M DM

Publication Date: 2012-02-13

Variant appearance in text: JAK2: Y931C

PubMed Link: 22271575

Variant Present in the following documents:

• Main text

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Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.

Leukemia

Deshpande, A A; Reddy, M M MM; Schade, G O M GO; Ray, A A; Chowdary, T K TK; Griffin, J D JD; Sattler, M M

Publication Date: 2012-04

Variant appearance in text: JAK2: Y931C

PubMed Link: 21926964

Variant Present in the following documents:

• Main text
• nihms318343.pdf

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: JAK2: Y931C

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.

Haematologica

Hornakova, Tekla T; Springuel, Lorraine L; Devreux, Julien J; Dusa, Alexandra A; Constantinescu, Stefan N SN; Knoops, Laurent L; Renauld, Jean-Christophe JC

Publication Date: 2011-06

Variant appearance in text: JAK2: Y931C

PubMed Link: 21393331

Variant Present in the following documents:

• Main text

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