Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms.
Cancers
Bochicchio, Maria Teresa MT; Di Battista, Valeria V; Poggio, Pietro P; Carrà, Giovanna G; Morotti, Alessandro A; Brancaccio, Mara M; Lucchesi, Alessandro A
Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia.
Npj Precision Oncology
Downes, Charlotte E J CEJ; McClure, Barbara J BJ; Bruning, John B JB; Page, Elyse E; Breen, James J; Rehn, Jacqueline J; Yeung, David T DT; White, Deborah L DL
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.
Scientific Reports
Kesarwani, Meenu M; Huber, Erika E; Kincaid, Zachary Z; Evelyn, Chris R CR; Biesiada, Jacek J; Rance, Mark M; Thapa, Mahendra B MB; Shah, Neil P NP; Meller, Jarek J; Zheng, Yi Y; Azam, Mohammad M
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.
Cancer Discovery
Zhu, Zehua Z; Aref, Amir R AR; Cohoon, Travis J TJ; Barbie, Thanh U TU; Imamura, Yu Y; Yang, Shenghong S; Moody, Susan E SE; Shen, Rhine R RR; Schinzel, Anna C AC; Thai, Tran C TC; Reibel, Jacob B JB; Tamayo, Pablo P; Godfrey, Jason T JT; Qian, Zhi Rong ZR; Page, Asher N AN; Maciag, Karolina K; Chan, Edmond M EM; Silkworth, Whitney W; Labowsky, Mary T MT; Rozhansky, Lior L; Mesirov, Jill P JP; Gillanders, William E WE; Ogino, Shuji S; Hacohen, Nir N; Gaudet, Suzanne S; Eck, Michael J MJ; Engelman, Jeffrey A JA; Corcoran, Ryan B RB; Wong, Kwok-Kin KK; Hahn, William C WC; Barbie, David A DA
A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27.
Biomarker Research
Tirado, Carlos A CA; Shabsovich, David D; DeNicola, Matthew M; Rao, Dinesh D; Yang, Lynn L; Garcia, Rolando R; Rao, Nagesh N
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.
The Journal Of Experimental Medicine
Weigert, Oliver O; Lane, Andrew A AA; Bird, Liat L; Kopp, Nadja N; Chapuy, Bjoern B; van Bodegom, Diederik D; Toms, Angela V AV; Marubayashi, Sachie S; Christie, Amanda L AL; McKeown, Michael M; Paranal, Ronald M RM; Bradner, James E JE; Yoda, Akinori A; Gaul, Christoph C; Vangrevelinghe, Eric E; Romanet, Vincent V; Murakami, Masato M; Tiedt, Ralph R; Ebel, Nicolas N; Evrot, Emeline E; De Pover, Alain A; Régnier, Catherine H CH; Erdmann, Dirk D; Hofmann, Francesco F; Eck, Michael J MJ; Sallan, Stephen E SE; Levine, Ross L RL; Kung, Andrew L AL; Baffert, Fabienne F; Radimerski, Thomas T; Weinstock, David M DM