JAK2 c.2803G>C ;(p.G935R)

Variant ID: 9-5090487-G-C

NM_004972.3(JAK2):c.2803G>C;(p.G935R)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms.

Cancers
Bochicchio, Maria Teresa MT; Di Battista, Valeria V; Poggio, Pietro P; Carrà, Giovanna G; Morotti, Alessandro A; Brancaccio, Mara M; Lucchesi, Alessandro A
Publication Date: 2022-02-15

Variant appearance in text: JAK2: G935R
PubMed Link: 35205715
Variant Present in the following documents:
  • Main text
  • cancers-14-00972.pdf
View BVdb publication page



Targeted Therapies in Cancer: To Be or Not to Be, Selective.

Biomedicines
Montoya, Skye S; Soong, Deborah D; Nguyen, Nina N; Affer, Maurizio M; Munamarty, Sailasya P SP; Taylor, Justin J
Publication Date: 2021-11-01

Variant appearance in text: JAK2: G935R
PubMed Link: 34829820
Variant Present in the following documents:
  • Main text
  • biomedicines-09-01591.pdf
View BVdb publication page



Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia.

Npj Precision Oncology
Downes, Charlotte E J CEJ; McClure, Barbara J BJ; Bruning, John B JB; Page, Elyse E; Breen, James J; Rehn, Jacqueline J; Yeung, David T DT; White, Deborah L DL
Publication Date: 2021-08-10

Variant appearance in text: JAK2: G935R
PubMed Link: 34376782
Variant Present in the following documents:
  • Main text
  • 41698_2021_Article_215.pdf
View BVdb publication page



Challenges and Perspectives for Therapeutic Targeting of Myeloproliferative Neoplasms.

Hemasphere
Brkic, Sime S; Meyer, Sara C SC
Publication Date: 2021-01

Variant appearance in text: JAK2: G935R
PubMed Link: 33403355
Variant Present in the following documents:
  • Main text
  • hs9-5-e516.pdf
View BVdb publication page



Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy.

Cancers
Jego, Gaëtan G; Hermetet, François F; Girodon, François F; Garrido, Carmen C
Publication Date: 2019-12-19

Variant appearance in text: JAK2: G935R
PubMed Link: 31861612
Variant Present in the following documents:
  • Main text
  • cancers-12-00021.pdf
View BVdb publication page



Structure-guided selection of specificity determining positions in the human Kinome.

Bmc Genomics
Moll, Mark M; Finn, Paul W PW; Kavraki, Lydia E LE
Publication Date: 2016-08-18

Variant appearance in text: JAK2: G935R
PubMed Link: 27556159
Variant Present in the following documents:
  • Main text
  • 12864_2016_Article_2790.pdf
View BVdb publication page



Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.

Scientific Reports
Kesarwani, Meenu M; Huber, Erika E; Kincaid, Zachary Z; Evelyn, Chris R CR; Biesiada, Jacek J; Rance, Mark M; Thapa, Mahendra B MB; Shah, Neil P NP; Meller, Jarek J; Zheng, Yi Y; Azam, Mohammad M
Publication Date: 2015-09-30

Variant appearance in text: JAK2: G935R
PubMed Link: 26419724
Variant Present in the following documents:
  • Main text
  • srep14538.pdf
View BVdb publication page



Novel therapies for myelofibrosis.

Leukemia & Lymphoma
Stein, Brady L BL; Cervantes, Francisco F; Giles, Francis F; Harrison, Claire N CN; Verstovsek, Srdan S
Publication Date: 2015

Variant appearance in text: JAK2: G935R
PubMed Link: 25860240
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Cancer Discovery
Zhu, Zehua Z; Aref, Amir R AR; Cohoon, Travis J TJ; Barbie, Thanh U TU; Imamura, Yu Y; Yang, Shenghong S; Moody, Susan E SE; Shen, Rhine R RR; Schinzel, Anna C AC; Thai, Tran C TC; Reibel, Jacob B JB; Tamayo, Pablo P; Godfrey, Jason T JT; Qian, Zhi Rong ZR; Page, Asher N AN; Maciag, Karolina K; Chan, Edmond M EM; Silkworth, Whitney W; Labowsky, Mary T MT; Rozhansky, Lior L; Mesirov, Jill P JP; Gillanders, William E WE; Ogino, Shuji S; Hacohen, Nir N; Gaudet, Suzanne S; Eck, Michael J MJ; Engelman, Jeffrey A JA; Corcoran, Ryan B RB; Wong, Kwok-Kin KK; Hahn, William C WC; Barbie, David A DA
Publication Date: 2014-04

Variant appearance in text: JAK2: G935R
PubMed Link: 24444711
Variant Present in the following documents:
  • Main text
View BVdb publication page



A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27.

Biomarker Research
Tirado, Carlos A CA; Shabsovich, David D; DeNicola, Matthew M; Rao, Dinesh D; Yang, Lynn L; Garcia, Rolando R; Rao, Nagesh N
Publication Date: 2013-11-25

Variant appearance in text: JAK2: G935R
PubMed Link: 24274401
Variant Present in the following documents:
  • Main text
  • 2050-7771-1-31.pdf
View BVdb publication page



The interplay between inhibition of JAK2 and HSP90.

Jak-Stat
Fridman, Jordan S JS; Sarlis, Nicholas J NJ
Publication Date: 2012-04-01

Variant appearance in text: JAK2: G935R
PubMed Link: 24058754
Variant Present in the following documents:
  • Main text
View BVdb publication page



Therapy with JAK2 inhibitors for myeloproliferative neoplasms.

Hematology/Oncology Clinics Of North America
Santos, Fabio P S FP; Verstovsek, Srdan S
Publication Date: 2012-10

Variant appearance in text: JAK2: G935R
PubMed Link: 23009939
Variant Present in the following documents:
  • Main text
View BVdb publication page



Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor.

Plos One
Marit, Michael R MR; Chohan, Manprit M; Matthew, Natasha N; Huang, Kai K; Kuntz, Douglas A DA; Rose, David R DR; Barber, Dwayne L DL
Publication Date: 2012

Variant appearance in text: JAK2: G935R
PubMed Link: 22916261
Variant Present in the following documents:
  • Main text
  • pone.0043437.pdf
View BVdb publication page



Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.

The Journal Of Experimental Medicine
Weigert, Oliver O; Lane, Andrew A AA; Bird, Liat L; Kopp, Nadja N; Chapuy, Bjoern B; van Bodegom, Diederik D; Toms, Angela V AV; Marubayashi, Sachie S; Christie, Amanda L AL; McKeown, Michael M; Paranal, Ronald M RM; Bradner, James E JE; Yoda, Akinori A; Gaul, Christoph C; Vangrevelinghe, Eric E; Romanet, Vincent V; Murakami, Masato M; Tiedt, Ralph R; Ebel, Nicolas N; Evrot, Emeline E; De Pover, Alain A; Régnier, Catherine H CH; Erdmann, Dirk D; Hofmann, Francesco F; Eck, Michael J MJ; Sallan, Stephen E SE; Levine, Ross L RL; Kung, Andrew L AL; Baffert, Fabienne F; Radimerski, Thomas T; Weinstock, David M DM
Publication Date: 2012-02-13

Variant appearance in text: JAK2: G935R
PubMed Link: 22271575
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.

Leukemia
Deshpande, A A; Reddy, M M MM; Schade, G O M GO; Ray, A A; Chowdary, T K TK; Griffin, J D JD; Sattler, M M
Publication Date: 2012-04

Variant appearance in text: JAK2: Gly935Arg
PubMed Link: 21926964
Variant Present in the following documents:
  • Main text
  • nihms318343.pdf
View BVdb publication page