Publications:

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.

Pharmaceuticals (Basel, Switzerland)

Virtanen, Anniina T AT; Haikarainen, Teemu T; Sampathkumar, Parthasarathy P; Palmroth, Maaria M; Liukkonen, Sanna S; Liu, Jianping J; Nekhotiaeva, Natalia N; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2023-01-04

Variant appearance in text: JAK2: D976N

PubMed Link: 36678572

Variant Present in the following documents:

• Main text
• pharmaceuticals-16-00075.pdf

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Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

The Journal Of Allergy And Clinical Immunology

Hammarén, Henrik M HM; Virtanen, Anniina T AT; Abraham, Bobin George BG; Peussa, Heidi H; Hubbard, Stevan R SR; Silvennoinen, Olli O

Publication Date: 2019-04

Variant appearance in text: JAK2: D976N

PubMed Link: 30092288

Variant Present in the following documents:

• Main text

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Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.

Scientific Reports

Kesarwani, Meenu M; Huber, Erika E; Kincaid, Zachary Z; Evelyn, Chris R CR; Biesiada, Jacek J; Rance, Mark M; Thapa, Mahendra B MB; Shah, Neil P NP; Meller, Jarek J; Zheng, Yi Y; Azam, Mohammad M

Publication Date: 2015-09-30

Variant appearance in text: JAK2: D976N

PubMed Link: 26419724

Variant Present in the following documents:

• Main text
• srep14538.pdf

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Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell

Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R

Publication Date: 2015-09-24

Variant appearance in text: JAK2: D976N

PubMed Link: 26388441

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

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