PMID: 17601350

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

BMC genetics
SE Harris, H Fox, AF Wright, C Hayward, JM Starr, LJ Whalley, IJ Deary
2007-07-02

251 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
5-95152313-A-G GLRX c.225T>C p.Ile75Ile Synonymous 2/3 -
6-32147761-T-C RNF5 c.328-25T>C - IntronicSNV - 4/5
2-220145286-C-G DNAJB2 c.66-14C>G - IntronicSNV - 2/9
20-33525407-G-A GSS c.609-581C>T - IntronicSNV - 6/12
8-10190040-C-T MSRA c.543+12541C>T - IntronicSNV - 5/5
8-9918383-A-G MSRA c.142+6215A>G - IntronicSNV - 1/5
8-10111294-G-A MSRA c.331+8561G>A - IntronicSNV - 3/5
8-10200924-G-T MSRA c.543+23425G>T - IntronicSNV - 5/5
6-46623698-T-C SLC25A27 c.225T>C p.Ala75Ala Synonymous 2/9 -
17-42983901-A-T GFAP c.*814T>A - 3-UTRSNV 9/9 -
5-42800724-A-G CCDC152 c.*841A>G - 3-UTRSNV 9/9 -
8-9918383-A-T MSRA c.142+6215A>T - IntronicSNV - 1/5
6-43753325-G-A VEGFA c.*1026G>A - 3-UTRSNV 8/8 -
21-27362519-A-T APP c.1090+7156T>A - IntronicSNV - 8/17
8-10126348-C-A MSRA c.331+23615C>A - IntronicSNV - 3/5
5-132903856-C-A FSTL4 c.127-946G>T - IntronicSNV - 2/15
9-128001119-C-T HSPA5 c.997-13G>A - IntronicSNV - 5/7
8-10059483-C-G MSRA c.143-5860C>G - IntronicSNV - 1/5
8-10111294-G-T MSRA c.331+8561G>T - IntronicSNV - 3/5
5-132903856-C-G FSTL4 c.127-946G>C - IntronicSNV - 2/15
5-132440285-C-G HSPA4 c.*157C>G - 3-UTRSNV 19/19 -
5-1809713-G-A NDUFS6 c.187-4740G>A - IntronicSNV - 2/3
6-108897386-A-T FOXO3 c.621+14354A>T - IntronicSNV - 1/2
10-17279562-G-T VIM c.*292G>T - 3-UTRSNV 10/10 -
1-110200360-T-C GSTM4 c.260-34T>C - IntronicSNV - 4/7
1-110201580-C-T GSTM4 c.457-42C>T - IntronicSNV - 6/7
11-67352256-C-A GSTP1 c.232+13C>A - IntronicSNV - 4/6
11-67352256-C-T GSTP1 c.232+13C>T - IntronicSNV - 4/6
3-133494354-C-T TF c.1765C>T p.Pro589Ser Missense 15/17 -
3-15084869-A-G NR2C2 c.*354A>G - 3-UTRSNV 15/15 -
6-108897386-A-G FOXO3 c.621+14354A>G - IntronicSNV - 1/2
6-108932004-T-C FOXO3 c.621+48972T>C - IntronicSNV - 1/2
2-113591081-G-A IL1B c.171C>T p.Tyr57Tyr Synonymous 4/7 -
21-27402812-T-C APP c.663-8454A>G - IntronicSNV - 5/17
21-27443650-G-A APP c.356-17986C>T - IntronicSNV - 3/17
10-106058901-G-T GSTO2 c.591G>T p.Thr197Thr Synonymous 7/7 -
20-3721456-C-T HSPA12B c.44-6C>T - IntronicSNV - 2/12
10-23399992-T-A MSRB2 c.296+745T>A - IntronicSNV - 3/4
10-23399992-T-C MSRB2 c.296+745T>C - IntronicSNV - 3/4
17-26092555-G-A NOS2 c.2428+6C>T - IntronicSNV - 20/26
6-108975464-C-G FOXO3 c.622-9194C>G - IntronicSNV - 1/2
11-122928634-A-T HSPA8 c.1756-7T>A - IntronicSNV - 8/8
15-79237247-C-G CTSH c.77G>C p.Cys26Ser Missense 1/12 -
X-23700473-G-A PRDX4 c.600-40G>A - IntronicSNV - 4/6
8-10104820-C-A MSRA c.331+2087C>A - IntronicSNV - 3/5
2-220145286-C-T DNAJB2 c.66-14C>T - IntronicSNV - 2/9
2-240961728-T-G NDUFA10 c.105A>C p.Lys35Asn Missense 2/10 -
2-240961728-T-C NDUFA10 c.105A>G p.Lys35Lys Synonymous 2/10 -
15-41689166-C-T NDUFAF1 c.92G>A p.Arg31His Missense 2/5 -
15-41689166-C-A NDUFAF1 c.92G>T p.Arg31Leu Missense 2/5 -
10-75673101-T-C PLAU c.422T>C p.Leu141Pro Missense 6/11 -
6-52615415-T-G GSTA2 c.629A>C p.Glu210Ala Missense 7/7 -
6-46620252-C-G CYP39A1 c.68G>C p.Arg23Pro Missense 1/12 -
6-32151994-A-T AGER c.6T>A p.Ala2Ala Synonymous 1/11 -
19-14682804-G-T NDUFB7 c.9C>A p.Ala3Ala Synonymous 1/3 -
11-117163824-C-G BACE1 c.486G>C p.Val162Val Synonymous 4/8 -
8-9976748-G-A MSRA c.142+64580G>A - IntronicSNV - 1/5
2-207012483-A-G NDUFS1 c.414T>C p.Asp138Asp Synonymous 6/19 -
14-77794283-T-A GSTZ1 c.245T>A p.Met82Lys Missense 5/9 -
14-77794283-T-C GSTZ1 c.245T>C p.Met82Thr Missense 5/9 -
21-27362519-A-G APP c.1090+7156T>C - IntronicSNV - 8/17
22-19882984-T-A TXNRD2 c.895A>T p.Ser299Cys Missense 11/18 -
22-19882984-T-G TXNRD2 c.895A>C p.Ser299Arg Missense 11/18 -
12-117669914-G-A NOS1 c.3258C>T p.Asp1086Asp Synonymous 22/29 -
8-9933235-G-A MSRA c.142+21067G>A - IntronicSNV - 1/5
6-46620135-C-T CYP39A1 c.177+8G>A - IntronicSNV - 1/11
12-117738237-G-C NOS1 c.853-10006C>G - IntronicSNV - 3/28
16-4529613-A-G HMOX2 c.-160+3125A>G - intron_variant - 1/6
21-27277885-T-C APP c.1910-496A>G - IntronicSNV - 14/17
1-161170977-C-T NDUFS2 c.1-1199C>T - IntronicSNV - 1/14
1-161176806-A-G NDUFS2 c.393+419A>G - IntronicSNV - 4/14
6-43746169-C-T VEGFA c.856-28C>T - IntronicSNV - 3/7
16-4529613-A-T HMOX2 c.-160+3125A>T - intron_variant - 1/6
11-34482908-C-T CAT c.1167C>T p.Asp389Asp Synonymous 9/13 -
3-126329910-A-C TXNRD3 c.1698T>G p.Tyr566* Nonsense 14/16 -
12-4764137-G-A NDUFA9 c.318+49G>A - IntronicSNV - 3/10
8-134297943-G-C NDRG1 c.1-1389C>G - IntronicSNV - 1/15
21-27387570-C-T APP c.865+6586G>A - IntronicSNV - 6/17
8-10126684-G-C MSRA c.331+23951G>C - IntronicSNV - 3/5
20-33540000-G-A GSS c.1-345C>T - IntronicSNV - 1/12
19-54606405-T-C NDUFA3 c.11-17T>C - IntronicSNV - 1/3
10-106058901-G-A GSTO2 c.591G>A p.Thr197Thr Synonymous 7/7 -
18-9117867-T-G NDUFV2 c.86T>G p.Val29Gly Missense 2/8 -
10-23404754-A-T MSRB2 c.297-3479A>T - IntronicSNV - 3/4
10-75676464-C-T PLAU c.*141C>T - 3-UTRSNV 11/11 -
12-117752069-C-T NOS1 c.726-2672G>A - IntronicSNV - 2/28
3-133475812-G-A TF c.829G>A p.Gly277Ser Missense 7/17 -
12-4768193-A-G NDUFA9 c.411-9A>G - IntronicSNV - 4/10
11-18267027-C-T SAA2 c.266G>A p.Arg89His Missense 4/4 -
5-137892170-G-A HSPA9 c.1933C>T p.Leu645Leu Synonymous 16/17 -
2-220146651-G-A DNAJB2 c.230-10G>A - IntronicSNV - 4/9
2-220146651-G-T DNAJB2 c.230-10G>T - IntronicSNV - 4/9
6-53372145-T-C GCLC c.970+133A>G - IntronicSNV - 8/14
7-95035950-G-T PON2 c.777+349C>A - IntronicSNV - 7/8
3-49396751-T-C RHOA c.*891A>G - 3-UTRSNV 5/5 -
2-207024107-G-T NDUFS1 c.-47C>A - 5_prime_UTR_variant 1/19 -
2-207024107-G-C NDUFS1 c.-47C>G - 5_prime_UTR_variant 1/19 -
20-3734514-T-A C20orf27 c.*191A>T - 3-UTRSNV 6/6 -
20-3734514-T-C C20orf27 c.*191A>G - 3-UTRSNV 6/6 -
17-80229340-C-T CSNK1D c.76+1842G>A - IntronicSNV - 1/9
12-4768193-A-T NDUFA9 c.411-9A>T - IntronicSNV - 4/10
10-118448298-C-T HSPA12A c.663+3564G>A - IntronicSNV - 6/11
11-18267027-C-A SAA2 c.266G>T p.Arg89Leu Missense 4/4 -
19-45971961-C-G FOSB c.117C>G p.Ala39Ala Synonymous 1/4 -
8-9966586-A-G MSRA c.142+54418A>G - IntronicSNV - 1/5
16-23601488-A-G NDUFAB1 c.169-2848T>C - IntronicSNV - 1/4
6-108968677-G-T FOXO3 c.622-15981G>T - IntronicSNV - 1/2
6-108968677-G-C FOXO3 c.622-15981G>C - IntronicSNV - 1/2
19-45973056-T-C FOSB c.127-831T>C - IntronicSNV - 1/3
5-52979097-G-A NDUFS4 c.*46G>A - 3-UTRSNV 5/5 -
10-23404754-A-G MSRB2 c.297-3479A>G - IntronicSNV - 3/4
20-33522869-T-C GSS c.834+510A>G - IntronicSNV - 9/12
19-12911926-C-T PRDX2 c.104-43G>A - IntronicSNV - 2/5
12-117665264-A-C NOS1 c.3588T>G p.Thr1196Thr Synonymous 23/29 -
5-52864795-T-C NDUFS4 c.98+8205T>C - IntronicSNV - 1/4
12-117665264-A-G NOS1 c.3588T>C p.Thr1196Thr Synonymous 23/29 -
12-117691490-G-A NOS1 c.2601C>T p.Pro867Pro Synonymous 17/29 -
3-148896430-A-G CP c.2662-12T>C - IntronicSNV - 15/18
21-27442596-A-G APP c.356-16932T>C - IntronicSNV - 3/17
8-9941021-C-T MSRA c.142+28853C>T - IntronicSNV - 1/5
7-150706640-G-A NOS3 c.2479G>A p.Val827Met Missense 20/27 -
16-4544505-C-T HMOX2 c.-42+10750C>T - intron_variant - 2/6
21-27488767-C-A APP c.58-4304G>T - IntronicSNV - 1/17
20-57571763-A-G CTSZ c.732T>C p.Ser244Ser Synonymous 5/6 -
6-52701143-C-T GSTA5 c.163G>A p.Val55Ile Missense 4/7 -
8-9982105-C-T MSRA c.142+69937C>T - IntronicSNV - 1/5
19-14682804-G-A NDUFB7 c.9C>T p.Ala3Ala Synonymous 1/3 -
19-14682804-G-C NDUFB7 c.9C>G p.Ala3Ala Synonymous 1/3 -
21-44485350-G-A CBS c.699C>T p.Tyr233Tyr Synonymous 8/17 -
21-27465597-C-T APP c.226-3209G>A - IntronicSNV - 2/17
21-27488767-C-T APP c.58-4304G>A - IntronicSNV - 1/17
8-10201532-G-A MSRA c.543+24033G>A - IntronicSNV - 5/5
9-113017905-C-G TXN c.24+787G>C - IntronicSNV - 1/3
1-45982844-A-T PRDX1 c.107-1365T>A - IntronicSNV - 2/5
1-45982844-A-G PRDX1 c.107-1365T>C - IntronicSNV - 2/5
8-10018717-C-G MSRA c.143-46626C>G - IntronicSNV - 1/5
20-3726565-C-T HSPA12B c.562C>T p.Leu188Leu Synonymous 7/13 -
8-134279775-T-C NDRG1 c.100-2880A>G - IntronicSNV - 3/15
10-69678078-C-T SIRT1 c.*1728C>T - 3-UTRSNV 9/9 -
17-42987524-T-C GFAP c.1171+459A>G - IntronicSNV - 7/8
8-9933235-G-T MSRA c.142+21067G>T - IntronicSNV - 1/5
21-27402989-T-A APP c.663-8631A>T - IntronicSNV - 5/17
1-110279701-C-T GSTM3 c.670G>A p.Val224Ile Missense 9/9 -
15-79224747-C-T CTSH c.459G>A p.Ala153Ala Synonymous 6/12 -
13-47408570-T-G HTR2A c.*402A>C - 3-UTRSNV 4/4 -
7-150704250-C-T NOS3 c.1998C>T p.Ala666Ala Synonymous 17/27 -
7-150704250-C-A NOS3 c.1998C>A p.Ala666Ala Synonymous 17/27 -
7-150704250-C-G NOS3 c.1998C>G p.Ala666Ala Synonymous 17/27 -
17-26096597-G-A NOS2 c.1823C>T p.Ser608Leu Missense 16/27 -
21-27458409-A-G APP c.355+3850T>C - IntronicSNV - 3/17
6-43742527-G-A VEGFA c.658+398G>A - IntronicSNV - 2/7
9-124906456-C-T NDUFA8 c.*64G>A - 3-UTRSNV 4/4 -
10-118472715-T-C HSPA12A c.41-5919A>G - IntronicSNV - 1/11
10-118472715-T-A HSPA12A c.41-5919A>T - IntronicSNV - 1/11
14-77787088-C-T POMT2 c.1-64G>A - 5-UTRSNV 1/21 -
12-12874571-T-C CDKN1B c.*610T>C - 3_prime_UTR_variant 3/3 -
8-10000966-A-G MSRA c.143-64377A>G - IntronicSNV - 1/5
8-10108903-G-T MSRA c.331+6170G>T - IntronicSNV - 3/5
8-10108903-G-C MSRA c.331+6170G>C - IntronicSNV - 3/5
8-10108903-G-A MSRA c.331+6170G>A - IntronicSNV - 3/5
21-27500333-C-T APP c.58-15870G>A - IntronicSNV - 1/17
12-12874917-C-A CDKN1B c.*956C>A - 3_prime_UTR_variant 3/3 -
22-19907099-C-A TXNRD2 c.196G>T p.Ala66Ser Missense 3/18 -
13-47421836-C-T HTR2A c.614-12062G>A - IntronicSNV - 3/3
13-47466622-G-A HTR2A c.516C>T p.Asp172Asp Synonymous 3/4 -
5-42800808-C-T CCDC152 c.*925C>T - 3-UTRSNV 9/9 -
17-56357818-C-T MPO c.157G>A p.Val53Ile Missense 2/12 -
10-106039185-A-T GSTO2 c.424A>T p.Asn142Tyr Missense 5/7 -
1-110201580-C-G GSTM4 c.457-42C>G - IntronicSNV - 6/7
3-126329910-A-G TXNRD3 c.1698T>C p.Tyr566Tyr Synonymous 14/16 -
8-10149212-A-C MSRA c.332-9832A>C - IntronicSNV - 3/5
3-179322385-A-C MRPL47 c.28T>G p.Cys10Gly Missense 1/7 -
6-43747577-T-C VEGFA c.963-892T>C - IntronicSNV - 5/7
6-43747577-T-G VEGFA c.963-892T>G - IntronicSNV - 5/7
3-148916235-T-A CP c.1632A>T p.Glu544Asp Missense 9/19 -
3-148906027-A-G CP c.1714-38T>C - IntronicSNV - 9/18
8-134292516-A-G NDRG1 c.64-6T>C - IntronicSNV - 2/15
11-67353844-C-T GSTP1 c.445-16C>T - IntronicSNV - 6/6
7-136701308-T-A CHRM2 c.*295T>A - 3-UTRSNV 4/4 -
10-69666598-T-C SIRT1 c.994T>C p.Leu332Leu Synonymous 5/9 -
17-56357818-C-A MPO c.157G>T p.Val53Phe Missense 2/12 -
22-36872750-T-G TXN2 c.387+30A>C - IntronicSNV - 3/3
6-32147761-T-A RNF5 c.328-25T>A - IntronicSNV - 4/5
5-52856504-G-C NDUFS4 c.12G>C p.Val4Val Synonymous 1/5 -
15-41689166-C-G NDUFAF1 c.92G>C p.Arg31Pro Missense 2/5 -
11-67353844-C-A GSTP1 c.445-16C>A - IntronicSNV - 6/6
22-42486801-G-A NDUFA6 c.26C>T p.Ser9Phe Missense 1/3 -
22-42486801-G-C NDUFA6 c.26C>G p.Ser9Cys Missense 1/3 -
14-77791519-A-G GSTZ1 c.67+255A>G - IntronicSNV - 2/8
11-117159878-A-T BACE1 c.*404T>A - 3-UTRSNV 8/8 -
14-77794192-C-T GSTZ1 c.217-63C>T - IntronicSNV - 4/8
6-52617731-C-G GSTA2 c.335G>C p.Ser112Thr Missense 5/7 -
10-94276526-A-T IDE c.662-1727T>A - IntronicSNV - 4/24
6-52701143-C-G GSTA5 c.163G>C p.Val55Leu Missense 4/7 -
7-95041271-C-T PON2 c.368-180G>A - IntronicSNV - 4/8
12-12874571-T-A CDKN1B c.*610T>A - 3_prime_UTR_variant 3/3 -
9-124914613-C-T NDUFA8 c.126G>A p.Glu42Glu Synonymous 2/4 -
18-9117867-T-C NDUFV2 c.86T>C p.Val29Ala Missense 2/8 -
3-148904434-T-G CP c.1950A>C p.Gly650Gly Synonymous 11/19 -
12-12870508-C-G CDKN1B c.1-266C>G - 5-UTRSNV 1/3 -
3-133465283-A-G TF c.1-2A>G - 5-UTRSNV 1/17 -
8-30584923-G-A GSR c.306+124C>T - IntronicSNV - 1/12
5-52942197-A-G NDUFS4 c.312A>G p.Arg104Arg Synonymous 3/5 -
3-133475722-C-T TF c.739C>T p.Leu247Leu Synonymous 7/17 -
10-118497592-T-A HSPA12A c.40+4349A>T - IntronicSNV - 1/11
10-75673879-C-T PLAU c.822C>T p.Asn274Asn Synonymous 8/11 -
16-2009697-C-T NDUFB10 c.72C>T p.Ile24Ile Synonymous 1/4 -
19-12910979-G-T PRDX2 c.380+12C>A - IntronicSNV - 4/5
17-26109102-G-A NOS2 c.661C>T p.Arg221Trp Missense 7/27 -
19-8376431-G-A NDUFA7 c.300C>T p.Pro100Pro Synonymous 4/4 -
19-8376431-G-C NDUFA7 c.300C>G p.Pro100Pro Synonymous 4/4 -
19-8376431-G-T NDUFA7 c.300C>A p.Pro100Pro Synonymous 4/4 -
21-44323590-T-A NDUFV3 c.170-5384T>A - IntronicSNV - 2/2
21-44323590-T-G NDUFV3 c.170-5384T>G - IntronicSNV - 2/2
3-179322385-A-T MRPL47 c.28T>A p.Cys10Ser Missense 1/7 -
21-27535027-C-T APP c.57+7855G>A - IntronicSNV - 1/17
6-31777946-C-T HSPA1L c.1804G>A p.Glu602Lys Missense 2/2 -
12-104703836-A-G TXNRD1 c.121-1232A>G - IntronicSNV - 2/14
15-79231478-T-C CTSH c.123+4A>G - IntronicSNV - 2/11
10-75673748-A-C PLAU c.691A>C p.Lys231Gln Missense 8/11 -
21-44323590-T-C NDUFV3 c.170-5384T>C - IntronicSNV - 2/2
5-52942083-A-T NDUFS4 c.198A>T p.Gly66Gly Synonymous 3/5 -
11-73689104-G-A UCP2 c.164C>T p.Ala55Val Missense 4/8 -
12-117701714-A-T NOS1 c.2202T>A p.Ile734Ile Synonymous 13/29 -
17-26105932-G-A NOS2 c.1155C>T p.Asp385Asp Synonymous 10/27 -
12-117738237-G-A NOS1 c.853-10006C>T - IntronicSNV - 3/28
17-42989063-C-T GFAP c.883G>A p.Asp295Asn Missense 5/9 -
6-52849325-C-T GSTA4 c.351G>A p.Gln117Gln Synonymous 5/7 -
12-117701714-A-G NOS1 c.2202T>C p.Ile734Ile Synonymous 13/29 -
7-150695726-T-C NOS3 c.774T>C p.Asp258Asp Synonymous 7/27 -
12-104709559-C-T TXNRD1 c.321C>T p.Leu107Leu Synonymous 5/15 -
8-10024813-G-A MSRA c.143-40530G>A - IntronicSNV - 1/5
8-10024813-G-T MSRA c.143-40530G>T - IntronicSNV - 1/5
10-75673748-A-G PLAU c.691A>G p.Lys231Glu Missense 8/11 -
12-12870695-T-C CDKN1B c.1-79T>C - 5-UTRSNV 1/3 -
10-106039185-A-G GSTO2 c.424A>G p.Asn142Asp Missense 5/7 -
17-56348106-T-C MPO c.2149A>G p.Ile717Val Missense 12/12 -
16-23601488-A-T NDUFAB1 c.169-2848T>A - IntronicSNV - 1/4
21-27459674-C-G APP c.355+2585G>C - IntronicSNV - 3/17
21-27459674-C-T APP c.355+2585G>A - IntronicSNV - 3/17
22-19866462-C-T TXNRD2 c.1276-502G>A - IntronicSNV - 14/17
19-14629150-G-A DNAJB1 c.12C>T p.Asp4Asp Synonymous 1/3 -
22-19921003-T-C TXNRD2 c.104-2382A>G - IntronicSNV - 1/17
8-10067407-G-A MSRA c.211+1996G>A - IntronicSNV - 2/5
10-23408278-C-T MSRB2 c.342C>T p.Ser114Ser Synonymous 4/5 -
12-117674129-C-G NOS1 c.3042-1566G>C - IntronicSNV - 20/28
5-52942083-A-C NDUFS4 c.198A>C p.Gly66Gly Synonymous 3/5 -
4-24801834-C-G SOD3 c.691C>G p.Arg231Gly Missense 2/2 -
11-1782594-G-A CTSD c.173C>T p.Ala58Val Missense 2/9 -
10-102289078-C-A NDUFB8 c.212+59G>T - IntronicSNV - 2/4
X-23701410-A-C PRDX4 c.731-378A>C - IntronicSNV - 5/6