PMID: 18262190

Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

Atherosclerosis
E Polisecki, I Peter, M Robertson, AD McMahon, I Ford, C Packard, J Shepherd, JW Jukema, GJ Blauw, RG Westendorp, AJ de Craen, S Trompet, BM Buckley, MB Murphy, JM Ordovas, EJ Schaefer,
2008-09

4 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
1-55509624-G-A PCSK9 c.316G>A p.Gly106Arg Missense 2/12 -
1-55512267-C-A PCSK9 c.471C>A p.Asn157Lys Missense 3/12 -
1-55509624-G-C PCSK9 c.316G>C p.Gly106Arg Missense 2/12 -
1-55529187-G-A PCSK9 c.2009G>A p.Gly670Glu Missense 12/12 -