PMID: 18622260

Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke.

Pharmacogenetics and genomics
LA Hindorff, RN Lemaitre, NL Smith, JC Bis, KD Marciante, KM Rice, T Lumley, DA Enquobahrie, G Li, SR Heckbert, BM Psaty
2008-08

88 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-87137018-C-T ABCB1 c.3489+1573G>A - IntronicSNV - 27/28
7-87229501-T-A ABCB1 c.1-1A>T - 5-UTRSNV 3/29 -
7-150700946-C-A NOS3 c.1752+1554C>A - IntronicSNV - 14/26
5-74655498-T-G HMGCR c.2457+117T>G - IntronicSNV - 18/19
15-58767754-C-A LIPC c.88+43435C>A - IntronicSNV - 1/8
16-57015545-C-A CETP c.1215-14C>A - IntronicSNV - 12/15
7-87181849-G-T ABCB1 c.999+1228C>A - IntronicSNV - 10/28
15-58763678-T-C LIPC c.88+39359T>C - IntronicSNV - 1/8
15-58831363-A-G LIPC c.273+647A>G - IntronicSNV - 2/8
15-58833938-G-A LIPC c.274-46G>A - IntronicSNV - 2/8
16-57015545-C-T CETP c.1215-14C>T - IntronicSNV - 12/15
15-58800141-G-A LIPC c.89-30391G>A - IntronicSNV - 1/8
15-58768822-G-A LIPC c.88+44503G>A - IntronicSNV - 1/8
16-57011185-G-A CETP c.982-818G>A - IntronicSNV - 10/15
15-58831363-A-T LIPC c.273+647A>T - IntronicSNV - 2/8
7-150704843-G-C NOS3 c.2112+479G>C - IntronicSNV - 17/26
15-58751018-G-A LIPC c.88+26699G>A - IntronicSNV - 1/8
15-58837394-C-T LIPC c.575-547C>T - IntronicSNV - 4/8
7-150704843-G-A NOS3 c.2112+479G>A - IntronicSNV - 17/26
7-150694606-A-G NOS3 c.582+593A>G - IntronicSNV - 5/26
5-74637711-A-T HMGCR c.1-720A>T - IntronicSNV - 1/19
15-58839337-G-A LIPC c.808+1163G>A - IntronicSNV - 5/8
15-58724371-C-T LIPC c.88+52C>T - IntronicSNV - 1/8
15-58830966-C-T LIPC c.273+250C>T - IntronicSNV - 2/8
7-87278760-G-A ABCB1 c.-330-48366C>T - intron_variant - 1/28
16-57003146-T-C CETP c.234-152T>C - IntronicSNV - 2/15
15-58808174-G-A LIPC c.89-22358G>A - IntronicSNV - 1/8
7-150702432-A-T NOS3 c.1753-1083A>T - IntronicSNV - 14/26
16-57002732-T-G CETP c.234-566T>G - IntronicSNV - 2/15
7-150706915-G-A NOS3 c.2512+242G>A - IntronicSNV - 20/26
15-58808174-G-C LIPC c.89-22358G>C - IntronicSNV - 1/8
15-58730889-A-G LIPC c.88+6570A>G - IntronicSNV - 1/8
7-150702781-C-T NOS3 c.1753-734C>T - IntronicSNV - 14/26
19-11205975-G-A LDLR c.68-4924G>A - IntronicSNV - 1/17
19-11205975-G-C LDLR c.68-4924G>C - IntronicSNV - 1/17
7-150702781-C-A NOS3 c.1753-734C>A - IntronicSNV - 14/26
19-11228965-C-A LDLR c.1845+1291C>A - IntronicSNV - 12/17
15-58847928-A-G LIPC c.1052-5135A>G - IntronicSNV - 6/8
19-11233941-A-G LDLR c.2232A>G p.Arg744Arg Synonymous 15/18 -
5-74656175-G-A HMGCR c.*8G>A - 3-UTRSNV 20/20 -
15-58750132-G-A LIPC c.88+25813G>A - IntronicSNV - 1/8
15-58724706-G-T LIPC c.88+387G>T - IntronicSNV - 1/8
15-58826632-T-C LIPC c.89-3900T>C - IntronicSNV - 1/8
15-58826632-T-A LIPC c.89-3900T>A - IntronicSNV - 1/8
16-57007353-C-T CETP c.861C>T p.Phe287Phe Synonymous 9/16 -
15-58834741-G-A LIPC c.465G>A p.Val155Val Synonymous 4/9 -
15-58834741-G-T LIPC c.465G>T p.Val155Val Synonymous 4/9 -
15-58742196-T-C LIPC c.88+17877T>C - IntronicSNV - 1/8
7-87212990-T-A ABCB1 c.286+1838A>T - IntronicSNV - 5/28
7-87149922-C-T ABCB1 c.2786+170G>A - IntronicSNV - 23/28
19-11238473-A-C LDLR c.2312-211A>C - IntronicSNV - 15/17
7-87171152-T-C ABCB1 c.2212-372A>G - IntronicSNV - 18/28
19-11238473-A-T LDLR c.2312-211A>T - IntronicSNV - 15/17
15-58724706-G-A LIPC c.88+387G>A - IntronicSNV - 1/8
19-11238473-A-G LDLR c.2312-211A>G - IntronicSNV - 15/17
15-58743709-C-T LIPC c.88+19390C>T - IntronicSNV - 1/8
7-150689943-G-A NOS3 c.1-949G>A - IntronicSNV - 1/26
7-150689943-G-C NOS3 c.1-949G>C - IntronicSNV - 1/26
19-11242044-G-A LDLR c.*52G>A - 3-UTRSNV 18/18 -
15-58738070-C-T LIPC c.88+13751C>T - IntronicSNV - 1/8
7-87191848-A-G ABCB1 c.703-1145T>C - IntronicSNV - 8/28
15-58822697-G-A LIPC c.89-7835G>A - IntronicSNV - 1/8
15-58822697-G-T LIPC c.89-7835G>T - IntronicSNV - 1/8
15-58847807-T-C LIPC c.1052-5256T>C - IntronicSNV - 6/8
15-58808079-T-G LIPC c.89-22453T>G - IntronicSNV - 1/8
15-58733752-C-G LIPC c.88+9433C>G - IntronicSNV - 1/8
7-87138511-G-A ABCB1 c.3489+80C>T - IntronicSNV - 27/28
19-11242658-T-C LDLR c.*666T>C - 3-UTRSNV 18/18 -
19-11242658-T-A LDLR c.*666T>A - 3-UTRSNV 18/18 -
7-150703242-A-G NOS3 c.1753-273A>G - IntronicSNV - 14/26
15-58749675-C-T LIPC c.88+25356C>T - IntronicSNV - 1/8
15-58742418-G-A LIPC c.88+18099G>A - IntronicSNV - 1/8
15-58835317-C-T LIPC c.574+467C>T - IntronicSNV - 4/8
19-11226944-C-T LDLR c.1705+56C>T - IntronicSNV - 11/17
15-58767754-C-G LIPC c.88+43435C>G - IntronicSNV - 1/8
15-58835317-C-A LIPC c.574+467C>A - IntronicSNV - 4/8
7-87229440-T-C ABCB1 c.61A>G p.Asn21Asp Missense 3/29 -
7-87229440-T-G ABCB1 c.61A>C p.Asn21His Missense 3/29 -
7-87229440-T-A ABCB1 c.61A>T p.Asn21Tyr Missense 3/29 -
5-74648496-G-T HMGCR c.1368+1069G>T - IntronicSNV - 11/19
15-58835639-T-C LIPC c.574+789T>C - IntronicSNV - 4/8
7-87229501-T-C ABCB1 c.1-1A>G - 5-UTRSNV 3/29 -
7-87169702-A-C ABCB1 c.2319+971T>G - IntronicSNV - 19/28
7-150706915-G-C NOS3 c.2512+242G>C - IntronicSNV - 20/26
19-11242307-G-C LDLR c.*315G>C - 3-UTRSNV 18/18 -
7-87199564-C-T ABCB1 c.287-25G>A - IntronicSNV - 5/28
7-87199564-C-A ABCB1 c.287-25G>T - IntronicSNV - 5/28
5-74641707-G-A HMGCR c.450+224G>A - IntronicSNV - 5/19