PMID: 21444836

Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.

Hypertension (Dallas, Tex. : 1979)
AD Johnson, C Newton-Cheh, DI Chasman, GB Ehret, T Johnson, L Rose, K Rice, GC Verwoert, LJ Launer, V Gudnason, MG Larson, A Chakravarti, BM Psaty, M Caulfield, CM van Duijn, PM Ridker, PB Munroe, D Levy, , ,
2011-05

60 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
16-56946197-A-G SLC12A3 c.2952-979A>G - IntronicSNV - 25/25
7-81915186-A-C CACNA2D1 c.294+49265T>G - IntronicSNV - 3/38
7-81780722-T-A CACNA2D1 c.355-14730A>T - IntronicSNV - 4/38
8-26682677-T-G ADRA1A c.883+38927A>C - IntronicSNV - 1/2
10-78777704-C-T KCNMA1 c.2015+1067G>A - IntronicSNV - 17/26
1-230846591-C-A AGT c.6G>T p.Arg2Arg Synonymous 2/5 -
10-119094063-T-C PDZD8 c.995+6428A>G - IntronicSNV - 2/4
8-26682677-T-C ADRA1A c.883+38927A>G - IntronicSNV - 1/2
4-149347854-C-T NR3C2 c.1757+8402G>A - IntronicSNV - 2/8
10-119026175-C-T SLC18A2 c.992-69C>T - IntronicSNV - 10/15
16-23403744-A-G COG7 c.2103T>C p.Pro701Pro Synonymous 16/17 -
1-204091014-T-C SOX13 c.776-14T>C - IntronicSNV - 7/13
1-230846591-C-T AGT c.6G>A p.Arg2Arg Synonymous 2/5 -
3-154863088-G-A MME c.1416+842G>A - IntronicSNV - 14/22
1-230846591-C-G AGT c.6G>C p.Arg2Arg Synonymous 2/5 -
17-65012762-G-C CACNG4 c.221-1543G>C - IntronicSNV - 1/3
16-23366528-C-G SCNN1B c.586-92C>G - IntronicSNV - 3/12
15-48444748-T-A MYEF2 c.1088-267A>T - IntronicSNV - 10/16
15-48561701-G-A SLC12A1 c.2296-154G>A - IntronicSNV - 18/26
19-13358354-G-A CACNA1A c.4879-2275C>T - IntronicSNV - 30/47
1-230846593-G-T AGT c.4C>A p.Arg2Arg Synonymous 2/5 -
10-79224002-G-C KCNMA1 c.379-60221C>G - IntronicSNV - 1/26
17-65005835-T-C CACNG4 c.221-8470T>C - IntronicSNV - 1/3
16-23135775-G-A USP31 c.634-16271C>T - IntronicSNV - 1/15
16-23430501-C-A COG7 c.1010-353G>T - IntronicSNV - 7/16
5-159399101-C-G ADRA1B c.1165C>G p.Arg389Gly Missense 2/2 -
17-65005835-T-G CACNG4 c.221-8470T>G - IntronicSNV - 1/3
1-1203938-T-C UBE2J2 c.1-566A>G - IntronicSNV - 1/6
1-230815197-G-A COG2 c.1166+399G>A - IntronicSNV - 10/17
1-230845977-G-A AGT c.620C>T p.Thr207Met Missense 2/5 -
16-56943541-A-G SLC12A3 c.2952-3635A>G - IntronicSNV - 25/25
12-2601742-C-T CACNA1C c.917-614C>T - IntronicSNV - 6/46
5-159360485-G-A ADRA1B c.949+15624G>A - IntronicSNV - 1/1
5-159360485-G-T ADRA1B c.949+15624G>T - IntronicSNV - 1/1
17-65012762-G-T CACNG4 c.221-1543G>T - IntronicSNV - 1/3
10-119043554-C-T PDZD8 c.2690G>A p.Arg897Gln Missense 5/5 -
17-64995842-C-A CACNG4 c.221-18463C>A - IntronicSNV - 1/3
17-64995842-C-T CACNG4 c.221-18463C>T - IntronicSNV - 1/3
17-61569540-G-A ACE c.2912+798G>A - IntronicSNV - 19/24
1-204094902-T-C SOX13 c.1593-84T>C - IntronicSNV - 13/13
19-49140206-C-G DBP c.46G>C p.Gly16Arg Missense 1/4 -
12-6466081-A-G SCNN1A c.876-1035T>C - IntronicSNV - 4/12
8-86380000-T-G CA2 c.232+2302T>G - IntronicSNV - 2/6
8-86380000-T-A CA2 c.232+2302T>A - IntronicSNV - 2/6
12-2622479-T-C CACNA1C c.1390+329T>C - IntronicSNV - 9/46
20-10258339-G-C SNAP25 c.79G>C p.Glu27Gln Missense 3/8 -
1-153658187-A-T NPR1 c.1606-95A>T - IntronicSNV - 8/21
17-61558229-A-G ACE c.848-223A>G - IntronicSNV - 5/24
10-79316459-G-A KCNMA1 c.378+80564C>T - IntronicSNV - 1/26
8-26712981-A-C ADRA1A c.883+8623T>G - IntronicSNV - 1/2
8-26712981-A-T ADRA1A c.883+8623T>A - IntronicSNV - 1/2
10-79316459-G-C KCNMA1 c.378+80564C>G - IntronicSNV - 1/26
16-56847929-C-A NUP93 c.490-4647C>A - IntronicSNV - 5/21
16-56933519-G-A SLC12A3 c.2738G>A p.Arg913Gln Missense 23/26 -
4-148979174-G-T ARHGAP10 c.2028-5125G>T - IntronicSNV - 20/22
5-159344461-G-A ADRA1B c.549G>A p.Gly183Gly Synonymous 1/2 -
1-230848702-C-T AGT c.-4+1130G>A - intron_variant - 1/4
1-230848702-C-G AGT c.-4+1130G>C - intron_variant - 1/4
3-154811957-G-A MME c.196+9074G>A - IntronicSNV - 3/22
1-153652288-T-C NPR1 c.704T>C p.Met235Thr Missense 1/22 -