PMID: 21708280

Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.

Mutation research
K Srivastava, A Srivastava, KL Sharma, B Mittal
2011

108 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
1-119965519-C-T HSD3B2 c.*276C>T - 3-UTRSNV 4/4 -
15-51504811-A-C CYP19A1 c.1022-53T>G - IntronicSNV - 8/9
17-26092037-C-T NOS2 c.2428+524G>A - IntronicSNV - 20/26
22-19951207-C-A COMT c.408C>A p.Leu136Leu Synonymous 4/6 -
2-38302390-G-C CYP1B1 c.142C>G p.Arg48Gly Missense 2/3 -
4-74607055-C-T CXCL8 c.65-204C>T - IntronicSNV - 1/3
19-45409167-C-G APOE c.-24+69C>G - intron_variant - 1/3
7-99366093-G-C CYP3A4 c.554C>G p.Thr185Ser Missense 7/13 -
9-137328286-G-A RXRA c.1242-27G>A - IntronicSNV - 9/9
9-137321156-A-G RXRA c.1043+70A>G - IntronicSNV - 7/9
6-152382088-TTTTT-TTTTTTTTTT ESR1 c.1236-38_1236-34dup - IntronicInsertion - 5/7
3-12434608-G-A PPARG c.535+357G>A - IntronicSNV - 4/6
10-131506190-C-T MGMT c.250C>T p.Leu84Phe Missense 3/5 -
20-31367079-G-T DNMT3B c.1-1051G>T - IntronicSNV - 1/22
1-186648197-C-G PTGS2 c.306G>C p.Val102Val Synonymous 3/10 -
15-51507968-G-A CYP19A1 c.790C>T p.Arg264Cys Missense 7/10 -
9-110081018-A-G RAD23B c.554-15A>G - IntronicSNV - 5/9
2-113537339-A-G IL1A c.320-96T>C - IntronicSNV - 4/6
19-11224181-C-T LDLR c.1359-30C>T - IntronicSNV - 9/17
2-21237544-G-A APOB c.3697-79C>T - IntronicSNV - 23/28
19-11233941-A-G LDLR c.2232A>G p.Arg744Arg Synonymous 15/18 -
2-31805706-G-C SRD5A2 c.262C>G - missense_variant 2/6 -
2-21259612-A-G APOB c.693+360T>C - IntronicSNV - 6/28
12-25398244-C-A KRAS c.75G>T p.Gln25His Missense 2/6 -
1-207753621-A-G CR1 c.3623A>G p.His1208Arg Missense 22/39 -
19-11224181-C-A LDLR c.1359-30C>A - IntronicSNV - 9/17
5-132013886-G-A IL4 c.184-1520G>A - IntronicSNV - 2/3
20-31367079-G-C DNMT3B c.1-1051G>C - IntronicSNV - 1/22
2-219000310-C-T CXCR2 c.786C>T p.Leu262Leu Synonymous 3/3 -
17-7536527-G-A SHBG c.1066G>A p.Asp356Asn Missense 8/8 -
15-51529112-T-G CYP19A1 c.240A>C p.Val80Val Synonymous 3/10 -
15-51529112-T-C CYP19A1 c.240A>G p.Val80Val Synonymous 3/10 -
5-132013886-G-C IL4 c.184-1520G>C - IntronicSNV - 2/3
2-219000966-G-T CXCR2 c.*359G>T - 3-UTRSNV 3/3 -
2-21237544-G-T APOB c.3697-79C>A - IntronicSNV - 23/28
14-64724051-C-T ESR2 c.984G>A p.Val328Val Synonymous 6/9 -
14-64724051-C-G ESR2 c.984G>C p.Val328Val Synonymous 6/9 -
14-64724051-C-A ESR2 c.984G>T p.Val328Val Synonymous 6/9 -
4-74606669-T-G CXCL8 c.64+230T>G - IntronicSNV - 1/3
7-150696008-A-G NOS3 c.817-26A>G - IntronicSNV - 7/26
1-101203698-C-T VCAM1 c.2079C>T p.Asp693Asp Synonymous 9/9 -
15-51529112-T-A CYP19A1 c.240A>T p.Val80Val Synonymous 3/10 -
15-51508120-A-C CYP19A1 c.744-106T>G - IntronicSNV - 6/9
9-110084328-C-T RAD23B c.746C>T p.Ala249Val Missense 7/10 -
1-119965564-C-G HSD3B2 c.*321C>G - 3-UTRSNV 4/4 -
2-44066247-G-C ABCG8 c.55G>C p.Asp19His Missense 1/13 -
1-207760804-C-T CR1 c.4254C>T p.Val1418Val Synonymous 26/39 -
2-31805706-G-A SRD5A2 c.262C>T - synonymous_variant 2/6 -
1-182543331-A-G RNASEL c.*1196T>C - 3-UTRSNV 7/7 -
3-12434608-G-T PPARG c.535+357G>T - IntronicSNV - 4/6
2-31805706-G-T SRD5A2 c.262C>A - missense_variant 2/6 -
19-11241915-A-G LDLR c.2548-42A>G - IntronicSNV - 17/17
15-51520206-T-C CYP19A1 c.297-76A>G - IntronicSNV - 3/9
19-11242044-G-A LDLR c.*52G>A - 3-UTRSNV 18/18 -
1-186645488-A-G PTGS2 c.970+111T>C - IntronicSNV - 7/9
1-186645488-A-C PTGS2 c.970+111T>G - IntronicSNV - 7/9
2-21231524-G-A APOB c.8216C>T p.Pro2739Leu Missense 26/29 -
1-206945046-C-T IL10 c.166-286G>A - IntronicSNV - 1/4
20-31367079-G-A DNMT3B c.1-1051G>A - IntronicSNV - 1/22
1-206945046-C-A IL10 c.166-286G>T - IntronicSNV - 1/4
19-45409167-C-T APOE c.-24+69C>T - intron_variant - 1/3
2-113537352-T-G IL1A c.320-109A>C - IntronicSNV - 4/6
9-98997810-C-G HSD17B3 c.865G>C p.Gly289Arg Missense 11/11 -
6-152382092-T-TT ESR1 c.1236-34_1236-34dup - IntronicInsertion - 5/7
5-131877524-G-A IL5 c.384C>T p.Thr128Thr Synonymous 4/4 -
3-9798140-C-G OGG1 c.748-15C>G - IntronicSNV - 4/6
10-135348544-T-A CYP2E1 c.967+1143T>A - IntronicSNV - 6/8
5-132013963-A-C IL4 c.184-1443A>C - IntronicSNV - 2/3
2-47630550-C-G MSH2 c.211+9C>G - IntronicSNV - 1/15
2-202151163-A-G CASP8 c.1356-19A>G - IntronicSNV - 9/9
2-202151163-A-C CASP8 c.1356-19A>C - IntronicSNV - 9/9
2-47630550-C-A MSH2 c.211+9C>A - IntronicSNV - 1/15
6-31543827-G-A TNF c.186+123G>A - IntronicSNV - 1/3
6-152420095-G-A ESR1 c.1782G>A p.Thr594Thr Synonymous 8/8 -
2-44099433-C-A ABCG8 c.1199C>A p.Thr400Lys Missense 8/13 -
12-25380306-CA-AC KRAS c.151_152delTGinsAC p.Cys51Thr Missense 3/6 -
2-47630550-C-T MSH2 c.211+9C>T - IntronicSNV - 1/15
15-81601322-A-G IL16 c.*183A>G - 3-UTRSNV 19/19 -
1-186641058-G-C PTGS2 c.*2427C>G - 3-UTRSNV 10/10 -
1-101203827-G-A VCAM1 c.2208G>A p.Lys736Lys Synonymous 9/9 -
1-186641058-G-A PTGS2 c.*2427C>T - 3-UTRSNV 10/10 -
1-186641058-G-T PTGS2 c.*2427C>A - 3-UTRSNV 10/10 -
2-21232195-G-C APOB c.7545C>G p.Thr2515Thr Synonymous 26/29 -
6-152265522-G-C ESR1 c.975G>C p.Pro325Pro Synonymous 4/8 -
19-44056412-C-G XRCC1 c.839G>C p.Arg280Pro Missense 9/17 -
15-75017176-C-A CYP1A1 c.-27+606G>T - intron_variant - 1/6
2-219000966-G-A CXCR2 c.*359G>A - 3-UTRSNV 3/3 -
19-11224265-A-G LDLR c.1413A>G p.Arg471Arg Synonymous 10/18 -
2-21232195-G-T APOB c.7545C>A p.Thr2515Thr Synonymous 26/29 -
12-25398244-C-G KRAS c.75G>C p.Gln25His Missense 2/6 -
1-186643768-A-C PTGS2 c.1532T>G p.Val511Gly Missense 10/10 -
1-186643768-A-G PTGS2 c.1532T>C p.Val511Ala Missense 10/10 -
2-219029108-C-G CXCR1 c.827G>C p.Ser276Thr Missense 2/2 -
15-81601340-G-T IL16 c.*201G>T - 3-UTRSNV 19/19 -
6-33166034-A-G RXRB c.640+51T>C - IntronicSNV - 3/9
15-81601340-G-A IL16 c.*201G>A - 3-UTRSNV 19/19 -
5-132018169-C-A IL4 c.361-9C>A - IntronicSNV - 3/3
10-45891484-A-G ALOX5 c.431+100A>G - IntronicSNV - 3/13
4-26491111-A-G CCKAR c.113-5T>C - IntronicSNV - 1/4
5-131877524-G-T IL5 c.384C>A p.Thr128Thr Synonymous 4/4 -
6-35378778-C-T PPARD c.1-87C>T - 5-UTRSNV 3/8 -
1-186648197-C-T PTGS2 c.306G>A p.Val102Val Synonymous 3/10 -
2-219000734-T-C CXCR2 c.*127T>C - 3-UTRSNV 3/3 -
2-44099433-C-T ABCG8 c.1199C>T p.Thr400Met Missense 8/13 -
1-186646323-A-C PTGS2 c.640-275T>G - IntronicSNV - 5/9
8-19812812-C-T LPL c.776-540C>T - IntronicSNV - 5/9
15-51504811-A-T CYP19A1 c.1022-53T>A - IntronicSNV - 8/9
6-33162215-A-C RXRB c.*244T>G - 3-UTRSNV 10/10 -