PMID: 23033454

Variation in genes related to obesity, weight, and weight change and risk of contralateral breast cancer in the WECARE Study population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JD Brooks, L Bernstein, SN Teraoka, JA Knight, L Mellemkjær, EM John, KE Malone, AS Reiner, CF Lynch, P Concannon, RW Haile, JL Bernstein,
2012-12

190 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
12-1870525-T-C ADIPOR2 c.171+6845T>C - IntronicSNV - 2/7
12-1826556-C-T ADIPOR2 c.-87+26199C>T - intron_variant - 1/7
13-110422531-C-T IRS2 c.4012+11858G>A - IntronicSNV - 1/1
1-66058801-A-T LEPR c.703+253A>T - IntronicSNV - 6/19
1-66058801-A-G LEPR c.703+253A>G - IntronicSNV - 6/19
19-44172025-C-T PLAUR c.56-182G>A - IntronicSNV - 1/6
13-110423795-C-T IRS2 c.4012+10594G>A - IntronicSNV - 1/1
13-110435953-A-G IRS2 c.2448T>C p.Cys816Cys Synonymous 1/2 -
3-186571559-A-G ADIPOQ c.215-414A>G - IntronicSNV - 2/2
7-127890062-T-C LEP c.1-2010T>C - IntronicSNV - 1/2
3-186560782-G-A ADIPOQ c.-9+244G>A - intron_variant - 1/2
14-62200201-G-T HIF1A c.881-655G>T - IntronicSNV - 7/14
1-65979280-T-C LEPR c.1-51969T>C - IntronicSNV - 2/19
1-65979280-T-A LEPR c.1-51969T>A - IntronicSNV - 2/19
13-41217734-G-C FOXO1 c.630+21986C>G - IntronicSNV - 1/2
7-127894592-G-A LEP c.280G>A p.Val94Met Missense 3/3 -
1-66038998-T-A LEPR c.494+866T>A - IntronicSNV - 5/19
3-186566498-G-A ADIPOQ c.1-4350G>A - IntronicSNV - 1/2
1-202922194-T-C ADIPOR1 c.1-1996A>G - IntronicSNV - 1/7
7-100771717-G-A SERPINE1 c.43G>A p.Ala15Thr Missense 2/9 -
13-110426000-G-A IRS2 c.4012+8389C>T - IntronicSNV - 1/1
13-110430768-G-A IRS2 c.4012+3621C>T - IntronicSNV - 1/1
13-110430768-G-C IRS2 c.4012+3621C>G - IntronicSNV - 1/1
17-47102038-A-G IGF2BP1 c.237-942A>G - IntronicSNV - 2/14
19-44165091-G-A PLAUR c.311-4299C>T - IntronicSNV - 3/6
10-75672961-G-A PLAU c.369-87G>A - IntronicSNV - 5/10
2-676177-C-G TMEM18 c.58-547G>C - IntronicSNV - 1/4
2-676177-C-A TMEM18 c.58-547G>T - IntronicSNV - 1/4
2-676177-C-T TMEM18 c.58-547G>A - IntronicSNV - 1/4
1-202909974-G-C ADIPOR1 c.*727C>G - 3-UTRSNV 8/8 -
1-65986079-G-A LEPR c.1-45170G>A - IntronicSNV - 2/19
1-65935143-A-G LEPR c.-21+44082A>G - intron_variant - 2/19
1-66037929-C-T LEPR c.371-80C>T - IntronicSNV - 4/19
3-186571486-T-C ADIPOQ c.214+425T>C - IntronicSNV - 2/2
16-53800629-C-G FTO c.46-43423C>G - IntronicSNV - 1/8
1-65896674-A-G LEPR c.-21+5613A>G - intron_variant - 2/19
14-62205175-T-A HIF1A c.1536+84T>A - IntronicSNV - 10/14
17-47115038-C-T IGF2BP1 c.402-492C>T - IntronicSNV - 5/14
13-41212732-A-C FOXO1 c.630+26988T>G - IntronicSNV - 1/2
1-65906762-C-T LEPR c.-21+15701C>T - intron_variant - 2/19
7-100774705-G-A SERPINE1 c.506-451G>A - IntronicSNV - 3/8
14-62181954-G-A HIF1A c.36-5146G>A - IntronicSNV - 1/14
12-1831293-A-G ADIPOR2 c.-87+30936A>G - intron_variant - 1/7
13-110424075-A-T IRS2 c.4012+10314T>A - IntronicSNV - 1/1
17-47082244-T-C IGF2BP1 c.236+5713T>C - IntronicSNV - 2/14
1-65966564-A-G LEPR c.1-64685A>G - IntronicSNV - 2/19
13-41143148-T-C FOXO1 c.631-8151A>G - IntronicSNV - 1/2
7-127894305-G-A LEP c.145-152G>A - IntronicSNV - 2/2
1-202926513-C-T ADIPOR1 c.-95+800G>A - intron_variant - 1/7
7-127882070-G-A LEP c.-29+711G>A - intron_variant - 1/2
14-62166755-G-C HIF1A c.35+4198G>C - IntronicSNV - 1/14
1-66003854-T-G LEPR c.1-27395T>G - IntronicSNV - 2/19
17-47119135-G-A IGF2BP1 c.941+273G>A - IntronicSNV - 8/14
12-1896956-C-T ADIPOR2 c.*1718C>T - 3-UTRSNV 8/8 -
1-202915555-C-T ADIPOR1 c.430+12G>A - IntronicSNV - 4/7
12-1889282-T-G ADIPOR2 c.464-335T>G - IntronicSNV - 4/7
1-66067396-T-C LEPR c.1285+31T>C - IntronicSNV - 9/19
17-47088156-A-C IGF2BP1 c.236+11625A>C - IntronicSNV - 2/14
19-44163061-T-C PLAUR c.311-2269A>G - IntronicSNV - 3/6
14-62207557-C-T HIF1A c.1744C>T p.Pro582Ser Missense 12/15 -
12-1891528-G-A ADIPOR2 c.838+1286G>A - IntronicSNV - 6/7
13-41139712-T-C FOXO1 c.631-4715A>G - IntronicSNV - 1/2
19-44169738-G-C PLAUR c.167-127C>G - IntronicSNV - 2/6
19-44169738-G-A PLAUR c.167-127C>T - IntronicSNV - 2/6
17-47091283-C-A IGF2BP1 c.237-11697C>A - IntronicSNV - 2/14
3-186563803-C-T ADIPOQ c.-9+3265C>T - intron_variant - 1/2
12-1866204-T-A ADIPOR2 c.171+2524T>A - IntronicSNV - 2/7
19-44161498-C-G PLAUR c.311-706G>C - IntronicSNV - 3/6
13-41233931-A-G FOXO1 c.630+5789T>C - IntronicSNV - 1/2
1-65891901-A-T LEPR c.-21+840A>T - intron_variant - 2/19
13-41223110-C-T FOXO1 c.630+16610G>A - IntronicSNV - 1/2
14-62200518-T-C HIF1A c.881-338T>C - IntronicSNV - 7/14
1-65887013-A-C LEPR c.-97+590A>C - intron_variant - 1/19
12-1828527-C-T ADIPOR2 c.-87+28170C>T - intron_variant - 1/7
13-41146301-T-C FOXO1 c.631-11304A>G - IntronicSNV - 1/2
14-62194239-G-A HIF1A c.639G>A p.Lys213Lys Synonymous 6/15 -
7-127891087-G-A LEP c.1-985G>A - IntronicSNV - 1/2
12-1831355-G-A ADIPOR2 c.-87+30998G>A - intron_variant - 1/7
1-65963016-C-T LEPR c.1-68233C>T - IntronicSNV - 2/19
14-62189531-T-C HIF1A c.457+990T>C - IntronicSNV - 4/14
13-110409931-A-C IRS2 c.4013-1276T>G - IntronicSNV - 1/1
13-110409336-A-C IRS2 c.4013-681T>G - IntronicSNV - 1/1
13-110409336-A-G IRS2 c.4013-681T>C - IntronicSNV - 1/1
1-66080787-T-A LEPR c.1996-904T>A - IntronicSNV - 14/19
1-66080787-T-C LEPR c.1996-904T>C - IntronicSNV - 14/19
2-672496-C-T TMEM18 c.233+312G>A - IntronicSNV - 3/4
17-47131901-A-G IGF2BP1 c.*5095A>G - 3-UTRSNV 15/15 -
1-66048389-A-G LEPR c.495-9951A>G - IntronicSNV - 5/19
17-47088156-A-T IGF2BP1 c.236+11625A>T - IntronicSNV - 2/14
17-47090298-G-T IGF2BP1 c.237-12682G>T - IntronicSNV - 2/14
17-47090298-G-C IGF2BP1 c.237-12682G>C - IntronicSNV - 2/14
12-1815252-A-T ADIPOR2 c.-87+14895A>T - intron_variant - 1/7
7-100779244-C-T SERPINE1 c.1087+162C>T - IntronicSNV - 7/8
1-66037929-C-G LEPR c.371-80C>G - IntronicSNV - 4/19
1-65937880-A-T LEPR c.-21+46819A>T - intron_variant - 2/19
13-110416505-G-A IRS2 c.4013-7850C>T - IntronicSNV - 1/1
1-202926113-G-A ADIPOR1 c.-95+1200C>T - intron_variant - 1/7
10-75673101-T-C PLAU c.422T>C p.Leu141Pro Missense 6/11 -
7-100781615-G-A SERPINE1 c.*892G>A - 3-UTRSNV 9/9 -
14-62200201-G-C HIF1A c.881-655G>C - IntronicSNV - 7/14
1-65894342-C-G LEPR c.-21+3281C>G - intron_variant - 2/19
7-100776953-G-A SERPINE1 c.701-23G>A - IntronicSNV - 4/8
7-100776953-G-C SERPINE1 c.701-23G>C - IntronicSNV - 4/8
13-41133489-T-C FOXO1 c.*171A>G - IntronicSNV 3/3 -
14-62204295-C-G HIF1A c.1249+468C>G - IntronicSNV - 9/14
13-41223396-A-G FOXO1 c.630+16324T>C - IntronicSNV - 1/2
13-41155776-C-G FOXO1 c.631-20779G>C - IntronicSNV - 1/2
1-202923178-T-C ADIPOR1 c.1-2980A>G - IntronicSNV - 1/7
1-66064113-T-C LEPR c.850-230T>C - IntronicSNV - 7/19
14-62173187-A-G HIF1A c.35+10630A>G - IntronicSNV - 1/14
13-41137804-A-T FOXO1 c.631-2807T>A - IntronicSNV - 1/2
1-65906173-C-T LEPR c.-21+15112C>T - intron_variant - 2/19
1-65975847-G-T LEPR c.1-55402G>T - IntronicSNV - 2/19
12-1882589-T-G ADIPOR2 c.291+462T>G - IntronicSNV - 3/7
12-1883378-G-A ADIPOR2 c.291+1251G>A - IntronicSNV - 3/7
1-65897981-G-T LEPR c.-21+6920G>T - intron_variant - 2/19
1-65897981-G-A LEPR c.-21+6920G>A - intron_variant - 2/19
1-65894342-C-T LEPR c.-21+3281C>T - intron_variant - 2/19
13-110434310-G-A IRS2 c.4012+79C>T - IntronicSNV - 1/1
1-65906490-C-G LEPR c.-21+15429C>G - intron_variant - 2/19
1-65906490-C-A LEPR c.-21+15429C>A - intron_variant - 2/19
1-66073814-G-T LEPR c.1604-622G>T - IntronicSNV - 11/19
12-1803234-C-T ADIPOR2 c.-87+2877C>T - intron_variant - 1/7
13-41161770-G-A FOXO1 c.631-26773C>T - IntronicSNV - 1/2
7-100777267-T-C SERPINE1 c.899+93T>C - IntronicSNV - 5/8
16-53922838-C-T FTO c.1214C>T p.Ala405Val Missense 7/9 -
13-41137804-A-C FOXO1 c.631-2807T>G - IntronicSNV - 1/2
13-110430768-G-T IRS2 c.4012+3621C>A - IntronicSNV - 1/1
1-202916806-C-A ADIPOR1 c.258+626G>T - IntronicSNV - 3/7
1-202916806-C-T ADIPOR1 c.258+626G>A - IntronicSNV - 3/7
13-41223886-C-T FOXO1 c.630+15834G>A - IntronicSNV - 1/2
1-65891183-T-A LEPR c.-21+122T>A - intron_variant - 2/19
2-675831-G-T TMEM18 c.58-201C>A - IntronicSNV - 1/4
3-186568785-A-T ADIPOQ c.1-2063A>T - IntronicSNV - 1/2
10-75676464-C-T PLAU c.*141C>T - 3-UTRSNV 11/11 -
16-53828752-A-G FTO c.46-15300A>G - IntronicSNV - 1/8
1-65898972-G-C LEPR c.-21+7911G>C - intron_variant - 2/19
18-58039276-C-T MC4R c.307G>A p.Val103Ile Missense 1/1 -
17-47129121-G-C IGF2BP1 c.*2315G>C - 3-UTRSNV 15/15 -
17-47129121-G-A IGF2BP1 c.*2315G>A - 3-UTRSNV 15/15 -
1-65898972-G-A LEPR c.-21+7911G>A - intron_variant - 2/19
13-41189143-C-A FOXO1 c.630+50577G>T - IntronicSNV - 1/2
13-41189143-C-T FOXO1 c.630+50577G>A - IntronicSNV - 1/2
1-66036441-A-G LEPR c.326A>G p.Lys109Arg Missense 4/20 -
13-41161979-C-G FOXO1 c.631-26982G>C - IntronicSNV - 1/2
3-186570453-G-A ADIPOQ c.1-395G>A - IntronicSNV - 1/2
14-62171426-A-T HIF1A c.35+8869A>T - IntronicSNV - 1/14
13-41196877-T-C FOXO1 c.630+42843A>G - IntronicSNV - 1/2
13-110411796-G-A IRS2 c.4013-3141C>T - IntronicSNV - 1/1
16-53769677-G-A FTO c.45+31536G>A - IntronicSNV - 1/8
1-65890699-T-A LEPR c.-96-287T>A - intron_variant - 1/19
14-62205175-T-G HIF1A c.1536+84T>G - IntronicSNV - 10/14
14-62205175-T-C HIF1A c.1536+84T>C - IntronicSNV - 10/14
19-44163781-A-T PLAUR c.311-2989T>A - IntronicSNV - 3/6
1-202922040-C-T ADIPOR1 c.1-1842G>A - IntronicSNV - 1/7
1-66080160-G-A LEPR c.1996-1531G>A - IntronicSNV - 14/19
3-186568180-G-T ADIPOQ c.1-2668G>T - IntronicSNV - 1/2
7-100781909-C-T SERPINE1 c.*1186C>T - 3-UTRSNV 9/9 -
17-47123824-G-A IGF2BP1 c.1641+89G>A - IntronicSNV - 14/14
1-65988493-C-T LEPR c.1-42756C>T - IntronicSNV - 2/19
1-65888231-G-A LEPR c.-97+1808G>A - intron_variant - 1/19
3-186569607-G-A ADIPOQ c.1-1241G>A - IntronicSNV - 1/2
1-65966564-A-T LEPR c.1-64685A>T - IntronicSNV - 2/19
1-65975847-G-C LEPR c.1-55402G>C - IntronicSNV - 2/19
19-44172188-T-C PLAUR c.56-345A>G - IntronicSNV - 1/6
19-44162954-A-G PLAUR c.311-2162T>C - IntronicSNV - 3/6
17-47128247-C-T IGF2BP1 c.*1441C>T - 3-UTRSNV 15/15 -
13-110411568-C-T IRS2 c.4013-2913G>A - IntronicSNV - 1/1
12-1813774-A-G ADIPOR2 c.-87+13417A>G - intron_variant - 1/7
13-110427988-G-A IRS2 c.4012+6401C>T - IntronicSNV - 1/1
19-44162233-A-G PLAUR c.311-1441T>C - IntronicSNV - 3/6
12-1836979-C-T ADIPOR2 c.1-26531C>T - IntronicSNV - 1/7
3-186566728-A-C ADIPOQ c.1-4120A>C - IntronicSNV - 1/2
1-66096925-T-C LEPR c.2674-4949T>C - IntronicSNV - 19/19
19-44156472-T-C PLAUR c.659A>G p.Lys220Arg Missense 6/7 -
13-41140044-T-A FOXO1 c.631-5047A>T - IntronicSNV - 1/2
14-62171426-A-C HIF1A c.35+8869A>C - IntronicSNV - 1/14
3-186575392-G-C ADIPOQ c.*2899G>C - 3-UTRSNV 3/3 -
3-186575392-G-A ADIPOQ c.*2899G>A - 3-UTRSNV 3/3 -
7-127882070-G-T LEP c.-29+711G>T - intron_variant - 1/2
1-65948791-T-C LEPR c.-21+57730T>C - intron_variant - 2/19
7-127882070-G-C LEP c.-29+711G>C - intron_variant - 1/2
1-66036776-T-A LEPR c.370+291T>A - IntronicSNV - 4/19
12-1879385-A-G ADIPOR2 c.172-2623A>G - IntronicSNV - 2/7
3-186561634-G-A ADIPOQ c.-9+1096G>A - intron_variant - 1/2
17-47119135-G-C IGF2BP1 c.941+273G>C - IntronicSNV - 8/14
3-186566728-A-T ADIPOQ c.1-4120A>T - IntronicSNV - 1/2
14-62206548-C-A HIF1A c.1537-675C>A - IntronicSNV - 10/14
3-186572089-T-C ADIPOQ c.331T>C p.Tyr111His Missense 3/3 -
12-1882589-T-C ADIPOR2 c.291+462T>C - IntronicSNV - 3/7