PMID: 23236364

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

PloS one
CC Elbers, Y Guo, V Tragante, EP van Iperen, MB Lanktree, BA Castillo, F Chen, LR Yanek, MK Wojczynski, YR Li, B Ferwerda, CM Ballantyne, SG Buxbaum, YD Chen, WM Chen, LA Cupples, M Cushman, Y Duan, D Duggan, MK Evans, JK Fernandes, M Fornage, M Garcia, WT Garvey, N Glazer, F Gomez, TB Harris, I Halder, VJ Howard, MF Keller, MI Kamboh, C Kooperberg, SB Kritchevsky, A LaCroix, K Liu, Y Liu, K Musunuru, AB Newman, NC Onland-Moret, J Ordovas, I Peter, W Post, S Redline, SE Reis, R Saxena, PJ Schreiner, KA Volcik, X Wang, S Yusuf, AB Zonderland, SS Anand, DM Becker, B Psaty, DJ Rader, AP Reiner, SS Rich, JI Rotter, MM Sale, MY Tsai, IB Borecki, RA Hegele, S Kathiresan, MA Nalls, HA Taylor, H Hakonarson, S Sivapalaratnam, FW Asselbergs, F Drenos, JG Wilson, BJ Keating
2012

107 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
11-46746258-G-C F2 c.560-1151G>C - IntronicSNV - 6/13
4-88005203-G-A AFF1 c.1039-69G>A - IntronicSNV - 3/19
16-57006590-C-G CETP c.750+595C>G - IntronicSNV - 8/15
16-57006590-C-T CETP c.750+595C>T - IntronicSNV - 8/15
2-21265695-T-C APOB c.122-347A>G - IntronicSNV - 2/28
11-61623140-C-T FADS2 c.745-1343C>T - IntronicSNV - 5/11
11-116648900-T-C ZPR1 c.*741A>G - IntergenicSNV 14/14 -
11-116662331-G-T APOA5 c.132C>A p.Ile44Ile Synonymous 3/4 -
11-116691675-T-C APOA4 c.1099A>G p.Thr367Ala Missense 3/3 -
2-21231524-G-A APOB c.8216C>T p.Pro2739Leu Missense 26/29 -
11-61623140-C-A FADS2 c.745-1343C>A - IntronicSNV - 5/11
1-55518160-C-A PCSK9 c.657+76C>A - IntronicSNV - 4/11
3-148423081-A-G AGTR1 c.-131-2650A>G - intron_variant - 1/2
11-116691675-T-A APOA4 c.1099A>T p.Thr367Ser Missense 3/3 -
11-116654086-A-C ZPR1 c.981+160T>G - IntronicSNV - 10/13
2-21231524-G-T APOB c.8216C>A p.Pro2739Gln Missense 26/29 -
8-19816934-T-C LPL c.1139+43T>C - IntronicSNV - 7/9
17-64210580-A-G APOH c.973T>C p.Cys325Arg Missense 7/8 -
11-116619073-C-G BUD13 c.*125G>C - 3-UTRSNV 10/10 -
11-116619073-C-T BUD13 c.*125G>A - 3-UTRSNV 10/10 -
16-57007446-T-A CETP c.930+24T>A - IntronicSNV - 9/15
16-57007446-T-G CETP c.930+24T>G - IntronicSNV - 9/15
16-67976851-C-A LCAT c.340G>T p.Val114Leu Missense 3/6 -
16-67976851-C-T LCAT c.340G>A p.Val114Met Missense 3/6 -
16-67976851-C-G LCAT c.340G>C p.Val114Leu Missense 3/6 -
7-72989390-A-G TBL2 c.131-547T>C - IntronicSNV - 1/6
1-55517940-G-A PCSK9 c.524-11G>A - IntronicSNV - 3/11
12-121416988-A-G HNF1A c.326+91A>G - IntronicSNV - 1/9
1-55517940-G-T PCSK9 c.524-11G>T - IntronicSNV - 3/11
1-109814880-C-T CELSR2 c.7927-20C>T - IntronicSNV - 28/33
1-55529187-G-A PCSK9 c.2009G>A p.Gly670Glu Missense 12/12 -
9-131583170-T-C ENDOG c.611+43T>C - IntronicSNV - 2/2
9-131583170-T-A ENDOG c.611+43T>A - IntronicSNV - 2/2
13-114549015-T-C GAS6 c.343+485A>G - IntronicSNV - 4/14
7-80283323-A-G CD36 c.121-2533A>G - IntronicSNV - 3/13
9-131583170-T-G ENDOG c.611+43T>G - IntronicSNV - 2/2
13-114549015-T-A GAS6 c.343+485A>T - IntronicSNV - 4/14
17-64210580-A-C APOH c.973T>G p.Cys325Gly Missense 7/8 -
19-19610596-C-G GATAD2A c.1204+1065C>G - IntronicSNV - 8/11
19-10388462-G-A ICAM1 c.331+2758G>A - IntronicSNV - 2/6
8-19823192-T-C LPL c.*371T>C - 3-UTRSNV 10/10 -
11-116620256-C-A BUD13 c.1767-965G>T - IntronicSNV - 9/9
19-19610596-C-T GATAD2A c.1204+1065C>T - IntronicSNV - 8/11
1-204126245-A-G REN c.698+244T>C - IntronicSNV - 6/9
8-18255709-A-G NAT2 c.1-1805A>G - IntronicSNV - 1/1
1-204126245-A-T REN c.698+244T>A - IntronicSNV - 6/9
11-116629153-G-A BUD13 c.1361-30C>T - IntronicSNV - 6/9
11-116651463-T-G ZPR1 c.1180-910A>C - IntronicSNV - 12/13
20-39797465-T-C PLCG1 c.2438T>C p.Ile813Thr Missense 21/32 -
11-61551356-T-C MYRF c.3033T>C p.Ser1011Ser Synonymous 23/26 -
1-55520212-G-A PCSK9 c.800-1454G>A - IntronicSNV - 5/11
9-136149722-A-C ABO c.28+856T>G - IntronicSNV - 1/7
11-116660813-G-A APOA5 c.*31C>T - 3-UTRSNV 4/4 -
11-116662785-G-A APOA5 c.1-209C>T - IntronicSNV - 1/3
12-125290856-A-T SCARB1 c.1009+1451T>A - IntronicSNV - 7/12
9-136149722-A-G ABO c.28+856T>C - IntronicSNV - 1/7
11-116654159-A-G ZPR1 c.981+87T>C - IntronicSNV - 10/13
2-211061670-G-T ACADL c.985-1608C>A - IntronicSNV - 8/10
6-32409708-C-T HLA-DRA c.83-517C>T - IntronicSNV - 1/4
16-67208048-C-G NOL3 c.1-25C>G - IntronicSNV 1/4 -
11-116661488-C-T APOA5 c.457G>A p.Val153Met Missense 4/4 -
11-47286290-T-C NR1H3 c.808+2721T>C - IntronicSNV - 6/8
20-44534651-G-A PLTP c.705+256C>T - IntronicSNV - 8/15
8-19824492-T-C LPL c.*1671T>C - 3-UTRSNV 10/10 -
8-19824492-T-A LPL c.*1671T>A - 3-UTRSNV 10/10 -
11-116660768-G-A APOA5 c.*76C>T - 3-UTRSNV 4/4 -
11-116623659-C-T BUD13 c.1766+4203G>A - IntronicSNV - 9/9
11-116654435-C-T ZPR1 c.892-100G>A - IntronicSNV - 9/13
19-42911769-G-A LIPE c.1831C>T p.Arg611Cys Missense 5/10 -
1-63061906-C-T DOCK7 c.1683-9611G>A - IntronicSNV - 14/48
11-116629949-C-T BUD13 c.1255-54G>A - IntronicSNV - 5/9
11-116651463-T-A ZPR1 c.1180-910A>T - IntronicSNV - 12/13
15-58727325-A-G LIPC c.88+3006A>G - IntronicSNV - 1/8
11-116691634-C-A APOA4 c.1140G>T p.Gln380His Missense 3/3 -
11-116646858-C-T ZPR1 c.*2783G>A - IntergenicSNV 14/14 -
11-116628401-T-C BUD13 c.1684+81A>G - IntronicSNV - 8/9
11-61551356-T-G MYRF c.3033T>G p.Ser1011Arg Missense 23/26 -
11-116661392-C-T APOA5 c.553G>A p.Gly185Ser Missense 4/4 -
11-116661392-C-A APOA5 c.553G>T p.Gly185Cys Missense 4/4 -
11-116619051-G-A BUD13 c.*147C>T - 3-UTRSNV 10/10 -
9-107665739-G-A ABCA1 c.66+156C>T - IntronicSNV - 2/49
11-61551356-T-A MYRF c.3033T>A p.Ser1011Arg Missense 23/26 -
7-150668514-T-C KCNH2 c.307+3285A>G - IntronicSNV - 2/14
7-150668514-T-A KCNH2 c.307+3285A>T - IntronicSNV - 2/14
11-116653296-C-T ZPR1 c.1093-336G>A - IntronicSNV - 11/13
11-116658031-T-G ZPR1 c.333+167A>C - IntronicSNV - 2/13
11-116653296-C-G ZPR1 c.1093-336G>C - IntronicSNV - 11/13
19-11202460-T-A LDLR c.67+2169T>A - IntronicSNV - 1/17
8-59412066-T-G CYP7A1 c.80+512A>C - IntronicSNV - 1/5
12-132330531-G-T MMP17 c.1204+537G>T - IntronicSNV - 8/9
12-132330531-G-A MMP17 c.1204+537G>A - IntronicSNV - 8/9
2-21237544-G-A APOB c.3697-79C>T - IntronicSNV - 23/28
1-230294916-C-T GALNT2 c.127-19048C>T - IntronicSNV - 1/15
11-116631690-G-A BUD13 c.1037-22C>T - IntronicSNV - 4/9
11-116633862-G-A BUD13 c.443C>T p.Pro148Leu Missense 4/10 -
11-116652207-C-T ZPR1 c.1179+667G>A - IntronicSNV - 12/13
16-67208048-C-T NOL3 c.1-25C>T - IntronicSNV 1/4 -
11-116660686-G-A APOA5 c.*158C>T - 3-UTRSNV 4/4 -
22-38576315-C-T PLA2G6 c.-46+1356G>A - intron_variant - 1/15
11-116640237-A-G BUD13 c.237+608T>C - IntronicSNV - 2/9
11-116652301-C-T ZPR1 c.1179+573G>A - IntronicSNV - 12/13
1-55518160-C-G PCSK9 c.657+76C>G - IntronicSNV - 4/11
7-80300449-T-G CD36 c.975T>G p.Tyr325* Nonsense 10/14 -
15-58724792-T-A LIPC c.88+473T>A - IntronicSNV - 1/8
11-116660450-A-G APOA5 c.*394T>C - 3-UTRSNV 4/4 -
14-61995673-C-T PRKCH c.1434-120C>T - IntronicSNV - 10/13
2-21237544-G-T APOB c.3697-79C>A - IntronicSNV - 23/28