PMID: 24225950

Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.

The Journal of biological chemistry
Y Zhang, C Eigenbrot, L Zhou, S Shia, W Li, C Quan, J Tom, P Moran, P Di Lello, NJ Skelton, M Kong-Beltran, A Peterson, D Kirchhofer

12 variants were identified in this publication

Variant ID Gene cDNA Protein Consequence Exon Intron
1-55523142-TT-GC PCSK9 c.1135_1136delTTinsGC p.Phe379Ala Missense 7/12 -
1-55523112-AT-GC PCSK9 c.1105_1106delATinsGC p.Ile369Ala Missense 7/12 -
1-55523107-A-C PCSK9 c.1100A>C p.Asp367Ala Missense 7/12 -
1-55523128-A-C PCSK9 c.1121A>C p.Asp374Ala Missense 7/12 -
1-55518007-CG-GC PCSK9 c.580_581delCGinsGC p.Arg194Ala Missense 4/12 -
1-55512268-CT-GC PCSK9 c.472_473delCTinsGC p.Leu158Ala Missense 3/12 -
1-55523148-T-G PCSK9 c.1141T>G p.Ser381Ala Missense 7/12 -
1-55523146-T-C PCSK9 c.1139T>C p.Val380Ala Missense 7/12 -
1-55518378-A-C PCSK9 c.713A>C p.Asp238Ala Missense 5/12 -
1-55512259-C-G PCSK9 c.463C>G p.Pro155Ala Missense 3/12 -
1-55512253-AG-GC PCSK9 c.457_458delAGinsGC p.Ser153Ala Missense 3/12 -
1-55523151-CA-GC PCSK9 c.1144_1145delCAinsGC p.Gln382Ala Missense 7/12 -