PMID: 25419701

Exploring the distribution of genetic markers of pharmacogenomics relevance in Brazilian and Mexican populations.

PloS one
V Bonifaz-Peña, AV Contreras, CJ Struchiner, RA Roela, TK Furuya-Mazzotti, R Chammas, C Rangel-Escareño, L Uribe-Figueroa, MJ Gómez-Vázquez, HL McLeod, A Hidalgo-Miranda, EJ Parra, JC Fernández-López, G Suarez-Kurtz
2014

1702 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
6-52842839-C-T GSTA4 c.*429G>A - 3-UTRSNV 7/7 -
2-169783728-C-T ABCB11 c.3556G>A p.Glu1186Lys Missense 26/28 -
5-131663062-T-C SLC22A4 c.917T>C p.Ile306Thr Missense 5/10 -
15-75045612-G-C CYP1A2 c.1253+1G>C - IntronicSNV - 6/6
15-75045612-G-A CYP1A2 c.1253+1G>A - IntronicSNV - 6/6
6-43270326-A-G SLC22A7 c.1271-67A>G - IntronicSNV - 7/9
7-87178626-C-T ABCB1 c.1725+38G>A - IntronicSNV - 15/28
2-234601707-A-T UGT1A10 c.855+55684A>T - IntronicSNV - 1/4
7-99358459-G-A CYP3A4 c.1396C>T p.Pro466Ser Missense 12/13 -
2-234526680-T-A UGT1A8 c.327T>A p.Phe109Leu Missense 1/5 -
15-92707569-G-A SLCO3A1 c.*1204G>A - 3-UTRSNV 10/10 -
1-110280362-C-T GSTM3 c.384G>A p.Lys128Lys Synonymous 7/9 -
22-44220673-C-T SULT4A1 c.*1208G>A - 3-UTRSNV 7/7 -
7-99262860-T-C CYP3A5 c.599A>G p.Gln200Arg Missense 7/13 -
22-44220673-C-A SULT4A1 c.*1208G>T - 3-UTRSNV 7/7 -
5-142779601-G-A NR3C1 c.804C>T p.Pro268Pro Synonymous 2/9 -
1-171303690-T-C FMO4 c.968T>C p.Val323Ala Missense 8/10 -
4-70462042-C-T UGT2A2 c.949G>A p.Gly317Arg Missense 3/6 -
18-662164-G-C TYMS c.298G>C p.Glu100Gln Missense 3/7 -
6-44197181-G-A SLC29A1 c.84G>A p.Pro28Pro Synonymous 4/14 -
6-52617738-G-A GSTA2 c.328C>T p.Pro110Ser Missense 5/7 -
2-169887154-G-A ABCB11 c.-28+581C>T - intron_variant - 1/27
15-51502893-G-A CYP19A1 c.*112C>T - 3-UTRSNV 10/10 -
15-51502893-G-T CYP19A1 c.*112C>A - 3-UTRSNV 10/10 -
15-75012940-G-A CYP1A1 c.1429C>T p.Arg477Trp Missense 7/7 -
15-75012940-G-C CYP1A1 c.1429C>G p.Arg477Gly Missense 7/7 -
5-142659266-T-G NR3C1 c.*2188A>C - 3-UTRSNV 9/9 -
7-139661964-C-T TBXAS1 c.1066C>T - synonymous_variant 9/13 -
6-35339035-C-T PPARD c.-102+24108C>T - intron_variant - 2/7
3-121646641-A-G SLC15A2 c.1161A>G p.Ala387Ala Synonymous 14/22 -
1-150812049-G-T ARNT c.309C>A p.Thr103Thr Synonymous 5/21 -
21-37510224-C-T CBR3 c.391C>T p.Pro131Ser Missense 2/3 -
15-74635405-G-T CYP11A1 c.903C>A p.Ile301Ile Synonymous 5/9 -
10-106022789-C-A GSTO1 c.419C>A p.Ala140Asp Missense 4/6 -
21-43706776-G-A ABCG1 c.1006+672G>A - IntronicSNV - 8/14
10-73771706-G-A CHST3 c.*3477G>A - 3-UTRSNV 3/3 -
3-121643804-C-T SLC15A2 c.1048C>T p.Leu350Phe Missense 13/22 -
3-121643804-C-G SLC15A2 c.1048C>G p.Leu350Val Missense 13/22 -
10-96541615-C-T CYP2C19 c.680C>T p.Pro227Leu Missense 5/9 -
16-31104447-A-G VKORC1 c.283+186T>C - IntronicSNV - 2/2
16-89616967-G-A SPG7 c.1729G>A p.Gly577Ser Missense 13/17 -
8-18080333-T-C NAT1 c.777T>C p.Ser259Ser Synonymous 3/3 -
8-18080333-T-G NAT1 c.777T>G p.Ser259Arg Missense 3/3 -
4-70725821-C-T SULT1E1 c.-64G>A - 5_prime_UTR_variant 1/8 -
2-108994808-C-G SULT1C4 c.15C>G p.Asp5Glu Missense 1/7 -
19-41381501-T-C CYP2A7 c.*97A>G - 3-UTRSNV 8/8 -
15-51547938-C-G CYP19A1 c.1-12829G>C - IntronicSNV - 1/9
7-139661841-C-A TBXAS1 c.946C>A p.Arg316Arg Synonymous 9/13 -
4-70725456-G-C SULT1E1 c.-10+311C>G - intron_variant - 1/7
10-73769359-C-G CHST3 c.*1130C>G - 3-UTRSNV 3/3 -
15-74632028-G-A CYP11A1 c.1057C>T p.Arg353Trp Missense 6/9 -
1-171168585-A-T FMO2 c.585A>T p.Ser195Ser Synonymous 5/9 -
2-101009983-C-T CHST10 c.795G>A p.Thr265Thr Synonymous 7/7 -
6-35330898-T-C PPARD c.-102+15971T>C - intron_variant - 2/7
1-171168585-A-G FMO2 c.585A>G p.Ser195Ser Synonymous 5/9 -
5-74639259-T-G HMGCR c.166-419T>G - IntronicSNV - 2/19
2-101009326-T-C CHST10 c.*381A>G - 3-UTRSNV 7/7 -
10-101578641-C-G ABCC2 c.2366C>G p.Ser789Cys Missense 18/32 -
10-101578641-C-T ABCC2 c.2366C>T p.Ser789Phe Missense 18/32 -
5-142662280-G-C NR3C1 c.2034C>G p.Asp678Glu Missense 8/9 -
5-142662280-G-T NR3C1 c.2034C>A p.Asp678Glu Missense 8/9 -
6-32008469-G-C CYP21A2 c.1143G>C p.Glu381Asp Missense 9/10 -
6-160543123-T-C SLC22A1 c.156T>C p.Ser52Ser Synonymous 1/11 -
2-101019031-G-A CHST10 c.187C>T p.Leu63Leu Synonymous 4/7 -
1-171080080-G-A FMO3 c.769G>A p.Val257Met Missense 6/9 -
1-110280362-C-G GSTM3 c.384G>C p.Lys128Asn Missense 7/9 -
7-17385270-C-T AHR c.*2582C>T - 3-UTRSNV 11/11 -
6-160679400-C-A SLC22A2 c.390G>T p.Thr130Thr Synonymous 1/11 -
6-160679400-C-T SLC22A2 c.390G>A p.Thr130Thr Synonymous 1/11 -
4-100052733-C-A ADH4 c.765G>T p.Pro255Pro Synonymous 6/9 -
19-41384675-T-A CYP2A7 c.668A>T p.His223Leu Missense 4/8 -
10-101559094-A-G ABCC2 c.998A>G p.Asp333Gly Missense 8/32 -
2-169882084-A-G ABCB11 c.-28+5651T>C - intron_variant - 1/27
2-38302350-C-T CYP1B1 c.182G>A p.Gly61Glu Missense 2/3 -
20-61299341-G-A SLCO4A1 c.1639-23G>A - IntronicSNV - 8/11
19-41518244-C-T CYP2B6 c.1006C>T p.Arg336Cys Missense 7/9 -
3-12475399-C-T PPARG c.1189C>T p.Arg397Cys Missense 7/7 -
19-41511803-C-G CYP2B6 c.485-1007C>G - IntronicSNV - 3/8
6-160858188-G-A SLC22A3 c.1233G>A p.Ala411Ala Synonymous 7/11 -
1-171176912-T-C FMO2 c.1239T>C p.Asn413Asn Synonymous 8/9 -
1-171176912-T-A FMO2 c.1239T>A p.Asn413Lys Missense 8/9 -
1-171176912-T-G FMO2 c.1239T>G p.Asn413Lys Missense 8/9 -
2-101010043-G-A CHST10 c.735C>T p.Gly245Gly Synonymous 7/7 -
2-169779764-C-A ABCB11 c.*368G>T - 3-UTRSNV 28/28 -
2-169779764-C-T ABCB11 c.*368G>A - 3-UTRSNV 28/28 -
1-171254794-C-T FMO1 c.*111C>T - 3-UTRSNV 9/9 -
1-20915701-A-C CDA c.79A>C p.Lys27Gln Missense 1/4 -
1-98165062-C-A DPYD c.525G>T p.Ser175Ser Synonymous 6/23 -
2-169847323-C-T ABCB11 c.896G>A p.Arg299Lys Missense 9/28 -
19-15789098-A-G CYP4F12 c.226A>G p.Asn76Asp Missense 3/13 -
1-171303737-G-C FMO4 c.1015G>C p.Glu339Gln Missense 8/10 -
7-139715641-G-A TBXAS1 c.1345G>A - missense_variant 11/13 -
10-101603631-A-G ABCC2 c.3817A>G p.Thr1273Ala Missense 27/32 -
19-41381656-T-C CYP2A7 c.1274A>G p.Lys425Arg Missense 8/8 -
2-169779764-C-G ABCB11 c.*368G>C - 3-UTRSNV 28/28 -
20-61288423-G-T SLCO4A1 c.617G>T p.Arg206Met Missense 2/12 -
20-61288423-G-A SLCO4A1 c.617G>A p.Arg206Lys Missense 2/12 -
9-117093110-T-C ORM2 c.296T>C p.Val99Ala Missense 3/6 -
8-18257924-A-T NAT2 c.411A>T p.Leu137Phe Missense 2/2 -
18-9517043-A-G RALBP1 c.445A>G p.Lys149Glu Missense 3/10 -
7-91746400-G-A CYP51A1 c.1309C>T p.Pro437Ser Missense 9/10 -
4-100204574-G-A ADH1A c.568-811C>T - IntronicSNV - 5/8
19-15726147-A-G CYP4F8 c.-2+56A>G - intron_variant - 1/13
14-77793237-G-A GSTZ1 c.124G>A p.Gly42Arg Missense 3/9 -
13-103710684-C-G SLC10A2 c.426G>C p.Pro142Pro Synonymous 2/6 -
13-103710684-C-T SLC10A2 c.426G>A p.Pro142Pro Synonymous 2/6 -
7-150558366-C-T AOC1 c.*69C>T - 3-UTRSNV 5/5 -
7-95025600-G-A PON3 c.63C>T p.Phe21Phe Synonymous 1/9 -
12-21325716-T-C SLCO1B1 c.217T>C p.Phe73Leu Missense 3/15 -
10-82035560-C-T MAT1A c.768+572G>A - IntronicSNV - 6/8
5-131671634-G-A SLC22A4 c.1385G>A p.Gly462Glu Missense 8/10 -
18-669117-C-A TYMS c.500C>A p.Thr167Asn Missense 4/7 -
7-99361626-A-G CYP3A4 c.875T>C p.Leu292Pro Missense 10/13 -
8-143955221-C-T CYP11B1 c.*568G>A - 3-UTRSNV 9/9 -
2-101009376-A-G CHST10 c.*331T>C - 3-UTRSNV 7/7 -
3-119534659-C-T NR1I2 c.1141C>T p.Arg381Trp Missense 8/9 -
7-99332765-C-T CYP3A7 c.1-49G>A - 5-UTRSNV 1/13 -
18-662247-A-G TYMS c.381A>G p.Glu127Glu Synonymous 3/7 -
11-64333296-A-G SLC22A11 c.1058+487A>G - IntronicSNV - 6/9
3-126262092-G-A CHST13 c.*671G>A - 3-UTRSNV 3/3 -
14-70245157-A-G SLC10A1 c.836T>C p.Ile279Thr Missense 4/5 -
7-87082366-G-A ABCB4 c.430C>T p.Arg144* Nonsense 6/28 -
10-73770355-A-T CHST3 c.*2126A>T - 3-UTRSNV 3/3 -
10-101578577-C-G ABCC2 c.2302C>G p.Arg768Gly Missense 18/32 -
1-171251196-A-G FMO1 c.907A>G p.Ile303Val Missense 7/9 -
2-169875245-G-T ABCB11 c.1-610C>A - IntronicSNV - 1/27
2-234601669-T-G UGT1A10 c.855+55646T>G - IntronicSNV - 1/4
6-35324741-T-C PPARD c.-102+9814T>C - intron_variant - 2/7
13-99376273-C-T SLC15A1 c.258G>A p.Ser86Ser Synonymous 5/23 -
16-31102589-G-A VKORC1 c.358C>T p.Leu120Leu Synonymous 3/3 -
10-135345675-G-A CYP2E1 c.535G>A p.Val179Ile Missense 4/9 -
19-41633980-C-G CYP2F1 c.1469C>G p.Pro490Arg Missense 10/10 -
19-41633980-C-T CYP2F1 c.1469C>T p.Pro490Leu Missense 10/10 -
1-171162516-G-C FMO2 c.175G>C p.Val59Leu Missense 3/9 -
1-171168545-T-C FMO2 c.545T>C p.Phe182Ser Missense 5/9 -
5-142660229-A-G NR3C1 c.*1225T>C - 3-UTRSNV 9/9 -
10-96612671-A-C CYP2C19 c.1473A>C - Missense 9/9 -
19-41350996-C-T CYP2A6 c.1161+203G>A - IntronicSNV - 7/8
1-110256075-A-G GSTM5 c.178-31A>G - IntronicSNV - 3/7
2-234526705-A-G UGT1A8 c.352A>G p.Asn118Asp Missense 1/5 -
4-70066319-G-A UGT2B11 c.1429C>T p.Arg477* Nonsense 6/6 -
8-18258358-A-G NAT2 c.845A>G p.Lys282Arg Missense 2/2 -
10-73770355-A-G CHST3 c.*2126A>G - 3-UTRSNV 3/3 -
10-73770355-A-C CHST3 c.*2126A>C - 3-UTRSNV 3/3 -
10-96522463-A-G CYP2C19 c.1A>G p.Met1Val Missense 1/9 -
16-31104402-C-T VKORC1 c.283+231G>A - IntronicSNV - 2/2
4-69964271-A-T UGT2B7 c.735A>T p.Thr245Thr Synonymous 2/6 -
12-21958221-C-T ABCC9 c.4537G>A p.Ala1513Thr Missense 38/38 -
7-87038681-T-C ABCB4 c.2952A>G p.Ala984Ala Synonymous 24/28 -
1-171173121-C-T FMO2 c.745C>T p.Arg249* Nonsense 6/9 -
12-105153570-C-T CHST11 c.*1989C>T - 3-UTRSNV 3/3 -
2-169870855-A-G ABCB11 c.108T>C p.Asp36Asp Synonymous 4/28 -
1-150808889-C-G ARNT c.522G>C p.Val174Val Synonymous 6/21 -
8-143994136-A-G CYP11B2 c.1208T>C p.Val403Ala Missense 8/9 -
19-41381503-C-T CYP2A7 c.*95G>A - 3-UTRSNV 8/8 -
20-48127684-G-C PTGIS c.1239C>G p.Asp413Glu Missense 9/10 -
4-89039360-A-G ABCG2 c.742T>C p.Ser248Pro Missense 7/16 -
10-96741054-T-A CYP2C9 c.1076T>A p.Ile359Asn Missense 7/9 -
7-139715542-C-G TBXAS1 c.1246C>G - missense_variant 11/13 -
2-234665983-A-G UGT1A4 c.868-9697A>G - IntronicSNV - 1/4
2-234676924-C-T UGT1A1 c.1143C>T p.Ser381Ser Synonymous 4/5 -
8-143961102-C-T CYP11B1 c.128G>A p.Arg43Gln Missense 1/9 -
10-96612495-C-T CYP2C19 c.1297C>T p.Arg433Trp Missense 9/9 -
7-87190668-C-A ABCB1 c.738G>T p.Ala246Ala Synonymous 9/29 -
15-74635405-G-C CYP11A1 c.903C>G p.Ile301Met Missense 5/9 -
22-19951237-C-T COMT c.438C>T p.Ala146Ala Synonymous 4/6 -
4-70615488-T-C SULT1B1 c.326A>G p.His109Arg Missense 4/8 -
20-48127684-G-T PTGIS c.1239C>A p.Asp413Glu Missense 9/10 -
20-48127684-G-A PTGIS c.1239C>T p.Asp413Asp Synonymous 9/10 -
13-52534376-C-T ATP7B c.2029G>A p.Glu677Lys Missense 7/21 -
10-96741054-T-C CYP2C9 c.1076T>C p.Ile359Thr Missense 7/9 -
17-19645412-C-T ALDH3A1 c.594G>A p.Thr198Thr Synonymous 5/11 -
6-35330030-T-G PPARD c.-102+15103T>G - intron_variant - 2/7
2-234676924-C-G UGT1A1 c.1143C>G p.Ser381Arg Missense 4/5 -
1-113456368-A-C SLC16A1 c.*145T>G - 3-UTRSNV 5/5 -
7-99365994-G-C CYP3A4 c.653C>G p.Pro218Arg Missense 7/13 -
8-18257624-T-C NAT2 c.111T>C p.Phe37Phe Synonymous 2/2 -
7-87160810-T-C ABCB1 c.2485A>G p.Ile829Val Missense 22/29 -
4-74283844-A-G ALB c.1468A>G p.Lys490Glu Missense 12/15 -
8-18257704-G-A NAT2 c.191G>A p.Arg64Gln Missense 2/2 -
21-46945782-G-T SLC19A1 c.1242C>A p.Ile414Ile Synonymous 5/6 -
5-131714072-G-A SLC22A5 c.396G>A p.Trp132* Nonsense 2/10 -
15-75047245-G-A CYP1A2 c.1367G>A p.Arg456His Missense 7/7 -
6-35359874-G-A PPARD c.1-18991G>A - IntronicSNV - 2/7
10-73770651-T-C CHST3 c.*2422T>C - 3-UTRSNV 3/3 -
7-87056224-G-A ABCB4 c.1906C>T p.Gln636* Nonsense 16/28 -
11-74880413-A-T SLCO2B1 c.644A>T p.Asp215Val Missense 5/14 -
6-35357693-C-G PPARD c.1-21172C>G - IntronicSNV - 2/7
2-234669759-G-C UGT1A1 c.826G>C p.Gly276Arg Missense 1/5 -
19-15740220-C-T CYP4F8 c.*52C>T - 3_prime_UTR_variant 14/14 -
14-77794283-T-A GSTZ1 c.245T>A p.Met82Lys Missense 5/9 -
14-77794283-T-C GSTZ1 c.245T>C p.Met82Thr Missense 5/9 -
19-49090601-C-T SULT2B1 c.285C>T p.Ala95Ala Synonymous 2/6 -
7-150556056-G-C AOC1 c.1776G>C p.Thr592Thr Synonymous 3/5 -
12-58158176-A-G CYP27B1 c.1121T>C p.Val374Ala Missense 6/9 -
10-96748635-C-T CYP2C9 c.1323C>T p.Ala441Ala Synonymous 9/9 -
10-96541756-T-C CYP2C19 c.819+2T>C - IntronicSNV - 5/8
2-234681416-T-C UGT1A1 c.*211T>C - 3-UTRSNV 5/5 -
10-135345675-G-T CYP2E1 c.535G>T p.Val179Phe Missense 4/9 -
18-24722839-G-C CHST9 c.1-66C>G - 5-UTRSNV 2/6 -
7-95053880-G-A PON2 c.92C>T p.Ser31Phe Missense 2/9 -
2-234669558-C-A UGT1A1 c.625C>A p.Arg209Arg Synonymous 1/5 -
12-21329813-C-A SLCO1B1 c.463C>A p.Pro155Thr Missense 5/15 -
16-69744855-G-C NQO1 c.*24C>G - 3-UTRSNV 6/6 -
16-69744855-G-A NQO1 c.*24C>T - 3-UTRSNV 6/6 -
2-101023228-G-T CHST10 c.1-91C>A - IntronicSNV 2/7 -
8-18258358-A-C NAT2 c.845A>C p.Lys282Thr Missense 2/2 -
15-75044578-A-T CYP1A2 c.1156A>T p.Ile386Phe Missense 5/7 -
15-75047426-C-T CYP1A2 c.1548C>T p.Asn516Asn Synonymous 7/7 -
4-70351050-A-G UGT2B4 c.1186T>C p.Phe396Leu Missense 5/6 -
3-38318499-C-T SLC22A13 c.1443C>T p.Pro481Pro Synonymous 9/10 -
3-38318499-C-G SLC22A13 c.1443C>G p.Pro481Pro Synonymous 9/10 -
6-35312254-G-A PPARD c.-186+1796G>A - intron_variant - 1/7
2-234580589-C-G UGT1A10 c.855+34566C>G - IntronicSNV - 1/4
13-103698168-A-T SLC10A2 c.*315T>A - 3-UTRSNV 6/6 -
2-234669558-C-T UGT1A1 c.625C>T p.Arg209Trp Missense 1/5 -
1-20931474-G-A CDA c.208G>A p.Ala70Thr Missense 2/4 -
4-70455150-T-G UGT2A2 c.1551A>C p.Gln517His Missense 6/6 -
13-99356612-A-C SLC15A1 c.1347T>G p.Ala449Ala Synonymous 17/23 -
13-99356612-A-G SLC15A1 c.1347T>C p.Ala449Ala Synonymous 17/23 -
4-100349135-C-A ADH7 c.395G>T p.Arg132Leu Missense 5/9 -
4-100349135-C-T ADH7 c.395G>A p.Arg132His Missense 5/9 -
15-92685078-G-A SLCO3A1 c.1513-5136G>A - IntronicSNV - 7/9
15-92685078-G-C SLCO3A1 c.1513-5136G>C - IntronicSNV - 7/9
11-64359079-G-A SLC22A12 c.51G>A p.Gln17Gln Synonymous 1/10 -
7-87133470-T-A ABCB1 c.*89A>T - 3-UTRSNV 29/29 -
6-46625274-A-G SLC25A27 c.299-1425A>G - IntronicSNV - 2/8
17-19645938-A-C ALDH3A1 c.400T>G p.Ser134Ala Missense 4/11 -
15-51502082-A-T CYP19A1 c.*923T>A - 3-UTRSNV 10/10 -
15-75044552-G-C CYP1A2 c.1130G>C p.Arg377Pro Missense 5/7 -
6-52709117-G-A GSTA5 c.-31+1737C>T - intron_variant - 1/6
16-16173221-C-T ABCC1 c.2001C>T p.Ser667Ser Synonymous 16/31 -
17-19645938-A-T ALDH3A1 c.400T>A p.Ser134Thr Missense 4/11 -
10-96495793-C-A CYP2C18 c.*592C>A - 3-UTRSNV 9/9 -
4-70346057-T-G UGT2B4 c.*295A>C - 3-UTRSNV 6/6 -
14-77795520-A-C GSTZ1 c.397A>C p.Asn133His Missense 6/9 -
19-41515255-C-A CYP2B6 c.777C>A p.Ser259Arg Missense 5/9 -
21-43716022-G-A ABCG1 c.1806-252G>A - IntronicSNV - 14/14
12-22068629-G-A ABCC9 c.789C>T p.Cys263Cys Synonymous 5/38 -
6-160645832-C-T SLC22A2 c.1506G>A p.Val502Val Synonymous 10/11 -
6-43270097-T-C SLC22A7 c.1215T>C p.Ala405Ala Synonymous 7/10 -
10-82035150-A-C MAT1A c.769-195T>G - IntronicSNV - 6/8
7-87133366-T-C ABCB1 c.*193A>G - 3-UTRSNV 29/29 -
7-87175271-C-T ABCB1 c.1795G>A p.Ala599Thr Missense 16/29 -
18-9537835-G-C RALBP1 c.*1900G>C - 3-UTRSNV 10/10 -
6-160663326-C-T SLC22A2 c.1388G>A p.Arg463Lys Missense 8/11 -
2-38298169-G-C CYP1B1 c.1328C>G p.Ala443Gly Missense 3/3 -
2-38298169-G-A CYP1B1 c.1328C>T p.Ala443Val Missense 3/3 -
10-101563785-C-T ABCC2 c.1219C>T p.Leu407Leu Synonymous 10/32 -
2-234545765-T-C UGT1A10 c.597T>C p.Asp199Asp Synonymous 1/5 -
19-15739597-A-T CYP4F8 c.1338A>T - synonymous_variant 13/14 -
10-82034839-T-C MAT1A c.885A>G p.Ala295Ala Synonymous 7/9 -
10-82034839-T-A MAT1A c.885A>T p.Ala295Ala Synonymous 7/9 -
10-73772762-C-T CHST3 c.*4533C>T - 3-UTRSNV 3/3 -
10-101605503-C-T ABCC2 c.4110C>T p.Leu1370Leu Synonymous 29/32 -
6-52767205-T-G GSTA3 c.211A>C p.Ile71Leu Missense 4/7 -
1-171083149-T-C FMO3 c.830T>C p.Val277Ala Missense 7/9 -
1-150814923-A-G ARNT c.228-2793T>C - IntronicSNV - 4/20
2-169787318-G-A ABCB11 c.3268C>T p.Arg1090* Nonsense 25/28 -
8-18257994-C-T NAT2 c.481C>T p.Leu161Leu Synonymous 2/2 -
1-171072947-G-A FMO3 c.154G>A p.Ala52Thr Missense 3/9 -
20-48129706-G-A PTGIS c.1117C>T p.Arg373* Nonsense 8/10 -
6-160557643-C-G SLC22A1 c.1022C>G p.Pro341Arg Missense 6/11 -
7-139572123-G-A TBXAS1 c.179G>A - missense_variant 2/13 -
6-160557643-C-T SLC22A1 c.1022C>T p.Pro341Leu Missense 6/11 -
14-23248112-A-G SLC7A7 c.660T>C p.Gly220Gly Synonymous 5/11 -
7-150557665-C-T AOC1 c.1933C>T p.His645Tyr Missense 4/5 -
7-139572123-G-T TBXAS1 c.179G>T - missense_variant 2/13 -
5-142779601-G-T NR3C1 c.804C>A p.Pro268Pro Synonymous 2/9 -
6-35378124-G-A PPARD c.1-741G>A - IntronicSNV - 2/7
19-41596742-C-T CYP2A13 c.654+273C>T - IntronicSNV - 4/8
12-105155627-A-G CHST11 c.*4046A>G - 3-UTRSNV 3/3 -
12-21477462-A-T SLCO1A2 c.61-5605T>A - IntronicSNV - 1/13
5-142779601-G-C NR3C1 c.804C>G p.Pro268Pro Synonymous 2/9 -
6-35395578-G-A PPARD c.*1722G>A - 3-UTRSNV 8/8 -
6-35395578-G-C PPARD c.*1722G>C - 3-UTRSNV 8/8 -
19-41381538-C-G CYP2A7 c.*60G>C - 3-UTRSNV 8/8 -
10-96741058-C-A CYP2C9 c.1080C>A p.Asp360Glu Missense 7/9 -
6-52766983-T-C GSTA3 c.272+161A>G - IntronicSNV - 4/6
4-99997530-A-T ADH5 c.738T>A p.Phe246Leu Missense 6/9 -
7-87144641-C-G ABCB1 c.3188G>C p.Gly1063Ala Missense 26/29 -
1-110210780-C-G GSTM2 c.36+7C>G - IntronicSNV - 1/7
1-110210780-C-A GSTM2 c.36+7C>A - IntronicSNV - 1/7
1-110210780-C-T GSTM2 c.36+7C>T - IntronicSNV - 1/7
21-37507767-G-A CBR3 c.277G>A p.Val93Ile Missense 1/3 -
5-142662280-G-A NR3C1 c.2034C>T p.Asp678Asp Synonymous 8/9 -
22-44221247-A-G SULT4A1 c.*634T>C - 3-UTRSNV 7/7 -
15-51504556-G-A CYP19A1 c.1224C>T p.Pro408Pro Synonymous 9/10 -
19-41351267-C-T CYP2A6 c.1093G>A p.Val365Met Missense 7/9 -
22-19951103-G-A COMT c.304G>A p.Ala102Thr Missense 4/6 -
8-143994806-A-T CYP11B2 c.1016T>A p.Ile339Asn Missense 6/9 -
19-41381540-C-T CYP2A7 c.*58G>A - 3-UTRSNV 8/8 -
7-99270222-G-T CYP3A5 c.299C>A p.Ser100Tyr Missense 4/13 -
10-96609752-C-G CYP2C19 c.1228C>G p.Arg410Gly Missense 8/9 -
6-35376422-A-C PPARD c.1-2443A>C - IntronicSNV - 2/7
13-103696987-T-C SLC10A2 c.*1496A>G - 3-UTRSNV 6/6 -
2-234676568-A-G UGT1A1 c.1070A>G p.Gln357Arg Missense 3/5 -
12-21353529-T-A SLCO1B1 c.1058T>A p.Ile353Asn Missense 9/15 -
12-112221055-C-T ALDH2 c.313C>T p.Leu105Leu Synonymous 3/13 -
19-41383828-G-C CYP2A7 c.749C>G p.Ala250Gly Missense 5/8 -
21-37518362-A-G CBR3 c.398-12A>G - IntronicSNV - 2/2
4-100048414-T-C ADH4 c.925A>G p.Ile309Val Missense 7/9 -
8-143994806-A-G CYP11B2 c.1016T>C p.Ile339Thr Missense 6/9 -
7-99270222-G-C CYP3A5 c.299C>G p.Ser100Cys Missense 4/13 -
10-96609752-C-T CYP2C19 c.1228C>T p.Arg410Cys Missense 8/9 -
15-45556120-T-G SLC28A2 c.488T>G p.Leu163Trp Missense 6/18 -
2-31571786-A-G XDH c.3030T>C p.Phe1010Phe Synonymous 27/36 -
12-21015760-G-A SLCO1B3 c.699G>A p.Met233Ile Missense 8/16 -
5-131730807-T-G SLC22A5 c.*843T>G - 3-UTRSNV 10/10 -
5-131730807-T-C SLC22A5 c.*843T>C - 3-UTRSNV 10/10 -
13-103698168-A-C SLC10A2 c.*315T>G - 3-UTRSNV 6/6 -
2-234590926-G-A UGT1A10 c.855+44903G>A - IntronicSNV - 1/4
10-101604162-C-T ABCC2 c.3927C>T p.Tyr1309Tyr Synonymous 28/32 -
18-669087-G-T TYMS c.470G>T p.Gly157Val Missense 4/7 -
10-101577123-A-G ABCC2 c.2153A>G p.Asn718Ser Missense 17/32 -
10-96447562-T-A CYP2C18 c.204T>A p.Tyr68* Nonsense 2/9 -
8-18258372-T-C NAT2 c.859T>C p.Ser287Pro Missense 2/2 -
12-58158293-C-T CYP27B1 c.1004G>A p.Arg335Gln Missense 6/9 -
17-19559736-C-T ALDH3A2 c.529C>T p.Arg177* Nonsense 4/10 -
17-19559736-C-G ALDH3A2 c.529C>G p.Arg177Gly Missense 4/10 -
4-70724270-C-T SULT1E1 c.1-908G>A - IntronicSNV - 1/7
4-100268190-A-T ADH1C c.232T>A - Missense 3/9 -
10-82035173-T-G MAT1A c.769-218A>C - IntronicSNV - 6/8
10-82035173-T-C MAT1A c.769-218A>G - IntronicSNV - 6/8
10-82035173-T-A MAT1A c.769-218A>T - IntronicSNV - 6/8
6-35318784-G-A PPARD c.-102+3857G>A - intron_variant - 2/7
4-100268190-A-C ADH1C c.232T>G - Missense 3/9 -
12-58156848-C-T CYP27B1 c.*77G>A - 3-UTRSNV 9/9 -
7-99270276-A-C CYP3A5 c.245T>G p.Leu82Arg Missense 4/13 -
3-183637845-T-C ABCC5 c.*1243A>G - 3-UTRSNV 30/30 -
19-15756618-C-T CYP4F3 c.288C>T p.His96His Synonymous 3/13 -
1-98157332-G-A DPYD c.703C>T p.Arg235Trp Missense 7/23 -
8-18258012-G-A NAT2 c.499G>A p.Glu167Lys Missense 2/2 -
8-18258012-G-C NAT2 c.499G>C p.Glu167Gln Missense 2/2 -
3-183660585-G-A ABCC5 c.3624C>T p.Leu1208Leu Synonymous 25/30 -
6-160662609-G-A SLC22A2 c.1398C>T p.Gly466Gly Synonymous 9/11 -
2-31606670-G-A XDH c.837C>T p.Val279Val Synonymous 10/36 -
19-16006380-T-G CYP4F2 c.279A>C p.Gly93Gly Synonymous 3/13 -
16-75513531-C-G CHST6 c.196G>C p.Val66Leu Missense 3/3 -
1-171073038-T-C FMO3 c.245T>C p.Met82Thr Missense 3/9 -
12-22063889-C-T ABCC9 c.1035G>A p.Lys345Lys Synonymous 7/38 -
7-87079406-T-A ABCB4 c.711A>T p.Ile237Ile Synonymous 8/28 -
3-121641693-G-A SLC15A2 c.852G>A p.Ala284Ala Synonymous 9/22 -
5-131730011-C-T SLC22A5 c.*47C>T - 3-UTRSNV 10/10 -
19-16006323-G-T CYP4F2 c.336C>A p.Asn112Lys Missense 3/13 -
19-16006323-G-A CYP4F2 c.336C>T p.Asn112Asn Synonymous 3/13 -
4-70346127-A-G UGT2B4 c.*225T>C - 3-UTRSNV 6/6 -
4-70346127-A-C UGT2B4 c.*225T>G - 3-UTRSNV 6/6 -
7-87229440-T-G ABCB1 c.61A>C p.Asn21His Missense 3/29 -
1-171076888-G-T FMO3 c.394G>T p.Asp132Tyr Missense 4/9 -
15-75047169-C-T CYP1A2 c.1291C>T p.Arg431Trp Missense 7/7 -
19-41601609-T-G CYP2A13 c.1304-56T>G - IntronicSNV - 8/8
15-45561693-G-A SLC28A2 c.1526G>A p.Gly509Glu Missense 14/18 -
7-87145825-C-T ABCB1 c.3084G>A p.Pro1028Pro Synonymous 25/29 -
2-234669631-T-G UGT1A1 c.698T>G p.Leu233Arg Missense 1/5 -
4-115544713-C-T UGT8 c.677C>T p.Pro226Leu Missense 1/5 -
12-21353478-C-G SLCO1B1 c.1007C>G p.Pro336Arg Missense 9/15 -
16-31105554-A-C VKORC1 c.173+324T>G - IntronicSNV - 1/2
2-108925220-A-G SULT1C2 c.*300A>G - 3-UTRSNV 9/9 -
20-52781091-C-T CYP24A1 c.744G>A p.Thr248Thr Synonymous 6/12 -
8-18257703-C-A NAT2 c.190C>A p.Arg64Arg Synonymous 2/2 -
4-70346127-A-T UGT2B4 c.*225T>A - 3-UTRSNV 6/6 -
7-87229440-T-C ABCB1 c.61A>G p.Asn21Asp Missense 3/29 -
7-87229440-T-A ABCB1 c.61A>T p.Asn21Tyr Missense 3/29 -
6-43269386-C-A SLC22A7 c.1011C>A p.Arg337Arg Synonymous 6/10 -
9-75520910-A-T ALDH1A1 c.1397T>A p.Phe466Tyr Missense 12/13 -
1-226032928-G-A EPHX1 c.1248G>A p.Lys416Lys Synonymous 9/9 -
13-52524488-T-G ATP7B c.2495A>C p.Lys832Thr Missense 10/21 -
16-89619475-T-G SPG7 c.1868T>G p.Phe623Cys Missense 14/17 -
21-43707101-C-G ABCG1 c.1007-898C>G - IntronicSNV - 8/14
16-31105392-G-T VKORC1 c.173+486C>A - IntronicSNV - 1/2
4-70346565-A-T UGT2B4 c.1374T>A p.Asp458Glu Missense 6/6 -
1-60370601-A-T CYP2J2 c.1133T>A p.Leu378Gln Missense 7/9 -
8-18257947-A-C NAT2 c.434A>C p.Gln145Pro Missense 2/2 -
21-43716901-A-T ABCG1 c.*399A>T - 3-UTRSNV 15/15 -
7-99370245-T-C CYP3A4 c.286A>G p.Lys96Glu Missense 4/13 -
2-169779851-A-C ABCB11 c.*281T>G - 3-UTRSNV 28/28 -
12-21011480-T-G SLCO1B3 c.334T>G p.Ser112Ala Missense 5/16 -
1-60377930-T-C CYP2J2 c.427A>G p.Thr143Ala Missense 3/9 -
12-21011480-T-C SLCO1B3 c.334T>C p.Ser112Pro Missense 5/16 -
8-18080001-G-C NAT1 c.445G>C p.Val149Leu Missense 3/3 -
9-86920236-T-C SLC28A3 c.267A>G p.Thr89Thr Synonymous 5/19 -
9-86920236-T-A SLC28A3 c.267A>T p.Thr89Thr Synonymous 5/19 -
21-37518706-G-A CBR3 c.730G>A p.Val244Met Missense 3/3 -
15-75015305-C-T CYP1A1 c.134G>A p.Gly45Asp Missense 2/7 -
2-234676519-C-T UGT1A1 c.1021C>T p.Arg341* Nonsense 3/5 -
22-51065808-G-A ARSA c.251C>T p.Pro84Leu Missense 2/8 -
2-219677022-C-T CYP27A1 c.524C>T p.Thr175Met Missense 3/9 -
6-160858188-G-C SLC22A3 c.1233G>C p.Ala411Ala Synonymous 7/11 -
1-97915624-A-G DPYD c.1896T>C p.Phe632Phe Synonymous 14/23 -
1-226027659-C-T EPHX1 c.852C>T p.Pro284Pro Synonymous 6/9 -
19-16040292-A-G CYP4F11 c.318T>C p.Ile106Ile Synonymous 2/12 -
2-234669180-T-C UGT1A1 c.247T>C p.Phe83Leu Missense 1/5 -
2-234669180-T-A UGT1A1 c.247T>A p.Phe83Ile Missense 1/5 -
16-89620328-G-A SPG7 c.2063G>A p.Arg688Gln Missense 15/17 -
14-23595721-A-G SLC7A8 c.*665T>C - 3-UTRSNV 9/9 -
4-70460328-C-A UGT2A2 c.1198G>T p.Val400Phe Missense 5/6 -
13-99356584-G-T SLC15A1 c.1375C>A p.Arg459Ser Missense 17/23 -
13-99356584-G-A SLC15A1 c.1375C>T p.Arg459Cys Missense 17/23 -
16-31105353-G-A VKORC1 c.173+525C>T - IntronicSNV - 1/2
7-87229501-T-C ABCB1 c.1-1A>G - 5-UTRSNV 3/29 -
2-234668570-C-T UGT1A4 c.868-7110C>T - IntronicSNV - 1/4
8-143961201-C-T CYP11B1 c.29G>A p.Cys10Tyr Missense 1/9 -
1-171076888-G-C FMO3 c.394G>C p.Asp132His Missense 4/9 -
4-115544777-A-G UGT8 c.741A>G p.Ala247Ala Synonymous 1/5 -
1-226027659-C-A EPHX1 c.852C>A p.Pro284Pro Synonymous 6/9 -
7-17385198-C-T AHR c.*2510C>T - 3-UTRSNV 11/11 -
12-21475627-T-C SLCO1A2 c.61-3770A>G - IntronicSNV - 1/13
4-70460328-C-T UGT2A2 c.1198G>A p.Val400Ile Missense 5/6 -
2-234669155-C-A UGT1A1 c.222C>A p.Tyr74* Nonsense 1/5 -
2-234681544-G-A UGT1A1 c.*339G>A - 3-UTRSNV 5/5 -
13-52548140-A-T ATP7B c.1216T>A p.Ser406Thr Missense 2/21 -
4-70513139-C-T UGT2A1 c.224G>A p.Arg75Lys Missense 2/7 -
3-119535961-A-G NR1I2 c.1207A>G p.Ile403Val Missense 9/9 -
2-169847412-A-G ABCB11 c.807T>C p.Tyr269Tyr Synonymous 9/28 -
2-234676519-C-G UGT1A1 c.1021C>G p.Arg341Gly Missense 3/5 -
6-52701143-C-T GSTA5 c.163G>A p.Val55Ile Missense 4/7 -
7-122837541-C-T SLC13A1 c.99+2361G>A - IntronicSNV - 1/14
1-97915615-G-A DPYD c.1905C>T p.Asn635Asn Synonymous 14/23 -
4-100205887-G-A ADH1A c.333C>T p.Tyr111Tyr Synonymous 4/9 -
11-114167240-A-G NNMT c.1-39A>G - 5-UTRSNV 1/3 -
16-69743760-A-G NQO1 c.*1119T>C - 3-UTRSNV 6/6 -
13-103697728-G-A SLC10A2 c.*755C>T - 3-UTRSNV 6/6 -
15-75044195-G-A CYP1A2 c.1042G>A p.Asp348Asn Missense 4/7 -
2-169847323-C-A ABCB11 c.896G>T p.Arg299Ile Missense 9/28 -
8-18257703-C-T NAT2 c.190C>T p.Arg64Trp Missense 2/2 -
7-99247772-A-G CYP3A5 c.1337T>C p.Phe446Ser Missense 12/13 -
1-171077331-T-A FMO3 c.596T>A p.Ile199Asn Missense 5/9 -
1-171077331-T-C FMO3 c.596T>C p.Ile199Thr Missense 5/9 -
2-234581346-G-A UGT1A9 c.766G>A p.Asp256Asn Missense 1/5 -
11-17428556-A-C ABCC8 c.3041T>G p.Leu1014Trp Missense 25/39 -
5-142780337-C-G NR3C1 c.68G>C p.Arg23Thr Missense 2/9 -
4-69962449-G-C UGT2B7 c.211G>C p.Ala71Pro Missense 1/6 -
5-142780337-C-T NR3C1 c.68G>A p.Arg23Lys Missense 2/9 -
7-87175289-G-A ABCB1 c.1777C>T p.Arg593Cys Missense 16/29 -
7-87175289-G-T ABCB1 c.1777C>A p.Arg593Ser Missense 16/29 -
19-16034714-A-T CYP4F11 c.826T>A p.Cys276Ser Missense 6/12 -
12-21487544-A-G SLCO1A2 c.38T>C p.Ile13Thr Missense 1/14 -
8-143954759-C-A CYP11B1 c.*1030G>T - 3-UTRSNV 9/9 -
2-234621869-A-T UGT1A10 c.856-53811A>T - IntronicSNV - 1/4
6-35322763-A-G PPARD c.-102+7836A>G - intron_variant - 2/7
13-52544805-C-G ATP7B c.1366G>C p.Val456Leu Missense 3/21 -
7-99445132-C-T CYP3A43 c.341-8082C>T - IntronicSNV - 4/9
8-18079746-C-T NAT1 c.190C>T p.Arg64Trp Missense 3/3 -
12-21036411-A-G SLCO1B3 c.1557A>G p.Ala519Ala Synonymous 13/16 -
2-234627536-C-A UGT1A4 c.70C>A p.Pro24Thr Missense 1/5 -
8-143957734-G-C CYP11B1 c.877C>G p.Leu293Val Missense 5/9 -
2-169830328-A-G ABCB11 c.1331T>C p.Val444Ala Missense 13/28 -
1-110211956-C-T GSTM2 c.222C>T p.Asn74Asn Synonymous 4/8 -
19-41601609-T-C CYP2A13 c.1304-56T>C - IntronicSNV - 8/8
1-226016558-G-A EPHX1 c.128G>A p.Arg43Lys Missense 2/9 -
19-16034714-A-G CYP4F11 c.826T>C p.Cys276Arg Missense 6/12 -
19-15789140-A-G CYP4F12 c.268A>G p.Ile90Val Missense 3/13 -
7-87144678-G-C ABCB1 c.3151C>G p.Pro1051Ala Missense 26/29 -
18-9536691-G-A RALBP1 c.*756G>A - 3-UTRSNV 10/10 -
16-31104720-C-T VKORC1 c.196G>A p.Val66Met Missense 2/3 -
16-31105171-G-A VKORC1 c.174-429C>T - IntronicSNV - 1/2
13-52544805-C-A ATP7B c.1366G>T p.Val456Leu Missense 3/21 -
13-103698363-A-G SLC10A2 c.*120T>C - 3-UTRSNV 6/6 -
19-34175603-C-T CHST8 c.-589C>T - 5_prime_UTR_variant 1/4 -
2-234627536-C-T UGT1A4 c.70C>T p.Pro24Ser Missense 1/5 -
10-101611277-C-T ABCC2 c.4527C>T p.Asn1509Asn Synonymous 32/32 -
7-99358566-A-G CYP3A4 c.1289T>C p.Ile430Thr Missense 12/13 -
7-86990746-G-A CROT c.281G>A p.Arg94His Missense 5/18 -
1-226016558-G-C EPHX1 c.128G>C p.Arg43Thr Missense 2/9 -
4-69962449-G-T UGT2B7 c.211G>T p.Ala71Ser Missense 1/6 -
4-69962449-G-A UGT2B7 c.211G>A p.Ala71Thr Missense 1/6 -
6-35369491-A-G PPARD c.1-9374A>G - IntronicSNV - 2/7
5-131721174-A-G SLC22A5 c.807A>G p.Leu269Leu Synonymous 4/10 -
7-87160790-T-C ABCB1 c.2505A>G p.Val835Val Synonymous 22/29 -
7-87160790-T-G ABCB1 c.2505A>C p.Val835Val Synonymous 22/29 -
19-41512824-C-G CYP2B6 c.499C>G p.Pro167Ala Missense 4/9 -
4-100273864-C-T ADH1C c.1-32G>A - 5-UTRSNV 1/9 -
10-101604107-C-T ABCC2 c.3872C>T p.Pro1291Leu Missense 28/32 -
19-41356281-T-C CYP2A6 c.51A>G p.Val17Val Synonymous 1/9 -
12-22068749-C-A ABCC9 c.669G>T p.Leu223Leu Synonymous 5/38 -
7-87180198-C-T ABCB1 c.1000-44G>A - IntronicSNV - 10/28
1-98348885-G-A DPYD c.85C>T p.Arg29Cys Missense 2/23 -
2-108922036-T-G SULT1C2 c.796T>G p.Ser266Ala Missense 8/9 -
7-139715598-C-T TBXAS1 c.1302C>T - synonymous_variant 11/13 -
13-52524488-T-C ATP7B c.2495A>G p.Lys832Arg Missense 10/21 -
8-18257924-A-C NAT2 c.411A>C p.Leu137Phe Missense 2/2 -
3-38315821-C-G SLC22A13 c.437C>G p.Ala146Gly Missense 2/10 -
8-143955095-A-G CYP11B1 c.*694T>C - 3-UTRSNV 9/9 -
9-117093939-G-C ORM2 c.421G>C p.Gly141Arg Missense 4/6 -
9-117093939-G-A ORM2 c.421G>A p.Gly141Arg Missense 4/6 -
4-89052957-G-A ABCG2 c.376C>T p.Gln126* Nonsense 4/16 -
2-234622061-C-A UGT1A10 c.856-53619C>A - IntronicSNV - 1/4
1-171178833-T-C FMO2 c.*741T>C - 3-UTRSNV 9/9 -
16-16215891-G-T ABCC1 c.3450G>T p.Pro1150Pro Synonymous 24/31 -
2-234545345-G-A UGT1A10 c.177G>A p.Met59Ile Missense 1/5 -
1-171236840-C-G FMO1 c.291C>G p.His97Gln Missense 3/9 -
2-234665659-T-A UGT1A4 c.868-10021T>A - IntronicSNV - 1/4
1-171308832-A-G FMO4 c.1251-1720A>G - IntronicSNV - 9/9
6-52847431-T-C GSTA4 c.487A>G p.Thr163Ala Missense 6/7 -
6-160560845-A-C SLC22A1 c.1222A>C p.Met408Leu Missense 7/11 -
16-75513531-C-A CHST6 c.196G>T p.Val66Phe Missense 3/3 -
11-114167344-A-G NNMT c.66A>G p.Glu22Glu Synonymous 1/3 -
10-96466592-A-G CYP2C18 c.694A>G p.Lys232Glu Missense 5/9 -
1-171083403-G-A FMO3 c.1084G>A p.Glu362Lys Missense 7/9 -
1-171083403-G-C FMO3 c.1084G>C p.Glu362Gln Missense 7/9 -
7-91763623-A-G CYP51A1 c.56T>C p.Val19Ala Missense 1/10 -
15-74637475-C-T CYP11A1 c.535G>A p.Val179Ile Missense 3/9 -
3-121660000-T-G SLC15A2 c.*146T>G - 3-UTRSNV 22/22 -
5-131724639-G-A SLC22A5 c.978G>A p.Gln326Gln Synonymous 6/10 -
1-110279663-C-A GSTM3 c.*30G>T - 3-UTRSNV 9/9 -
9-117087099-C-A ORM1 c.358C>A p.Leu120Met Missense 4/6 -
7-139636026-G-A TBXAS1 c.370G>A - missense_variant 5/13 -
7-139636026-G-T TBXAS1 c.370G>T - missense_variant 5/13 -
19-41515483-G-A CYP2B6 c.822+183G>A - IntronicSNV - 5/8
8-27348788-C-A EPHX2 c.63C>A p.Gly21Gly Synonymous 1/19 -
8-27348788-C-T EPHX2 c.63C>T p.Gly21Gly Synonymous 1/19 -
1-161192511-C-G APOA2 c.185+197G>C - IntronicSNV - 3/3
2-234621922-T-C UGT1A10 c.856-53758T>C - IntronicSNV - 1/4
6-35377922-G-C PPARD c.1-943G>C - IntronicSNV - 2/7
1-226032896-T-C EPHX1 c.1216T>C p.Leu406Leu Synonymous 9/9 -
16-71571663-C-T CHST4 c.1083C>T p.His361His Synonymous 2/2 -
16-89619475-T-C SPG7 c.1868T>C p.Phe623Ser Missense 14/17 -
16-71571663-C-A CHST4 c.1083C>A p.His361Gln Missense 2/2 -
16-89617008-C-T SPG7 c.1770C>T p.Ala590Ala Synonymous 13/17 -
16-87874736-G-C SLC7A5 c.690C>G p.Asn230Lys Missense 3/10 -
8-18080176-C-A NAT1 c.620C>A p.Thr207Lys Missense 3/3 -
8-18080176-C-T NAT1 c.620C>T p.Thr207Ile Missense 3/3 -
7-139706915-G-C TBXAS1 c.1159G>C - missense_variant 10/13 -
16-66970561-A-T CES2 c.76+947A>T - intron_variant - 1/11
16-16236004-T-A ABCC1 c.*866T>A - 3-UTRSNV 31/31 -
16-16236650-T-C ABCC1 c.*1512T>C - 3-UTRSNV 31/31 -
16-16236650-T-A ABCC1 c.*1512T>A - 3-UTRSNV 31/31 -
6-35376287-C-T PPARD c.1-2578C>T - IntronicSNV - 2/7
11-17418477-C-A ABCC8 c.4105G>T p.Ala1369Ser Missense 33/39 -
7-99264573-A-G CYP3A5 c.432+2T>C - IntronicSNV - 5/12
19-41700493-G-C CYP2S1 c.222G>C p.Pro74Pro Synonymous 2/9 -
7-99264573-A-T CYP3A5 c.432+2T>A - IntronicSNV - 5/12
19-41700493-G-A CYP2S1 c.222G>A p.Pro74Pro Synonymous 2/9 -
4-100140306-A-T ADH6 c.4T>A p.Cys2Ser Missense 1/8 -
10-135347397-T-G CYP2E1 c.963T>G p.Ile321Met Missense 6/9 -
2-101009082-C-T CHST10 c.*625G>A - 3-UTRSNV 7/7 -
10-135347397-T-C CYP2E1 c.963T>C p.Ile321Ile Synonymous 6/9 -
6-35317301-C-G PPARD c.-102+2374C>G - intron_variant - 2/7
6-35317301-C-T PPARD c.-102+2374C>T - intron_variant - 2/7
10-73772336-T-C CHST3 c.*4107T>C - 3-UTRSNV 3/3 -
2-31562412-C-T XDH c.3717G>A p.Glu1239Glu Synonymous 34/36 -
7-87179143-A-G ABCB1 c.1554+24T>C - IntronicSNV - 14/28
7-139706956-G-T TBXAS1 c.1203G>T p.Thr401Thr Synonymous 10/13 -
7-139706956-G-A TBXAS1 c.1203G>A p.Thr401Thr Synonymous 10/13 -
21-43716901-A-G ABCG1 c.*399A>G - 3-UTRSNV 15/15 -
7-99454482-G-T CYP3A43 c.495G>T p.Met165Ile Missense 6/10 -
2-101009908-G-A CHST10 c.870C>T p.Ala290Ala Synonymous 7/7 -
7-94946084-A-G PON1 c.163T>C p.Leu55Leu Synonymous 3/9 -
19-15726487-G-C CYP4F8 c.60G>C p.Leu20Leu Synonymous 2/14 -
19-15726487-G-T CYP4F8 c.60G>T p.Leu20Leu Synonymous 2/14 -
15-75013563-G-C CYP1A1 c.1143C>G p.Phe381Leu Missense 5/7 -
8-70605072-G-T SLCO5A1 c.1623-10494C>A - IntronicSNV - 6/9
2-101010006-C-A CHST10 c.772G>T p.Asp258Tyr Missense 7/7 -
2-101010006-C-T CHST10 c.772G>A p.Asp258Asn Missense 7/7 -
2-234675807-A-G UGT1A1 c.992A>G p.Gln331Arg Missense 2/5 -
15-75013563-G-A CYP1A1 c.1143C>T p.Phe381Phe Synonymous 5/7 -
7-99459256-C-G CYP3A43 c.717C>G p.Ala239Ala Synonymous 8/10 -
7-99459256-C-T CYP3A43 c.717C>T p.Ala239Ala Synonymous 8/10 -
10-96522512-T-A CYP2C19 c.50T>A p.Leu17His Missense 1/9 -
10-96522512-T-C CYP2C19 c.50T>C p.Leu17Pro Missense 1/9 -
2-234676567-C-T UGT1A1 c.1069C>T p.Gln357* Nonsense 3/5 -
11-45679197-A-G CHST1 c.-226-5041T>C - intron_variant - 1/3
6-44199202-C-T SLC29A1 c.864+4C>T - IntronicSNV - 10/13
1-110260742-T-C GSTM5 c.*694T>C - 3-UTRSNV 8/8 -
19-16000319-G-C CYP4F2 c.832C>G p.Leu278Val Missense 7/13 -
19-16000319-G-A CYP4F2 c.832C>T p.Leu278Phe Missense 7/13 -
19-41703793-G-A CYP2S1 c.453G>A p.Ala151Ala Synonymous 3/9 -
5-131663062-T-G SLC22A4 c.917T>G p.Ile306Arg Missense 5/10 -
6-35365346-G-A PPARD c.1-13519G>A - IntronicSNV - 2/7
6-52701143-C-G GSTA5 c.163G>C p.Val55Leu Missense 4/7 -
4-74283381-G-T ALB c.1423G>T p.Asp475Tyr Missense 11/15 -
3-183685534-A-T ABCC5 c.1782T>A p.Cys594* Nonsense 12/30 -
16-75513662-A-C CHST6 c.65T>G p.Leu22Arg Missense 3/3 -
1-110260510-G-C GSTM5 c.*462G>C - 3-UTRSNV 8/8 -
11-67353677-G-T GSTP1 c.439G>T p.Asp147Tyr Missense 6/7 -
17-19575103-T-G ALDH3A2 c.1277T>G p.Leu426* Nonsense 9/10 -
1-171076936-G-A FMO3 c.442G>A p.Gly148Arg Missense 4/9 -
12-105152997-T-C CHST11 c.*1416T>C - 3-UTRSNV 3/3 -
14-70263648-C-T SLC10A1 c.225G>A p.Thr75Thr Synonymous 1/5 -
1-171254890-C-T FMO1 c.*207C>T - 3-UTRSNV 9/9 -
12-105152997-T-A CHST11 c.*1416T>A - 3-UTRSNV 3/3 -
12-105152997-T-G CHST11 c.*1416T>G - 3-UTRSNV 3/3 -
3-183660603-G-A ABCC5 c.3606C>T p.Tyr1202Tyr Synonymous 25/30 -
3-183660603-G-T ABCC5 c.3606C>A p.Tyr1202* Nonsense 25/30 -
1-171061893-G-A FMO3 c.94G>A p.Glu32Lys Missense 2/9 -
12-21353529-T-C SLCO1B1 c.1058T>C p.Ile353Thr Missense 9/15 -
7-139653196-A-C TBXAS1 c.480A>C - synonymous_variant 6/13 -
7-87190668-C-T ABCB1 c.738G>A p.Ala246Ala Synonymous 9/29 -
2-27427402-A-G SLC5A6 c.932T>C p.Ile311Thr Missense 9/17 -
16-66971963-C-T CES2 c.100C>T - missense_variant 2/12 -
12-58164992-G-C METTL1 c.159C>G p.Phe53Leu Missense 2/6 -
1-171083174-C-T FMO3 c.855C>T p.Asn285Asn Synonymous 7/9 -
7-87178693-C-T ABCB1 c.1696G>A p.Glu566Lys Missense 15/29 -
15-51534995-A-G CYP19A1 c.115T>C p.Trp39Arg Missense 2/10 -
7-99359670-G-C CYP3A4 c.1244C>G p.Pro415Arg Missense 11/13 -
4-100239291-G-T ADH1B c.171C>A p.Asn57Lys Missense 3/9 -
1-20918912-T-C CDA c.154+3136T>C - IntronicSNV - 1/3
4-100239291-G-A ADH1B c.171C>T p.Asn57Asn Synonymous 3/9 -
6-35376414-A-C PPARD c.1-2451A>C - IntronicSNV - 2/7
1-171083232-G-T FMO3 c.913G>T p.Glu305* Nonsense 7/9 -
7-150557665-C-G AOC1 c.1933C>G p.His645Asp Missense 4/5 -
6-160579629-G-A SLC22A1 c.*15G>A - 3-UTRSNV 11/11 -
4-70346565-A-G UGT2B4 c.1374T>C p.Asp458Asp Synonymous 6/6 -
19-15807305-T-C CYP4F12 c.1380T>C p.Pro460Pro Synonymous 12/13 -
1-171083225-C-T FMO3 c.906C>T p.Asn302Asn Synonymous 7/9 -
11-67351624-C-G GSTP1 c.21C>G p.Val7Val Synonymous 2/7 -
5-142780212-A-G NR3C1 c.193T>C p.Phe65Leu Missense 2/9 -
2-169788931-G-A ABCB11 c.3169C>T p.Arg1057* Nonsense 24/28 -
8-59409373-T-C CYP7A1 c.698A>G p.Asn233Ser Missense 3/6 -
22-42525772-G-A CYP2D6 c.320C>T p.Thr107Ile Missense 2/9 -
4-69964337-A-T UGT2B7 c.801A>T p.Pro267Pro Synonymous 2/6 -
15-92647645-G-C SLCO3A1 c.882G>C p.Glu294Asp Missense 4/10 -
19-15756618-C-G CYP4F3 c.288C>G p.His96Gln Missense 3/13 -
6-52617731-C-G GSTA2 c.335G>C p.Ser112Thr Missense 5/7 -
16-89619540-T-A SPG7 c.1933T>A p.Ser645Thr Missense 14/17 -
2-234681090-T-A UGT1A1 c.1487T>A p.Leu496* Nonsense 5/5 -
6-18130993-C-T TPMT c.644G>A p.Arg215His Missense 9/9 -
19-15752365-G-A CYP4F3 c.140G>A p.Arg47His Missense 2/13 -
1-47282772-C-T CYP4B1 c.1123C>T p.Arg375Cys Missense 9/12 -
16-31102324-G-A VKORC1 c.*131C>T - 3-UTRSNV 3/3 -
4-100349083-G-T ADH7 c.447C>A p.Val149Val Synonymous 5/9 -
4-100349083-G-A ADH7 c.447C>T p.Val149Val Synonymous 5/9 -
12-58158293-C-G CYP27B1 c.1004G>C p.Arg335Pro Missense 6/9 -
4-69512691-G-A UGT2B15 c.*131C>T - 3-UTRSNV 6/6 -
15-45559774-T-C SLC28A2 c.1064T>C p.Phe355Ser Missense 11/18 -
6-52617664-A-G GSTA2 c.402T>C p.Pro134Pro Synonymous 5/7 -
1-98058828-A-T DPYD c.1074T>A p.Arg358Arg Synonymous 10/23 -
8-143955113-G-A CYP11B1 c.*676C>T - 3-UTRSNV 9/9 -
1-113454571-A-G SLC16A1 c.*1942T>C - 3-UTRSNV 5/5 -
19-41383827-T-C CYP2A7 c.750A>G p.Ala250Ala Synonymous 5/8 -
17-19552312-C-T ALDH3A2 c.28C>T p.Gln10* Nonsense 1/10 -
17-19552312-C-G ALDH3A2 c.28C>G p.Gln10Glu Missense 1/10 -
8-143961043-C-G CYP11B1 c.187G>C p.Asp63His Missense 1/9 -
11-74904362-T-C SLCO2B1 c.1175T>C p.Ile392Thr Missense 9/14 -
16-31102324-G-T VKORC1 c.*131C>A - 3-UTRSNV 3/3 -
9-117086027-T-G ORM1 c.199T>G p.Phe67Val Missense 2/6 -
2-234681544-G-T UGT1A1 c.*339G>T - 3-UTRSNV 5/5 -
2-234681544-G-C UGT1A1 c.*339G>C - 3-UTRSNV 5/5 -
6-52615226-A-T GSTA2 c.*149T>A - 3-UTRSNV 7/7 -
2-234602277-G-T UGT1A10 c.855+56254G>T - IntronicSNV - 1/4
7-87195533-T-A ABCB1 c.555A>T p.Gly185Gly Synonymous 8/29 -
13-95859035-C-G ABCC4 c.912G>C p.Lys304Asn Missense 8/31 -
13-95859035-C-A ABCC4 c.912G>T p.Lys304Asn Missense 8/31 -
13-95859035-C-T ABCC4 c.912G>A p.Lys304Lys Synonymous 8/31 -
10-94836881-C-A CYP26A1 c.1314C>A p.Gly438Gly Synonymous 7/7 -
10-96534922-G-A CYP2C19 c.276G>A p.Glu92Glu Synonymous 2/9 -
10-96534922-G-C CYP2C19 c.276G>C p.Glu92Asp Missense 2/9 -
10-135351362-T-C CYP2E1 c.1263T>C p.Phe421Phe Synonymous 8/9 -
10-135351362-T-G CYP2E1 c.1263T>G p.Phe421Leu Missense 8/9 -
10-94836881-C-G CYP26A1 c.1314C>G p.Gly438Gly Synonymous 7/7 -
9-117087099-C-T ORM1 c.358C>T p.Leu120Leu Synonymous 4/6 -
9-137329930-C-T RXRA c.*1470C>T - 3-UTRSNV 10/10 -
6-35376350-A-C PPARD c.1-2515A>C - IntronicSNV - 2/7
19-16040292-A-T CYP4F11 c.318T>A p.Ile106Ile Synonymous 2/12 -
5-131649364-C-T SLC22A4 c.555C>T p.Phe185Phe Synonymous 3/10 -
2-234676905-C-T UGT1A1 c.1124C>T p.Ser375Phe Missense 4/5 -
6-160663420-T-G SLC22A2 c.1294A>C p.Lys432Gln Missense 8/11 -
11-17418477-C-T ABCC8 c.4105G>A p.Ala1369Thr Missense 33/39 -
7-99359670-G-A CYP3A4 c.1244C>T p.Pro415Leu Missense 11/13 -
2-234681031-C-A UGT1A1 c.1428C>A p.Pro476Pro Synonymous 5/5 -
2-109001295-A-C SULT1C4 c.615+1329A>C - IntronicSNV - 5/6
8-143995761-C-T CYP11B2 c.873G>A p.Ala291Ala Synonymous 5/9 -
7-91753050-G-A CYP51A1 c.888C>T p.Tyr296Tyr Synonymous 6/10 -
15-45557318-G-C SLC28A2 c.734G>C p.Ser245Thr Missense 8/18 -
16-66976006-A-G CES2 c.1138-2A>G - splice_acceptor_variant - 8/11
11-64334114-C-T SLC22A11 c.1059-957C>T - IntronicSNV - 6/9
1-98165091-T-C DPYD c.496A>G p.Met166Val Missense 6/23 -
5-142780212-A-C NR3C1 c.193T>G p.Phe65Val Missense 2/9 -
2-234681031-C-T UGT1A1 c.1428C>T p.Pro476Pro Synonymous 5/5 -
17-37828496-T-C PGAP3 c.*560A>G - 3-UTRSNV 8/8 -
10-96602623-G-A CYP2C19 c.991G>A p.Val331Ile Missense 7/9 -
20-52773622-C-T CYP24A1 c.*96G>A - IntronicSNV 12/12 -
5-142678361-G-A NR3C1 c.1764C>T p.His588His Synonymous 6/9 -
6-52842781-T-C GSTA4 c.*487A>G - 3-UTRSNV 7/7 -
2-108925184-A-T SULT1C2 c.*264A>T - 3-UTRSNV 9/9 -
7-99447241-T-C CYP3A43 c.341-5973T>C - IntronicSNV - 4/9
2-108917348-C-T SULT1C2 c.373-8C>T - IntronicSNV - 4/8
12-112230513-A-T ALDH2 c.1010A>T p.Glu337Val Missense 9/13 -
13-95672950-A-G ABCC4 c.*879T>C - 3-UTRSNV 31/31 -
2-101012060-A-G CHST10 c.444T>C p.Ile148Ile Synonymous 6/7 -
7-99250236-G-T CYP3A5 c.1193C>A p.Thr398Asn Missense 11/13 -
2-169826641-G-A ABCB11 c.1723C>T p.Arg575* Nonsense 15/28 -
1-60377885-G-C CYP2J2 c.472C>G p.Arg158Gly Missense 3/9 -
1-60377885-G-A CYP2J2 c.472C>T p.Arg158Cys Missense 3/9 -
13-95727780-T-A ABCC4 c.2712A>T p.Leu904Phe Missense 22/31 -
4-70460328-C-G UGT2A2 c.1198G>C p.Val400Leu Missense 5/6 -
8-143955338-T-G CYP11B1 c.*451A>C - 3-UTRSNV 9/9 -
3-42915878-C-T CYP8B1 c.1431G>A p.Pro477Pro Synonymous 1/1 -
2-108999425-A-G SULT1C4 c.394-124A>G - IntronicSNV - 3/6
6-35338106-C-G PPARD c.-102+23179C>G - intron_variant - 2/7
6-52849325-C-T GSTA4 c.351G>A p.Gln117Gln Synonymous 5/7 -
5-142780339-C-A NR3C1 c.66G>T p.Glu22Asp Missense 2/9 -
1-46874804-A-G FAAH c.1109A>G p.His370Arg Missense 9/15 -
12-21459876-T-A SLCO1A2 c.382A>T p.Asn128Tyr Missense 4/14 -
4-69964338-T-C UGT2B7 c.802T>C p.Tyr268His Missense 2/6 -
10-101542579-G-A ABCC2 c.1-23G>A - 5-UTRSNV 1/32 -
13-52548140-A-C ATP7B c.1216T>G p.Ser406Ala Missense 2/21 -
1-171179287-C-T FMO2 c.*1003C>T - 3_prime_UTR_variant 9/9 -
19-41633980-C-A CYP2F1 c.1469C>A p.Pro490Gln Missense 10/10 -
7-122838090-G-C SLC13A1 c.99+1812C>G - IntronicSNV - 1/14
14-23242828-T-C SLC7A7 c.1527A>G p.Lys509Lys Synonymous 11/11 -
5-142780339-C-T NR3C1 c.66G>A p.Glu22Glu Synonymous 2/9 -
12-21476983-A-G SLCO1A2 c.61-5126T>C - IntronicSNV - 1/13
1-60377389-A-T CYP2J2 c.575T>A p.Ile192Asn Missense 4/9 -
5-142661490-A-G NR3C1 c.2298T>C p.Asn766Asn Synonymous 9/9 -
1-150814902-G-T ARNT c.228-2772C>A - IntronicSNV - 4/20
1-171303565-C-T FMO4 c.843C>T p.Phe281Phe Synonymous 8/10 -
3-142841740-C-T CHST2 c.*489C>T - 3-UTRSNV 2/2 -
3-119534626-G-A NR1I2 c.1108G>A p.Ala370Thr Missense 8/9 -
12-21392047-A-G SLCO1B1 c.2000A>G p.Glu667Gly Missense 15/15 -
1-47276819-G-A CYP4B1 c.330G>A p.Lys110Lys Synonymous 3/12 -
8-18257795-C-T NAT2 c.282C>T p.Tyr94Tyr Synonymous 2/2 -
15-75042204-C-G CYP1A2 c.125C>G p.Pro42Arg Missense 2/7 -
2-219676988-C-T CYP27A1 c.490C>T p.Arg164Trp Missense 3/9 -
19-16025176-C-T CYP4F11 c.1336G>A p.Asp446Asn Missense 11/12 -
19-16025176-C-G CYP4F11 c.1336G>C p.Asp446His Missense 11/12 -
4-74283858-T-C ALB c.1482T>C p.Ser494Ser Synonymous 12/15 -
13-99339905-G-C SLC15A1 c.1757C>G p.Pro586Arg Missense 21/23 -
13-99339905-G-A SLC15A1 c.1757C>T p.Pro586Leu Missense 21/23 -
3-38307510-T-C SLC22A13 c.159T>C p.Ala53Ala Synonymous 1/10 -
7-87229501-T-A ABCB1 c.1-1A>T - 5-UTRSNV 3/29 -
15-51502844-A-C CYP19A1 c.*161T>G - 3-UTRSNV 10/10 -
19-41703763-G-A CYP2S1 c.423G>A p.Gly141Gly Synonymous 3/9 -
2-27430237-T-C SLC5A6 c.282A>G p.Arg94Arg Synonymous 3/17 -
12-21450350-T-C SLCO1A2 c.1063A>G p.Ile355Val Missense 8/14 -
6-35325718-C-T PPARD c.-102+10791C>T - intron_variant - 2/7
10-96731936-A-G CYP2C9 c.895A>G p.Thr299Ala Missense 6/9 -
1-171154959-A-G FMO2 c.107A>G p.Asp36Gly Missense 2/9 -
6-35369806-C-A PPARD c.1-9059C>A - IntronicSNV - 2/7
13-103698110-G-C SLC10A2 c.*373C>G - 3-UTRSNV 6/6 -
2-169779896-T-A ABCB11 c.*236A>T - 3-UTRSNV 28/28 -
2-169779896-T-C ABCB11 c.*236A>G - 3-UTRSNV 28/28 -
2-169779896-T-G ABCB11 c.*236A>C - 3-UTRSNV 28/28 -
6-43269348-C-T SLC22A7 c.973C>T p.Arg325Trp Missense 6/10 -
16-31102321-C-T VKORC1 c.*134G>A - 3-UTRSNV 3/3 -
6-46620437-G-C CYP39A1 c.1-118C>G - 5-UTRSNV 1/12 -
2-101008949-C-T CHST10 c.*758G>A - 3-UTRSNV 7/7 -
2-234601859-C-A UGT1A10 c.855+55836C>A - IntronicSNV - 1/4
6-35369834-C-T PPARD c.1-9031C>T - IntronicSNV - 2/7
13-95815415-C-T ABCC4 c.2269G>A p.Glu757Lys Missense 18/31 -
1-171162516-G-A FMO2 c.175G>A p.Val59Ile Missense 3/9 -
6-52770596-G-A GSTA3 c.37C>T p.Arg13Trp Missense 2/7 -
6-52770596-G-T GSTA3 c.37C>A p.Arg13Arg Synonymous 2/7 -
15-51502986-G-A CYP19A1 c.*19C>T - 3-UTRSNV 10/10 -
19-41381517-A-G CYP2A7 c.*81T>C - 3-UTRSNV 8/8 -
19-41381517-A-C CYP2A7 c.*81T>G - 3-UTRSNV 8/8 -
8-143954747-T-C CYP11B1 c.*1042A>G - 3-UTRSNV 9/9 -
21-43701977-A-G ABCG1 c.622-407A>G - IntronicSNV - 5/14
2-234681645-G-C UGT1A1 c.*440G>C - 3-UTRSNV 5/5 -
16-16230411-C-T ABCC1 c.4202C>T p.Thr1401Met Missense 29/31 -
16-16230411-C-G ABCC1 c.4202C>G p.Thr1401Arg Missense 29/31 -
1-97915615-G-C DPYD c.1905C>G p.Asn635Lys Missense 14/23 -
8-18079517-A-T NAT1 c.1-40A>T - IntronicSNV - 2/2
2-234676883-G-A UGT1A1 c.1102G>A p.Ala368Thr Missense 4/5 -
12-21422492-G-C SLCO1A2 c.2003C>G p.Thr668Ser Missense 14/14 -
7-99332807-C-T CYP3A7 c.1-91G>A - 5-UTRSNV 1/13 -
15-75044464-G-A CYP1A2 c.1043-1G>A - IntronicSNV - 4/6
2-234676982-G-C UGT1A1 c.1201G>C p.Ala401Pro Missense 4/5 -
21-43710909-C-G ABCG1 c.1427-293C>G - IntronicSNV - 11/14
1-226019599-T-C EPHX1 c.303T>C p.Phe101Phe Synonymous 3/9 -
16-28603643-T-C SULT1A2 c.716A>G p.Asn239Ser Missense 7/8 -
6-35340894-C-G PPARD c.-102+25967C>G - intron_variant - 2/7
3-121647286-C-G SLC15A2 c.1225C>G p.Pro409Ala Missense 15/22 -
4-69512691-G-C UGT2B15 c.*131C>G - 3-UTRSNV 6/6 -
19-15807830-T-C CYP4F12 c.1510T>C p.Leu504Leu Synonymous 13/13 -
2-169850291-C-A ABCB11 c.713G>T p.Gly238Val Missense 8/28 -
2-169850291-C-G ABCB11 c.713G>C p.Gly238Ala Missense 8/28 -
8-18080116-G-A NAT1 c.560G>A p.Arg187Gln Missense 3/3 -
3-119526131-G-A NR1I2 c.34G>A p.Ala12Thr Missense 2/9 -
22-44221471-C-T SULT4A1 c.*410G>A - 3-UTRSNV 7/7 -
14-100193559-G-T CYP46A1 c.*495G>T - 3-UTRSNV 15/15 -
13-99340576-G-A SLC15A1 c.1609C>T p.Pro537Ser Missense 20/23 -
7-87035792-C-T ABCB4 c.3298G>A p.Ala1100Thr Missense 26/28 -
19-41356319-C-T CYP2A6 c.13G>A p.Gly5Arg Missense 1/9 -
2-38298187-G-T CYP1B1 c.1310C>A p.Pro437Gln Missense 3/3 -
15-51502298-A-G CYP19A1 c.*707T>C - 3-UTRSNV 10/10 -
22-44221471-C-A SULT4A1 c.*410G>T - 3-UTRSNV 7/7 -
19-16008384-G-C CYP4F2 c.38C>G p.Pro13Arg Missense 2/13 -
4-70499234-T-C UGT2A2 c.742+5383A>G - IntronicSNV - 1/5
15-75012981-G-A CYP1A1 c.1388C>T p.Ala463Val Missense 7/7 -
15-75012981-G-C CYP1A1 c.1388C>G p.Ala463Gly Missense 7/7 -
14-100193559-G-A CYP46A1 c.*495G>A - 3-UTRSNV 15/15 -
10-73772014-G-A CHST3 c.*3785G>A - 3-UTRSNV 3/3 -
4-74280857-A-G ALB c.1164A>G p.Ala388Ala Synonymous 9/15 -
14-23282110-A-G SLC7A7 c.498T>C p.Ile166Ile Synonymous 3/11 -
14-23282110-A-C SLC7A7 c.498T>G p.Ile166Met Missense 3/11 -
12-58157000-C-T CYP27B1 c.1452G>A p.Ala484Ala Synonymous 9/9 -
3-14485170-C-T SLC6A6 c.28C>T p.Leu10Leu Synonymous 3/15 -
2-108910712-A-C SULT1C2 c.179A>C p.Asp60Ala Missense 3/9 -
19-49102399-C-T SULT2B1 c.789C>T p.Cys263Cys Synonymous 6/6 -
8-18257877-G-T NAT2 c.364G>T p.Asp122Tyr Missense 2/2 -
8-18257877-G-C NAT2 c.364G>C p.Asp122His Missense 2/2 -
1-110213953-G-A GSTM2 c.405G>A p.Leu135Leu Synonymous 6/8 -
4-70611119-A-G SULT1B1 c.375+4320T>C - IntronicSNV - 4/7
8-18080015-G-A NAT1 c.459G>A p.Thr153Thr Synonymous 3/3 -
4-70078295-G-A UGT2B11 c.866C>T p.Pro289Leu Missense 2/6 -
22-51064039-G-C ARSA c.1178C>G p.Thr393Ser Missense 7/8 -
1-47560735-T-G CYP4Z1 c.876+394T>G - IntronicSNV - 7/11
5-74633081-T-C HMGCR c.-68T>C - 5_prime_UTR_variant 1/20 -
8-18080115-C-T NAT1 c.559C>T p.Arg187* Nonsense 3/3 -
10-96740981-C-T CYP2C9 c.1003C>T p.Arg335Trp Missense 7/9 -
11-17428556-A-T ABCC8 c.3041T>A p.Leu1014* Nonsense 25/39 -
12-21392011-A-T SLCO1B1 c.1964A>T p.Asp655Val Missense 15/15 -
11-74907637-C-T SLCO2B1 c.1512C>T p.Cys504Cys Synonymous 10/14 -
15-75041341-T-G CYP1A2 c.-10+103T>G - intron_variant - 1/6
10-135351264-G-A CYP2E1 c.1165G>A p.Val389Ile Missense 8/9 -
10-135351264-G-T CYP2E1 c.1165G>T p.Val389Leu Missense 8/9 -
10-101560169-G-A ABCC2 c.1058G>A p.Arg353His Missense 9/32 -
4-89052248-G-C ABCG2 c.496C>G p.Gln166Glu Missense 5/16 -
3-12458208-C-G PPARG c.741C>G p.Phe247Leu Missense 6/7 -
2-234601965-A-G UGT1A10 c.855+55942A>G - IntronicSNV - 1/4
19-41351967-T-C CYP2A6 c.867A>G p.Lys289Lys Synonymous 6/9 -
7-139657510-A-G TBXAS1 c.769A>G p.Asn257Asp Missense 8/13 -
1-146658711-G-A FMO5 c.1370C>T p.Pro457Leu Missense 9/9 -
2-27428295-A-G SLC5A6 c.657T>C p.Ile219Ile Synonymous 7/17 -
2-27428295-A-T SLC5A6 c.657T>A p.Ile219Ile Synonymous 7/17 -
9-137331525-G-C RXRA c.*3065G>C - 3-UTRSNV 10/10 -
11-74907637-C-A SLCO2B1 c.1512C>A p.Cys504* Nonsense 10/14 -
7-91742728-C-G CYP51A1 c.*251G>C - 3-UTRSNV 10/10 -
4-70724053-T-C SULT1E1 c.1-691A>G - IntronicSNV - 1/7
2-234676880-C-G UGT1A3 c.1102C>G p.Arg368Gly Missense 4/5 -
6-35376713-A-G PPARD c.1-2152A>G - IntronicSNV - 2/7
6-35376713-A-C PPARD c.1-2152A>C - IntronicSNV - 2/7
2-234676880-C-T UGT1A1 c.1099C>T p.Arg367Cys Missense 4/5 -
3-119533910-T-C NR1I2 c.879T>C p.Asn293Asn Synonymous 6/9 -
15-74631994-T-C CYP11A1 c.1091A>G p.Gln364Arg Missense 6/9 -
10-96522463-A-T CYP2C19 c.1A>T p.Met1Leu Missense 1/9 -
4-71895260-C-G DCK c.*165C>G - 3-UTRSNV 7/7 -
4-71895260-C-T DCK c.*165C>T - 3-UTRSNV 7/7 -
2-27424892-G-A SLC5A6 c.1326C>T p.Phe442Phe Synonymous 13/17 -
2-169870882-A-G ABCB11 c.99-18T>C - IntronicSNV - 3/27
2-38298187-G-A CYP1B1 c.1310C>T p.Pro437Leu Missense 3/3 -
20-48160852-A-G PTGIS c.511T>C p.Phe171Leu Missense 4/10 -
4-100197638-C-G ADH1A c.*143G>C - 3-UTRSNV 9/9 -
7-87160789-T-C ABCB1 c.2506A>G p.Ile836Val Missense 22/29 -
1-171086457-C-T FMO3 c.1474C>T p.Arg492Trp Missense 9/9 -
11-62766431-A-T SLC22A8 c.723T>A p.Thr241Thr Synonymous 5/11 -
6-160543229-T-C SLC22A1 c.262T>C p.Cys88Arg Missense 1/11 -
6-18134078-C-A TPMT c.537G>T p.Gln179His Missense 7/9 -
7-139715563-C-T TBXAS1 c.1270C>T p.Gln424* Nonsense 11/13 -
4-69964271-A-G UGT2B7 c.735A>G p.Thr245Thr Synonymous 2/6 -
8-143954290-G-A CYP11B1 c.*1499C>T - 3-UTRSNV 9/9 -
19-15996820-G-A CYP4F2 c.1029C>T p.His343His Synonymous 9/13 -
19-15760053-G-A CYP4F3 c.609G>A p.Leu203Leu Synonymous 6/13 -
13-95858978-T-C ABCC4 c.969A>G p.Ser323Ser Synonymous 8/31 -
12-112241723-G-A ALDH2 c.1467G>A p.Gly489Gly Synonymous 12/13 -
7-122809234-T-C SLC13A1 c.521A>G p.Asn174Ser Missense 4/15 -
7-99445791-G-T CYP3A43 c.341-7423G>T - IntronicSNV - 4/9
7-99366093-G-C CYP3A4 c.554C>G p.Thr185Ser Missense 7/13 -
6-52774462-C-T GSTA3 c.-45G>A - 5_prime_UTR_variant 1/7 -
10-96741051-A-G CYP2C9 c.1073A>G p.Tyr358Cys Missense 7/9 -
10-96741051-A-C CYP2C9 c.1073A>C p.Tyr358Ser Missense 7/9 -
12-58159173-C-G CYP27B1 c.496G>C p.Val166Leu Missense 3/9 -
9-86905096-G-A SLC28A3 c.1122C>T p.Ser374Ser Synonymous 12/19 -
2-38302451-C-G CYP1B1 c.81G>C p.Leu27Leu Synonymous 2/3 -
4-70160309-C-G UGT2B28 c.1372C>G p.His458Asp Missense 6/6 -
2-27424603-C-T SLC5A6 c.1475G>A p.Ser492Asn Missense 14/17 -
11-62748776-G-A SLC22A6 c.877C>T p.Arg293Trp Missense 5/10 -
13-103705044-A-C SLC10A2 c.511T>G p.Ser171Ala Missense 3/6 -
18-24722839-G-A CHST9 c.1-66C>T - 5-UTRSNV 2/6 -
7-99375702-C-T CYP3A4 c.167G>A p.Gly56Asp Missense 3/13 -
1-150795775-C-T ARNT c.1244G>A p.Arg415Gln Missense 13/21 -
1-146672866-A-G FMO5 c.1051T>C p.Ser351Pro Missense 7/9 -
8-70584628-T-C SLCO5A1 c.*476A>G - 3-UTRSNV 10/10 -
19-15739230-C-T CYP4F8 c.1231C>T - stop_gained 11/14 -
1-171072991-G-C FMO3 c.198G>C p.Met66Ile Missense 3/9 -
1-60370710-C-T CYP2J2 c.1024G>A p.Asp342Asn Missense 7/9 -
1-171072991-G-T FMO3 c.198G>T p.Met66Ile Missense 3/9 -
1-60370710-C-G CYP2J2 c.1024G>C p.Asp342His Missense 7/9 -
6-35374466-G-A PPARD c.1-4399G>A - IntronicSNV - 2/7
22-42526670-C-T CYP2D6 c.124G>A p.Gly42Arg Missense 1/9 -
10-96829245-T-G CYP2C8 c.1-86A>C - 5-UTRSNV 1/9 -
1-98157279-A-G DPYD c.756T>C p.Gly252Gly Synonymous 7/23 -
12-21358855-A-G SLCO1B1 c.1385A>G p.Asp462Gly Missense 11/15 -
4-70611119-A-T SULT1B1 c.375+4320T>A - IntronicSNV - 4/7
10-101542579-G-C ABCC2 c.1-23G>C - 5-UTRSNV 1/32 -
11-62752123-C-T SLC22A6 c.40G>A p.Gly14Ser Missense 1/10 -
2-31589847-G-A XDH c.2211C>T p.Ile737Ile Synonymous 21/36 -
4-100239284-T-A ADH1B c.178A>T p.Thr60Ser Missense 3/9 -
12-58156510-C-T CYP27B1 c.*415G>A - 3-UTRSNV 9/9 -
18-9536249-C-T RALBP1 c.*314C>T - 3-UTRSNV 10/10 -
2-219677319-C-T CYP27A1 c.691C>T p.Arg231* Nonsense 4/9 -
14-23284572-A-G SLC7A7 c.-86T>C - 5_prime_UTR_variant 2/11 -
4-89042853-A-G ABCG2 c.623T>C p.Phe208Ser Missense 6/16 -
22-42525772-G-T CYP2D6 c.320C>A p.Thr107Asn Missense 2/9 -
22-42523592-G-A CYP2D6 c.1030C>T p.Arg344* Nonsense 7/9 -
13-95886884-A-C ABCC4 c.511T>G p.Cys171Gly Missense 4/31 -
20-48160902-T-G PTGIS c.461A>C p.Glu154Ala Missense 4/10 -
3-121659860-C-G SLC15A2 c.*6C>G - 3-UTRSNV 22/22 -
3-126256669-T-G CHST13 c.180+1473T>G - IntronicSNV - 2/2
2-234681134-G-C UGT1A1 c.1531G>C p.Ala511Pro Missense 5/5 -
7-87180198-C-A ABCB1 c.1000-44G>T - IntronicSNV - 10/28
4-70079975-A-G UGT2B11 c.466T>C p.Cys156Arg Missense 1/6 -
7-139706915-G-A TBXAS1 c.1159G>A - missense_variant 10/13 -
2-38298434-G-A CYP1B1 c.1063C>T p.Arg355* Nonsense 3/3 -
7-87214983-T-C ABCB1 c.131A>G p.Asn44Ser Missense 5/29 -
13-95886884-A-T ABCC4 c.511T>A p.Cys171Ser Missense 4/31 -
4-100047812-G-A ADH4 c.1051C>T p.Leu351Leu Synonymous 8/9 -
2-234621869-A-G UGT1A10 c.856-53811A>G - IntronicSNV - 1/4
2-234675738-G-A UGT1A1 c.923G>A p.Gly308Glu Missense 2/5 -
4-70079975-A-C UGT2B11 c.466T>G p.Cys156Gly Missense 1/6 -
16-66970975-A-G CES2 c.77-965A>G - intron_variant - 1/11
11-114182607-C-T NNMT c.363-160C>T - IntronicSNV - 2/2
8-143995743-C-T CYP11B2 c.891G>A p.Ala297Ala Synonymous 5/9 -
11-64326677-T-G SLC22A11 c.464T>G p.Val155Gly Missense 2/10 -
11-114182607-C-A NNMT c.363-160C>A - IntronicSNV - 2/2
10-96707539-C-A CYP2C9 c.485C>A p.Ser162* Nonsense 4/9 -
1-171178152-A-G FMO2 c.1476A>G - synonymous_variant 9/9 -
7-17379110-G-A AHR c.1661G>A p.Arg554Lys Missense 10/11 -
13-95672478-A-G ABCC4 c.*1351T>C - 3-UTRSNV 31/31 -
6-35350042-C-T PPARD c.1-28823C>T - IntronicSNV - 2/7
7-87046751-A-C ABCB4 c.2559T>G p.Gly853Gly Synonymous 21/28 -
6-35311988-G-A PPARD c.-186+1530G>A - intron_variant - 1/7
4-100240002-T-C ADH1B c.60A>G p.Lys20Lys Synonymous 2/9 -
7-91756859-T-C CYP51A1 c.555A>G p.Thr185Thr Synonymous 4/10 -
7-91756859-T-G CYP51A1 c.555A>C p.Thr185Thr Synonymous 4/10 -
7-94993261-A-T PON3 c.609T>A p.Tyr203* Nonsense 6/9 -
10-101591418-G-T ABCC2 c.2934G>T p.Ser978Ser Synonymous 22/32 -
7-94993261-A-G PON3 c.609T>C p.Tyr203Tyr Synonymous 6/9 -
7-87056157-C-T ABCB4 c.1973G>A p.Trp658* Nonsense 16/28 -
19-48389426-A-G SULT2A1 c.89T>C p.Phe30Ser Missense 1/6 -
15-74636323-G-A CYP11A1 c.636C>T p.Asn212Asn Synonymous 4/9 -
1-97981343-A-T DPYD c.1679T>A p.Ile560Asn Missense 13/23 -
4-70602840-C-T SULT1B1 c.376-2858G>A - IntronicSNV - 4/7
13-95727780-T-C ABCC4 c.2712A>G p.Leu904Leu Synonymous 22/31 -
20-52771250-G-A CYP24A1 c.*61C>T - 3_prime_UTR_variant 12/12 -
2-27422605-C-T SLC5A6 c.*699G>A - 3-UTRSNV 17/17 -
2-31565119-G-C XDH c.3449C>G p.Pro1150Arg Missense 32/36 -
10-106027073-C-T GSTO1 c.636C>T p.Val212Val Synonymous 6/6 -
1-171083242-A-G FMO3 c.923A>G p.Glu308Gly Missense 7/9 -
6-35376679-A-C PPARD c.1-2186A>C - IntronicSNV - 2/7
4-89042912-T-C ABCG2 c.564A>G p.Gly188Gly Synonymous 6/16 -
6-46620271-G-C CYP39A1 c.49C>G p.Leu17Val Missense 1/12 -
16-71570992-T-G CHST4 c.412T>G p.Cys138Gly Missense 2/2 -
4-100268279-C-T ADH1C c.143G>A p.Arg48His Missense 3/9 -
16-71570992-T-C CHST4 c.412T>C p.Cys138Arg Missense 2/2 -
3-14485193-C-G SLC6A6 c.51C>G p.Ile17Met Missense 3/15 -
3-121615317-G-A SLC15A2 c.170G>A p.Arg57His Missense 2/22 -
3-121615317-G-T SLC15A2 c.170G>T p.Arg57Leu Missense 2/22 -
4-100268279-C-A ADH1C c.143G>T p.Arg48Leu Missense 3/9 -
7-99273815-G-A CYP3A5 c.88C>T p.His30Tyr Missense 2/13 -
6-35320447-C-T PPARD c.-102+5520C>T - intron_variant - 2/7
1-97915614-C-G DPYD c.1905+1G>C - IntronicSNV - 14/22
1-226033030-G-C EPHX1 c.1350G>C p.Ser450Ser Synonymous 9/9 -
1-226033030-G-A EPHX1 c.1350G>A p.Ser450Ser Synonymous 9/9 -
1-146672906-C-T FMO5 c.1011G>A p.Pro337Pro Synonymous 7/9 -
15-75013026-A-T CYP1A1 c.1343T>A p.Ile448Asn Missense 7/7 -
8-18080487-C-G NAT1 c.*58C>G - 3-UTRSNV 3/3 -
8-18080487-C-T NAT1 c.*58C>T - 3-UTRSNV 3/3 -
15-75013026-A-G CYP1A1 c.1343T>C p.Ile448Thr Missense 7/7 -
1-171086441-A-G FMO3 c.1458A>G p.Ile486Met Missense 9/9 -
4-69512917-C-T UGT2B15 c.1498G>A p.Ala500Thr Missense 6/6 -
10-96495232-C-T CYP2C18 c.*31C>T - 3-UTRSNV 9/9 -
11-64323562-A-G SLC22A11 c.91A>G p.Ile31Val Missense 1/10 -
8-18257877-G-A NAT2 c.364G>A p.Asp122Asn Missense 2/2 -
6-52615415-T-G GSTA2 c.629A>C p.Glu210Ala Missense 7/7 -
7-139715578-G-A TBXAS1 c.1285G>A p.Gly429Ser Missense 11/13 -
7-139657478-A-G TBXAS1 c.734A>G - missense_variant 8/13 -
1-60381650-G-C CYP2J2 c.333C>G p.Arg111Arg Synonymous 2/9 -
6-44200655-G-A SLC29A1 c.1171G>A p.Glu391Lys Missense 13/14 -
6-44200655-G-C SLC29A1 c.1171G>C p.Glu391Gln Missense 13/14 -
19-15756540-G-A CYP4F3 c.210G>A p.Ser70Ser Synonymous 3/13 -
2-31558873-C-T XDH c.3953G>A p.Cys1318Tyr Missense 36/36 -
6-35375526-C-A PPARD c.1-3339C>A - IntronicSNV - 2/7
6-35375526-C-T PPARD c.1-3339C>T - IntronicSNV - 2/7
3-126261345-G-C CHST13 c.950G>C p.Arg317Pro Missense 3/3 -
16-89613123-A-G SPG7 c.1507A>G p.Thr503Ala Missense 11/17 -
3-126261345-G-A CHST13 c.950G>A p.Arg317Gln Missense 3/3 -
6-52615353-C-T GSTA2 c.*22G>A - 3-UTRSNV 7/7 -
4-115589302-A-G UGT8 c.1104A>G p.Ile368Met Missense 4/5 -
6-52615353-C-G GSTA2 c.*22G>C - 3-UTRSNV 7/7 -
19-41349732-C-A CYP2A6 c.1454G>T p.Arg485Leu Missense 9/9 -
19-41349732-C-G CYP2A6 c.1454G>C p.Arg485Pro Missense 9/9 -
1-226016575-C-T EPHX1 c.145C>T p.Arg49Cys Missense 2/9 -
4-100239284-T-G ADH1B c.178A>C p.Thr60Pro Missense 3/9 -
5-131705676-C-G SLC22A5 c.12C>G p.Tyr4* Nonsense 1/10 -
10-106019447-C-G GSTO1 c.257C>G p.Ser86Cys Missense 3/6 -
10-101591418-G-A ABCC2 c.2934G>A p.Ser978Ser Synonymous 22/32 -
10-101591418-G-C ABCC2 c.2934G>C p.Ser978Ser Synonymous 22/32 -
2-234680912-A-T UGT1A1 c.1309A>T p.Lys437* Nonsense 5/5 -
7-139720020-G-A TBXAS1 c.*121G>A - 3-UTRSNV 13/13 -
6-160864758-A-G SLC22A3 c.1494A>G p.Leu498Leu Synonymous 9/11 -
6-35365457-A-G PPARD c.1-13408A>G - IntronicSNV - 2/7
4-74281998-A-T ALB c.1217A>T p.Glu406Val Missense 10/15 -
1-226019586-G-A EPHX1 c.290G>A p.Trp97* Nonsense 3/9 -
10-96708974-A-G CYP2C9 c.752A>G p.His251Arg Missense 5/9 -
9-117086329-C-T ORM1 c.289C>T p.Leu97Leu Synonymous 3/6 -
11-64329590-T-C SLC22A11 c.612T>C p.Ala204Ala Synonymous 3/10 -
11-64329590-T-G SLC22A11 c.612T>G p.Ala204Ala Synonymous 3/10 -
16-28602991-A-G SGF29 c.846A>G p.Arg282Arg Synonymous 10/10 -
9-117087125-C-G ORM1 c.384C>G p.Tyr128* Nonsense 4/6 -
9-117087125-C-T ORM1 c.384C>T p.Tyr128Tyr Synonymous 4/6 -
1-47403031-A-G CYP4A11 c.338-13T>C - IntronicSNV - 2/11
16-66977114-C-T CES2 c.1421-88C>T - intron_variant - 10/11
9-75540504-T-A ALDH1A1 c.529A>T p.Ile177Phe Missense 6/13 -
6-35353523-A-G PPARD c.1-25342A>G - IntronicSNV - 2/7
12-105152391-A-G CHST11 c.*810A>G - 3-UTRSNV 3/3 -
15-75041351-C-T CYP1A2 c.-10+113C>T - intron_variant - 1/6
8-143953937-A-C CYP11B1 c.*1852T>G - 3-UTRSNV 9/9 -
8-143953937-A-G CYP11B1 c.*1852T>C - 3-UTRSNV 9/9 -
19-41510286-G-C CYP2B6 c.419G>C p.Arg140Pro Missense 3/9 -
6-160664685-G-T SLC22A2 c.1198C>A p.Arg400Ser Missense 7/11 -
6-52699081-C-T GSTA5 c.273-1G>A - IntronicSNV - 4/6
7-122838633-G-T SLC13A1 c.99+1269C>A - IntronicSNV - 1/14
1-171162583-T-C FMO2 c.242T>C p.Phe81Ser Missense 3/9 -
1-171252287-A-C FMO1 c.1188A>C p.Val396Val Synonymous 8/9 -
15-92698643-G-A SLCO3A1 c.1753+4399G>A - IntronicSNV - 9/9
15-92698643-G-C SLCO3A1 c.1753+4399G>C - IntronicSNV - 9/9
4-70606026-A-G SULT1B1 c.376-6044T>C - IntronicSNV - 4/7
16-16236523-T-G ABCC1 c.*1385T>G - 3-UTRSNV 31/31 -
2-234667582-A-T UGT1A4 c.868-8098A>T - IntronicSNV - 1/4
2-234667582-A-C UGT1A4 c.868-8098A>C - IntronicSNV - 1/4
2-234667582-A-G UGT1A4 c.868-8098A>G - IntronicSNV - 1/4
10-96535173-T-C CYP2C19 c.358T>C p.Trp120Arg Missense 3/9 -
5-142659266-T-A NR3C1 c.*2188A>T - 3-UTRSNV 9/9 -
5-142659266-T-C NR3C1 c.*2188A>G - 3-UTRSNV 9/9 -
1-171076935-C-T FMO3 c.441C>T p.Ser147Ser Synonymous 4/9 -
15-51507968-G-A CYP19A1 c.790C>T p.Arg264Cys Missense 7/10 -
15-45556163-T-C SLC28A2 c.531T>C p.Phe177Phe Synonymous 6/18 -
7-87175272-G-A ABCB1 c.1794C>T p.Ile598Ile Synonymous 16/29 -
19-41383799-G-C CYP2A7 c.778C>G p.Arg260Gly Missense 5/8 -
2-234669462-T-C UGT1A1 c.529T>C p.Cys177Arg Missense 1/5 -
13-52507720-C-T ATP7B c.*1172G>A - 3-UTRSNV 21/21 -
2-234669457-T-A UGT1A1 c.524T>A p.Leu175Gln Missense 1/5 -
19-41383799-G-A CYP2A7 c.778C>T p.Arg260Cys Missense 5/8 -
2-169783827-G-A ABCB11 c.3457C>T p.Arg1153Cys Missense 26/28 -
6-160579596-A-C SLC22A1 c.1647A>C p.Ser549Ser Synonymous 11/11 -
4-70621074-A-G SULT1B1 c.1-139T>C - IntronicSNV - 1/7
20-48129688-G-T PTGIS c.1135C>A p.Arg379Ser Missense 8/10 -
20-48129688-G-C PTGIS c.1135C>G p.Arg379Gly Missense 8/10 -
20-48129688-G-A PTGIS c.1135C>T p.Arg379Cys Missense 8/10 -
10-73769507-C-T CHST3 c.*1278C>T - 3-UTRSNV 3/3 -
1-113458216-G-A SLC16A1 c.1229-1429C>T - IntronicSNV - 4/4
19-41510286-G-A CYP2B6 c.419G>A p.Arg140Gln Missense 3/9 -
6-52767227-C-A GSTA3 c.189G>T p.Met63Ile Missense 4/7 -
2-234590527-T-A UGT1A10 c.855+44504T>A - IntronicSNV - 1/4
2-234590527-T-G UGT1A10 c.855+44504T>G - IntronicSNV - 1/4
19-41512918-T-C CYP2B6 c.593T>C p.Met198Thr Missense 4/9 -
17-37826619-T-C PNMT c.826T>C p.Trp276Arg Missense 3/3 -
17-37826619-T-A PNMT c.826T>A p.Trp276Arg Missense 3/3 -
10-104596924-C-A CYP17A1 c.195G>T p.Ser65Ser Synonymous 1/8 -
19-15806846-A-G CYP4F12 c.1216A>G p.Ile406Val Missense 10/13 -
19-15806846-A-C CYP4F12 c.1216A>C p.Ile406Leu Missense 10/13 -
19-16008386-C-G CYP4F2 c.36G>C p.Trp12Cys Missense 2/13 -
12-21331606-T-G SLCO1B1 c.578T>G p.Leu193Arg Missense 6/15 -
2-234637789-A-G UGT1A4 c.867+9456A>G - IntronicSNV - 1/4
4-100137393-G-A ADH6 c.45C>T p.Leu15Leu Synonymous 2/8 -
16-16162039-C-T ABCC1 c.1704C>T p.Tyr568Tyr Synonymous 13/31 -
17-19561110-G-A ALDH3A2 c.733G>A p.Asp245Asn Missense 5/10 -
1-171250044-C-T FMO1 c.747C>T p.Thr249Thr Synonymous 6/9 -
14-70243089-G-T SLC10A1 c.960C>A p.Ile320Ile Synonymous 5/5 -
6-46563817-A-T CYP39A1 c.912T>A p.Asn304Lys Missense 8/12 -
5-131676320-C-T SLC22A4 c.1507C>T p.Leu503Phe Missense 9/10 -
3-183699516-T-C ABCC5 c.1146A>G p.Gln382Gln Synonymous 8/30 -
19-41512828-C-T CYP2B6 c.503C>T p.Thr168Ile Missense 4/9 -
19-41510030-G-A CYP2B6 c.296G>A p.Gly99Glu Missense 2/9 -
6-160664685-G-A SLC22A2 c.1198C>T p.Arg400Cys Missense 7/11 -
2-101009668-A-G CHST10 c.*39T>C - 3-UTRSNV 7/7 -
13-99376180-G-T SLC15A1 c.351C>A p.Ser117Arg Missense 5/23 -
10-96829245-T-C CYP2C8 c.1-86A>G - 5-UTRSNV 1/9 -
7-87092213-G-A ABCB4 c.147C>T p.Ser49Ser Synonymous 4/28 -
19-41518773-C-T CYP2B6 c.1294+53C>T - IntronicSNV - 8/8
10-101595975-G-T ABCC2 c.3542G>T p.Arg1181Leu Missense 25/32 -
13-95726541-A-G ABCC4 c.2844T>C p.Phe948Phe Synonymous 23/31 -
6-32008648-C-T CYP21A2 c.1225C>T p.Arg409Cys Missense 10/10 -
6-32008648-C-G CYP21A2 c.1225C>G p.Arg409Gly Missense 10/10 -
6-32008648-C-A CYP21A2 c.1225C>A p.Arg409Ser Missense 10/10 -
13-99376180-G-A SLC15A1 c.351C>T p.Ser117Ser Synonymous 5/23 -
1-171080028-T-C FMO3 c.717T>C p.Phe239Phe Synonymous 6/9 -
6-35372524-G-C PPARD c.1-6341G>C - IntronicSNV - 2/7
19-41497274-C-T CYP2B6 c.64C>T p.Arg22Cys Missense 1/9 -
10-101604207-C-G ABCC2 c.3972C>G p.Ile1324Met Missense 28/32 -
10-101604207-C-T ABCC2 c.3972C>T p.Ile1324Ile Synonymous 28/32 -
10-101595996-T-A ABCC2 c.3563T>A p.Val1188Glu Missense 25/32 -
10-104597152-A-G CYP17A1 c.1-34T>C - 5-UTRSNV 1/8 -
10-101604163-C-G ABCC2 c.3928C>G p.Arg1310Gly Missense 28/32 -
1-171252287-A-G FMO1 c.1188A>G p.Val396Val Synonymous 8/9 -
10-104597152-A-T CYP17A1 c.1-34T>A - 5-UTRSNV 1/8 -
4-115544714-A-T UGT8 c.678A>T p.Pro226Pro Synonymous 1/5 -
2-234526987-A-G UGT1A8 c.634A>G p.Met212Val Missense 1/5 -
16-66971257-G-A CES2 c.77-683G>A - intron_variant - 1/11
5-74656274-G-A HMGCR c.*107G>A - 3-UTRSNV 20/20 -
2-234526987-A-T UGT1A8 c.634A>T p.Met212Leu Missense 1/5 -
22-42523610-C-T CYP2D6 c.1012G>A p.Val338Met Missense 7/9 -
22-42525132-G-C CYP2D6 c.408C>G p.Val136Val Synonymous 3/9 -
4-100237125-G-T ADH1B c.497C>A p.Pro166His Missense 5/9 -
7-150556055-C-G AOC1 c.1775C>G p.Thr592Arg Missense 3/5 -
2-169869901-A-G ABCB11 c.270T>C p.Phe90Phe Synonymous 5/28 -
14-70245193-G-A SLC10A1 c.800C>T p.Ser267Phe Missense 4/5 -
4-100062819-A-G ADH4 c.135T>C p.Ser45Ser Synonymous 3/9 -
10-96701715-T-C CYP2C9 c.269T>C p.Leu90Pro Missense 2/9 -
16-87866136-G-C SLC7A5 c.*440C>G - 3-UTRSNV 10/10 -
3-42916511-C-A CYP8B1 c.798G>T p.Gly266Gly Synonymous 1/1 -
10-96796796-G-A CYP2C8 c.*89C>T - 3-UTRSNV 9/9 -
2-234669759-G-T UGT1A1 c.826G>T p.Gly276Cys Missense 1/5 -
7-99361466-C-T CYP3A4 c.1023+12G>A - IntronicSNV - 10/12
22-44234791-C-T SULT4A1 c.464G>A p.Arg155Gln Missense 4/7 -
7-139717608-G-A TBXAS1 c.1502G>A - missense_variant 12/13 -
2-169842746-T-C ABCB11 c.957A>G p.Gly319Gly Synonymous 10/28 -
2-169842746-T-A ABCB11 c.957A>T p.Gly319Gly Synonymous 10/28 -
2-108925749-G-A SULT1C2 c.*829G>A - 3-UTRSNV 9/9 -
6-18131012-C-T TPMT c.626-1G>A - IntronicSNV - 8/8
2-38298383-T-C CYP1B1 c.1114A>G p.Met372Val Missense 3/3 -
7-91738788-C-G AKAP9 c.11687-648C>G - IntronicSNV - 49/49
4-70066319-G-T UGT2B11 c.1429C>A p.Arg477Arg Synonymous 6/6 -
7-139661964-C-G TBXAS1 c.1066C>G - missense_variant 9/13 -
19-15730331-A-T CYP4F8 c.374A>T p.Tyr125Phe Missense 4/14 -
3-38316933-G-A SLC22A13 c.879G>A p.Lys293Lys Synonymous 5/10 -
1-47395726-T-A CYP4A11 c.*61A>T - 3-UTRSNV 12/12 -
10-96541756-T-A CYP2C19 c.819+2T>A - IntronicSNV - 5/8
2-38298338-C-T CYP1B1 c.1159G>A p.Glu387Lys Missense 3/3 -
1-110213991-T-C GSTM2 c.443T>C p.Phe148Ser Missense 6/8 -
19-41512824-C-T CYP2B6 c.499C>T p.Pro167Ser Missense 4/9 -
18-669117-C-T TYMS c.500C>T p.Thr167Ile Missense 4/7 -
2-38298338-C-G CYP1B1 c.1159G>C p.Glu387Gln Missense 3/3 -
3-126262092-G-C CHST13 c.*671G>C - 3-UTRSNV 3/3 -
1-47280884-C-T CYP4B1 c.1018C>T p.Arg340Cys Missense 8/12 -
13-95672265-A-T ABCC4 c.*1564T>A - 3-UTRSNV 31/31 -
3-119529002-C-T NR1I2 c.292C>T p.Arg98Cys Missense 3/9 -
6-35377301-C-G PPARD c.1-1564C>G - IntronicSNV - 2/7
6-18143955-C-G TPMT c.238G>C p.Ala80Pro Missense 4/9 -
6-35377301-C-A PPARD c.1-1564C>A - IntronicSNV - 2/7
10-101595950-A-G ABCC2 c.3517A>G p.Ile1173Val Missense 25/32 -
10-101595950-A-T ABCC2 c.3517A>T p.Ile1173Phe Missense 25/32 -
2-38302350-C-G CYP1B1 c.182G>C p.Gly61Ala Missense 2/3 -
8-18079213-C-T NAT1 c.1-344C>T - IntronicSNV - 2/2
8-18079213-C-A NAT1 c.1-344C>A - IntronicSNV - 2/2
4-89039360-A-C ABCG2 c.742T>G p.Ser248Ala Missense 7/16 -
18-24497224-T-G CHST9 c.331A>C p.Thr111Pro Missense 6/6 -
18-24497190-C-A CHST9 c.365G>T p.Ser122Ile Missense 6/6 -
18-24497190-C-T CHST9 c.365G>A p.Ser122Asn Missense 6/6 -
19-41349774-A-G CYP2A6 c.1412T>C p.Ile471Thr Missense 9/9 -
2-108925752-G-A SULT1C2 c.*832G>A - 3-UTRSNV 9/9 -
2-108925752-G-C SULT1C2 c.*832G>C - 3-UTRSNV 9/9 -
13-99356611-C-T SLC15A1 c.1348G>A p.Val450Ile Missense 17/23 -
8-143955144-T-C CYP11B1 c.*645A>G - 3-UTRSNV 9/9 -
7-99258139-C-T CYP3A5 c.1009G>A p.Ala337Thr Missense 10/13 -
4-70454991-C-T UGT2A2 c.*99G>A - 3-UTRSNV 6/6 -
19-15794463-G-C CYP4F12 c.808G>C p.Val270Leu Missense 7/13 -
13-52520507-C-T ATP7B c.2973G>A p.Thr991Thr Synonymous 13/21 -
15-75012987-G-A CYP1A1 c.1382C>T p.Thr461Ile Missense 7/7 -
15-75012987-G-T CYP1A1 c.1382C>A p.Thr461Asn Missense 7/7 -
12-21329813-C-T SLCO1B1 c.463C>T p.Pro155Ser Missense 5/15 -
1-171083259-G-A FMO3 c.940G>A p.Glu314Lys Missense 7/9 -
1-171083259-G-T FMO3 c.940G>T p.Glu314* Nonsense 7/9 -
13-52515354-A-T ATP7B c.3419T>A p.Val1140Asp Missense 16/21 -
4-69972952-C-A UGT2B7 c.1062C>A p.Tyr354* Nonsense 4/6 -
13-52515354-A-G ATP7B c.3419T>C p.Val1140Ala Missense 16/21 -
7-99457605-C-G CYP3A43 c.688C>G p.Pro230Ala Missense 7/10 -
7-99457605-C-A CYP3A43 c.688C>A p.Pro230Thr Missense 7/10 -
4-69972952-C-T UGT2B7 c.1062C>T p.Tyr354Tyr Synonymous 4/6 -
1-171072975-A-G FMO3 c.182A>G p.Asn61Ser Missense 3/9 -
19-41518370-C-T CYP2B6 c.1132C>T p.Arg378* Nonsense 7/9 -
4-70346564-G-A UGT2B4 c.1375C>T p.Arg459* Nonsense 6/6 -
10-94824145-G-A CYP26C1 c.713G>A p.Arg238Gln Missense 4/6 -
6-160663420-T-C SLC22A2 c.1294A>G p.Lys432Glu Missense 8/11 -
11-17414570-C-T ABCC8 c.4714G>A p.Val1572Ile Missense 39/39 -
5-131719906-T-C SLC22A5 c.565T>C p.Phe189Leu Missense 3/10 -
19-41384675-T-C CYP2A7 c.668A>G p.His223Arg Missense 4/8 -
7-99367825-T-C CYP3A4 c.352A>G p.Ile118Val Missense 5/13 -
2-169791806-C-T ABCB11 c.2944G>A p.Gly982Arg Missense 23/28 -
7-75592925-T-C POR c.189-8806T>C - IntronicSNV - 2/15
7-99367825-T-A CYP3A4 c.352A>T p.Ile118Phe Missense 5/13 -
19-41381510-T-G CYP2A7 c.*88A>C - 3-UTRSNV 8/8 -
16-16173227-C-A ABCC1 c.2007C>A p.Pro669Pro Synonymous 16/31 -
20-48160961-C-T PTGIS c.402G>A p.Gln134Gln Synonymous 4/10 -
16-16173227-C-T ABCC1 c.2007C>T p.Pro669Pro Synonymous 16/31 -
1-98348909-G-A DPYD c.61C>T p.Arg21* Nonsense 2/23 -
20-48160961-C-A PTGIS c.402G>T p.Gln134His Missense 4/10 -
12-21358933-G-C SLCO1B1 c.1463G>C p.Gly488Ala Missense 11/15 -
13-95858996-T-A ABCC4 c.951A>T p.Arg317Ser Missense 8/31 -
13-95858996-T-C ABCC4 c.951A>G p.Arg317Arg Synonymous 8/31 -
2-31572994-G-T XDH c.2727C>A p.Asn909Lys Missense 25/36 -
10-96748777-C-T CYP2C9 c.1465C>T p.Pro489Ser Missense 9/9 -
10-96701991-G-T CYP2C9 c.374G>T p.Arg125Leu Missense 3/9 -
10-96701991-G-A CYP2C9 c.374G>A p.Arg125His Missense 3/9 -
10-96701991-G-C CYP2C9 c.374G>C p.Arg125Pro Missense 3/9 -
6-35356161-G-C PPARD c.1-22704G>C - IntronicSNV - 2/7
10-82035150-A-T MAT1A c.769-195T>A - IntronicSNV - 6/8
6-35356161-G-A PPARD c.1-22704G>A - IntronicSNV - 2/7
4-70723840-C-T SULT1E1 c.1-478G>A - IntronicSNV - 1/7
7-87082366-G-C ABCB4 c.430C>G p.Arg144Gly Missense 6/28 -
19-48374789-C-T SULT2A1 c.781G>A p.Ala261Thr Missense 6/6 -
7-122755445-A-G SLC13A1 c.*127T>C - 3-UTRSNV 15/15 -
8-18079919-C-T NAT1 c.363C>T p.Val121Val Synonymous 3/3 -
3-14485194-C-G SLC6A6 c.52C>G p.Leu18Val Missense 3/15 -
10-104597053-G-C CYP17A1 c.66C>G p.Cys22Trp Missense 1/8 -
1-171076952-C-T FMO3 c.458C>T p.Pro153Leu Missense 4/9 -
4-89042912-T-G ABCG2 c.564A>C p.Gly188Gly Synonymous 6/16 -
20-48164401-A-T PTGIS c.354T>A p.Ser118Arg Missense 3/10 -
19-48389509-C-T SULT2A1 c.6G>A p.Ser2Ser Synonymous 1/6 -
8-143955657-A-G CYP11B1 c.*132T>C - 3-UTRSNV 9/9 -
16-31102655-G-C VKORC1 c.292C>G p.Arg98Gly Missense 3/3 -
2-101009983-C-A CHST10 c.795G>T p.Thr265Thr Synonymous 7/7 -
3-38315821-C-T SLC22A13 c.437C>T p.Ala146Val Missense 2/10 -
6-35377922-G-A PPARD c.1-943G>A - IntronicSNV - 2/7
3-38315821-C-A SLC22A13 c.437C>A p.Ala146Asp Missense 2/10 -
7-87229452-A-G ABCB1 c.49T>C p.Phe17Leu Missense 3/29 -
10-101591385-C-A ABCC2 c.2901C>A p.Tyr967* Nonsense 22/32 -
16-75513675-G-C CHST6 c.52C>G p.Gln18Glu Missense 3/3 -
12-112228249-G-A ALDH2 c.564G>A p.Pro188Pro Synonymous 6/13 -
16-75513675-G-A CHST6 c.52C>T p.Gln18* Nonsense 3/3 -
16-16142079-G-T ABCC1 c.1299G>T p.Arg433Ser Missense 10/31 -
1-171254588-C-T FMO1 c.1504C>T p.Arg502* Nonsense 9/9 -
6-44201707-G-A SLC29A1 c.*442G>A - 3-UTRSNV 14/14 -
19-49079246-C-T SULT2B1 c.75C>T p.Pro25Pro Synonymous 1/6 -
22-44235828-G-T SULT4A1 c.378C>A p.Ser126Ser Synonymous 3/7 -
11-114167384-C-A NNMT c.106C>A p.Gln36Lys Missense 1/3 -
7-87092185-G-A ABCB4 c.175C>T p.Leu59Leu Synonymous 4/28 -
11-114167384-C-T NNMT c.106C>T p.Gln36* Nonsense 1/3 -
22-51064699-T-G ARSA c.862A>C p.Thr288Pro Missense 5/8 -
2-38298361-G-A CYP1B1 c.1136C>T p.Pro379Leu Missense 3/3 -
15-75014049-G-C CYP1A1 c.835C>G p.Arg279Gly Missense 3/7 -
9-86955595-T-G SLC28A3 c.1-47A>C - IntronicSNV 1/19 -
5-74633716-G-A HMGCR c.-24+591G>A - intron_variant - 1/19
20-48164497-C-A PTGIS c.258G>T p.Val86Val Synonymous 3/10 -
15-75014027-A-G CYP1A1 c.857T>C p.Ile286Thr Missense 3/7 -
8-18080196-T-G NAT1 c.640T>G p.Ser214Ala Missense 3/3 -
9-117086027-T-C ORM1 c.199T>C p.Phe67Leu Missense 2/6 -
20-48164497-C-T PTGIS c.258G>A p.Val86Val Synonymous 3/10 -
14-23282449-C-G SLC7A7 c.159G>C p.Ser53Ser Synonymous 3/11 -
19-49100068-G-A SULT2B1 c.673G>A p.Val225Ile Missense 5/6 -
10-73770073-C-T CHST3 c.*1844C>T - 3-UTRSNV 3/3 -
3-126247198-T-A CHST13 c.97+3926T>A - IntronicSNV - 1/2
14-23282449-C-T SLC7A7 c.159G>A p.Ser53Ser Synonymous 3/11 -
16-69744747-A-G NQO1 c.*132T>C - 3-UTRSNV 6/6 -
8-18080440-A-G NAT1 c.*11A>G - 3-UTRSNV 3/3 -
12-21032506-A-G SLCO1B3 c.1272A>G p.Leu424Leu Synonymous 11/16 -
1-171303644-A-T FMO4 c.922A>T p.Thr308Ser Missense 8/10 -
17-19554939-G-A ALDH3A2 c.233G>A p.Trp78* Nonsense 2/10 -
12-21032506-A-C SLCO1B3 c.1272A>C p.Leu424Leu Synonymous 11/16 -
10-96748635-C-A CYP2C9 c.1323C>A p.Ala441Ala Synonymous 9/9 -
7-87165750-C-G ABCB1 c.2481+24G>C - IntronicSNV - 21/28
7-87165750-C-T ABCB1 c.2481+24G>A - IntronicSNV - 21/28
7-87165750-C-A ABCB1 c.2481+24G>T - IntronicSNV - 21/28
4-115544609-G-T UGT8 c.573G>T p.Leu191Leu Synonymous 1/5 -
20-48140744-G-A PTGIS c.706C>T p.Arg236Cys Missense 6/10 -
4-115544609-G-A UGT8 c.573G>A p.Leu191Leu Synonymous 1/5 -
5-74656175-G-A HMGCR c.*8G>A - 3-UTRSNV 20/20 -
15-51507967-C-A CYP19A1 c.791G>T p.Arg264Leu Missense 7/10 -
10-104596981-G-A CYP17A1 c.138C>T p.His46His Synonymous 1/8 -
8-18080440-A-T NAT1 c.*11A>T - 3-UTRSNV 3/3 -
7-122754358-G-A SLC13A1 c.*1214C>T - 3-UTRSNV 15/15 -
7-150555915-A-G AOC1 c.1635A>G p.Pro545Pro Synonymous 3/5 -
4-70355211-T-A UGT2B4 c.948A>T p.Thr316Thr Synonymous 3/6 -
8-27362587-G-A EPHX2 c.461G>A p.Cys154Tyr Missense 4/19 -
4-70355211-T-C UGT2B4 c.948A>G p.Thr316Thr Synonymous 3/6 -
2-101010082-G-C CHST10 c.696C>G p.Thr232Thr Synonymous 7/7 -
2-101010082-G-T CHST10 c.696C>A p.Thr232Thr Synonymous 7/7 -
12-21054369-G-A SLCO1B3 c.1833G>A p.Gly611Gly Synonymous 15/16 -
7-99366070-T-C CYP3A4 c.577A>G p.Ile193Val Missense 7/13 -
7-87144640-G-C ABCB1 c.3189C>G p.Gly1063Gly Synonymous 26/29 -
7-99273821-G-A CYP3A5 c.82C>T p.Arg28Cys Missense 2/13 -
2-234665659-T-G UGT1A4 c.868-10021T>G - IntronicSNV - 1/4
1-171174691-G-A FMO2 c.1101G>A p.Ala367Ala Synonymous 7/9 -
3-119530472-G-A NR1I2 c.418G>A p.Val140Met Missense 4/9 -
6-160551204-G-A SLC22A1 c.480G>A p.Leu160Leu Synonymous 2/11 -
6-160551204-G-C SLC22A1 c.480G>C p.Leu160Phe Missense 2/11 -
6-160551204-G-T SLC22A1 c.480G>T p.Leu160Phe Missense 2/11 -
3-183643407-G-T ABCC5 c.4148C>A p.Thr1383Asn Missense 29/30 -
4-70596385-T-G SULT1B1 c.612A>C p.Glu204Asp Missense 7/8 -
1-97544627-C-A DPYD c.2983G>T p.Val995Phe Missense 23/23 -
1-171083479-G-T FMO3 c.1160G>T p.Arg387Leu Missense 7/9 -
7-99367427-C-T CYP3A4 c.485G>A p.Arg162Gln Missense 6/13 -
10-101604130-A-C ABCC2 c.3895A>C p.Lys1299Gln Missense 28/32 -
19-41352762-G-C CYP2A6 c.831+18C>G - IntronicSNV - 5/8
4-70160259-A-G UGT2B28 c.1322A>G p.Asn441Ser Missense 6/6 -
7-99273745-T-C CYP3A5 c.158A>G p.Tyr53Cys Missense 2/13 -
7-87082292-G-A ABCB4 c.504C>T p.Asn168Asn Synonymous 6/28 -
8-27358505-A-G EPHX2 c.164A>G p.Lys55Arg Missense 2/19 -
6-35391787-C-G PPARD c.489C>G p.Asn163Lys Missense 6/8 -
6-35391787-C-T PPARD c.489C>T p.Asn163Asn Synonymous 6/8 -
1-113455099-G-A SLC16A1 c.*1414C>T - 3-UTRSNV 5/5 -
2-219676973-C-T CYP27A1 c.475C>T p.Gln159* Nonsense 3/9 -
3-119526176-C-T NR1I2 c.79C>T p.Pro27Ser Missense 2/9 -
19-16008257-T-C CYP4F2 c.165A>G p.Pro55Pro Synonymous 2/13 -
6-160560845-A-G SLC22A1 c.1222A>G p.Met408Val Missense 7/11 -
4-70345904-C-T UGT2B4 c.*448G>A - 3-UTRSNV 6/6 -
16-16139720-G-A ABCC1 c.1068G>A p.Thr356Thr Synonymous 9/31 -
19-41518708-C-A CYP2B6 c.1282C>A p.Pro428Thr Missense 8/9 -
1-171083398-T-C FMO3 c.1079T>C p.Leu360Pro Missense 7/9 -
10-96818119-G-C CYP2C8 c.792C>G p.Ile264Met Missense 5/9 -
6-35330030-T-C PPARD c.-102+15103T>C - intron_variant - 2/7
16-28607196-G-C SULT1A2 c.56C>G p.Pro19Arg Missense 2/8 -
16-28607196-G-A SULT1A2 c.56C>T p.Pro19Leu Missense 2/8 -
19-34176058-T-C CHST8 c.-134T>C - 5_prime_UTR_variant 1/4 -
10-101611294-G-A ABCC2 c.4544G>A p.Cys1515Tyr Missense 32/32 -
10-96818119-G-A CYP2C8 c.792C>T p.Ile264Ile Synonymous 5/9 -
19-15739597-A-C CYP4F8 c.1338A>C - synonymous_variant 13/14 -
6-32008696-G-A CYP21A2 c.1273G>A p.Gly425Ser Missense 10/10 -
10-104592870-G-A CYP17A1 c.849C>T p.Asp283Asp Synonymous 5/8 -
13-99340771-G-A SLC15A1 c.1527C>T p.Asn509Asn Synonymous 19/23 -
5-142680246-G-C NR3C1 c.1551C>G p.Asn517Lys Missense 5/9 -
13-99340771-G-C SLC15A1 c.1527C>G p.Asn509Lys Missense 19/23 -
10-82033470-G-C MAT1A c.*67C>G - 3-UTRSNV 9/9 -
1-97564154-C-T DPYD c.2657G>A p.Arg886His Missense 21/23 -
4-89052964-G-A ABCG2 c.369C>T p.Tyr123Tyr Synonymous 4/16 -
13-99356607-G-T SLC15A1 c.1352C>A p.Thr451Asn Missense 17/23 -
6-160557271-C-G SLC22A1 c.859C>G p.Arg287Gly Missense 5/11 -
10-104596924-C-T CYP17A1 c.195G>A p.Ser65Ser Synonymous 1/8 -
15-51529112-T-C CYP19A1 c.240A>G p.Val80Val Synonymous 3/10 -
1-113456546-A-T SLC16A1 c.1470T>A p.Asp490Glu Missense 5/5 -
17-19643684-T-A ALDH3A1 c.914A>T p.Tyr305Phe Missense 7/11 -
3-126247198-T-G CHST13 c.97+3926T>G - IntronicSNV - 1/2
1-110279701-C-T GSTM3 c.670G>A p.Val224Ile Missense 9/9 -
8-143955581-A-C CYP11B1 c.*208T>G - 3-UTRSNV 9/9 -
8-143955581-A-G CYP11B1 c.*208T>C - 3-UTRSNV 9/9 -
7-87195534-C-A ABCB1 c.554G>T p.Gly185Val Missense 8/29 -
2-234669558-C-G UGT1A1 c.625C>G p.Arg209Gly Missense 1/5 -
6-160557271-C-T SLC22A1 c.859C>T p.Arg287Trp Missense 5/11 -
7-99262835-C-T CYP3A5 c.624G>A p.Lys208Lys Synonymous 7/13 -
10-101591826-C-T ABCC2 c.3196C>T p.Arg1066* Nonsense 23/32 -
13-99358478-G-A SLC15A1 c.1179C>T p.Asn393Asn Synonymous 16/23 -
6-52843131-G-A GSTA4 c.*137C>T - 3-UTRSNV 7/7 -
6-52843131-G-T GSTA4 c.*137C>A - 3-UTRSNV 7/7 -
11-62763544-A-T SLC22A8 c.842T>A p.Val281Asp Missense 6/11 -
5-131726490-T-G SLC22A5 c.1161T>G p.Tyr387* Nonsense 7/10 -
11-62763544-A-G SLC22A8 c.842T>C p.Val281Ala Missense 6/11 -
3-121659860-C-T SLC15A2 c.*6C>T - 3-UTRSNV 22/22 -
3-119534153-C-G NR1I2 c.938-17C>G - IntronicSNV - 6/8
3-119534153-C-T NR1I2 c.938-17C>T - IntronicSNV - 6/8
1-98058899-C-T DPYD c.1003G>A p.Val335Met Missense 10/23 -
14-70245053-T-C SLC10A1 c.940A>G p.Lys314Glu Missense 4/5 -
1-98058899-C-A DPYD c.1003G>T p.Val335Leu Missense 10/23 -
1-113454637-C-A SLC16A1 c.*1876G>T - 3-UTRSNV 5/5 -
1-113454637-C-G SLC16A1 c.*1876G>C - 3-UTRSNV 5/5 -
2-169884648-T-C ABCB11 c.-28+3087A>G - intron_variant - 1/27
16-1273803-C-T TPSG1 c.74-209G>A - IntronicSNV - 2/5
1-171173089-G-A FMO2 c.713G>A p.Arg238Gln Missense 6/9 -
16-16138322-T-G ABCC1 c.825T>G p.Val275Val Synonymous 8/31 -
16-16138322-T-C ABCC1 c.825T>C p.Val275Val Synonymous 8/31 -
16-89623779-T-A SPG7 c.*278T>A - 3-UTRSNV 17/17 -
8-18258272-C-T NAT2 c.759C>T p.Val253Val Synonymous 2/2 -
8-18079653-C-T NAT1 c.97C>T p.Arg33* Nonsense 3/3 -
19-41518598-T-A CYP2B6 c.1172T>A p.Ile391Asn Missense 8/9 -
16-31103796-A-G VKORC1 c.283+837T>C - IntronicSNV - 2/2
4-100341861-C-T ADH7 c.690G>A p.Arg230Arg Synonymous 6/9 -
19-49096065-C-T SULT2B1 c.592C>T p.Leu198Leu Synonymous 4/6 -
10-73771784-G-A CHST3 c.*3555G>A - 3-UTRSNV 3/3 -
3-121659774-A-C SLC15A2 c.2110A>C p.Met704Leu Missense 22/22 -
12-58159210-G-C CYP27B1 c.459C>G p.Arg153Arg Synonymous 3/9 -
3-119534659-C-A NR1I2 c.1141C>A p.Arg381Arg Synonymous 8/9 -
4-74279326-G-A ALB c.1033G>A p.Glu345Lys Missense 8/15 -
10-82034933-C-T MAT1A c.791G>A p.Arg264His Missense 7/9 -
7-99358524-A-G CYP3A4 c.1331T>C p.Met444Thr Missense 12/13 -
20-52771261-G-A CYP24A1 c.*50C>T - 3_prime_UTR_variant 12/12 -
4-100266371-A-G ADH1C c.312T>C p.Cys104Cys Synonymous 4/9 -
12-22040823-G-A ABCC9 c.1848C>T p.Asp616Asp Synonymous 13/38 -
7-87079405-G-C ABCB4 c.712C>G p.Leu238Val Missense 8/28 -
7-87079405-G-A ABCB4 c.712C>T p.Leu238Phe Missense 8/28 -
12-58158230-C-T CYP27B1 c.1067G>A p.Ser356Asn Missense 6/9 -
16-69752373-C-T NQO1 c.72G>A p.Glu24Glu Synonymous 2/6 -
10-96798776-A-G CYP2C8 c.1169T>C p.Leu390Ser Missense 8/9 -
2-234580678-T-A UGT1A10 c.855+34655T>A - IntronicSNV - 1/4
16-16236431-G-A ABCC1 c.*1293G>A - 3-UTRSNV 31/31 -
16-16236431-G-T ABCC1 c.*1293G>T - 3-UTRSNV 31/31 -
15-75044552-G-A CYP1A2 c.1130G>A p.Arg377Gln Missense 5/7 -
17-19559758-C-T ALDH3A2 c.551C>T p.Thr184Met Missense 4/10 -
5-142659748-C-A NR3C1 c.*1706G>T - 3-UTRSNV 9/9 -
8-143994136-A-T CYP11B2 c.1208T>A p.Val403Glu Missense 8/9 -
12-21358855-A-C SLCO1B1 c.1385A>C p.Asp462Ala Missense 11/15 -
5-142659748-C-T NR3C1 c.*1706G>A - 3-UTRSNV 9/9 -
6-52767227-C-T GSTA3 c.189G>A p.Met63Ile Missense 4/7 -
19-41622481-G-C CYP2F1 c.293G>C p.Arg98Pro Missense 3/10 -
16-66974125-G-A CES2 c.424G>A - missense_variant,splice_region_variant 4/12 -
1-47280830-A-G CYP4B1 c.964A>G p.Ser322Gly Missense 8/12 -
1-47280859-G-A CYP4B1 c.993G>A p.Met331Ile Missense 8/12 -
4-71888232-C-G DCK c.356C>G p.Ala119Gly Missense 3/7 -
15-75012235-A-G CYP1A1 c.*595T>C - 3-UTRSNV 7/7 -
3-121615288-C-T SLC15A2 c.141C>T p.Ala47Ala Synonymous 2/22 -
6-35376403-C-A PPARD c.1-2462C>A - IntronicSNV - 2/7
11-64359079-G-C SLC22A12 c.51G>C p.Gln17His Missense 1/10 -
7-139706922-G-T TBXAS1 c.1169G>T p.Gly390Val Missense 10/13 -
6-35369806-C-T PPARD c.1-9059C>T - IntronicSNV - 2/7
19-41354629-C-A CYP2A6 c.383G>T p.Arg128Leu Missense 3/9 -
12-105155605-C-T CHST11 c.*4024C>T - 3-UTRSNV 3/3 -
19-41354629-C-G CYP2A6 c.383G>C p.Arg128Pro Missense 3/9 -
15-75042637-C-T CYP1A2 c.558C>T p.Phe186Phe Synonymous 2/7 -
15-75042637-C-A CYP1A2 c.558C>A p.Phe186Leu Missense 2/7 -
2-234581306-T-G UGT1A10 c.855+35283T>G - IntronicSNV - 1/4
4-70160299-A-G UGT2B28 c.1362A>G p.Val454Val Synonymous 6/6 -
3-14474225-T-C SLC6A6 c.-3-10907T>C - intron_variant - 2/14
1-226019500-T-C EPHX1 c.204T>C p.Asp68Asp Synonymous 3/9 -
12-21475091-C-T SLCO1A2 c.61-3234G>A - IntronicSNV - 1/13
7-87179809-C-A ABCB1 c.1199G>T p.Ser400Ile Missense 12/29 -
17-19561059-C-T ALDH3A2 c.682C>T p.Arg228Cys Missense 5/10 -
21-46961496-T-C SLC19A1 c.-50+786A>G - intron_variant - 1/5
7-87179809-C-T ABCB1 c.1199G>A p.Ser400Asn Missense 12/29 -
6-35322975-A-G PPARD c.-102+8048A>G - intron_variant - 2/7
6-35322975-A-T PPARD c.-102+8048A>T - intron_variant - 2/7
6-18143901-C-A TPMT c.292G>T p.Glu98* Nonsense 4/9 -
7-75616105-G-A POR c.*306G>A - 3-UTRSNV 16/16 -
1-171174531-A-G FMO2 c.941A>G p.Glu314Gly Missense 7/9 -
19-41354533-A-T CYP2A6 c.479T>A p.Leu160His Missense 3/9 -
10-101544447-A-T ABCC2 c.116A>T p.Tyr39Phe Missense 2/32 -
14-23282152-G-A SLC7A7 c.456C>T p.Phe152Phe Synonymous 3/11 -
1-60359335-A-T CYP2J2 c.1497T>A p.Val499Val Synonymous 9/9 -
8-70744812-G-A SLCO5A1 c.97C>T p.Leu33Phe Missense 2/10 -
3-121648168-G-A SLC15A2 c.1526G>A p.Arg509Lys Missense 17/22 -
10-96741058-C-G CYP2C9 c.1080C>G p.Asp360Glu Missense 7/9 -
8-143955074-A-T CYP11B1 c.*715T>A - 3-UTRSNV 9/9 -
6-160828142-T-C SLC22A3 c.603T>C p.Phe201Phe Synonymous 3/11 -
6-160557260-C-T SLC22A1 c.848C>T p.Pro283Leu Missense 5/11 -
11-74876951-G-A SLCO2B1 c.405G>A p.Pro135Pro Synonymous 4/14 -
19-41515255-C-T CYP2B6 c.777C>T p.Ser259Ser Synonymous 5/9 -
10-101590120-G-C ABCC2 c.2677G>C p.Glu893Gln Missense 20/32 -
6-35362848-T-C PPARD c.1-16017T>C - IntronicSNV - 2/7
7-87138659-A-T ABCB1 c.3421T>A p.Ser1141Thr Missense 27/29 -
6-46563817-A-G CYP39A1 c.912T>C p.Asn304Asn Synonymous 8/12 -
10-101590120-G-A ABCC2 c.2677G>A p.Glu893Lys Missense 20/32 -
16-31104509-C-T VKORC1 c.283+124G>A - IntronicSNV - 2/2
16-31104509-C-G VKORC1 c.283+124G>C - IntronicSNV - 2/2
19-16003388-G-A CYP4F2 c.348C>T p.Ala116Ala Synonymous 4/13 -
19-16003388-G-C CYP4F2 c.348C>G p.Ala116Ala Synonymous 4/13 -
16-31102655-G-A VKORC1 c.292C>T p.Arg98Trp Missense 3/3 -
10-96798749-T-C CYP2C8 c.1196A>G p.Lys399Arg Missense 8/9 -
4-71888240-C-T DCK c.364C>T p.Pro122Ser Missense 3/7 -
1-171076966-G-A FMO3 c.472G>A p.Glu158Lys Missense 4/9 -
7-139636010-G-A TBXAS1 c.357G>A p.Lys119Lys Synonymous 5/13 -
7-139636010-G-T TBXAS1 c.357G>T p.Lys119Asn Missense 5/13 -
7-139636010-G-C TBXAS1 c.357G>C p.Lys119Asn Missense 5/13 -
6-35371753-A-G PPARD c.1-7112A>G - IntronicSNV - 2/7
6-46624537-G-A SLC25A27 c.298+766G>A - IntronicSNV - 2/8
9-75543888-T-C ALDH1A1 c.362A>G p.Asn121Ser Missense 4/13 -
19-41381503-C-G CYP2A7 c.*95G>C - 3-UTRSNV 8/8 -
6-160543229-T-A SLC22A1 c.262T>A p.Cys88Ser Missense 1/11 -
2-38298404-C-G CYP1B1 c.1093G>C p.Gly365Arg Missense 3/3 -
2-38298404-C-A CYP1B1 c.1093G>T p.Gly365Trp Missense 3/3 -
7-139717487-C-T TBXAS1 c.1381C>T - missense_variant 12/13 -
19-41600808-C-T CYP2A13 c.1162-56C>T - IntronicSNV - 7/8
1-98165062-C-T DPYD c.525G>A p.Ser175Ser Synonymous 6/23 -
9-86917301-T-C SLC28A3 c.338A>G p.Tyr113Cys Missense 6/19 -
6-52767028-G-C GSTA3 c.272+116C>G - IntronicSNV - 4/6
6-52767028-G-A GSTA3 c.272+116C>T - IntronicSNV - 4/6
2-234580678-T-C UGT1A9 c.98T>C p.Met33Thr Missense 1/5 -
7-99358459-G-C CYP3A4 c.1396C>G p.Pro466Ala Missense 12/13 -
7-139717487-C-G TBXAS1 c.1381C>G - missense_variant 12/13 -
7-139717487-C-A TBXAS1 c.1381C>A - synonymous_variant 12/13 -
19-41622481-G-A CYP2F1 c.293G>A p.Arg98His Missense 3/10 -
16-89617008-C-G SPG7 c.1770C>G p.Ala590Ala Synonymous 13/17 -
10-101591737-T-A ABCC2 c.3107T>A p.Ile1036Lys Missense 23/32 -
10-101591737-T-C ABCC2 c.3107T>C p.Ile1036Thr Missense 23/32 -
11-114182507-C-T NNMT c.363-260C>T - IntronicSNV - 2/2
3-142839415-G-C CHST2 c.1-244G>C - IntronicSNV 1/2 -
18-24496917-T-G CHST9 c.638A>C p.Lys213Thr Missense 6/6 -
7-139655297-C-G TBXAS1 c.582C>G p.Val194Val Synonymous 7/13 -
6-44198362-T-C SLC29A1 c.647T>C p.Ile216Thr Missense 8/14 -
10-96818106-T-A CYP2C8 c.805A>T p.Ile269Phe Missense 5/9 -
7-99367788-C-T CYP3A4 c.389G>A p.Arg130Gln Missense 5/13 -
7-99367788-C-G CYP3A4 c.389G>C p.Arg130Pro Missense 5/13 -
10-82033438-T-A MAT1A c.*99A>T - 3-UTRSNV 9/9 -
15-75013804-C-A CYP1A1 c.993G>T p.Met331Ile Missense 4/7 -
16-16139720-G-T ABCC1 c.1068G>T p.Thr356Thr Synonymous 9/31 -
1-171083232-G-A FMO3 c.913G>A p.Glu305Lys Missense 7/9 -
7-99359829-G-A CYP3A4 c.1085C>T p.Thr362Met Missense 11/13 -
7-99359829-G-T CYP3A4 c.1085C>A p.Thr362Lys Missense 11/13 -
6-35358945-C-G PPARD c.1-19920C>G - IntronicSNV - 2/7
2-169830328-A-C ABCB11 c.1331T>G p.Val444Gly Missense 13/28 -
6-35358945-C-T PPARD c.1-19920C>T - IntronicSNV - 2/7
2-169830328-A-T ABCB11 c.1331T>A p.Val444Asp Missense 13/28 -
21-37518362-A-T CBR3 c.398-12A>T - IntronicSNV - 2/2
12-21355583-A-T SLCO1B1 c.1294A>T p.Asn432Tyr Missense 10/15 -
14-77795520-A-G GSTZ1 c.397A>G p.Asn133Asp Missense 6/9 -
12-21355583-A-G SLCO1B1 c.1294A>G p.Asn432Asp Missense 10/15 -
7-87179443-G-A ABCB1 c.1350+44C>T - IntronicSNV - 13/28
8-18080308-A-T NAT1 c.752A>T p.Asp251Val Missense 3/3 -
19-41352941-A-G CYP2A6 c.670T>C p.Ser224Pro Missense 5/9 -
1-60366757-T-A CYP2J2 c.1210A>T p.Asn404Tyr Missense 8/9 -
16-69743760-A-T NQO1 c.*1119T>A - 3-UTRSNV 6/6 -
13-99358401-C-G SLC15A1 c.1256G>C p.Gly419Ala Missense 16/23 -
8-18258316-G-A NAT2 c.803G>A p.Arg268Lys Missense 2/2 -
8-18258316-G-T NAT2 c.803G>T p.Arg268Ile Missense 2/2 -
2-31572992-G-A XDH c.2729C>T p.Thr910Met Missense 25/36 -
1-20945055-C-T CDA c.435C>T p.Thr145Thr Synonymous 4/4 -
15-74659880-C-T CYP11A1 c.47G>A p.Cys16Tyr Missense 1/9 -
1-171086490-G-C FMO3 c.1507G>C p.Gly503Arg Missense 9/9 -
12-105152960-A-G CHST11 c.*1379A>G - 3-UTRSNV 3/3 -
7-99365983-A-G CYP3A4 c.664T>C p.Ser222Pro Missense 7/13 -
7-99365983-A-T CYP3A4 c.664T>A p.Ser222Thr Missense 7/13 -
20-61303290-C-T SLCO4A1 c.*45C>T - 3-UTRSNV 12/12 -
2-31572992-G-C XDH c.2729C>G p.Thr910Arg Missense 25/36 -
2-31572992-G-T XDH c.2729C>A p.Thr910Lys Missense 25/36 -
15-92689112-A-G SLCO3A1 c.1513-1102A>G - IntronicSNV - 7/9
10-96707539-C-T CYP2C9 c.485C>T p.Ser162Leu Missense 4/9 -
3-121647286-C-T SLC15A2 c.1225C>T p.Pro409Ser Missense 15/22 -
3-183637722-T-G ABCC5 c.*1366A>C - 3-UTRSNV 30/30 -
2-169789016-T-C ABCB11 c.3084A>G p.Ala1028Ala Synonymous 24/28 -
19-15728933-C-T CYP4F8 c.321C>T p.Val107Val Synonymous 3/14 -
2-169780295-C-T ABCB11 c.3803G>A p.Arg1268Gln Missense 28/28 -
16-16177275-G-A ABCC1 c.2168G>A p.Arg723Gln Missense 17/31 -
12-21331625-C-T SLCO1B1 c.597C>T p.Phe199Phe Synonymous 6/15 -
15-75013804-C-T CYP1A1 c.993G>A p.Met331Ile Missense 4/7 -
8-27361241-C-T EPHX2 c.307C>T p.Arg103Cys Missense 3/19 -
1-171076936-G-T FMO3 c.442G>T p.Gly148* Nonsense 4/9 -
12-21459854-T-A SLCO1A2 c.404A>T p.Asn135Ile Missense 4/14 -
7-99364798-A-T CYP3A4 c.751T>A p.Ser251Thr Missense 8/13 -
7-99364798-A-C CYP3A4 c.751T>G p.Ser251Ala Missense 8/13 -
2-234665782-G-A UGT1A4 c.868-9898G>A - IntronicSNV - 1/4
4-100128682-C-T ADH6 c.885G>A p.Val295Val Synonymous 7/8 -
4-100140306-A-C ADH6 c.4T>G p.Cys2Gly Missense 1/8 -
2-234637905-C-T UGT1A3 c.133C>T p.Arg45Trp Missense 1/5 -
2-108910712-A-G SULT1C2 c.179A>G p.Asp60Gly Missense 3/9 -
19-16001215-C-A CYP4F2 c.554G>T p.Gly185Val Missense 6/13 -
7-94946084-A-C PON1 c.163T>G p.Leu55Val Missense 3/9 -
19-41497346-A-T CYP2B6 c.136A>T p.Met46Leu Missense 1/9 -
8-143955095-A-C CYP11B1 c.*694T>G - 3-UTRSNV 9/9 -
1-110213953-G-T GSTM2 c.405G>T p.Leu135Leu Synonymous 6/8 -
19-41622189-G-T CYP2F1 c.96G>T p.Pro32Pro Synonymous 2/10 -
6-44197181-G-T SLC29A1 c.84G>T p.Pro28Pro Synonymous 4/14 -
2-38298328-C-T CYP1B1 c.1169G>A p.Arg390His Missense 3/3 -
7-99381661-A-G CYP3A4 c.44T>C p.Leu15Pro Missense 1/13 -
12-58158558-C-T CYP27B1 c.942G>A p.Leu314Leu Synonymous 5/9 -
10-101604163-C-T ABCC2 c.3928C>T p.Arg1310* Nonsense 28/32 -
2-234526668-G-A UGT1A8 c.315G>A p.Leu105Leu Synonymous 1/5 -
7-139661890-T-C TBXAS1 c.992T>C - missense_variant 9/13 -
2-234526666-T-A UGT1A8 c.313T>A p.Leu105Met Missense 1/5 -
7-87178727-C-G ABCB1 c.1662G>C p.Leu554Leu Synonymous 15/29 -
1-47279175-C-T CYP4B1 c.517C>T p.Arg173Trp Missense 5/12 -
11-17434263-G-A ABCC8 c.2506C>T p.Arg836* Nonsense 21/39 -
1-110283069-C-A GSTM3 c.1-160G>T - 5-UTRSNV 2/9 -
7-95041718-T-C PON2 c.273A>G p.Lys91Lys Synonymous 4/9 -
10-73772999-G-A CHST3 c.*4770G>A - 3-UTRSNV 3/3 -
19-41512792-C-T CYP2B6 c.485-18C>T - IntronicSNV - 3/8
4-89034649-C-A ABCG2 c.1000G>T p.Glu334* Nonsense 9/16 -
14-70245977-A-G SLC10A1 c.668T>C p.Ile223Thr Missense 3/5 -
12-21476591-G-A SLCO1A2 c.61-4734C>T - IntronicSNV - 1/13
9-75545882-G-A ALDH1A1 c.225C>T p.Ser75Ser Synonymous 3/13 -
6-35363730-G-A PPARD c.1-15135G>A - IntronicSNV - 2/7
7-99366081-A-G CYP3A4 c.566T>C p.Phe189Ser Missense 7/13 -
19-41622189-G-A CYP2F1 c.96G>A p.Pro32Pro Synonymous 2/10 -
11-66133643-G-A SLC29A2 c.927C>T p.Pro309Pro Synonymous 9/12 -
10-101610533-C-T ABCC2 c.4488C>T p.His1496His Synonymous 31/32 -
10-82033470-G-A MAT1A c.*67C>T - 3-UTRSNV 9/9 -
15-51507967-C-T CYP19A1 c.791G>A p.Arg264His Missense 7/10 -
19-41354629-C-T CYP2A6 c.383G>A p.Arg128Gln Missense 3/9 -
7-87178727-C-T ABCB1 c.1662G>A p.Leu554Leu Synonymous 15/29 -
7-94937439-C-T PON1 c.582G>A p.Trp194* Nonsense 6/9 -
20-48156189-G-A PTGIS c.591C>T p.Arg197Arg Synonymous 5/10 -
7-87230193-A-G ABCB1 c.-129T>C - 5_prime_UTR_variant 2/29 -
6-35335290-G-A PPARD c.-102+20363G>A - intron_variant - 2/7
2-234545773-C-T UGT1A10 c.605C>T p.Thr202Ile Missense 1/5 -
7-87165854-C-T ABCB1 c.2401G>A p.Val801Met Missense 21/29 -
4-115544714-A-G UGT8 c.678A>G p.Pro226Pro Synonymous 1/5 -
7-87145914-C-T ABCB1 c.2995G>A p.Ala999Thr Missense 25/29 -
6-46624537-G-C SLC25A27 c.298+766G>C - IntronicSNV - 2/8
1-150814923-A-C ARNT c.228-2793T>G - IntronicSNV - 4/20
22-24300580-C-T GSTT2B c.417G>A p.Met139Ile Missense 4/5 -
10-96748737-A-T CYP2C9 c.1425A>T p.Gly475Gly Synonymous 9/9 -
8-70584809-T-G SLCO5A1 c.*295A>C - 3-UTRSNV 10/10 -
6-43273604-A-C CRIP3 c.563T>G p.Ile188Ser Missense 8/8 -
12-58159210-G-A CYP27B1 c.459C>T p.Arg153Arg Synonymous 3/9 -
18-24628442-T-G CHST9 c.147A>C p.Gln49His Missense 3/6 -
15-75014049-G-A CYP1A1 c.835C>T p.Arg279Trp Missense 3/7 -
17-37826355-A-T PNMT c.562A>T p.Ser188Cys Missense 3/3 -
7-139715645-C-A TBXAS1 c.1349C>A - missense_variant 11/13 -
2-169779712-T-C ABCB11 c.*420A>G - 3-UTRSNV 28/28 -
2-234527183-G-A UGT1A8 c.830G>A p.Cys277Tyr Missense 1/5 -
13-95673135-C-T ABCC4 c.*694G>A - 3-UTRSNV 31/31 -
6-43273604-A-G CRIP3 c.563T>C p.Ile188Thr Missense 8/8 -
3-119533733-G-T NR1I2 c.795-93G>T - IntronicSNV - 5/8
3-119533733-G-A NR1I2 c.795-93G>A - IntronicSNV - 5/8
22-42523858-T-G CYP2D6 c.971A>C p.His324Pro Missense 6/9 -
7-87145914-C-A ABCB1 c.2995G>T p.Ala999Ser Missense 25/29 -
11-17483210-G-A ABCC8 c.742C>T p.Arg248* Nonsense 5/39 -
11-17483210-G-T ABCC8 c.742C>A p.Arg248Arg Synonymous 5/39 -
1-97981421-C-T DPYD c.1601G>A p.Ser534Asn Missense 13/23 -
12-21329817-A-G SLCO1B1 c.467A>G p.Glu156Gly Missense 5/15 -
1-226016575-C-G EPHX1 c.145C>G p.Arg49Gly Missense 2/9 -
10-101606861-G-T ABCC2 c.4290G>T p.Val1430Val Synonymous 30/32 -
2-169783827-G-C ABCB11 c.3457C>G p.Arg1153Gly Missense 26/28 -
20-48129706-G-T PTGIS c.1117C>A p.Arg373Arg Synonymous 8/10 -
1-150795840-C-A ARNT c.1198-19G>T - IntronicSNV - 12/20
2-169877085-T-C ABCB11 c.1-2450A>G - IntronicSNV - 1/27
3-14467432-T-C SLC6A6 c.-4+9471T>C - intron_variant - 2/14
3-14467432-T-G SLC6A6 c.-4+9471T>G - intron_variant - 2/14
3-183696387-G-A ABCC5 c.1200C>T p.Ser400Ser Synonymous 9/30 -
3-12475557-C-T PPARG c.1347C>T p.His449His Synonymous 7/7 -
2-169828550-T-C ABCB11 c.1445A>G p.Asp482Gly Missense 14/28 -
20-48124462-G-A PTGIS c.1498C>T p.Pro500Ser Missense 10/10 -
14-70246018-A-G SLC10A1 c.627T>C p.Asn209Asn Synonymous 3/5 -
15-75013563-G-T CYP1A1 c.1143C>A p.Phe381Leu Missense 5/7 -
20-52786219-G-A CYP24A1 c.552C>T p.Ala184Ala Synonymous 4/12 -
8-18080001-G-A NAT1 c.445G>A p.Val149Ile Missense 3/3 -
12-21457434-T-G SLCO1A2 c.516A>C p.Glu172Asp Missense 5/14 -
10-96709037-A-G CYP2C9 c.815A>G p.Glu272Gly Missense 5/9 -
13-103710684-C-A SLC10A2 c.426G>T p.Pro142Pro Synonymous 2/6 -
11-62767307-G-T SLC22A8 c.445C>A p.Arg149Ser Missense 4/11 -
11-62767307-G-A SLC22A8 c.445C>T p.Arg149Cys Missense 4/11 -
7-99454482-G-A CYP3A43 c.495G>A p.Met165Ile Missense 6/10 -
4-70346564-G-C UGT2B4 c.1375C>G p.Arg459Gly Missense 6/6 -
9-86900926-G-A SLC28A3 c.1381C>T p.Leu461Leu Synonymous 14/19 -
6-43270151-C-T SLC22A7 c.1269C>T p.Ser423Ser Synonymous 7/10 -
10-73772014-G-C CHST3 c.*3785G>C - 3-UTRSNV 3/3 -
3-119500035-C-T NR1I2 c.-1135C>T - 5_prime_UTR_variant 1/9 -
2-201534389-A-G AOX1 c.3890A>G p.His1297Arg Missense 34/35 -
16-87866138-G-C SLC7A5 c.*438C>G - 3-UTRSNV 10/10 -
7-99454482-G-C CYP3A43 c.495G>C p.Met165Ile Missense 6/10 -
12-21331599-T-C SLCO1B1 c.571T>C p.Leu191Leu Synonymous 6/15 -
4-70346564-G-T UGT2B4 c.1375C>A p.Arg459Arg Synonymous 6/6 -
7-87160645-G-A ABCB1 c.2650C>T p.Leu884Leu Synonymous 22/29 -
13-95673791-A-C ABCC4 c.*38T>G - 3-UTRSNV 31/31 -
6-52698964-T-C GSTA5 c.389A>G p.Asn130Ser Missense 5/7 -
3-119530497-G-A NR1I2 c.443G>A p.Arg148Gln Missense 4/9 -
3-183685534-A-G ABCC5 c.1782T>C p.Cys594Cys Synonymous 12/30 -
22-42523843-C-G CYP2D6 c.985+1G>C - IntronicSNV - 6/8
22-42523843-C-T CYP2D6 c.985+1G>A - IntronicSNV - 6/8
11-114183137-A-C NNMT c.733A>C p.Thr245Pro Missense 3/3 -
2-234527001-A-C UGT1A8 c.648A>C p.Glu216Asp Missense 1/5 -
2-234527001-A-G UGT1A8 c.648A>G p.Glu216Glu Synonymous 1/5 -
10-101595975-G-A ABCC2 c.3542G>A p.Arg1181Gln Missense 25/32 -
3-12458208-C-T PPARG c.741C>T p.Phe247Phe Synonymous 6/7 -
7-87214875-G-T ABCB1 c.239C>A p.Ala80Glu Missense 5/29 -
19-34175603-C-A CHST8 c.-589C>A - 5_prime_UTR_variant 1/4 -
13-99338531-C-T SLC15A1 c.1848G>A p.Ser616Ser Synonymous 22/23 -
1-171178090-T-C FMO2 c.1414T>C - Missense 9/9 -
16-69744774-T-G NQO1 c.*105A>C - 3-UTRSNV 6/6 -
2-38298092-G-A CYP1B1 c.1405C>T p.Arg469Trp Missense 3/3 -
19-49096065-C-G SULT2B1 c.592C>G p.Leu198Val Missense 4/6 -
1-171083479-G-A FMO3 c.1160G>A p.Arg387His Missense 7/9 -
8-18080440-A-C NAT1 c.*11A>C - 3-UTRSNV 3/3 -
7-91743150-A-G CYP51A1 c.1359T>C p.His453His Synonymous 10/10 -
13-52585548-G-T ATP7B c.1-75C>A - 5-UTRSNV 1/21 -
13-95673518-T-C ABCC4 c.*311A>G - 3-UTRSNV 31/31 -
10-73769543-G-A CHST3 c.*1314G>A - 3-UTRSNV 3/3 -
12-22063115-A-G ABCC9 c.1296T>C p.Pro432Pro Synonymous 8/38 -
3-119530542-A-G NR1I2 c.488A>G p.Asp163Gly Missense 4/9 -
11-74907421-G-T SLCO2B1 c.1434-138G>T - IntronicSNV - 9/13
4-71859622-A-T DCK c.70A>T p.Ile24Phe Missense 1/7 -
19-41599665-C-T CYP2A13 c.962C>T p.Pro321Leu Missense 6/9 -
22-42522613-G-C CYP2D6 c.1457C>G p.Thr486Ser Missense 9/9 -
4-69536084-A-C UGT2B15 c.253T>G p.Tyr85Asp Missense 1/6 -
15-45554267-C-A SLC28A2 c.225C>A p.Ser75Arg Missense 4/18 -
15-75042142-C-G CYP1A2 c.63C>G p.Phe21Leu Missense 2/7 -
12-105154087-G-A CHST11 c.*2506G>A - 3-UTRSNV 3/3 -
6-35362525-G-A PPARD c.1-16340G>A - IntronicSNV - 2/7
6-35362525-G-C PPARD c.1-16340G>C - IntronicSNV - 2/7
2-108925749-G-C SULT1C2 c.*829G>C - 3-UTRSNV 9/9 -
1-171174762-G-C FMO2 c.1172G>C p.Arg391Thr Missense 7/9 -
15-75045575-G-A CYP1A2 c.1217G>A p.Cys406Tyr Missense 6/7 -
16-31103545-T-A VKORC1 c.284-882A>T - IntronicSNV - 2/2
1-110201699-T-C GSTM4 c.534T>C p.Phe178Phe Synonymous 7/8 -
18-662215-T-C TYMS c.349T>C p.Phe117Leu Missense 3/7 -
8-18079577-T-G NAT1 c.21T>G p.Leu7Leu Synonymous 3/3 -
7-75616105-G-C POR c.*306G>C - 3-UTRSNV 16/16 -
2-108925077-A-T SULT1C2 c.*157A>T - 3-UTRSNV 9/9 -
10-101610455-G-A ABCC2 c.4410G>A p.Glu1470Glu Synonymous 31/32 -
10-104590702-C-T CYP17A1 c.1284G>A p.Pro428Pro Synonymous 8/8 -
1-171086490-G-A FMO3 c.1507G>A p.Gly503Arg Missense 9/9 -
4-71859622-A-G DCK c.70A>G p.Ile24Val Missense 1/7 -
10-73769590-C-T CHST3 c.*1361C>T - 3-UTRSNV 3/3 -
10-96798735-G-C CYP2C8 c.1210C>G p.Pro404Ala Missense 8/9 -
3-14530721-A-G GRIP2 c.*4452T>C - 3_prime_UTR_variant 25/25 -
19-48389425-A-G SULT2A1 c.90T>C p.Phe30Phe Synonymous 1/6 -
2-219677004-C-A CYP27A1 c.506C>A p.Ala169Glu Missense 3/9 -
2-219677004-C-T CYP27A1 c.506C>T p.Ala169Val Missense 3/9 -
20-52774635-A-G CYP24A1 c.1226T>C p.Leu409Ser Missense 9/12 -
19-41352912-T-C CYP2A6 c.699A>G p.Pro233Pro Synonymous 5/9 -
13-95672547-A-G ABCC4 c.*1282T>C - 3-UTRSNV 31/31 -
1-171179477-C-T FMO2 c.*1193C>T - 3_prime_UTR_variant 9/9 -
12-21392011-A-G SLCO1B1 c.1964A>G p.Asp655Gly Missense 15/15 -
22-51064399-A-C ARSA c.1072T>G p.Phe358Val Missense 6/8 -
4-100349669-C-G ADH7 c.275G>C p.Gly92Ala Missense 3/9 -
19-41700469-G-A CYP2S1 c.198G>A p.Pro66Pro Synonymous 2/9 -
1-171176879-G-A FMO2 c.1206G>A p.Glu402Glu Synonymous 8/9 -
22-19951804-G-A COMT c.597G>A p.Pro199Pro Synonymous 5/6 -
7-87021023-G-C CROT c.1420G>C p.Val474Leu Missense 14/18 -
8-143955097-C-A CYP11B1 c.*692G>T - 3-UTRSNV 9/9 -
8-143955097-C-T CYP11B1 c.*692G>A - 3-UTRSNV 9/9 -
19-41497346-A-G CYP2B6 c.136A>G p.Met46Val Missense 1/9 -
19-16045141-T-C CYP4F11 c.78A>G p.Gly26Gly Synonymous 1/12 -
1-110282891-T-G GSTM3 c.19A>C p.Met7Leu Missense 2/9 -
1-110282891-T-C GSTM3 c.19A>G p.Met7Val Missense 2/9 -
6-35337958-T-G PPARD c.-102+23031T>G - intron_variant - 2/7
10-73772014-G-T CHST3 c.*3785G>T - 3-UTRSNV 3/3 -
5-74652199-A-G HMGCR c.1912A>G p.Ile638Val Missense 15/20 -
8-59407065-C-T CYP7A1 c.1039G>A p.Asp347Asn Missense 4/6 -
12-21329802-A-G SLCO1B1 c.452A>G p.Asn151Ser Missense 5/15 -
10-101578577-C-A ABCC2 c.2302C>A p.Arg768Arg Synonymous 18/32 -
2-169881691-A-T ABCB11 c.-28+6044T>A - intron_variant - 1/27
7-87133655-G-C ABCB1 c.3747C>G p.Gly1249Gly Synonymous 29/29 -
15-75044578-A-G CYP1A2 c.1156A>G p.Ile386Val Missense 5/7 -
1-98058867-A-G DPYD c.1035T>C p.Phe345Phe Synonymous 10/23 -
1-226032229-C-T EPHX1 c.1071C>T p.Asn357Asn Synonymous 8/9 -
1-20916791-A-G CDA c.154+1015A>G - IntronicSNV - 1/3
2-38298383-T-A CYP1B1 c.1114A>T p.Met372Leu Missense 3/3 -
16-16215891-G-A ABCC1 c.3450G>A p.Pro1150Pro Synonymous 24/31 -
6-52708797-G-A GSTA5 c.-31+2057C>T - intron_variant - 1/6
10-101578577-C-T ABCC2 c.2302C>T p.Arg768Trp Missense 18/32 -
16-31103545-T-C VKORC1 c.284-882A>G - IntronicSNV - 2/2
10-96612671-A-T CYP2C19 c.1473A>T - Missense 9/9 -
2-169881691-A-G ABCB11 c.-28+6044T>C - intron_variant - 1/27
8-59403576-C-T CYP7A1 c.*458G>A - 3-UTRSNV 6/6 -
4-70455150-T-C UGT2A2 c.1551A>G p.Gln517Gln Synonymous 6/6 -
13-52523808-C-T ATP7B c.2855G>A p.Arg952Lys Missense 12/21 -
19-48389425-A-T SULT2A1 c.90T>A p.Phe30Leu Missense 1/6 -
7-139653197-C-A TBXAS1 c.484C>A p.Leu162Ile Missense 6/13 -
7-139653197-C-G TBXAS1 c.484C>G p.Leu162Val Missense 6/13 -
15-74635369-G-A CYP11A1 c.939C>T p.Phe313Phe Synonymous 5/9 -
19-41510282-A-G CYP2B6 c.415A>G p.Lys139Glu Missense 3/9 -
2-169801403-T-C ABCB11 c.2412A>G p.Ala804Ala Synonymous 20/28 -
4-70455478-G-T UGT2A2 c.1332-109C>A - IntronicSNV - 5/5