PMID: 27701660

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.

JAMA
LA Lotta, SJ Sharp, S Burgess, JRB Perry, ID Stewart, SM Willems, J Luan, E Ardanaz, L Arriola, B Balkau, H Boeing, P Deloukas, NG Forouhi, PW Franks, S Grioni, R Kaaks, TJ Key, C Navarro, PM Nilsson, K Overvad, D Palli, S Panico, JR QuirĂ³s, E Riboli, O Rolandsson, C Sacerdote, EC Salamanca, N Slimani, AM Spijkerman, A Tjonneland, R Tumino, DL van der A, YT van der Schouw, MI McCarthy, I Barroso, S O'Rahilly, DB Savage, N Sattar, C Langenberg, RA Scott, NJ Wareham
2016-10-04

16 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-44682938-G-A OGDH c.223-1988G>A - IntronicSNV - 2/8
1-55638546-T-C USP24 c.559-353A>G - IntronicSNV - 3/67
2-44072576-G-T ABCG8 c.166-718G>T - IntronicSNV - 2/12
7-44200884-T-C GCK c.46-7822A>G - IntronicSNV - 1/9
5-74656539-T-G HMGCR c.*372T>G - 3-UTRSNV 20/20 -
5-74648496-G-T HMGCR c.1368+1069G>T - IntronicSNV - 11/19
5-74675717-T-G COL4A3BP c.1748-419A>C - IntronicSNV - 16/17
1-55521242-T-G PCSK9 c.800-424T>G - IntronicSNV - 5/11
1-55521242-T-A PCSK9 c.800-424T>A - IntronicSNV - 5/11
5-74890618-A-G POLK c.1528+744A>G - IntronicSNV - 12/14
1-55518752-C-T PCSK9 c.799+288C>T - IntronicSNV - 5/11
1-55517344-C-G PCSK9 c.524-607C>G - IntronicSNV - 3/11
1-55517344-C-T PCSK9 c.524-607C>T - IntronicSNV - 3/11
2-44072576-G-C ABCG8 c.166-718G>C - IntronicSNV - 2/12
1-55505647-G-A PCSK9 c.137G>A p.Arg46His Missense 1/12 -
5-74656539-T-C HMGCR c.*372T>C - 3-UTRSNV 20/20 -