PMID: 27984508

Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics and genomics

DH Hovelson, Z Xue, M Zawistowski, MG Ehm, EC Harris, SL Stocker, AS Gross, IJ Jang, I Ieiri, JE Lee, LR Cardon, SL Chissoe, G Abecasis, MR Nelson

2017-03

1419 variants were identified in this publication

Variant ID	Gene	cDNA	Protein	Consequence	Exon	Intron
15-75042581-G-A	CYP1A2	c.502G>A	p.Glu168Lys	Missense	2/7	-
2-234621825-T-C	UGT1A10	c.856-53855T>C	-	IntronicSNV	-	1/4
5-131663062-T-C	SLC22A4	c.917T>C	p.Ile306Thr	Missense	5/10	-
15-75045612-G-C	CYP1A2	c.1253+1G>C	-	IntronicSNV	-	6/6
15-75045612-G-A	CYP1A2	c.1253+1G>A	-	IntronicSNV	-	6/6
2-234601707-A-T	UGT1A10	c.855+55684A>T	-	IntronicSNV	-	1/4
7-99358459-G-A	CYP3A4	c.1396C>T	p.Pro466Ser	Missense	12/13	-
4-69433950-C-A	UGT2B17	c.253G>T	p.Asp85Tyr	Missense	1/6	-
2-234526680-T-A	UGT1A8	c.327T>A	p.Phe109Leu	Missense	1/5	-
8-18257916-C-G	NAT2	c.403C>G	p.Leu135Val	Missense	2/2	-
22-42523534-AC-ACAC	CYP2D6	c.1088_1089dup	p.Gln364Cysfs*12	Frameshift	7/9	-
4-70160343-G-A	UGT2B28	c.1406G>A	p.Cys469Tyr	Missense	6/6	-
7-99262860-T-C	CYP3A5	c.599A>G	p.Gln200Arg	Missense	7/13	-
8-143957163-C-G	CYP11B1	c.1086G>C	p.Leu362Leu	Synonymous	6/9	-
15-75012940-G-A	CYP1A1	c.1429C>T	p.Arg477Trp	Missense	7/7	-
15-75012940-G-C	CYP1A1	c.1429C>G	p.Arg477Gly	Missense	7/7	-
19-41349759-T-C	CYP2A6	c.1427A>G	p.Lys476Arg	Missense	9/9	-
19-48377926-G-A	SULT2A1	c.733C>T	p.Leu245Phe	Missense	5/6	-
2-234591340-T-G	UGT1A10	c.855+45317T>G	-	IntronicSNV	-	1/4
10-106022789-C-A	GSTO1	c.419C>A	p.Ala140Asp	Missense	4/6	-
2-234622282-C-G	UGT1A10	c.856-53398C>G	-	IntronicSNV	-	1/4
2-234622282-C-T	UGT1A10	c.856-53398C>T	-	IntronicSNV	-	1/4
22-42526721-G-A	CYP2D6	c.73C>T	p.Arg25Trp	Missense	1/9	-
3-121643804-C-G	SLC15A2	c.1048C>G	p.Leu350Val	Missense	13/22	-
3-121643804-C-T	SLC15A2	c.1048C>T	p.Leu350Phe	Missense	13/22	-
10-96541615-C-T	CYP2C19	c.680C>T	p.Pro227Leu	Missense	5/9	-
8-18080333-T-C	NAT1	c.777T>C	p.Ser259Ser	Synonymous	3/3	-
8-18080333-T-G	NAT1	c.777T>G	p.Ser259Arg	Missense	3/3	-
16-16235077-C-T	ABCC1	c.4535C>T	p.Ser1512Leu	Missense	31/31	-
13-95839008-T-C	ABCC4	c.1492A>G	p.Lys498Glu	Missense	11/31	-
6-160671651-G-A	SLC22A2	c.602C>T	p.Thr201Met	Missense	3/11	-
2-234627937-T-C	UGT1A4	c.471T>C	p.Cys157Cys	Synonymous	1/5	-
6-160679630-G-A	SLC22A2	c.160C>T	p.Pro54Ser	Missense	1/11	-
10-101578641-C-G	ABCC2	c.2366C>G	p.Ser789Cys	Missense	18/32	-
10-101578641-C-T	ABCC2	c.2366C>T	p.Ser789Phe	Missense	18/32	-
10-101595954-G-A	ABCC2	c.3521G>A	p.Arg1174His	Missense	25/32	-
1-171080080-G-A	FMO3	c.769G>A	p.Val257Met	Missense	6/9	-
6-160679400-C-T	SLC22A2	c.390G>A	p.Thr130Thr	Synonymous	1/11	-
6-160679400-C-A	SLC22A2	c.390G>T	p.Thr130Thr	Synonymous	1/11	-
10-101559094-A-G	ABCC2	c.998A>G	p.Asp333Gly	Missense	8/32	-
14-24459486-C-A	DHRS4L2	c.140C>A	p.Thr47Lys	Missense	4/9	-
14-24459486-C-T	DHRS4L2	c.140C>T	p.Thr47Met	Missense	4/9	-
4-100229017-G-A	ADH1B	c.1108C>T	p.Arg370Cys	Missense	9/9	-
4-89036166-C-G	ABCG2	c.886G>C	p.Asp296His	Missense	8/16	-
8-18080337-G-A	NAT1	c.781G>A	p.Glu261Lys	Missense	3/3	-
19-41518244-C-T	CYP2B6	c.1006C>T	p.Arg336Cys	Missense	7/9	-
6-160679630-G-T	SLC22A2	c.160C>A	p.Pro54Thr	Missense	1/11	-
2-234676965-G-T	UGT1A1	c.1184G>T	p.Gly395Val	Missense	4/5	-
11-17491730-G-A	ABCC8	c.330C>T	p.Ala110Ala	Synonymous	3/39	-
6-18143949-G-C	TPMT	c.244C>G	p.Arg82Gly	Missense	4/9	-
4-70160343-G-C	UGT2B28	c.1406G>C	p.Cys469Ser	Missense	6/6	-
8-18258122-G-T	NAT2	c.609G>T	p.Glu203Asp	Missense	2/2	-
2-234676965-G-A	UGT1A1	c.1184G>A	p.Gly395Asp	Missense	4/5	-
7-75615483-G-T	POR	c.1822G>T	p.Val608Phe	Missense	15/16	-
7-75615483-G-A	POR	c.1822G>A	p.Val608Ile	Missense	15/16	-
10-101603631-A-G	ABCC2	c.3817A>G	p.Thr1273Ala	Missense	27/32	-
10-96698440-A-T	CYP2C9	c.1A>T	p.Met1Leu	Missense	1/9	-
10-96698440-A-G	CYP2C9	c.1A>G	p.Met1Val	Missense	1/9	-
17-19463591-G-A	SLC47A1	c.1012G>A	p.Val338Ile	Missense	11/17	-
8-18257924-A-T	NAT2	c.411A>T	p.Leu137Phe	Missense	2/2	-
4-70361460-C-G	UGT2B4	c.120G>C	p.Lys40Asn	Missense	1/6	-
4-70709893-G-T	SULT1E1	c.758C>A	p.Pro253His	Missense	7/8	-
4-70723299-C-A	SULT1E1	c.64G>T	p.Asp22Tyr	Missense	2/8	-
4-70723299-C-T	SULT1E1	c.64G>A	p.Asp22Asn	Missense	2/8	-
22-42523475-C-T	CYP2D6	c.1147G>A	p.Glu383Lys	Missense	7/9	-
16-28607232-A-G	SULT1A2	c.20T>C	p.Ile7Thr	Missense	2/8	-
12-21457448-G-T	SLCO1A2	c.502C>A	p.Arg168Ser	Missense	5/14	-
12-21392079-C-T	SLCO1B1	c.2032C>T	p.His678Tyr	Missense	15/15	-
16-28607232-A-T	SULT1A2	c.20T>A	p.Ile7Asn	Missense	2/8	-
16-28607232-A-C	SULT1A2	c.20T>G	p.Ile7Ser	Missense	2/8	-
10-96609775-A-C	CYP2C19	c.1251A>C	p.Gly417Gly	Synonymous	8/9	-
2-234676413-T-C	UGT1A1	c.997-82T>C	-	IntronicSNV	-	2/4
12-21325716-T-C	SLCO1B1	c.217T>C	p.Phe73Leu	Missense	3/15	-
5-131671634-G-A	SLC22A4	c.1385G>A	p.Gly462Glu	Missense	8/10	-
6-160677671-T-C	SLC22A2	c.493A>G	p.Met165Val	Missense	2/11	-
7-99361626-A-G	CYP3A4	c.875T>C	p.Leu292Pro	Missense	10/13	-
3-119534659-C-T	NR1I2	c.1141C>T	p.Arg381Trp	Missense	8/9	-
6-18149105-A-G	TPMT	c.140+114T>C	-	IntronicSNV	-	2/8
6-18149105-A-T	TPMT	c.140+114T>A	-	IntronicSNV	-	2/8
13-99358411-C-G	SLC15A1	c.1246G>C	p.Val416Leu	Missense	16/23	-
2-234637853-G-A	UGT1A4	c.867+9520G>A	-	IntronicSNV	-	1/4
13-99358411-C-T	SLC15A1	c.1246G>A	p.Val416Met	Missense	16/23	-
14-70245157-A-G	SLC10A1	c.836T>C	p.Ile279Thr	Missense	4/5	-
2-234627737-C-T	UGT1A4	c.271C>T	p.Arg91Cys	Missense	1/5	-
10-101578577-C-G	ABCC2	c.2302C>G	p.Arg768Gly	Missense	18/32	-
8-18258113-A-G	NAT2	c.600A>G	p.Glu200Glu	Synonymous	2/2	-
19-41350587-T-C	CYP2A6	c.1252A>G	p.Asn418Asp	Missense	8/9	-
4-69973906-G-C	UGT2B7	c.1176G>C	p.Gly392Gly	Synonymous	5/6	-
1-98165030-T-C	DPYD	c.557A>G	p.Tyr186Cys	Missense	6/23	-
2-234601669-T-G	UGT1A10	c.855+55646T>G	-	IntronicSNV	-	1/4
2-169842697-A-T	ABCB11	c.1006T>A	p.Cys336Ser	Missense	10/28	-
16-16173232-G-T	ABCC1	c.2012G>T	p.Gly671Val	Missense	16/31	-
10-135345675-G-A	CYP2E1	c.535G>A	p.Val179Ile	Missense	4/9	-
22-42525182-A-T	CYP2D6	c.358T>A	p.Phe120Ile	Missense	3/9	-
4-69536080-A-G	UGT2B15	c.257T>C	p.Leu86Ser	Missense	1/6	-
2-234526705-A-G	UGT1A8	c.352A>G	p.Asn118Asp	Missense	1/5	-
19-41350996-C-T	CYP2A6	c.1161+203G>A	-	IntronicSNV	-	7/8
2-234669074-C-T	UGT1A1	c.141C>T	p.Ile47Ile	Synonymous	1/5	-
5-131728298-G-T	SLC22A5	c.1441G>T	p.Val481Phe	Missense	8/10	-
5-131728298-G-A	SLC22A5	c.1441G>A	p.Val481Ile	Missense	8/10	-
2-234526807-G-A	UGT1A8	c.454G>A	p.Ala152Thr	Missense	1/5	-
8-18258358-A-G	NAT2	c.845A>G	p.Lys282Arg	Missense	2/2	-
2-234676979-A-G	UGT1A1	c.1198A>G	p.Asn400Asp	Missense	4/5	-
2-234676979-A-C	UGT1A1	c.1198A>C	p.Asn400His	Missense	4/5	-
2-234580967-A-T	UGT1A10	c.855+34944A>T	-	IntronicSNV	-	1/4
2-234580967-A-G	UGT1A10	c.855+34944A>G	-	IntronicSNV	-	1/4
10-96612671-A-C	CYP2C19	c.1473A>C	-	Missense	9/9	-
6-18134121-C-T	TPMT	c.495-1G>A	-	IntronicSNV	-	6/8
2-234627608-T-G	UGT1A4	c.142T>G	p.Leu48Val	Missense	1/5	-
8-18257716-G-A	NAT2	c.203G>A	p.Cys68Tyr	Missense	2/2	-
6-18149358-T-C	TPMT	c.1A>G	p.Met1Val	Missense	2/9	-
1-97770920-C-T	DPYD	c.2194G>A	p.Val732Ile	Missense	18/23	-
2-234622382-G-C	UGT1A10	c.856-53298G>C	-	IntronicSNV	-	1/4
19-41355738-C-G	CYP2A6	c.328G>C	p.Val110Leu	Missense	2/9	-
19-41355738-C-T	CYP2A6	c.328G>A	p.Val110Ile	Missense	2/9	-
2-234602202-A-C	UGT1A10	c.855+56179A>C	-	IntronicSNV	-	1/4
2-234675696-T-C	UGT1A1	c.881T>C	p.Ile294Thr	Missense	2/5	-
2-234527044-G-A	UGT1A8	c.691G>A	p.Ala231Thr	Missense	1/5	-
6-18134115-G-C	TPMT	c.500C>G	p.Ala167Gly	Missense	7/9	-
10-96602752-G-A	CYP2C19	c.1120G>A	p.Val374Ile	Missense	7/9	-
10-96522463-A-G	CYP2C19	c.1A>G	p.Met1Val	Missense	1/9	-
2-234621764-A-G	UGT1A10	c.856-53916A>G	-	IntronicSNV	-	1/4
4-69964271-A-T	UGT2B7	c.735A>T	p.Thr245Thr	Synonymous	2/6	-
6-18139214-G-A	TPMT	c.474C>T	p.Ile158Ile	Synonymous	6/9	-
7-75615113-G-C	POR	c.1615G>C	p.Gly539Arg	Missense	13/16	-
12-21391976-A-C	SLCO1B1	c.1929A>C	p.Leu643Phe	Missense	15/15	-
16-28617485-C-G	SULT1A1	c.667G>C	p.Val223Leu	Missense	7/8	-
16-28617485-C-T	SULT1A1	c.667G>A	p.Val223Met	Missense	7/8	-
6-160543008-C-T	SLC22A1	c.41C>T	p.Ser14Phe	Missense	1/11	-
6-160543008-C-G	SLC22A1	c.41C>G	p.Ser14Cys	Missense	1/11	-
13-95863016-A-T	ABCC4	c.551T>A	p.Met184Lys	Missense	5/31	-
2-234581336-G-C	UGT1A10	c.855+35313G>C	-	IntronicSNV	-	1/4
10-96741054-T-A	CYP2C9	c.1076T>A	p.Ile359Asn	Missense	7/9	-
4-89039360-A-G	ABCG2	c.742T>C	p.Ser248Pro	Missense	7/16	-
10-96741054-T-C	CYP2C9	c.1076T>C	p.Ile359Thr	Missense	7/9	-
13-95858880-G-A	ABCC4	c.1067C>T	p.Thr356Met	Missense	8/31	-
7-99367404-C-T	CYP3A4	c.508G>A	p.Val170Ile	Missense	6/13	-
2-234676924-C-T	UGT1A1	c.1143C>T	p.Ser381Ser	Synonymous	4/5	-
2-234676924-C-G	UGT1A1	c.1143C>G	p.Ser381Arg	Missense	4/5	-
10-96612495-C-T	CYP2C19	c.1297C>T	p.Arg433Trp	Missense	9/9	-
8-18257624-T-C	NAT2	c.111T>C	p.Phe37Phe	Synonymous	2/2	-
7-99365994-G-C	CYP3A4	c.653C>G	p.Pro218Arg	Missense	7/13	-
8-18257704-G-A	NAT2	c.191G>A	p.Arg64Gln	Missense	2/2	-
15-75012979-G-T	CYP1A1	c.1390C>A	p.Arg464Ser	Missense	7/7	-
4-69696504-T-C	UGT2B10	c.1494T>C	p.Ala498Ala	Synonymous	6/6	-
4-69696504-T-G	UGT2B10	c.1494T>G	p.Ala498Ala	Synonymous	6/6	-
4-70346408-A-G	UGT2B4	c.1531T>C	p.Cys511Arg	Missense	6/6	-
15-75047245-G-A	CYP1A2	c.1367G>A	p.Arg456His	Missense	7/7	-
19-41509950-G-A	CYP2B6	c.216G>A	p.Pro72Pro	Synonymous	2/9	-
19-41509950-G-C	CYP2B6	c.216G>C	p.Pro72Pro	Synonymous	2/9	-
11-74880413-A-T	SLCO2B1	c.644A>T	p.Asp215Val	Missense	5/14	-
2-234669759-G-C	UGT1A1	c.826G>C	p.Gly276Arg	Missense	1/5	-
11-67351297-G-A	GSTP1	c.1-18G>A	-	5-UTRSNV	1/7	-
8-18258279-A-G	NAT2	c.766A>G	p.Lys256Glu	Missense	2/2	-
10-96731876-C-A	CYP2C9	c.835C>A	p.Pro279Thr	Missense	6/9	-
19-41515993-C-G	CYP2B6	c.917C>G	p.Thr306Ser	Missense	6/9	-
19-41515993-C-T	CYP2B6	c.917C>T	p.Thr306Ile	Missense	6/9	-
10-96541756-T-C	CYP2C19	c.819+2T>C	-	IntronicSNV	-	5/8
3-119526149-G-A	NR1I2	c.52G>A	p.Glu18Lys	Missense	2/9	-
11-62761083-C-T	SLC22A8	c.1342G>A	p.Val448Ile	Missense	10/11	-
2-234681416-T-C	UGT1A1	c.*211T>C	-	3-UTRSNV	5/5	-
10-135345675-G-T	CYP2E1	c.535G>T	p.Val179Phe	Missense	4/9	-
2-234621782-C-A	UGT1A10	c.856-53898C>A	-	IntronicSNV	-	1/4
8-30553990-G-A	GSR	c.702C>T	p.Ser234Ser	Synonymous	7/13	-
12-21329813-C-A	SLCO1B1	c.463C>A	p.Pro155Thr	Missense	5/15	-
15-75045542-C-T	CYP1A2	c.1184C>T	p.Thr395Met	Missense	6/7	-
8-18258358-A-C	NAT2	c.845A>C	p.Lys282Thr	Missense	2/2	-
4-70361460-C-T	UGT2B4	c.120G>A	p.Lys40Lys	Synonymous	1/6	-
2-234621782-C-T	UGT1A10	c.856-53898C>T	-	IntronicSNV	-	1/4
22-42526712-G-A	CYP2D6	c.82C>T	p.Arg28Cys	Missense	1/9	-
22-42526712-G-T	CYP2D6	c.82C>A	p.Arg28Ser	Missense	1/9	-
15-75044578-A-T	CYP1A2	c.1156A>T	p.Ile386Phe	Missense	5/7	-
11-62763557-G-A	SLC22A8	c.829C>T	p.Arg277Trp	Missense	6/11	-
19-41356246-C-A	CYP2A6	c.86G>T	p.Ser29Ile	Missense	1/9	-
15-75047426-C-T	CYP1A2	c.1548C>T	p.Asn516Asn	Synonymous	7/7	-
10-135351137-G-C	CYP2E1	c.1156-118G>C	-	IntronicSNV	-	7/8
4-70351050-A-G	UGT2B4	c.1186T>C	p.Phe396Leu	Missense	5/6	-
10-101542578-C-T	ABCC2	c.1-24C>T	-	5-UTRSNV	1/32	-
2-234627496-G-A	UGT1A4	c.30G>A	p.Pro10Pro	Synonymous	1/5	-
19-41350664-A-T	CYP2A6	c.1175T>A	p.Phe392Tyr	Missense	8/9	-
6-18148247-T-A	TPMT	c.141-101A>T	-	IntronicSNV	-	2/8
2-234621898-C-G	UGT1A10	c.856-53782C>G	-	IntronicSNV	-	1/4
2-234580589-C-G	UGT1A10	c.855+34566C>G	-	IntronicSNV	-	1/4
2-234545861-C-T	UGT1A10	c.693C>T	p.Ala231Ala	Synonymous	1/5	-
2-234621898-C-T	UGT1A10	c.856-53782C>T	-	IntronicSNV	-	1/4
2-234669558-C-T	UGT1A1	c.625C>T	p.Arg209Trp	Missense	1/5	-
2-169833100-C-G	ABCB11	c.1295G>C	p.Arg432Thr	Missense	12/28	-
2-234669558-C-A	UGT1A1	c.625C>A	p.Arg209Arg	Synonymous	1/5	-
15-75043592-C-T	CYP1A2	c.894C>T	p.Ser298Ser	Synonymous	3/7	-
10-101590526-G-A	ABCC2	c.2801G>A	p.Arg934Gln	Missense	21/32	-
15-75043592-C-A	CYP1A2	c.894C>A	p.Ser298Arg	Missense	3/7	-
2-234622412-G-C	UGT1A10	c.856-53268G>C	-	IntronicSNV	-	1/4
6-160645832-C-T	SLC22A2	c.1506G>A	p.Val502Val	Synonymous	10/11	-
13-95863008-C-A	ABCC4	c.559G>T	p.Gly187Trp	Missense	5/31	-
6-160663326-C-T	SLC22A2	c.1388G>A	p.Arg463Lys	Missense	8/11	-
1-171083149-T-C	FMO3	c.830T>C	p.Val277Ala	Missense	7/9	-
10-101605538-A-G	ABCC2	c.4145A>G	p.Gln1382Arg	Missense	29/32	-
4-69973921-C-T	UGT2B7	c.1191C>T	p.Ala397Ala	Synonymous	5/6	-
6-160557643-C-T	SLC22A1	c.1022C>T	p.Pro341Leu	Missense	6/11	-
22-42524944-G-GAAAGGGGCGAAAGGGGCG	CYP2D6	c.522_523insTTTCGCCCCTTTCGCCCC	p.Pro174_asn175insPheargpropheargpro	InFrameInsertion	4/9	-
15-75044552-G-C	CYP1A2	c.1130G>C	p.Arg377Pro	Missense	5/7	-
16-16208716-G-A	ABCC1	c.3173G>A	p.Arg1058Gln	Missense	23/31	-
19-41515255-C-A	CYP2B6	c.777C>A	p.Ser259Arg	Missense	5/9	-
7-75583457-G-C	POR	c.147G>C	p.Lys49Asn	Missense	2/16	-
7-75583457-G-A	POR	c.147G>A	p.Lys49Lys	Synonymous	2/16	-
2-234627668-C-T	UGT1A4	c.202C>T	p.His68Tyr	Missense	1/5	-
6-18132367-A-G	TPMT	c.622T>C	p.Phe208Leu	Missense	8/9	-
4-69973921-C-G	UGT2B7	c.1191C>G	p.Ala397Ala	Synonymous	5/6	-
2-234622294-C-T	UGT1A10	c.856-53386C>T	-	IntronicSNV	-	1/4
8-18257994-C-T	NAT2	c.481C>T	p.Leu161Leu	Synonymous	2/2	-
1-171072947-G-A	FMO3	c.154G>A	p.Ala52Thr	Missense	3/9	-
2-234545765-T-C	UGT1A10	c.597T>C	p.Asp199Asp	Synonymous	1/5	-
2-234591277-T-A	UGT1A10	c.855+45254T>A	-	IntronicSNV	-	1/4
6-160557643-C-G	SLC22A1	c.1022C>G	p.Pro341Arg	Missense	6/11	-
15-75042327-C-T	CYP1A2	c.248C>T	p.Thr83Met	Missense	2/7	-
19-41518644-C-A	CYP2B6	c.1218C>A	p.Asp406Glu	Missense	8/9	-
10-96741058-C-A	CYP2C9	c.1080C>A	p.Asp360Glu	Missense	7/9	-
2-234627508-A-T	UGT1A4	c.42A>T	p.Thr14Thr	Synonymous	1/5	-
19-41518644-C-T	CYP2B6	c.1218C>T	p.Asp406Asp	Synonymous	8/9	-
19-41351267-C-T	CYP2A6	c.1093G>A	p.Val365Met	Missense	7/9	-
2-234545294-G-A	UGT1A10	c.126G>A	p.Gln42Gln	Synonymous	1/5	-
10-96609752-C-G	CYP2C19	c.1228C>G	p.Arg410Gly	Missense	8/9	-
22-42525176-C-A	CYP2D6	c.364G>T	p.Ala122Ser	Missense	3/9	-
12-21015760-G-A	SLCO1B3	c.699G>A	p.Met233Ile	Missense	8/16	-
12-21353529-T-A	SLCO1B1	c.1058T>A	p.Ile353Asn	Missense	9/15	-
2-234590926-G-A	UGT1A10	c.855+44903G>A	-	IntronicSNV	-	1/4
22-42526669-C-T	CYP2D6	c.125G>A	p.Gly42Glu	Missense	1/9	-
10-101577123-A-G	ABCC2	c.2153A>G	p.Asn718Ser	Missense	17/32	-
6-160543090-C-G	SLC22A1	c.123C>G	p.Phe41Leu	Missense	1/11	-
17-19480643-G-T	SLC47A1	c.1490G>T	p.Cys497Phe	Missense	17/17	-
10-96609752-C-T	CYP2C19	c.1228C>T	p.Arg410Cys	Missense	8/9	-
15-45556120-T-G	SLC28A2	c.488T>G	p.Leu163Trp	Missense	6/18	-
22-42522916-C-T	CYP2D6	c.1252G>A	p.Glu418Lys	Missense	8/9	-
13-95715113-C-T	ABCC4	c.3211G>A	p.Val1071Ile	Missense	26/31	-
2-234676568-A-G	UGT1A1	c.1070A>G	p.Gln357Arg	Missense	3/5	-
13-95813572-C-T	ABCC4	c.2326G>A	p.Val776Ile	Missense	19/31	-
2-234545509-G-A	UGT1A10	c.341G>A	p.Ser114Asn	Missense	1/5	-
15-45561551-C-T	SLC28A2	c.1384C>T	p.Leu462Phe	Missense	14/18	-
2-234621953-C-T	UGT1A10	c.856-53727C>T	-	IntronicSNV	-	1/4
17-19480643-G-A	SLC47A1	c.1490G>A	p.Cys497Tyr	Missense	17/17	-
7-99270276-A-C	CYP3A5	c.245T>G	p.Leu82Arg	Missense	4/13	-
8-18258012-G-A	NAT2	c.499G>A	p.Glu167Lys	Missense	2/2	-
1-98157332-G-A	DPYD	c.703C>T	p.Arg235Trp	Missense	7/23	-
8-18258012-G-C	NAT2	c.499G>C	p.Glu167Gln	Missense	2/2	-
2-234622310-C-T	UGT1A10	c.856-53370C>T	-	IntronicSNV	-	1/4
2-234545517-C-T	UGT1A10	c.349C>T	p.Leu117Phe	Missense	1/5	-
10-96698494-C-A	CYP2C9	c.55C>A	p.Leu19Ile	Missense	1/9	-
6-160662609-G-A	SLC22A2	c.1398C>T	p.Gly466Gly	Synonymous	9/11	-
2-234622067-A-T	UGT1A10	c.856-53613A>T	-	IntronicSNV	-	1/4
3-121641693-G-A	SLC15A2	c.852G>A	p.Ala284Ala	Synonymous	9/22	-
10-96612542-C-A	CYP2C19	c.1344C>A	p.Phe448Leu	Missense	9/9	-
8-18257703-C-A	NAT2	c.190C>A	p.Arg64Arg	Synonymous	2/2	-
7-87229440-T-C	ABCB1	c.61A>G	p.Asn21Asp	Missense	3/29	-
4-89039297-G-A	ABCG2	c.805C>T	p.Pro269Ser	Missense	7/16	-
7-87229440-T-G	ABCB1	c.61A>C	p.Asn21His	Missense	3/29	-
7-87229440-T-A	ABCB1	c.61A>T	p.Asn21Tyr	Missense	3/29	-
4-69696582-G-C	UGT2B10	c.1572G>C	p.Lys524Asn	Missense	6/6	-
22-44248601-C-T	SULT4A1	c.169+9493G>A	-	IntronicSNV	-	1/6
7-75610876-C-T	POR	c.683C>T	p.Pro228Leu	Missense	7/16	-
2-234590850-G-A	UGT1A10	c.855+44827G>A	-	IntronicSNV	-	1/4
1-171076888-G-T	FMO3	c.394G>T	p.Asp132Tyr	Missense	4/9	-
15-75047169-C-T	CYP1A2	c.1291C>T	p.Arg431Trp	Missense	7/7	-
2-234669155-C-A	UGT1A1	c.222C>A	p.Tyr74*	Nonsense	1/5	-
2-234545898-C-A	UGT1A10	c.730C>A	p.Leu244Ile	Missense	1/5	-
2-234526785-G-A	UGT1A8	c.432G>A	p.Ala144Ala	Synonymous	1/5	-
2-234669631-T-G	UGT1A1	c.698T>G	p.Leu233Arg	Missense	1/5	-
1-171073038-T-C	FMO3	c.245T>C	p.Met82Thr	Missense	3/9	-
7-99367428-G-A	CYP3A4	c.484C>T	p.Arg162Trp	Missense	6/13	-
4-70346565-A-T	UGT2B4	c.1374T>A	p.Asp458Glu	Missense	6/6	-
22-44251189-G-A	SULT4A1	c.169+6905C>T	-	IntronicSNV	-	1/6
12-21011480-T-G	SLCO1B3	c.334T>G	p.Ser112Ala	Missense	5/16	-
12-21011480-T-C	SLCO1B3	c.334T>C	p.Ser112Pro	Missense	5/16	-
1-171076888-G-C	FMO3	c.394G>C	p.Asp132His	Missense	4/9	-
2-234669180-T-C	UGT1A1	c.247T>C	p.Phe83Leu	Missense	1/5	-
2-234669180-T-A	UGT1A1	c.247T>A	p.Phe83Ile	Missense	1/5	-
2-234675829-C-T	UGT1A1	c.996+18C>T	-	IntronicSNV	-	2/4
12-21028208-G-C	SLCO1B3	c.767G>C	p.Gly256Ala	Missense	9/16	-
2-234638451-T-G	UGT1A4	c.867+10118T>G	-	IntronicSNV	-	1/4
4-89052266-G-A	ABCG2	c.478C>T	p.Arg160Trp	Missense	5/16	-
13-99356584-G-T	SLC15A1	c.1375C>A	p.Arg459Ser	Missense	17/23	-
13-99356584-G-A	SLC15A1	c.1375C>T	p.Arg459Cys	Missense	17/23	-
1-161202605-G-A	NR1I3	c.540C>T	p.Pro180Pro	Synonymous	5/9	-
19-41510059-C-T	CYP2B6	c.325C>T	p.Arg109Trp	Missense	2/9	-
8-18257947-A-C	NAT2	c.434A>C	p.Gln145Pro	Missense	2/2	-
4-69973956-G-C	UGT2B7	c.1226G>C	p.Arg409Thr	Missense	5/6	-
4-69973956-G-A	UGT2B7	c.1226G>A	p.Arg409Lys	Missense	5/6	-
8-18080001-G-C	NAT1	c.445G>C	p.Val149Leu	Missense	3/3	-
2-234669619-C-T	UGT1A1	c.686C>T	p.Pro229Leu	Missense	1/5	-
2-234669619-C-A	UGT1A1	c.686C>A	p.Pro229Gln	Missense	1/5	-
10-101556957-A-C	ABCC2	c.736A>C	p.Met246Leu	Missense	7/32	-
10-101556957-A-T	ABCC2	c.736A>T	p.Met246Leu	Missense	7/32	-
2-101014446-G-T	CHST10	c.351C>A	p.Asp117Glu	Missense	5/7	-
5-125887715-T-G	ALDH7A1	c.1315A>C	p.Lys439Gln	Missense	14/18	-
2-234675780-T-C	UGT1A1	c.965T>C	p.Ile322Thr	Missense	2/5	-
2-234681544-G-A	UGT1A1	c.*339G>A	-	3-UTRSNV	5/5	-
12-21487544-A-G	SLCO1A2	c.38T>C	p.Ile13Thr	Missense	1/14	-
8-18258351-G-A	NAT2	c.838G>A	p.Val280Met	Missense	2/2	-
2-234676519-C-T	UGT1A1	c.1021C>T	p.Arg341*	Nonsense	3/5	-
2-234676519-C-G	UGT1A1	c.1021C>G	p.Arg341Gly	Missense	3/5	-
4-69693187-G-C	UGT2B10	c.1228G>C	p.Ala410Pro	Missense	5/6	-
4-69693187-G-A	UGT2B10	c.1228G>A	p.Ala410Thr	Missense	5/6	-
2-234526397-C-G	UGT1A8	c.44C>G	p.Ser15Cys	Missense	1/5	-
4-69683875-C-G	UGT2B10	c.847C>G	p.Pro283Ala	Missense	2/6	-
2-234545483-A-G	UGT1A10	c.315A>G	p.Ile105Met	Missense	1/5	-
4-70350967-T-A	UGT2B4	c.1269A>T	p.Thr423Thr	Synonymous	5/6	-
2-234591205-T-C	UGT1A7	c.622T>C	p.Trp208Arg	Missense	1/5	-
7-99247772-A-G	CYP3A5	c.1337T>C	p.Phe446Ser	Missense	12/13	-
1-171077331-T-A	FMO3	c.596T>A	p.Ile199Asn	Missense	5/9	-
1-171077331-T-C	FMO3	c.596T>C	p.Ile199Thr	Missense	5/9	-
6-18143949-G-A	TPMT	c.244C>T	p.Arg82Trp	Missense	4/9	-
2-234621972-G-C	UGT1A10	c.856-53708G>C	-	IntronicSNV	-	1/4
2-234621976-A-T	UGT1A10	c.856-53704A>T	-	IntronicSNV	-	1/4
10-96612542-C-G	CYP2C19	c.1344C>G	p.Phe448Leu	Missense	9/9	-
2-234668570-C-T	UGT1A4	c.868-7110C>T	-	IntronicSNV	-	1/4
8-18258351-G-T	NAT2	c.838G>T	p.Val280Leu	Missense	2/2	-
8-18257703-C-T	NAT2	c.190C>T	p.Arg64Trp	Missense	2/2	-
15-75044195-G-A	CYP1A2	c.1042G>A	p.Asp348Asn	Missense	4/7	-
2-234581346-G-A	UGT1A9	c.766G>A	p.Asp256Asn	Missense	1/5	-
2-38298203-C-G	CYP1B1	c.1294G>C	p.Val432Leu	Missense	3/3	-
6-18139258-C-G	TPMT	c.430G>C	p.Gly144Arg	Missense	6/9	-
4-69403599-A-G	UGT2B17	c.1337T>C	p.Leu446Ser	Missense	6/6	-
2-234627805-T-A	UGT1A4	c.339T>A	p.Ser113Arg	Missense	1/5	-
2-234526784-C-T	UGT1A8	c.431C>T	p.Ala144Val	Missense	1/5	-
2-234627805-T-C	UGT1A4	c.339T>C	p.Ser113Ser	Synonymous	1/5	-
11-62746960-C-T	SLC22A6	c.1361G>A	p.Arg454Gln	Missense	8/10	-
8-18258122-G-C	NAT2	c.609G>C	p.Glu203Asp	Missense	2/2	-
6-18132378-A-G	TPMT	c.611T>C	p.Ile204Thr	Missense	8/9	-
2-234621869-A-T	UGT1A10	c.856-53811A>T	-	IntronicSNV	-	1/4
2-234590969-A-G	UGT1A10	c.855+44946A>G	-	IntronicSNV	-	1/4
7-99367392-C-T	CYP3A4	c.520G>A	p.Asp174Asn	Missense	6/13	-
10-96612522-C-G	CYP2C19	c.1324C>G	p.Arg442Gly	Missense	9/9	-
10-96612522-C-T	CYP2C19	c.1324C>T	p.Arg442Cys	Missense	9/9	-
2-201464350-T-C	AOX1	c.317T>C	p.Ile106Thr	Missense	5/35	-
13-95863016-A-G	ABCC4	c.551T>C	p.Met184Thr	Missense	5/31	-
8-18079746-C-T	NAT1	c.190C>T	p.Arg64Trp	Missense	3/3	-
12-21036411-A-G	SLCO1B3	c.1557A>G	p.Ala519Ala	Synonymous	13/16	-
2-234627536-C-T	UGT1A4	c.70C>T	p.Pro24Ser	Missense	1/5	-
2-234627536-C-A	UGT1A4	c.70C>A	p.Pro24Thr	Missense	1/5	-
19-41354538-G-T	CYP2A6	c.474C>A	p.Asp158Glu	Missense	3/9	-
9-86955538-C-T	SLC28A3	c.11G>A	p.Arg4Lys	Missense	2/19	-
19-41354538-G-C	CYP2A6	c.474C>G	p.Asp158Glu	Missense	3/9	-
2-169830328-A-G	ABCB11	c.1331T>C	p.Val444Ala	Missense	13/28	-
2-234591243-C-T	UGT1A7	c.660C>T	p.Cys220Cys	Synonymous	1/5	-
10-101604107-C-T	ABCC2	c.3872C>T	p.Pro1291Leu	Missense	28/32	-
4-69681936-G-A	UGT2B10	c.199G>A	p.Asp67Asn	Missense	1/6	-
4-69681936-G-T	UGT2B10	c.199G>T	p.Asp67Tyr	Missense	1/6	-
22-44249463-C-A	SULT4A1	c.169+8631G>T	-	IntronicSNV	-	1/6
12-21349885-A-G	SLCO1B1	c.733A>G	p.Ile245Val	Missense	8/15	-
19-41354534-G-T	CYP2A6	c.478C>A	p.Leu160Ile	Missense	3/9	-
5-131721174-A-G	SLC22A5	c.807A>G	p.Leu269Leu	Synonymous	4/10	-
2-234527073-A-G	UGT1A8	c.720A>G	p.Thr240Thr	Synonymous	1/5	-
4-69962449-G-T	UGT2B7	c.211G>T	p.Ala71Ser	Missense	1/6	-
4-69962449-G-A	UGT2B7	c.211G>A	p.Ala71Thr	Missense	1/6	-
4-69962449-G-C	UGT2B7	c.211G>C	p.Ala71Pro	Missense	1/6	-
19-48386992-C-G	SULT2A1	c.187G>C	p.Ala63Pro	Missense	2/6	-
19-41512824-C-G	CYP2B6	c.499C>G	p.Pro167Ala	Missense	4/9	-
4-69533785-G-C	UGT2B15	c.846C>G	p.His282Gln	Missense	2/6	-
4-69533785-G-T	UGT2B15	c.846C>A	p.His282Gln	Missense	2/6	-
19-41356281-T-C	CYP2A6	c.51A>G	p.Val17Val	Synonymous	1/9	-
1-98348885-G-A	DPYD	c.85C>T	p.Arg29Cys	Missense	2/23	-
2-234527035-C-A	UGT1A8	c.682C>A	p.Leu228Ile	Missense	1/5	-
2-108922036-T-G	SULT1C2	c.796T>G	p.Ser266Ala	Missense	8/9	-
10-96602622-C-T	CYP2C19	c.990C>T	p.Val330Val	Synonymous	7/9	-
8-18257924-A-C	NAT2	c.411A>C	p.Leu137Phe	Missense	2/2	-
13-95705380-G-A	ABCC4	c.3425C>T	p.Thr1142Met	Missense	27/31	-
2-234621960-T-A	UGT1A10	c.856-53720T>A	-	IntronicSNV	-	1/4
4-89052957-G-A	ABCG2	c.376C>T	p.Gln126*	Nonsense	4/16	-
5-131728202-T-G	SLC22A5	c.1345T>G	p.Tyr449Asp	Missense	8/10	-
8-18080644-A-T	NAT1	c.*215A>T	-	3-UTRSNV	3/3	-
6-160560845-A-C	SLC22A1	c.1222A>C	p.Met408Leu	Missense	7/11	-
2-234622061-C-A	UGT1A10	c.856-53619C>A	-	IntronicSNV	-	1/4
2-234545345-G-A	UGT1A10	c.177G>A	p.Met59Ile	Missense	1/5	-
2-234665659-T-A	UGT1A4	c.868-10021T>A	-	IntronicSNV	-	1/4
10-96701988-G-T	CYP2C9	c.371G>T	p.Arg124Leu	Missense	3/9	-
8-18257854-T-C	NAT2	c.341T>C	p.Ile114Thr	Missense	2/2	-
1-171083403-G-A	FMO3	c.1084G>A	p.Glu362Lys	Missense	7/9	-
1-171083403-G-C	FMO3	c.1084G>C	p.Glu362Gln	Missense	7/9	-
13-95815454-T-C	ABCC4	c.2230A>G	p.Met744Val	Missense	18/31	-
22-42522906-A-G	CYP2D6	c.1262T>C	p.Leu421Pro	Missense	8/9	-
2-234590974-C-A	UGT1A10	c.855+44951C>A	-	IntronicSNV	-	1/4
2-234545481-A-G	UGT1A10	c.313A>G	p.Ile105Val	Missense	1/5	-
2-234681624-T-C	UGT1A1	c.*419T>C	-	3-UTRSNV	5/5	-
2-234621922-T-C	UGT1A10	c.856-53758T>C	-	IntronicSNV	-	1/4
4-70160277-T-G	UGT2B28	c.1340T>G	p.Ile447Arg	Missense	6/6	-
8-18257858-C-T	NAT2	c.345C>T	p.Asp115Asp	Synonymous	2/2	-
10-96522472-T-C	CYP2C19	c.10T>C	p.Phe4Leu	Missense	1/9	-
10-135347397-T-C	CYP2E1	c.963T>C	p.Ile321Ile	Synonymous	6/9	-
2-31562412-C-T	XDH	c.3717G>A	p.Glu1239Glu	Synonymous	34/36	-
7-99264573-A-G	CYP3A5	c.432+2T>C	-	IntronicSNV	-	5/12
7-99264573-A-T	CYP3A5	c.432+2T>A	-	IntronicSNV	-	5/12
8-18258103-G-A	NAT2	c.590G>A	p.Arg197Gln	Missense	2/2	-
10-135347397-T-G	CYP2E1	c.963T>G	p.Ile321Met	Missense	6/9	-
7-99366047-T-A	CYP3A4	c.600A>T	p.Gln200His	Missense	7/13	-
4-69962589-A-T	UGT2B7	c.351A>T	p.Ser117Ser	Synonymous	1/6	-
8-18257542-T-C	NAT2	c.29T>C	p.Ile10Thr	Missense	2/2	-
7-75609780-G-C	POR	c.490G>C	p.Val164Leu	Missense	5/16	-
11-62762035-C-A	SLC22A8	c.1195G>T	p.Ala399Ser	Missense	8/11	-
4-69433662-C-A	UGT2B17	c.541G>T	p.Val181Phe	Missense	1/6	-
4-69433662-C-T	UGT2B17	c.541G>A	p.Val181Ile	Missense	1/6	-
2-234621933-C-T	UGT1A10	c.856-53747C>T	-	IntronicSNV	-	1/4
2-234675807-A-G	UGT1A1	c.992A>G	p.Gln331Arg	Missense	2/5	-
10-96522512-T-A	CYP2C19	c.50T>A	p.Leu17His	Missense	1/9	-
8-18080169-A-G	NAT1	c.613A>G	p.Met205Val	Missense	3/3	-
1-110256060-G-T	GSTM5	c.178-46G>T	-	IntronicSNV	-	3/7
8-18257542-T-G	NAT2	c.29T>G	p.Ile10Ser	Missense	2/2	-
8-18257542-T-A	NAT2	c.29T>A	p.Ile10Asn	Missense	2/2	-
22-42522751-C-T	CYP2D6	c.1319G>A	p.Arg440His	Missense	9/9	-
7-75609780-G-A	POR	c.490G>A	p.Val164Met	Missense	5/16	-
16-28620067-C-A	SULT1A1	c.110G>T	p.Arg37Leu	Missense	2/8	-
22-42525089-G-A	CYP2D6	c.451C>T	p.Gln151*	Nonsense	3/9	-
10-96522512-T-C	CYP2C19	c.50T>C	p.Leu17Pro	Missense	1/9	-
2-234676567-C-T	UGT1A1	c.1069C>T	p.Gln357*	Nonsense	3/5	-
8-18258196-C-T	NAT2	c.683C>T	p.Pro228Leu	Missense	2/2	-
10-96535210-G-A	CYP2C19	c.395G>A	p.Arg132Gln	Missense	3/9	-
5-131663062-T-G	SLC22A4	c.917T>G	p.Ile306Arg	Missense	5/10	-
6-18139228-C-T	TPMT	c.460G>A	p.Ala154Thr	Missense	6/9	-
2-234526729-A-G	UGT1A8	c.376A>G	p.Ser126Gly	Missense	1/5	-
7-94996741-A-G	PON3	c.427T>C	p.Phe143Leu	Missense	5/9	-
9-86955535-C-G	SLC28A3	c.14G>C	p.Ser5Thr	Missense	2/19	-
19-41349786-G-T	CYP2A6	c.1400C>A	p.Ser467*	Nonsense	9/9	-
4-89052299-C-T	ABCG2	c.445G>A	p.Ala149Thr	Missense	5/16	-
4-89052299-C-G	ABCG2	c.445G>C	p.Ala149Pro	Missense	5/16	-
1-171076936-G-A	FMO3	c.442G>A	p.Gly148Arg	Missense	4/9	-
12-21457448-G-A	SLCO1A2	c.502C>T	p.Arg168Cys	Missense	5/14	-
7-122755608-C-A	SLC13A1	c.1752G>T	p.Ser584Ser	Synonymous	15/15	-
6-160664680-G-A	SLC22A2	c.1203C>T	p.Ile401Ile	Synonymous	7/11	-
6-160664680-G-C	SLC22A2	c.1203C>G	p.Ile401Met	Missense	7/11	-
7-122755608-C-T	SLC13A1	c.1752G>A	p.Ser584Ser	Synonymous	15/15	-
2-234638448-G-A	UGT1A4	c.867+10115G>A	-	IntronicSNV	-	1/4
4-89042860-T-C	ABCG2	c.616A>G	p.Ile206Val	Missense	6/16	-
4-89042860-T-G	ABCG2	c.616A>C	p.Ile206Leu	Missense	6/16	-
22-42525134-C-T	CYP2D6	c.406G>A	p.Val136Ile	Missense	3/9	-
2-234621856-C-A	UGT1A10	c.856-53824C>A	-	IntronicSNV	-	1/4
10-96522469-C-T	CYP2C19	c.7C>T	p.Pro3Ser	Missense	1/9	-
2-234669773-C-G	UGT1A1	c.840C>G	p.Cys280Trp	Missense	1/5	-
16-28617413-A-C	SULT1A1	c.739T>G	p.Phe247Val	Missense	7/8	-
4-69403588-G-A	UGT2B17	c.1348C>T	p.His450Tyr	Missense	6/6	-
12-21353529-T-C	SLCO1B1	c.1058T>C	p.Ile353Thr	Missense	9/15	-
2-234545861-C-A	UGT1A10	c.693C>A	p.Ala231Ala	Synonymous	1/5	-
1-171061893-G-A	FMO3	c.94G>A	p.Glu32Lys	Missense	2/9	-
1-171083174-C-T	FMO3	c.855C>T	p.Asn285Asn	Synonymous	7/9	-
10-135342034-G-T	CYP2E1	c.227G>T	p.Arg76Leu	Missense	2/9	-
10-135342034-G-A	CYP2E1	c.227G>A	p.Arg76His	Missense	2/9	-
11-67353579-C-T	GSTP1	c.341C>T	p.Ala114Val	Missense	6/7	-
7-99359670-G-C	CYP3A4	c.1244C>G	p.Pro415Arg	Missense	11/13	-
1-97981395-T-C	DPYD	c.1627A>G	p.Ile543Val	Missense	13/23	-
11-62749434-A-T	SLC22A6	c.677T>A	p.Ile226Asn	Missense	4/10	-
4-70346565-A-G	UGT2B4	c.1374T>C	p.Asp458Asp	Synonymous	6/6	-
10-96701654-G-C	CYP2C9	c.208G>C	p.Gly70Arg	Missense	2/9	-
10-96701654-G-A	CYP2C9	c.208G>A	p.Gly70Ser	Missense	2/9	-
1-171083232-G-T	FMO3	c.913G>T	p.Glu305*	Nonsense	7/9	-
2-234527118-A-T	UGT1A8	c.765A>T	p.Thr255Thr	Synonymous	1/5	-
1-171083225-C-T	FMO3	c.906C>T	p.Asn302Asn	Synonymous	7/9	-
2-234527118-A-G	UGT1A8	c.765A>G	p.Thr255Thr	Synonymous	1/5	-
12-21453362-G-T	SLCO1A2	c.830C>A	p.Thr277Asn	Missense	7/14	-
22-42524944-G-GAAAGGGGCGAAAGGGGCGAAAGGGGCG	CYP2D6	c.522_523insTTTCGCCCCTTTCGCCCCTTTCGCCCC	p.Pro174_asn175insPheargpropheargpropheargpro	InFrameInsertion	4/9	-
22-42525772-G-A	CYP2D6	c.320C>T	p.Thr107Ile	Missense	2/9	-
2-234681090-T-A	UGT1A1	c.1487T>A	p.Leu496*	Nonsense	5/5	-
7-99245974-A-G	CYP3A5	c.1463T>C	p.Ile488Thr	Missense	13/13	-
2-234681544-G-T	UGT1A1	c.*339G>T	-	3-UTRSNV	5/5	-
2-234681544-G-C	UGT1A1	c.*339G>C	-	3-UTRSNV	5/5	-
2-234601919-G-A	UGT1A10	c.855+55896G>A	-	IntronicSNV	-	1/4
6-18149276-T-A	TPMT	c.83A>T	p.Glu28Val	Missense	2/9	-
2-234602277-G-T	UGT1A10	c.855+56254G>T	-	IntronicSNV	-	1/4
12-21453362-G-C	SLCO1A2	c.830C>G	p.Thr277Ser	Missense	7/14	-
2-234675826-T-C	UGT1A1	c.996+15T>C	-	IntronicSNV	-	2/4
2-234638295-A-T	UGT1A4	c.867+9962A>T	-	IntronicSNV	-	1/4
4-69964337-A-T	UGT2B7	c.801A>T	p.Pro267Pro	Synonymous	2/6	-
12-21331860-A-G	SLCO1B1	c.633A>G	p.Ile211Met	Missense	7/15	-
6-18130993-C-T	TPMT	c.644G>A	p.Arg215His	Missense	9/9	-
6-160577063-G-A	SLC22A1	c.1555G>A	p.Val519Ile	Missense	10/11	-
6-160577063-G-T	SLC22A1	c.1555G>T	p.Val519Phe	Missense	10/11	-
7-99250394-A-AA	CYP3A5	c.1035_1035dup	p.Thr346Tyrfs*3	Frameshift	11/13	-
2-201505835-C-A	AOX1	c.2583C>A	p.Asn861Lys	Missense	24/35	-
11-74904362-T-C	SLCO2B1	c.1175T>C	p.Ile392Thr	Missense	9/14	-
15-45559774-T-C	SLC28A2	c.1064T>C	p.Phe355Ser	Missense	11/18	-
11-17419279-C-T	ABCC8	c.3819G>A	p.Arg1273Arg	Synonymous	31/39	-
13-95859035-C-A	ABCC4	c.912G>T	p.Lys304Asn	Missense	8/31	-
22-44249905-G-A	SULT4A1	c.169+8189C>T	-	IntronicSNV	-	1/6
14-24761467-G-T	DHRS1	c.577C>A	p.Pro193Thr	Missense	6/9	-
13-95859035-C-G	ABCC4	c.912G>C	p.Lys304Asn	Missense	8/31	-
13-95859035-C-T	ABCC4	c.912G>A	p.Lys304Lys	Synonymous	8/31	-
7-99367403-A-G	CYP3A4	c.509T>C	p.Val170Ala	Missense	6/13	-
10-96534922-G-A	CYP2C19	c.276G>A	p.Glu92Glu	Synonymous	2/9	-
10-96534922-G-C	CYP2C19	c.276G>C	p.Glu92Asp	Missense	2/9	-
7-75614386-T-A	POR	c.1259T>A	p.Leu420Gln	Missense	12/16	-
7-75614386-T-C	POR	c.1259T>C	p.Leu420Pro	Missense	12/16	-
10-135351362-T-C	CYP2E1	c.1263T>C	p.Phe421Phe	Synonymous	8/9	-
10-135351362-T-G	CYP2E1	c.1263T>G	p.Phe421Leu	Missense	8/9	-
2-234627949-G-A	UGT1A4	c.483G>A	p.Leu161Leu	Synonymous	1/5	-
15-45545478-C-T	SLC28A2	c.65C>T	p.Pro22Leu	Missense	2/18	-
10-96701988-G-A	CYP2C9	c.371G>A	p.Arg124Gln	Missense	3/9	-
2-234621819-T-A	UGT1A10	c.856-53861T>A	-	IntronicSNV	-	1/4
22-42524310-C-G	CYP2D6	c.709G>C	p.Ala237Pro	Missense	5/9	-
22-42524310-C-A	CYP2D6	c.709G>T	p.Ala237Ser	Missense	5/9	-
1-98348908-C-T	DPYD	c.62G>A	p.Arg21Gln	Missense	2/23	-
10-101556957-A-G	ABCC2	c.736A>G	p.Met246Val	Missense	7/32	-
2-234676905-C-T	UGT1A1	c.1124C>T	p.Ser375Phe	Missense	4/5	-
2-234667809-C-T	UGT1A4	c.868-7871C>T	-	IntronicSNV	-	1/4
1-94574258-T-A	ABCA4	c.317A>T	p.Tyr106Phe	Missense	4/50	-
4-69962375-T-C	UGT2B7	c.137T>C	p.Leu46Pro	Missense	1/6	-
2-234621963-A-G	UGT1A10	c.856-53717A>G	-	IntronicSNV	-	1/4
2-234621963-A-C	UGT1A10	c.856-53717A>C	-	IntronicSNV	-	1/4
13-99376167-C-T	SLC15A1	c.364G>A	p.Val122Met	Missense	5/23	-
10-96602623-G-A	CYP2C19	c.991G>A	p.Val331Ile	Missense	7/9	-
22-42525182-A-G	CYP2D6	c.358T>C	p.Phe120Leu	Missense	3/9	-
2-234676872-C-T	UGT1A1	c.1091C>T	p.Pro364Leu	Missense	4/5	-
2-234622135-G-A	UGT1A10	c.856-53545G>A	-	IntronicSNV	-	1/4
2-108917348-C-T	SULT1C2	c.373-8C>T	-	IntronicSNV	-	4/8
6-160663420-T-G	SLC22A2	c.1294A>C	p.Lys432Gln	Missense	8/11	-
15-45557318-G-C	SLC28A2	c.734G>C	p.Ser245Thr	Missense	8/18	-
7-99359670-G-A	CYP3A4	c.1244C>T	p.Pro415Leu	Missense	11/13	-
2-201505835-C-T	AOX1	c.2583C>T	p.Asn861Asn	Synonymous	24/35	-
10-96824643-G-A	CYP2C8	c.556C>T	p.Arg186*	Nonsense	4/9	-
2-234676872-C-G	UGT1A1	c.1091C>G	p.Pro364Arg	Missense	4/5	-
22-42525077-C-T	CYP2D6	c.463G>A	p.Glu155Lys	Missense	3/9	-
19-41497286-A-T	CYP2B6	c.76A>T	p.Thr26Ser	Missense	1/9	-
2-234628270-G-A	UGT1A4	c.804G>A	p.Pro268Pro	Synonymous	1/5	-
6-160677683-A-G	SLC22A2	c.481T>C	p.Phe161Leu	Missense	2/11	-
22-42525823-G-A	CYP2D6	c.269C>T	p.Ala90Val	Missense	2/9	-
15-75044238-G-A	CYP1A2	c.1042+43G>A	-	IntronicSNV	-	4/6
7-99250236-G-T	CYP3A5	c.1193C>A	p.Thr398Asn	Missense	11/13	-
2-234669074-C-A	UGT1A1	c.141C>A	p.Ile47Ile	Synonymous	1/5	-
13-95899303-G-C	ABCC4	c.232C>G	p.Pro78Ala	Missense	3/31	-
2-108910751-G-A	SULT1C2	c.218G>A	p.Arg73Gln	Missense	3/9	-
2-234638207-C-CC	UGT1A4	c.867+9874_867+9874dup	-	IntronicInsertion	-	1/4
22-42524935-G-A	CYP2D6	c.517C>T	p.Arg173Cys	Missense	4/9	-
12-21459876-T-A	SLCO1A2	c.382A>T	p.Asn128Tyr	Missense	4/14	-
4-69964338-T-C	UGT2B7	c.802T>C	p.Tyr268His	Missense	2/6	-
6-160543148-C-T	SLC22A1	c.181C>T	p.Arg61Cys	Missense	1/11	-
12-21392047-A-G	SLCO1B1	c.2000A>G	p.Glu667Gly	Missense	15/15	-
22-44251852-T-C	SULT4A1	c.169+6242A>G	-	IntronicSNV	-	1/6
22-44251852-T-A	SULT4A1	c.169+6242A>T	-	IntronicSNV	-	1/6
15-75042204-C-G	CYP1A2	c.125C>G	p.Pro42Arg	Missense	2/7	-
12-21355489-C-G	SLCO1B1	c.1200C>G	p.Phe400Leu	Missense	10/15	-
12-21476983-A-G	SLCO1A2	c.61-5126T>C	-	IntronicSNV	-	1/13
11-62761083-C-A	SLC22A8	c.1342G>T	p.Val448Leu	Missense	10/11	-
16-16101752-G-C	ABCC1	c.128G>C	p.Cys43Ser	Missense	2/31	-
8-18079958-T-C	NAT1	c.402T>C	p.Pro134Pro	Synonymous	3/3	-
13-99339905-G-C	SLC15A1	c.1757C>G	p.Pro586Arg	Missense	21/23	-
8-18257795-C-T	NAT2	c.282C>T	p.Tyr94Tyr	Synonymous	2/2	-
2-234680679-A-C	UGT1A1	c.1305-229A>C	-	IntronicSNV	-	4/4
10-101594176-C-A	ABCC2	c.3298C>A	p.Arg1100Ser	Missense	24/32	-
13-99339905-G-A	SLC15A1	c.1757C>T	p.Pro586Leu	Missense	21/23	-
19-41354458-C-G	CYP2A6	c.493+61G>C	-	IntronicSNV	-	3/8
10-101594177-G-A	ABCC2	c.3299G>A	p.Arg1100His	Missense	24/32	-
19-41354458-C-A	CYP2A6	c.493+61G>T	-	IntronicSNV	-	3/8
2-234637917-C-T	UGT1A3	c.145C>T	p.Arg49Trp	Missense	1/5	-
2-234637917-C-G	UGT1A4	c.867+9584C>G	-	IntronicSNV	-	1/4
8-18257741-C-T	NAT2	c.228C>T	p.Tyr76Tyr	Synonymous	2/2	-
2-234638203-C-T	UGT1A4	c.867+9870C>T	-	IntronicSNV	-	1/4
8-18257741-C-A	NAT2	c.228C>A	p.Tyr76*	Nonsense	2/2	-
8-18257741-C-G	NAT2	c.228C>G	p.Tyr76*	Nonsense	2/2	-
4-69693103-G-A	UGT2B10	c.1144G>A	p.Ala382Thr	Missense	5/6	-
10-96447981-G-A	CYP2C18	c.431G>A	p.Arg144His	Missense	3/9	-
4-69974018-A-C	UGT2B7	c.1288A>C	p.Lys430Gln	Missense	5/6	-
12-21450350-T-C	SLCO1A2	c.1063A>G	p.Ile355Val	Missense	8/14	-
2-234622379-C-A	UGT1A10	c.856-53301C>A	-	IntronicSNV	-	1/4
2-234638245-C-G	UGT1A3	c.473C>G	p.Ala158Gly	Missense	1/5	-
2-234526510-C-A	UGT1A8	c.157C>A	p.His53Asn	Missense	1/5	-
15-75013005-C-T	CYP1A1	c.1364G>A	p.Arg455Gln	Missense	7/7	-
4-70351024-T-G	UGT2B4	c.1212A>C	p.Ala404Ala	Synonymous	5/6	-
4-70351024-T-C	UGT2B4	c.1212A>G	p.Ala404Ala	Synonymous	5/6	-
19-41386036-T-G	CYP2A7	c.454A>C	p.Ser152Arg	Missense	3/8	-
1-97915614-C-T	DPYD	c.1905+1G>A	-	IntronicSNV	-	14/22
13-95815415-C-T	ABCC4	c.2269G>A	p.Glu757Lys	Missense	18/31	-
13-95726518-C-A	ABCC4	c.2867G>T	p.Cys956Phe	Missense	23/31	-
2-234681645-G-C	UGT1A1	c.*440G>C	-	3-UTRSNV	5/5	-
16-16230411-C-T	ABCC1	c.4202C>T	p.Thr1401Met	Missense	29/31	-
16-16230411-C-G	ABCC1	c.4202C>G	p.Thr1401Arg	Missense	29/31	-
11-62751852-G-A	SLC22A6	c.311C>T	p.Pro104Leu	Missense	1/10	-
2-234627608-T-A	UGT1A4	c.142T>A	p.Leu48Met	Missense	1/5	-
15-58284937-C-T	ALDH1A2	c.701G>A	p.Gly234Asp	Missense	8/14	-
10-96731936-A-G	CYP2C9	c.895A>G	p.Thr299Ala	Missense	6/9	-
2-234638245-C-T	UGT1A3	c.473C>T	p.Ala158Val	Missense	1/5	-
2-234601859-C-A	UGT1A10	c.855+55836C>A	-	IntronicSNV	-	1/4
2-234622420-T-C	UGT1A10	c.856-53260T>C	-	IntronicSNV	-	1/4
19-41386036-T-C	CYP2A7	c.454A>G	p.Ser152Gly	Missense	3/8	-
2-234622429-T-C	UGT1A10	c.856-53251T>C	-	IntronicSNV	-	1/4
2-234638339-C-T	UGT1A4	c.867+10006C>T	-	IntronicSNV	-	1/4
5-131649424-G-A	SLC22A4	c.615G>A	p.Met205Ile	Missense	3/10	-
2-169847329-T-C	ABCB11	c.890A>G	p.Glu297Gly	Missense	9/28	-
22-42524817-C-T	CYP2D6	c.635G>A	p.Gly212Glu	Missense	4/9	-
12-21422492-G-C	SLCO1A2	c.2003C>G	p.Thr668Ser	Missense	14/14	-
2-234665498-C-T	UGT1A4	c.868-10182C>T	-	IntronicSNV	-	1/4
2-234676883-G-A	UGT1A1	c.1102G>A	p.Ala368Thr	Missense	4/5	-
2-234676982-G-C	UGT1A1	c.1201G>C	p.Ala401Pro	Missense	4/5	-
11-62749344-G-A	SLC22A6	c.767C>T	p.Ala256Val	Missense	4/10	-
4-70146704-G-A	UGT2B28	c.486G>A	p.Ala162Ala	Synonymous	1/6	-
2-234591343-C-G	UGT1A10	c.855+45320C>G	-	IntronicSNV	-	1/4
13-99378664-C-G	SLC15A1	c.61G>C	p.Val21Leu	Missense	3/23	-
22-44227556-A-G	SULT4A1	c.603+1964T>C	-	IntronicSNV	-	5/6
3-121647286-C-G	SLC15A2	c.1225C>G	p.Pro409Ala	Missense	15/22	-
2-234545495-A-T	UGT1A10	c.327A>T	p.Leu109Phe	Missense	1/5	-
19-41356310-G-A	CYP2A6	c.22C>T	p.Leu8Leu	Synonymous	1/9	-
19-41356319-C-T	CYP2A6	c.13G>A	p.Gly5Arg	Missense	1/9	-
8-18080116-G-A	NAT1	c.560G>A	p.Arg187Gln	Missense	3/3	-
8-18257971-C-T	NAT2	c.458C>T	p.Thr153Ile	Missense	2/2	-
10-101610393-G-C	ABCC2	c.4348G>C	p.Ala1450Pro	Missense	31/32	-
2-234601755-C-T	UGT1A10	c.855+55732C>T	-	IntronicSNV	-	1/4
11-62763248-G-A	SLC22A8	c.929C>T	p.Ala310Val	Missense	7/11	-
22-42525811-T-C	CYP2D6	c.281A>G	p.His94Arg	Missense	2/9	-
13-99378664-C-T	SLC15A1	c.61G>A	p.Val21Ile	Missense	3/23	-
7-75615277-G-A	POR	c.1706G>A	p.Cys569Tyr	Missense	14/16	-
13-99340576-G-A	SLC15A1	c.1609C>T	p.Pro537Ser	Missense	20/23	-
2-169850291-C-A	ABCB11	c.713G>T	p.Gly238Val	Missense	8/28	-
2-169850291-C-G	ABCB11	c.713G>C	p.Gly238Ala	Missense	8/28	-
2-234545887-C-T	UGT1A10	c.719C>T	p.Thr240Met	Missense	1/5	-
13-95899303-G-A	ABCC4	c.232C>T	p.Pro78Ser	Missense	3/31	-
10-96541701-G-C	CYP2C19	c.766G>C	p.Asp256His	Missense	5/9	-
6-18143853-C-T	TPMT	c.340G>A	p.Glu114Lys	Missense	4/9	-
10-96541701-G-A	CYP2C19	c.766G>A	p.Asp256Asn	Missense	5/9	-
8-18257877-G-T	NAT2	c.364G>T	p.Asp122Tyr	Missense	2/2	-
7-75610876-C-A	POR	c.683C>A	p.Pro228Gln	Missense	7/16	-
16-48221319-C-T	ABCC11	c.2726G>A	p.Ser909Asn	Missense	22/31	-
2-108910712-A-C	SULT1C2	c.179A>C	p.Asp60Ala	Missense	3/9	-
8-18257877-G-C	NAT2	c.364G>C	p.Asp122His	Missense	2/2	-
19-41349750-C-A	CYP2A6	c.1436G>T	p.Gly479Val	Missense	9/9	-
15-75041341-T-G	CYP1A2	c.-10+103T>G	-	intron_variant	-	1/6
6-18139941-G-A	TPMT	c.374C>T	p.Ser125Leu	Missense	5/9	-
10-101560169-G-A	ABCC2	c.1058G>A	p.Arg353His	Missense	9/32	-
13-95953517-G-T	ABCC4	c.52C>A	p.Leu18Ile	Missense	1/31	-
4-89052248-G-C	ABCG2	c.496C>G	p.Gln166Glu	Missense	5/16	-
2-108910751-G-C	SULT1C2	c.218G>C	p.Arg73Pro	Missense	3/9	-
2-234601965-A-G	UGT1A10	c.855+55942A>G	-	IntronicSNV	-	1/4
7-99359800-G-A	CYP3A4	c.1114C>T	p.Leu372Phe	Missense	11/13	-
10-135342034-G-C	CYP2E1	c.227G>C	p.Arg76Pro	Missense	2/9	-
12-21392011-A-T	SLCO1B1	c.1964A>T	p.Asp655Val	Missense	15/15	-
5-131729439-T-C	SLC22A5	c.1522T>C	p.Phe508Leu	Missense	9/10	-
4-69962360-C-T	UGT2B7	c.122C>T	p.Thr41Ile	Missense	1/6	-
8-18080015-G-A	NAT1	c.459G>A	p.Thr153Thr	Synonymous	3/3	-
8-18080115-C-T	NAT1	c.559C>T	p.Arg187*	Nonsense	3/3	-
13-95953517-G-A	ABCC4	c.52C>T	p.Leu18Phe	Missense	1/31	-
10-96740981-C-T	CYP2C9	c.1003C>T	p.Arg335Trp	Missense	7/9	-
19-41351967-T-C	CYP2A6	c.867A>G	p.Lys289Lys	Synonymous	6/9	-
2-234665537-T-C	UGT1A4	c.868-10143T>C	-	IntronicSNV	-	1/4
22-42525044-T-C	CYP2D6	c.496A>G	p.Asn166Asp	Missense	3/9	-
22-42525767-T-C	CYP2D6	c.325A>G	p.Ile109Val	Missense	2/9	-
10-101557063-G-A	ABCC2	c.842G>A	p.Ser281Asn	Missense	7/32	-
2-234627631-C-A	UGT1A4	c.165C>A	p.Gly55Gly	Synonymous	1/5	-
10-135351264-G-A	CYP2E1	c.1165G>A	p.Val389Ile	Missense	8/9	-
10-135351264-G-T	CYP2E1	c.1165G>T	p.Val389Leu	Missense	8/9	-
2-234627631-C-T	UGT1A4	c.165C>T	p.Gly55Gly	Synonymous	1/5	-
5-131729878-A-G	SLC22A5	c.1588A>G	p.Met530Val	Missense	10/10	-
2-234622204-C-T	UGT1A10	c.856-53476C>T	-	IntronicSNV	-	1/4
10-96522463-A-T	CYP2C19	c.1A>T	p.Met1Leu	Missense	1/9	-
10-96818199-C-G	CYP2C8	c.712G>C	p.Ala238Pro	Missense	5/9	-
2-234545443-T-A	UGT1A10	c.275T>A	p.Val92Asp	Missense	1/5	-
2-234676880-C-G	UGT1A3	c.1102C>G	p.Arg368Gly	Missense	4/5	-
2-234676880-C-T	UGT1A1	c.1099C>T	p.Arg367Cys	Missense	4/5	-
9-86907624-T-C	SLC28A3	c.982A>G	p.Ile328Val	Missense	11/19	-
12-21358855-A-G	SLCO1B1	c.1385A>G	p.Asp462Gly	Missense	11/15	-
6-18134078-C-A	TPMT	c.537G>T	p.Gln179His	Missense	7/9	-
2-234581336-G-T	UGT1A10	c.855+35313G>T	-	IntronicSNV	-	1/4
11-74873726-C-T	SLCO2B1	c.43C>T	p.Pro15Ser	Missense	2/14	-
11-74873726-C-G	SLCO2B1	c.43C>G	p.Pro15Ala	Missense	2/14	-
10-96698528-C-T	CYP2C9	c.89C>T	p.Pro30Leu	Missense	1/9	-
4-69433714-C-T	UGT2B17	c.489G>A	p.Glu163Glu	Synonymous	1/6	-
7-99375702-C-T	CYP3A4	c.167G>A	p.Gly56Asp	Missense	3/13	-
7-122809234-T-C	SLC13A1	c.521A>G	p.Asn174Ser	Missense	4/15	-
10-96702066-G-A	CYP2C9	c.449G>A	p.Arg150His	Missense	3/9	-
10-96702066-G-T	CYP2C9	c.449G>T	p.Arg150Leu	Missense	3/9	-
7-99366047-T-C	CYP3A4	c.600A>G	p.Gln200Gln	Synonymous	7/13	-
4-100232723-T-C	ADH1B	c.919A>G	p.Met307Val	Missense	7/9	-
4-69416569-C-T	UGT2B17	c.1139G>A	p.Gly380Asp	Missense	5/6	-
6-160543317-C-G	SLC22A1	c.350C>G	p.Pro117Arg	Missense	1/11	-
6-160543317-C-T	SLC22A1	c.350C>T	p.Pro117Leu	Missense	1/11	-
10-96827293-T-C	CYP2C8	c.324A>G	p.Lys108Lys	Synonymous	2/9	-
10-96827293-T-A	CYP2C8	c.324A>T	p.Lys108Asn	Missense	2/9	-
22-42526670-C-T	CYP2D6	c.124G>A	p.Gly42Arg	Missense	1/9	-
10-96534917-G-C	CYP2C19	c.271G>C	p.Gly91Arg	Missense	2/9	-
19-41522631-A-G	CYP2B6	c.1375A>G	p.Met459Val	Missense	9/9	-
1-171086457-C-T	FMO3	c.1474C>T	p.Arg492Trp	Missense	9/9	-
6-160543229-T-C	SLC22A1	c.262T>C	p.Cys88Arg	Missense	1/11	-
4-70160338-G-C	UGT2B28	c.1401G>C	p.Val467Val	Synonymous	6/6	-
4-69964271-A-G	UGT2B7	c.735A>G	p.Thr245Thr	Synonymous	2/6	-
2-234581336-G-A	UGT1A9	c.756G>A	p.Leu252Leu	Synonymous	1/5	-
7-75615113-G-A	POR	c.1615G>A	p.Gly539Arg	Missense	13/16	-
11-62748776-G-A	SLC22A6	c.877C>T	p.Arg293Trp	Missense	5/10	-
13-95735484-T-C	ABCC4	c.2596A>G	p.Ile866Val	Missense	21/31	-
2-234665763-A-G	UGT1A4	c.868-9917A>G	-	IntronicSNV	-	1/4
13-95858978-T-C	ABCC4	c.969A>G	p.Ser323Ser	Synonymous	8/31	-
7-75608875-C-T	POR	c.344C>T	p.Ala115Val	Missense	4/16	-
19-41354171-G-T	CYP2A6	c.607C>A	p.Arg203Ser	Missense	4/9	-
10-96702066-G-C	CYP2C9	c.449G>C	p.Arg150Pro	Missense	3/9	-
7-99366093-G-C	CYP3A4	c.554C>G	p.Thr185Ser	Missense	7/13	-
10-96805708-C-G	CYP2C8	c.820G>C	p.Glu274Gln	Missense	6/9	-
1-171072991-G-C	FMO3	c.198G>C	p.Met66Ile	Missense	3/9	-
1-171072991-G-T	FMO3	c.198G>T	p.Met66Ile	Missense	3/9	-
2-234526871-C-G	UGT1A8	c.518C>G	p.Ala173Gly	Missense	1/5	-
6-160553407-G-T	SLC22A1	c.659G>T	p.Gly220Val	Missense	3/11	-
2-234526871-C-T	UGT1A8	c.518C>T	p.Ala173Val	Missense	1/5	-
6-160553407-G-C	SLC22A1	c.659G>C	p.Gly220Ala	Missense	3/11	-
4-69696582-G-A	UGT2B10	c.1572G>A	p.Lys524Lys	Synonymous	6/6	-
22-42525772-G-T	CYP2D6	c.320C>A	p.Thr107Asn	Missense	2/9	-
17-19463562-A-C	SLC47A1	c.983A>C	p.Asp328Ala	Missense	11/17	-
4-89042853-A-G	ABCG2	c.623T>C	p.Phe208Ser	Missense	6/16	-
4-70156313-T-A	UGT2B28	c.1094T>A	p.Leu365His	Missense	5/6	-
4-70156313-T-G	UGT2B28	c.1094T>G	p.Leu365Arg	Missense	5/6	-
14-23598976-G-A	SLC7A8	c.831C>T	p.Ser277Ser	Synonymous	7/9	-
1-97564155-G-A	DPYD	c.2656C>T	p.Arg886Cys	Missense	21/23	-
13-95886884-A-C	ABCC4	c.511T>G	p.Cys171Gly	Missense	4/31	-
6-18130918-T-G	TPMT	c.719A>C	p.Tyr240Ser	Missense	9/9	-
2-234590974-C-G	UGT1A10	c.855+44951C>G	-	IntronicSNV	-	1/4
2-234590974-C-T	UGT1A10	c.855+44951C>T	-	IntronicSNV	-	1/4
4-69512847-T-G	UGT2B15	c.1568A>C	p.Lys523Thr	Missense	6/6	-
11-62766439-G-A	SLC22A8	c.715C>T	p.Gln239*	Nonsense	5/11	-
22-42523592-G-A	CYP2D6	c.1030C>T	p.Arg344*	Nonsense	7/9	-
13-95886884-A-T	ABCC4	c.511T>A	p.Cys171Ser	Missense	4/31	-
2-234590857-G-A	UGT1A10	c.855+44834G>A	-	IntronicSNV	-	1/4
2-234621869-A-G	UGT1A10	c.856-53811A>G	-	IntronicSNV	-	1/4
2-234675738-G-A	UGT1A1	c.923G>A	p.Gly308Glu	Missense	2/5	-
4-70351024-T-A	UGT2B4	c.1212A>T	p.Ala404Ala	Synonymous	5/6	-
2-234526893-T-C	UGT1A8	c.540T>C	p.Gly180Gly	Synonymous	1/5	-
7-99367392-C-G	CYP3A4	c.520G>C	p.Asp174His	Missense	6/13	-
22-42526763-C-T	CYP2D6	c.31G>A	p.Val11Met	Missense	1/9	-
4-69528742-G-A	UGT2B15	c.989C>T	p.Ala330Val	Missense	3/6	-
9-86955535-C-T	SLC28A3	c.14G>A	p.Ser5Asn	Missense	2/19	-
2-234676504-C-T	UGT1A1	c.1006C>T	p.Arg336Trp	Missense	3/5	-
10-96824643-G-C	CYP2C8	c.556C>G	p.Arg186Gly	Missense	4/9	-
10-96707539-C-A	CYP2C9	c.485C>A	p.Ser162*	Nonsense	4/9	-
7-17379110-G-A	AHR	c.1661G>A	p.Arg554Lys	Missense	10/11	-
4-69962619-T-C	UGT2B7	c.381T>C	p.Cys127Cys	Synonymous	1/6	-
2-234669773-C-A	UGT1A1	c.840C>A	p.Cys280*	Nonsense	1/5	-
10-96522561-T-C	CYP2C19	c.99T>C	p.Pro33Pro	Synonymous	1/9	-
4-69968550-C-T	UGT2B7	c.896C>T	p.Ser299Phe	Missense	3/6	-
8-18257665-G-T	NAT2	c.152G>T	p.Gly51Val	Missense	2/2	-
1-97981343-A-T	DPYD	c.1679T>A	p.Ile560Asn	Missense	13/23	-
1-97981343-A-C	DPYD	c.1679T>G	p.Ile560Ser	Missense	13/23	-
6-18130956-A-T	TPMT	c.681T>A	p.His227Gln	Missense	9/9	-
1-171086441-A-G	FMO3	c.1458A>G	p.Ile486Met	Missense	9/9	-
1-171083242-A-G	FMO3	c.923A>G	p.Glu308Gly	Missense	7/9	-
4-69433763-T-A	UGT2B17	c.440A>T	p.Asp147Val	Missense	1/6	-
6-18148141-A-G	TPMT	c.146T>C	p.Leu49Ser	Missense	3/9	-
4-69512917-C-T	UGT2B15	c.1498G>A	p.Ala500Thr	Missense	6/6	-
1-97915614-C-G	DPYD	c.1905+1G>C	-	IntronicSNV	-	14/22
10-101610393-G-T	ABCC2	c.4348G>T	p.Ala1450Ser	Missense	31/32	-
15-75013026-A-G	CYP1A1	c.1343T>C	p.Ile448Thr	Missense	7/7	-
11-74880370-G-A	SLCO2B1	c.601G>A	p.Val201Met	Missense	5/14	-
2-234591343-C-T	UGT1A10	c.855+45320C>T	-	IntronicSNV	-	1/4
7-99273815-G-A	CYP3A5	c.88C>T	p.His30Tyr	Missense	2/13	-
2-234545932-C-G	UGT1A10	c.764C>G	p.Thr255Arg	Missense	1/5	-
2-234665498-C-A	UGT1A4	c.868-10182C>A	-	IntronicSNV	-	1/4
10-101610393-G-A	ABCC2	c.4348G>A	p.Ala1450Thr	Missense	31/32	-
15-75013026-A-T	CYP1A1	c.1343T>A	p.Ile448Asn	Missense	7/7	-
2-234526794-T-C	UGT1A8	c.441T>C	p.Leu147Leu	Synonymous	1/5	-
8-18257877-G-A	NAT2	c.364G>A	p.Asp122Asn	Missense	2/2	-
2-234526794-T-G	UGT1A8	c.441T>G	p.Leu147Leu	Synonymous	1/5	-
22-42526717-C-T	CYP2D6	c.77G>A	p.Arg26His	Missense	1/9	-
19-41354171-G-C	CYP2A6	c.607C>G	p.Arg203Gly	Missense	4/9	-
19-41354171-G-A	CYP2A6	c.607C>T	p.Arg203Cys	Missense	4/9	-
17-19584971-C-T	SLC47A2	c.1285G>A	p.Gly429Arg	Missense	14/17	-
19-41349732-C-G	CYP2A6	c.1454G>C	p.Arg485Pro	Missense	9/9	-
10-101594176-C-T	ABCC2	c.3298C>T	p.Arg1100Cys	Missense	24/32	-
19-41349732-C-A	CYP2A6	c.1454G>T	p.Arg485Leu	Missense	9/9	-
19-41497272-A-T	CYP2B6	c.62A>T	p.Gln21Leu	Missense	1/9	-
2-234680912-A-T	UGT1A1	c.1309A>T	p.Lys437*	Nonsense	5/5	-
15-75015206-A-G	CYP1A1	c.233T>C	p.Ile78Thr	Missense	2/7	-
11-64359297-G-A	SLC22A12	c.269G>A	p.Arg90His	Missense	1/10	-
10-96708974-A-G	CYP2C9	c.752A>G	p.His251Arg	Missense	5/9	-
1-110233147-C-T	GSTM1	c.528C>T	p.Asp176Asp	Synonymous	7/8	-
17-19437187-T-C	SLC47A1	c.1-66T>C	-	5-UTRSNV	1/17	-
4-69962774-C-A	UGT2B7	c.536C>A	p.Thr179Asn	Missense	1/6	-
2-234581374-T-A	UGT1A10	c.855+35351T>A	-	IntronicSNV	-	1/4
19-41351309-A-G	CYP2A6	c.1051T>C	p.Tyr351His	Missense	7/9	-
2-234622085-C-T	UGT1A10	c.856-53595C>T	-	IntronicSNV	-	1/4
4-69962774-C-T	UGT2B7	c.536C>T	p.Thr179Ile	Missense	1/6	-
6-160670282-A-C	SLC22A2	c.808T>G	p.Ser270Ala	Missense	4/11	-
2-234545642-T-C	UGT1A10	c.474T>C	p.Ala158Ala	Synonymous	1/5	-
8-18258151-C-T	NAT2	c.638C>T	p.Pro213Leu	Missense	2/2	-
15-75041351-C-T	CYP1A2	c.-10+113C>T	-	intron_variant	-	1/6
2-234665761-C-G	UGT1A4	c.868-9919C>G	-	IntronicSNV	-	1/4
15-75047191-C-T	CYP1A2	c.1313C>T	p.Thr438Ile	Missense	7/7	-
19-41510286-G-A	CYP2B6	c.419G>A	p.Arg140Gln	Missense	3/9	-
19-41510286-G-C	CYP2B6	c.419G>C	p.Arg140Pro	Missense	3/9	-
7-20691047-T-C	ABCB5	c.2T>C	p.Met1Thr	Missense	4/19	-
13-95830299-C-T	ABCC4	c.1592G>A	p.Arg531Gln	Missense	12/31	-
4-69683844-T-C	UGT2B10	c.816T>C	p.Asn272Asn	Synonymous	2/6	-
2-234667582-A-T	UGT1A4	c.868-8098A>T	-	IntronicSNV	-	1/4
15-75047191-C-A	CYP1A2	c.1313C>A	p.Thr438Asn	Missense	7/7	-
1-171076935-C-T	FMO3	c.441C>T	p.Ser147Ser	Synonymous	4/9	-
6-18130956-A-C	TPMT	c.681T>G	p.His227Gln	Missense	9/9	-
6-18130956-A-G	TPMT	c.681T>C	p.His227His	Synonymous	9/9	-
22-44253089-C-T	SULT4A1	c.169+5005G>A	-	IntronicSNV	-	1/6
4-89061114-C-T	ABCG2	c.34G>A	p.Val12Met	Missense	2/16	-
2-234669462-T-C	UGT1A1	c.529T>C	p.Cys177Arg	Missense	1/5	-
11-62752014-C-A	SLC22A6	c.149G>T	p.Arg50Leu	Missense	1/10	-
11-62752014-C-T	SLC22A6	c.149G>A	p.Arg50His	Missense	1/10	-
2-234637803-T-C	UGT1A3	c.31T>C	p.Trp11Arg	Missense	1/5	-
6-160664685-G-T	SLC22A2	c.1198C>A	p.Arg400Ser	Missense	7/11	-
2-234667582-A-C	UGT1A4	c.868-8098A>C	-	IntronicSNV	-	1/4
2-234667582-A-G	UGT1A4	c.868-8098A>G	-	IntronicSNV	-	1/4
10-96535173-T-C	CYP2C19	c.358T>C	p.Trp120Arg	Missense	3/9	-
4-69693154-C-T	UGT2B10	c.1195C>T	p.Pro399Ser	Missense	5/6	-
22-44253089-C-G	SULT4A1	c.169+5005G>C	-	IntronicSNV	-	1/6
2-234669457-T-A	UGT1A1	c.524T>A	p.Leu175Gln	Missense	1/5	-
2-234591005-G-C	UGT1A7	c.422G>C	p.Cys141Ser	Missense	1/5	-
11-62752014-C-G	SLC22A6	c.149G>C	p.Arg50Pro	Missense	1/10	-
2-169783827-G-A	ABCB11	c.3457C>T	p.Arg1153Cys	Missense	26/28	-
6-18130925-T-C	TPMT	c.712A>G	p.Lys238Glu	Missense	9/9	-
8-18258370-G-A	NAT2	c.857G>A	p.Gly286Glu	Missense	2/2	-
1-161203078-G-A	NR1I3	c.289C>T	p.Arg97Trp	Missense	4/9	-
19-41354198-T-C	CYP2A6	c.580A>G	p.Lys194Glu	Missense	4/9	-
19-41512918-T-C	CYP2B6	c.593T>C	p.Met198Thr	Missense	4/9	-
12-21331606-T-G	SLCO1B1	c.578T>G	p.Leu193Arg	Missense	6/15	-
22-42525035-C-T	CYP2D6	c.505G>A	p.Gly169Arg	Missense	3/9	-
22-42525035-C-A	CYP2D6	c.505G>T	p.Gly169*	Nonsense	3/9	-
7-75615552-G-A	POR	c.1891G>A	p.Val631Ile	Missense	15/16	-
13-99378642-A-T	SLC15A1	c.83T>A	p.Phe28Tyr	Missense	3/23	-
4-69693099-T-C	UGT2B10	c.1140T>C	p.Tyr380Tyr	Synonymous	5/6	-
15-75013643-G-A	CYP1A1	c.1063C>T	p.Arg355Trp	Missense	5/7	-
2-234637789-A-G	UGT1A4	c.867+9456A>G	-	IntronicSNV	-	1/4
5-131676320-C-T	SLC22A4	c.1507C>T	p.Leu503Phe	Missense	9/10	-
19-41510030-G-A	CYP2B6	c.296G>A	p.Gly99Glu	Missense	2/9	-
2-234637912-T-A	UGT1A4	c.867+9579T>A	-	IntronicSNV	-	1/4
19-41512828-C-T	CYP2B6	c.503C>T	p.Thr168Ile	Missense	4/9	-
13-99376180-G-T	SLC15A1	c.351C>A	p.Ser117Arg	Missense	5/23	-
6-160664685-G-A	SLC22A2	c.1198C>T	p.Arg400Cys	Missense	7/11	-
5-131647935-G-A	SLC22A4	c.475G>A	p.Val159Met	Missense	2/10	-
12-21331891-A-G	SLCO1B1	c.664A>G	p.Ile222Val	Missense	7/15	-
15-75013643-G-T	CYP1A1	c.1063C>A	p.Arg355Arg	Synonymous	5/7	-
2-234638203-C-G	UGT1A4	c.867+9870C>G	-	IntronicSNV	-	1/4
6-18143769-A-G	TPMT	c.366+58T>C	-	IntronicSNV	-	4/8
16-16139709-G-A	ABCC1	c.1057G>A	p.Val353Met	Missense	9/31	-
10-101595975-G-T	ABCC2	c.3542G>T	p.Arg1181Leu	Missense	25/32	-
13-99376180-G-A	SLC15A1	c.351C>T	p.Ser117Ser	Synonymous	5/23	-
16-16139709-G-T	ABCC1	c.1057G>T	p.Val353Leu	Missense	9/31	-
19-41497274-C-T	CYP2B6	c.64C>T	p.Arg22Cys	Missense	1/9	-
1-171080028-T-C	FMO3	c.717T>C	p.Phe239Phe	Synonymous	6/9	-
2-234627943-G-A	UGT1A4	c.477G>A	p.Ala159Ala	Synonymous	1/5	-
10-101604207-C-G	ABCC2	c.3972C>G	p.Ile1324Met	Missense	28/32	-
10-101604207-C-T	ABCC2	c.3972C>T	p.Ile1324Ile	Synonymous	28/32	-
10-101595996-T-A	ABCC2	c.3563T>A	p.Val1188Glu	Missense	25/32	-
10-101604163-C-G	ABCC2	c.3928C>G	p.Arg1310Gly	Missense	28/32	-
2-234638006-A-G	UGT1A4	c.867+9673A>G	-	IntronicSNV	-	1/4
2-234545473-C-T	UGT1A10	c.305C>T	p.Ala102Val	Missense	1/5	-
19-41356316-T-G	CYP2A6	c.16A>C	p.Met6Leu	Missense	1/9	-
2-234545473-C-A	UGT1A10	c.305C>A	p.Ala102Glu	Missense	1/5	-
2-234526987-A-G	UGT1A8	c.634A>G	p.Met212Val	Missense	1/5	-
14-70245193-G-A	SLC10A1	c.800C>T	p.Ser267Phe	Missense	4/5	-
2-234526987-A-T	UGT1A8	c.634A>T	p.Met212Leu	Missense	1/5	-
22-42525132-G-C	CYP2D6	c.408C>G	p.Val136Val	Synonymous	3/9	-
22-42523610-C-T	CYP2D6	c.1012G>A	p.Val338Met	Missense	7/9	-
3-119530419-G-T	NR1I2	c.365G>T	p.Arg122Leu	Missense	4/9	-
3-119530419-G-A	NR1I2	c.365G>A	p.Arg122Gln	Missense	4/9	-
10-96701715-T-C	CYP2C9	c.269T>C	p.Leu90Pro	Missense	2/9	-
7-2472892-C-A	CHST12	c.618C>A	p.His206Gln	Missense	2/2	-
7-2472892-C-T	CHST12	c.618C>T	p.His206His	Synonymous	2/2	-
2-234669759-G-T	UGT1A1	c.826G>T	p.Gly276Cys	Missense	1/5	-
10-135352356-A-T	CYP2E1	c.1370A>T	p.His457Leu	Missense	9/9	-
4-89018733-A-G	ABCG2	c.1519T>C	p.Phe507Leu	Missense	13/16	-
16-16173286-C-T	ABCC1	c.2066C>T	p.Ser689Leu	Missense	16/31	-
2-219674482-G-T	CYP27A1	c.438G>T	p.Pro146Pro	Synonymous	2/9	-
6-18131012-C-T	TPMT	c.626-1G>A	-	IntronicSNV	-	8/8
7-87133651-C-T	ABCB1	c.3751G>A	p.Val1251Ile	Missense	29/29	-
8-18258279-A-T	NAT2	c.766A>T	p.Lys256*	Nonsense	2/2	-
7-75614973-T-A	POR	c.1475T>A	p.Val492Glu	Missense	13/16	-
22-44251648-C-T	SULT4A1	c.169+6446G>A	-	IntronicSNV	-	1/6
11-14899811-G-A	CYP2R1	c.1363C>T	p.Arg455Trp	Missense	5/5	-
10-96541756-T-A	CYP2C19	c.819+2T>A	-	IntronicSNV	-	5/8
22-42523475-C-G	CYP2D6	c.1147G>C	p.Glu383Gln	Missense	7/9	-
4-69973863-A-G	UGT2B7	c.1133A>G	p.Asn378Ser	Missense	5/6	-
2-234622110-C-G	UGT1A10	c.856-53570C>G	-	IntronicSNV	-	1/4
4-69973863-A-C	UGT2B7	c.1133A>C	p.Asn378Thr	Missense	5/6	-
4-69973863-A-T	UGT2B7	c.1133A>T	p.Asn378Ile	Missense	5/6	-
19-41512824-C-T	CYP2B6	c.499C>T	p.Pro167Ser	Missense	4/9	-
2-234622110-C-T	UGT1A10	c.856-53570C>T	-	IntronicSNV	-	1/4
10-96535264-G-A	CYP2C19	c.449G>A	p.Arg150His	Missense	3/9	-
4-69417570-A-G	UGT2B17	c.1065T>C	p.Tyr355Tyr	Synonymous	4/6	-
12-21015737-C-G	SLCO1B3	c.676C>G	p.Leu226Val	Missense	8/16	-
6-18143955-C-G	TPMT	c.238G>C	p.Ala80Pro	Missense	4/9	-
3-119529002-C-T	NR1I2	c.292C>T	p.Arg98Cys	Missense	3/9	-
4-69973867-C-A	UGT2B7	c.1137C>A	p.Gly379Gly	Synonymous	5/6	-
19-41515263-A-G	CYP2B6	c.785A>G	p.Lys262Arg	Missense	5/9	-
10-101595882-G-A	ABCC2	c.3449G>A	p.Arg1150His	Missense	25/32	-
8-18258135-T-C	NAT2	c.622T>C	p.Tyr208His	Missense	2/2	-
6-160553314-C-T	SLC22A1	c.566C>T	p.Ser189Leu	Missense	3/11	-
19-41522715-C-A	CYP2B6	c.1459C>A	p.Arg487Ser	Missense	9/9	-
19-41522715-C-T	CYP2B6	c.1459C>T	p.Arg487Cys	Missense	9/9	-
10-101595950-A-G	ABCC2	c.3517A>G	p.Ile1173Val	Missense	25/32	-
10-101595950-A-T	ABCC2	c.3517A>T	p.Ile1173Phe	Missense	25/32	-
4-89039360-A-C	ABCG2	c.742T>G	p.Ser248Ala	Missense	7/16	-
6-18139200-C-T	TPMT	c.488G>A	p.Arg163His	Missense	6/9	-
19-41349774-A-G	CYP2A6	c.1412T>C	p.Ile471Thr	Missense	9/9	-
7-99258139-C-T	CYP3A5	c.1009G>A	p.Ala337Thr	Missense	10/13	-
2-234545496-A-C	UGT1A10	c.328A>C	p.Met110Leu	Missense	1/5	-
7-117307108-G-A	CFTR	c.4389G>A	p.Gln1463Gln	Synonymous	27/27	-
13-99356611-C-T	SLC15A1	c.1348G>A	p.Val450Ile	Missense	17/23	-
2-234545496-A-T	UGT1A10	c.328A>T	p.Met110Leu	Missense	1/5	-
15-75012987-G-A	CYP1A1	c.1382C>T	p.Thr461Ile	Missense	7/7	-
15-75012987-G-T	CYP1A1	c.1382C>A	p.Thr461Asn	Missense	7/7	-
12-21329813-C-T	SLCO1B1	c.463C>T	p.Pro155Ser	Missense	5/15	-
17-19618447-C-T	SLC47A2	c.207G>A	p.Ser69Ser	Synonymous	2/17	-
1-171083259-G-A	FMO3	c.940G>A	p.Glu314Lys	Missense	7/9	-
1-171083259-G-T	FMO3	c.940G>T	p.Glu314*	Nonsense	7/9	-
1-171072975-A-G	FMO3	c.182A>G	p.Asn61Ser	Missense	3/9	-
2-234545471-G-A	UGT1A10	c.303G>A	p.Gln101Gln	Synonymous	1/5	-
4-69972952-C-A	UGT2B7	c.1062C>A	p.Tyr354*	Nonsense	4/6	-
4-69972952-C-T	UGT2B7	c.1062C>T	p.Tyr354Tyr	Synonymous	4/6	-
19-41518370-C-T	CYP2B6	c.1132C>T	p.Arg378*	Nonsense	7/9	-
9-86924586-C-T	SLC28A3	c.200G>A	p.Arg67Lys	Missense	4/19	-
4-70346564-G-A	UGT2B4	c.1375C>T	p.Arg459*	Nonsense	6/6	-
6-160663420-T-C	SLC22A2	c.1294A>G	p.Lys432Glu	Missense	8/11	-
2-169791806-C-T	ABCB11	c.2944G>A	p.Gly982Arg	Missense	23/28	-
7-99367825-T-A	CYP3A4	c.352A>T	p.Ile118Phe	Missense	5/13	-
2-234675523-C-A	UGT1A1	c.865-157C>A	-	IntronicSNV	-	1/4
2-234545509-G-C	UGT1A10	c.341G>C	p.Ser114Thr	Missense	1/5	-
7-99367825-T-C	CYP3A4	c.352A>G	p.Ile118Val	Missense	5/13	-
22-42523855-G-C	CYP2D6	c.974C>G	p.Pro325Arg	Missense	6/9	-
10-96740982-G-A	CYP2C9	c.1004G>A	p.Arg335Gln	Missense	7/9	-
12-21069155-A-AC	SLCO1B3	c.2083_2084insC	p.Met695Thrfs*13	Frameshift	16/16	-
12-21349910-G-A	SLCO1B1	c.758G>A	p.Arg253Gln	Missense	8/15	-
12-21358933-G-C	SLCO1B1	c.1463G>C	p.Gly488Ala	Missense	11/15	-
10-96748777-C-T	CYP2C9	c.1465C>T	p.Pro489Ser	Missense	9/9	-
4-89018733-A-C	ABCG2	c.1519T>G	p.Phe507Val	Missense	13/16	-
2-234601714-G-T	UGT1A10	c.855+55691G>T	-	IntronicSNV	-	1/4
10-96701991-G-T	CYP2C9	c.374G>T	p.Arg125Leu	Missense	3/9	-
10-96701991-G-A	CYP2C9	c.374G>A	p.Arg125His	Missense	3/9	-
10-96701991-G-C	CYP2C9	c.374G>C	p.Arg125Pro	Missense	3/9	-
19-41355738-C-A	CYP2A6	c.328G>T	p.Val110Phe	Missense	2/9	-
19-48374789-C-T	SULT2A1	c.781G>A	p.Ala261Thr	Missense	6/6	-
17-19476126-G-A	SLC47A1	c.1438G>A	p.Val480Met	Missense	16/17	-
19-41518221-T-C	CYP2B6	c.983T>C	p.Ile328Thr	Missense	7/9	-
10-96824688-C-T	CYP2C8	c.511G>A	p.Gly171Ser	Missense	4/9	-
2-234680991-A-C	UGT1A1	c.1388A>C	p.Glu463Ala	Missense	5/5	-
2-234680991-A-G	UGT1A1	c.1388A>G	p.Glu463Gly	Missense	5/5	-
2-234680991-A-T	UGT1A1	c.1388A>T	p.Glu463Val	Missense	5/5	-
2-234627496-G-T	UGT1A4	c.30G>T	p.Pro10Pro	Synonymous	1/5	-
19-48377980-T-C	SULT2A1	c.679A>G	p.Lys227Glu	Missense	5/6	-
16-28617413-A-G	SULT1A1	c.739T>C	p.Phe247Leu	Missense	7/8	-
19-48377980-T-A	SULT2A1	c.679A>T	p.Lys227*	Nonsense	5/6	-
10-101564023-C-T	ABCC2	c.1457C>T	p.Thr486Ile	Missense	10/32	-
2-234638554-T-C	UGT1A4	c.867+10221T>C	-	IntronicSNV	-	1/4
2-234669681-T-C	UGT1A1	c.748T>C	p.Ser250Pro	Missense	1/5	-
13-95705380-G-C	ABCC4	c.3425C>G	p.Thr1142Arg	Missense	27/31	-
1-171076952-C-T	FMO3	c.458C>T	p.Pro153Leu	Missense	4/9	-
22-42524819-C-CC	CYP2D6	c.635_635dup	p.Leu213Thrfs*41	Frameshift	4/9	-
4-69962610-A-G	UGT2B7	c.372A>G	p.Arg124Arg	Synonymous	1/6	-
4-69962610-A-T	UGT2B7	c.372A>T	p.Arg124Ser	Missense	1/6	-
10-101591385-C-A	ABCC2	c.2901C>A	p.Tyr967*	Nonsense	22/32	-
1-171077372-C-T	FMO3	c.627+10C>T	-	IntronicSNV	-	5/8
15-75047363-C-A	CYP1A2	c.1485C>A	p.Tyr495*	Nonsense	7/7	-
15-75047363-C-T	CYP1A2	c.1485C>T	p.Tyr495Tyr	Synonymous	7/7	-
16-16142079-G-T	ABCC1	c.1299G>T	p.Arg433Ser	Missense	10/31	-
1-171077372-C-G	FMO3	c.627+10C>G	-	IntronicSNV	-	5/8
1-171077372-C-A	FMO3	c.627+10C>A	-	IntronicSNV	-	5/8
6-160671657-G-A	SLC22A2	c.596C>T	p.Thr199Ile	Missense	3/11	-
19-41384786-G-T	CYP2A7	c.557C>A	p.Ala186Asp	Missense	4/8	-
13-95839040-C-T	ABCC4	c.1460G>A	p.Gly487Glu	Missense	11/31	-
10-96540331-G-T	CYP2C19	c.557G>T	p.Arg186Leu	Missense	4/9	-
11-74883577-G-A	SLCO2B1	c.935G>A	p.Arg312Gln	Missense	7/14	-
10-96540331-G-A	CYP2C19	c.557G>A	p.Arg186His	Missense	4/9	-
2-234545881-C-T	UGT1A10	c.713C>T	p.Pro238Leu	Missense	1/5	-
4-89020503-A-G	ABCG2	c.1465T>C	p.Phe489Leu	Missense	12/16	-
12-21329738-A-T	SLCO1B1	c.388A>T	p.Asn130Tyr	Missense	5/15	-
11-74883577-G-T	SLCO2B1	c.935G>T	p.Arg312Leu	Missense	7/14	-
2-234621811-G-A	UGT1A10	c.856-53869G>A	-	IntronicSNV	-	1/4
2-234545451-C-G	UGT1A10	c.283C>G	p.His95Asp	Missense	1/5	-
2-234545451-C-T	UGT1A10	c.283C>T	p.His95Tyr	Missense	1/5	-
2-234545451-C-A	UGT1A10	c.283C>A	p.His95Asn	Missense	1/5	-
10-96827030-C-A	CYP2C8	c.416G>T	p.Arg139Met	Missense	3/9	-
16-16215877-G-A	ABCC1	c.3436G>A	p.Val1146Ile	Missense	24/31	-
9-86902991-G-T	SLC28A3	c.1252C>A	p.Leu418Ile	Missense	13/19	-
8-18080196-T-G	NAT1	c.640T>G	p.Ser214Ala	Missense	3/3	-
10-96827030-C-T	CYP2C8	c.416G>A	p.Arg139Lys	Missense	3/9	-
8-18080440-A-G	NAT1	c.*11A>G	-	3-UTRSNV	3/3	-
2-234675523-C-T	UGT1A1	c.865-157C>T	-	IntronicSNV	-	1/4
4-69681848-T-C	UGT2B10	c.111T>C	p.Asn37Asn	Synonymous	1/6	-
12-21032506-A-G	SLCO1B3	c.1272A>G	p.Leu424Leu	Synonymous	11/16	-
12-21032506-A-C	SLCO1B3	c.1272A>C	p.Leu424Leu	Synonymous	11/16	-
17-19445761-G-A	SLC47A1	c.191G>A	p.Gly64Asp	Missense	2/17	-
19-41356246-C-T	CYP2A6	c.86G>A	p.Ser29Asn	Missense	1/9	-
8-18080440-A-T	NAT1	c.*11A>T	-	3-UTRSNV	3/3	-
10-96535246-G-C	CYP2C19	c.431G>C	p.Arg144Pro	Missense	3/9	-
10-96535246-G-A	CYP2C19	c.431G>A	p.Arg144His	Missense	3/9	-
15-75047407-G-A	CYP1A2	c.1529G>A	p.Arg510Gln	Missense	7/7	-
15-75047407-G-T	CYP1A2	c.1529G>T	p.Arg510Leu	Missense	7/7	-
4-70355211-T-A	UGT2B4	c.948A>T	p.Thr316Thr	Synonymous	3/6	-
5-131662989-C-T	SLC22A4	c.844C>T	p.Arg282*	Nonsense	5/10	-
4-70355211-T-C	UGT2B4	c.948A>G	p.Thr316Thr	Synonymous	3/6	-
4-69533802-A-C	UGT2B15	c.829T>G	p.Phe277Val	Missense	2/6	-
16-16208683-G-A	ABCC1	c.3140G>A	p.Cys1047Tyr	Missense	23/31	-
15-75047184-G-A	CYP1A2	c.1306G>A	p.Asp436Asn	Missense	7/7	-
12-21054369-G-A	SLCO1B3	c.1833G>A	p.Gly611Gly	Synonymous	15/16	-
16-16208683-G-C	ABCC1	c.3140G>C	p.Cys1047Ser	Missense	23/31	-
16-16208683-G-T	ABCC1	c.3140G>T	p.Cys1047Phe	Missense	23/31	-
17-19480710-G-C	SLC47A1	c.1557G>C	p.Gln519His	Missense	17/17	-
7-99273821-G-A	CYP3A5	c.82C>T	p.Arg28Cys	Missense	2/13	-
2-234665659-T-G	UGT1A4	c.868-10021T>G	-	IntronicSNV	-	1/4
3-119530472-G-A	NR1I2	c.418G>A	p.Val140Met	Missense	4/9	-
2-220082984-T-C	ABCB6	c.412A>G	p.Met138Val	Missense	1/19	-
2-234627497-C-T	UGT1A4	c.31C>T	p.Arg11Trp	Missense	1/5	-
6-160551204-G-A	SLC22A1	c.480G>A	p.Leu160Leu	Synonymous	2/11	-
6-160551204-G-C	SLC22A1	c.480G>C	p.Leu160Phe	Missense	2/11	-
6-160551204-G-T	SLC22A1	c.480G>T	p.Leu160Phe	Missense	2/11	-
7-99364035-T-TT	CYP3A4	c.827_827dup	p.Asp276Glufs*9	Frameshift	9/13	-
1-97544627-C-A	DPYD	c.2983G>T	p.Val995Phe	Missense	23/23	-
7-99367427-C-T	CYP3A4	c.485G>A	p.Arg162Gln	Missense	6/13	-
22-42523621-T-G	CYP2D6	c.1001A>C	p.Glu334Ala	Missense	7/9	-
1-171083479-G-T	FMO3	c.1160G>T	p.Arg387Leu	Missense	7/9	-
10-101604130-A-C	ABCC2	c.3895A>C	p.Lys1299Gln	Missense	28/32	-
2-234545852-A-G	UGT1A10	c.684A>G	p.Leu228Leu	Synonymous	1/5	-
4-70160259-A-G	UGT2B28	c.1322A>G	p.Asn441Ser	Missense	6/6	-
7-99273745-T-C	CYP3A5	c.158A>G	p.Tyr53Cys	Missense	2/13	-
19-41352762-G-C	CYP2A6	c.831+18C>G	-	IntronicSNV	-	5/8
7-99366046-C-T	CYP3A4	c.601G>A	p.Asp201Asn	Missense	7/13	-
3-119526176-C-T	NR1I2	c.79C>T	p.Pro27Ser	Missense	2/9	-
19-41518708-C-A	CYP2B6	c.1282C>A	p.Pro428Thr	Missense	8/9	-
6-160560845-A-G	SLC22A1	c.1222A>G	p.Met408Val	Missense	7/11	-
8-18080343-A-G	NAT1	c.787A>G	p.Ile263Val	Missense	3/3	-
22-42523805-C-T	CYP2D6	c.985+39G>A	-	IntronicSNV	-	6/8
1-171083398-T-C	FMO3	c.1079T>C	p.Leu360Pro	Missense	7/9	-
2-234545481-A-T	UGT1A10	c.313A>T	p.Ile105Leu	Missense	1/5	-
4-89031974-AAA-TAT	ABCG2	c.1194+2479_1194+2481delinsATA	-	IntronicBlockSubstitution	-	9/15
10-96818119-G-C	CYP2C8	c.792C>G	p.Ile264Met	Missense	5/9	-
16-28607196-G-C	SULT1A2	c.56C>G	p.Pro19Arg	Missense	2/8	-
16-28607196-G-A	SULT1A2	c.56C>T	p.Pro19Leu	Missense	2/8	-
10-101567857-T-G	ABCC2	c.1686T>G	p.Phe562Leu	Missense	13/32	-
22-42524817-C-G	CYP2D6	c.635G>C	p.Gly212Ala	Missense	4/9	-
8-30537086-G-A	GSR	c.1520C>T	p.Thr507Ile	Missense	13/13	-
10-101611294-G-A	ABCC2	c.4544G>A	p.Cys1515Tyr	Missense	32/32	-
10-96818119-G-A	CYP2C8	c.792C>T	p.Ile264Ile	Synonymous	5/9	-
4-70146230-G-A	UGT2B28	c.12G>A	p.Lys4Lys	Synonymous	1/6	-
7-17378908-A-G	AHR	c.1459A>G	p.Asn487Asp	Missense	10/11	-
13-95847145-G-A	ABCC4	c.1208C>T	p.Pro403Leu	Missense	9/31	-
10-96602618-G-A	CYP2C19	c.986G>A	p.Arg329His	Missense	7/9	-
2-234668977-T-G	UGT1A1	c.44T>G	p.Leu15Arg	Missense	1/5	-
7-75615731-G-A	POR	c.1975G>A	p.Ala659Thr	Missense	16/16	-
6-18143837-T-G	TPMT	c.356A>C	p.Lys119Thr	Missense	4/9	-
2-234638101-T-A	UGT1A4	c.867+9768T>A	-	IntronicSNV	-	1/4
10-101559070-C-G	ABCC2	c.974C>G	p.Ser325*	Nonsense	8/32	-
10-101559070-C-A	ABCC2	c.974C>A	p.Ser325*	Nonsense	8/32	-
1-97564154-C-T	DPYD	c.2657G>A	p.Arg886His	Missense	21/23	-
1-110279701-C-T	GSTM3	c.670G>A	p.Val224Ile	Missense	9/9	-
2-234590616-C-A	UGT1A10	c.855+44593C>A	-	IntronicSNV	-	1/4
2-234590616-C-G	UGT1A10	c.855+44593C>G	-	IntronicSNV	-	1/4
8-18080651-A-C	NAT1	c.*222A>C	-	3-UTRSNV	3/3	-
13-99356607-G-T	SLC15A1	c.1352C>A	p.Thr451Asn	Missense	17/23	-
22-42523943-A-T	CYP2D6	c.886T>A	p.Cys296Ser	Missense	6/9	-
13-99376181-C-G	SLC15A1	c.350G>C	p.Ser117Thr	Missense	5/23	-
4-70146704-G-T	UGT2B28	c.486G>T	p.Ala162Ala	Synonymous	1/6	-
10-101591866-G-A	ABCC2	c.3236G>A	p.Arg1079Gln	Missense	23/32	-
13-99376181-C-T	SLC15A1	c.350G>A	p.Ser117Asn	Missense	5/23	-
6-160677669-C-G	SLC22A2	c.495G>C	p.Met165Ile	Missense	2/11	-
1-161203078-G-T	NR1I3	c.289C>A	p.Arg97Arg	Synonymous	4/9	-
12-21015737-C-T	SLCO1B3	c.676C>T	p.Leu226Leu	Synonymous	8/16	-
2-234669558-C-G	UGT1A1	c.625C>G	p.Arg209Gly	Missense	1/5	-
6-160677669-C-T	SLC22A2	c.495G>A	p.Met165Ile	Missense	2/11	-
5-131714106-C-T	SLC22A5	c.430C>T	p.Leu144Phe	Missense	2/10	-
1-97544543-G-T	DPYD	c.3067C>A	p.Pro1023Thr	Missense	23/23	-
6-160557271-C-G	SLC22A1	c.859C>G	p.Arg287Gly	Missense	5/11	-
2-234621780-T-C	UGT1A10	c.856-53900T>C	-	IntronicSNV	-	1/4
6-160557271-C-T	SLC22A1	c.859C>T	p.Arg287Trp	Missense	5/11	-
7-75610390-T-A	POR	c.541T>A	p.Tyr181Asn	Missense	6/16	-
7-99262835-C-T	CYP3A5	c.624G>A	p.Lys208Lys	Synonymous	7/13	-
15-75043593-G-A	CYP1A2	c.895G>A	p.Gly299Ser	Missense	3/7	-
2-234621972-G-A	UGT1A10	c.856-53708G>A	-	IntronicSNV	-	1/4
2-234545583-G-A	UGT1A10	c.415G>A	p.Glu139Lys	Missense	1/5	-
7-75610390-T-G	POR	c.541T>G	p.Tyr181Asp	Missense	6/16	-
7-87174198-G-T	ABCB1	c.2005C>A	p.Arg669Ser	Missense	17/29	-
7-87174198-G-A	ABCB1	c.2005C>T	p.Arg669Cys	Missense	17/29	-
16-28620067-C-T	SULT1A1	c.110G>A	p.Arg37Gln	Missense	2/8	-
4-70156392-A-G	UGT2B28	c.1173A>G	p.Val391Val	Synonymous	5/6	-
2-234591339-G-A	UGT1A10	c.855+45316G>A	-	IntronicSNV	-	1/4
15-75047184-G-C	CYP1A2	c.1306G>C	p.Asp436His	Missense	7/7	-
11-62763544-A-G	SLC22A8	c.842T>C	p.Val281Ala	Missense	6/11	-
5-131729935-C-T	SLC22A5	c.1645C>T	p.Pro549Ser	Missense	10/10	-
11-62763544-A-T	SLC22A8	c.842T>A	p.Val281Asp	Missense	6/11	-
13-99378664-C-A	SLC15A1	c.61G>T	p.Val21Phe	Missense	3/23	-
1-98058899-C-A	DPYD	c.1003G>T	p.Val335Leu	Missense	10/23	-
2-234590970-T-G	UGT1A7	c.387T>G	p.Asn129Lys	Missense	1/5	-
14-70245053-T-C	SLC10A1	c.940A>G	p.Lys314Glu	Missense	4/5	-
8-143999146-C-T	CYP11B2	c.111G>A	p.Pro37Pro	Synonymous	1/9	-
1-98058899-C-T	DPYD	c.1003G>A	p.Val335Met	Missense	10/23	-
16-16101842-C-T	ABCC1	c.218C>T	p.Thr73Ile	Missense	2/31	-
4-69533784-A-G	UGT2B15	c.847T>C	p.Cys283Arg	Missense	2/6	-
12-21392092-C-T	SLCO1B1	c.2045C>T	p.Ser682Phe	Missense	15/15	-
2-234545934-G-A	UGT1A10	c.766G>A	p.Asp256Asn	Missense	1/5	-
10-96540331-G-C	CYP2C19	c.557G>C	p.Arg186Pro	Missense	4/9	-
22-42523943-A-G	CYP2D6	c.886T>C	p.Cys296Arg	Missense	6/9	-
22-42525035-C-G	CYP2D6	c.505G>C	p.Gly169Arg	Missense	3/9	-
4-89016698-A-T	ABCG2	c.1711T>A	p.Phe571Ile	Missense	14/16	-
8-18258272-C-T	NAT2	c.759C>T	p.Val253Val	Synonymous	2/2	-
11-62763264-T-A	SLC22A8	c.913A>T	p.Ile305Phe	Missense	7/11	-
2-234627616-G-A	UGT1A4	c.150G>A	p.Glu50Glu	Synonymous	1/5	-
2-234627616-G-C	UGT1A4	c.150G>C	p.Glu50Asp	Missense	1/5	-
2-234669607-T-G	UGT1A1	c.674T>G	p.Val225Gly	Missense	1/5	-
8-18079653-C-T	NAT1	c.97C>T	p.Arg33*	Nonsense	3/3	-
19-41518598-T-A	CYP2B6	c.1172T>A	p.Ile391Asn	Missense	8/9	-
7-99358524-A-G	CYP3A4	c.1331T>C	p.Met444Thr	Missense	12/13	-
2-234638005-C-T	UGT1A4	c.867+9672C>T	-	IntronicSNV	-	1/4
3-119534659-C-A	NR1I2	c.1141C>A	p.Arg381Arg	Synonymous	8/9	-
22-42522660-A-G	CYP2D6	c.1410T>C	p.Thr470Thr	Synonymous	9/9	-
2-234545425-A-T	UGT1A10	c.257A>T	p.Gln86Leu	Missense	1/5	-
15-75044552-G-A	CYP1A2	c.1130G>A	p.Arg377Gln	Missense	5/7	-
2-234668870-G-C	UGT1A4	c.868-6810G>C	-	IntronicSNV	-	1/4
2-234580678-T-A	UGT1A10	c.855+34655T>A	-	IntronicSNV	-	1/4
2-234545520-G-A	UGT1A10	c.352G>A	p.Asp118Asn	Missense	1/5	-
4-69693162-T-C	UGT2B10	c.1203T>C	p.Asn401Asn	Synonymous	5/6	-
12-21358855-A-C	SLCO1B1	c.1385A>C	p.Asp462Ala	Missense	11/15	-
19-41512873-T-G	CYP2B6	c.548T>G	p.Val183Gly	Missense	4/9	-
2-234627616-G-T	UGT1A4	c.150G>T	p.Glu50Asp	Missense	1/5	-
12-21355598-G-A	SLCO1B1	c.1309G>A	p.Gly437Arg	Missense	10/15	-
9-86894964-C-T	SLC28A3	c.1754G>A	p.Arg585His	Missense	17/19	-
9-86905172-C-T	SLC28A3	c.1046G>A	p.Arg349Gln	Missense	12/19	-
12-21453351-T-C	SLCO1A2	c.841A>G	p.Ile281Val	Missense	7/14	-
15-75012235-A-G	CYP1A1	c.*595T>C	-	3-UTRSNV	7/7	-
19-41354629-C-G	CYP2A6	c.383G>C	p.Arg128Pro	Missense	3/9	-
19-41354629-C-A	CYP2A6	c.383G>T	p.Arg128Leu	Missense	3/9	-
4-70160299-A-G	UGT2B28	c.1362A>G	p.Val454Val	Synonymous	6/6	-
15-75042637-C-T	CYP1A2	c.558C>T	p.Phe186Phe	Synonymous	2/7	-
15-75042637-C-A	CYP1A2	c.558C>A	p.Phe186Leu	Missense	2/7	-
2-234581306-T-G	UGT1A10	c.855+35283T>G	-	IntronicSNV	-	1/4
7-75614497-G-C	POR	c.1370G>C	p.Arg457Pro	Missense	12/16	-
7-75614497-G-A	POR	c.1370G>A	p.Arg457His	Missense	12/16	-
7-87179809-C-T	ABCB1	c.1199G>A	p.Ser400Asn	Missense	12/29	-
7-87179809-C-A	ABCB1	c.1199G>T	p.Ser400Ile	Missense	12/29	-
10-101544447-A-T	ABCC2	c.116A>T	p.Tyr39Phe	Missense	2/32	-
6-18143901-C-A	TPMT	c.292G>T	p.Glu98*	Nonsense	4/9	-
22-42525811-T-A	CYP2D6	c.281A>T	p.His94Leu	Missense	2/9	-
19-41354533-A-T	CYP2A6	c.479T>A	p.Leu160His	Missense	3/9	-
10-96522517-A-C	CYP2C19	c.55A>C	p.Ile19Leu	Missense	1/9	-
8-70744812-G-A	SLCO5A1	c.97C>T	p.Leu33Phe	Missense	2/10	-
3-121648168-G-A	SLC15A2	c.1526G>A	p.Arg509Lys	Missense	17/22	-
10-96741058-C-G	CYP2C9	c.1080C>G	p.Asp360Glu	Missense	7/9	-
2-234590975-G-C	UGT1A10	c.855+44952G>C	-	IntronicSNV	-	1/4
6-160557260-C-T	SLC22A1	c.848C>T	p.Pro283Leu	Missense	5/11	-
22-44239499-T-C	SULT4A1	c.170-1687A>G	-	IntronicSNV	-	1/6
22-44239499-T-A	SULT4A1	c.170-1687A>T	-	IntronicSNV	-	1/6
2-234627992-A-T	UGT1A4	c.526A>T	p.Ile176Phe	Missense	1/5	-
2-234627992-A-C	UGT1A4	c.526A>C	p.Ile176Leu	Missense	1/5	-
19-41515255-C-T	CYP2B6	c.777C>T	p.Ser259Ser	Synonymous	5/9	-
7-87138659-A-T	ABCB1	c.3421T>A	p.Ser1141Thr	Missense	27/29	-
2-234590975-G-A	UGT1A10	c.855+44952G>A	-	IntronicSNV	-	1/4
10-101590120-G-C	ABCC2	c.2677G>C	p.Glu893Gln	Missense	20/32	-
12-21329761-G-A	SLCO1B1	c.411G>A	p.Ser137Ser	Synonymous	5/15	-
10-101590120-G-A	ABCC2	c.2677G>A	p.Glu893Lys	Missense	20/32	-
19-41354660-A-G	CYP2A6	c.352T>C	p.Phe118Leu	Missense	3/9	-
4-89015781-T-A	ABCG2	c.1768A>T	p.Asn590Tyr	Missense	15/16	-
10-96798749-T-C	CYP2C8	c.1196A>G	p.Lys399Arg	Missense	8/9	-
1-171076966-G-A	FMO3	c.472G>A	p.Glu158Lys	Missense	4/9	-
2-234591411-C-A	UGT1A10	c.855+45388C>A	-	IntronicSNV	-	1/4
2-234591411-C-G	UGT1A10	c.855+45388C>G	-	IntronicSNV	-	1/4
10-106027059-G-A	GSTO1	c.622G>A	p.Glu208Lys	Missense	6/6	-
2-234526719-G-A	UGT1A8	c.366G>A	p.Ser122Ser	Synonymous	1/5	-
2-234638114-G-A	UGT1A4	c.867+9781G>A	-	IntronicSNV	-	1/4
6-160645751-G-A	SLC22A2	c.1587C>T	p.Ala529Ala	Synonymous	10/11	-
1-98058782-G-A	DPYD	c.1120C>T	p.Pro374Ser	Missense	10/23	-
8-18258091-C-T	NAT2	c.578C>T	p.Thr193Met	Missense	2/2	-
2-234621787-C-G	UGT1A10	c.856-53893C>G	-	IntronicSNV	-	1/4
2-234580678-T-C	UGT1A9	c.98T>C	p.Met33Thr	Missense	1/5	-
7-99358459-G-C	CYP3A4	c.1396C>G	p.Pro466Ala	Missense	12/13	-
10-101544387-C-T	ABCC2	c.56C>T	p.Pro19Leu	Missense	2/32	-
12-21327529-T-C	SLCO1B1	c.245T>C	p.Val82Ala	Missense	4/15	-
10-101591737-T-A	ABCC2	c.3107T>A	p.Ile1036Lys	Missense	23/32	-
4-89013496-C-T	ABCG2	c.1858G>A	p.Asp620Asn	Missense	16/16	-
6-160543229-T-A	SLC22A1	c.262T>A	p.Cys88Ser	Missense	1/11	-
2-234526636-G-A	UGT1A8	c.283G>A	p.Asp95Asn	Missense	1/5	-
2-234526636-G-C	UGT1A8	c.283G>C	p.Asp95His	Missense	1/5	-
16-16103682-C-G	ABCC1	c.275C>G	p.Ser92Cys	Missense	3/31	-
16-16103682-C-T	ABCC1	c.275C>T	p.Ser92Phe	Missense	3/31	-
10-101591737-T-C	ABCC2	c.3107T>C	p.Ile1036Thr	Missense	23/32	-
11-62768242-G-T	SLC22A8	c.387C>A	p.Phe129Leu	Missense	3/11	-
4-69416556-T-C	UGT2B17	c.1152A>G	p.Ala384Ala	Synonymous	5/6	-
4-69520851-G-A	UGT2B15	c.1055C>T	p.Thr352Ile	Missense	4/6	-
17-19616017-G-A	SLC47A2	c.485C>T	p.Pro162Leu	Missense	5/17	-
2-234621986-A-C	UGT1A10	c.856-53694A>C	-	IntronicSNV	-	1/4
2-234621986-A-T	UGT1A10	c.856-53694A>T	-	IntronicSNV	-	1/4
6-110759924-T-A	SLC22A16	c.1310A>T	p.Gln437Leu	Missense	5/8	-
11-62749344-G-C	SLC22A6	c.767C>G	p.Ala256Gly	Missense	4/10	-
4-69535704-C-T	UGT2B15	c.633G>A	p.Arg211Arg	Synonymous	1/6	-
5-131705715-C-G	SLC22A5	c.51C>G	p.Phe17Leu	Missense	1/10	-
10-96602636-G-A	CYP2C19	c.1004G>A	p.Arg335Gln	Missense	7/9	-
17-19452968-C-T	SLC47A1	c.476C>T	p.Thr159Met	Missense	5/17	-
10-96818106-T-A	CYP2C8	c.805A>T	p.Ile269Phe	Missense	5/9	-
15-75013804-C-A	CYP1A1	c.993G>T	p.Met331Ile	Missense	4/7	-
7-99367788-C-T	CYP3A4	c.389G>A	p.Arg130Gln	Missense	5/13	-
7-99367788-C-G	CYP3A4	c.389G>C	p.Arg130Pro	Missense	5/13	-
19-41349874-T-A	CYP2A6	c.1312A>T	p.Asn438Tyr	Missense	9/9	-
7-75615304-A-G	POR	c.1733A>G	p.Tyr578Cys	Missense	14/16	-
4-70152499-T-A	UGT2B28	c.900T>A	p.Gly300Gly	Synonymous	3/6	-
6-160560824-G-A	SLC22A1	c.1201G>A	p.Gly401Ser	Missense	7/11	-
13-95735520-C-A	ABCC4	c.2560G>T	p.Val854Phe	Missense	21/31	-
1-171083232-G-A	FMO3	c.913G>A	p.Glu305Lys	Missense	7/9	-
7-99359829-G-A	CYP3A4	c.1085C>T	p.Thr362Met	Missense	11/13	-
7-99359829-G-T	CYP3A4	c.1085C>A	p.Thr362Lys	Missense	11/13	-
4-70350950-A-G	UGT2B4	c.1286T>C	p.Leu429Pro	Missense	5/6	-
22-42524936-AAAGGGGCG-AAAGGGGCGAAAGGGGCG	CYP2D6	c.514_522dup	-	SpliceAcceptorInsertion	4/9	-
2-169830328-A-T	ABCB11	c.1331T>A	p.Val444Asp	Missense	13/28	-
12-21355583-A-T	SLCO1B1	c.1294A>T	p.Asn432Tyr	Missense	10/15	-
6-18134076-T-A	TPMT	c.539A>T	p.Tyr180Phe	Missense	7/9	-
6-18134076-T-C	TPMT	c.539A>G	p.Tyr180Cys	Missense	7/9	-
8-18080308-A-T	NAT1	c.752A>T	p.Asp251Val	Missense	3/3	-
3-38357961-C-G	SLC22A14	c.1679C>G	p.Pro560Arg	Missense	9/10	-
3-38357961-C-A	SLC22A14	c.1679C>A	p.Pro560Gln	Missense	9/10	-
2-234601928-C-T	UGT1A10	c.855+55905C>T	-	IntronicSNV	-	1/4
2-169830328-A-C	ABCB11	c.1331T>G	p.Val444Gly	Missense	13/28	-
8-18257985-A-C	NAT2	c.472A>C	p.Ile158Leu	Missense	2/2	-
12-21355583-A-G	SLCO1B1	c.1294A>G	p.Asn432Asp	Missense	10/15	-
1-171086490-G-C	FMO3	c.1507G>C	p.Gly503Arg	Missense	9/9	-
6-18148082-G-A	TPMT	c.205C>T	p.Leu69Phe	Missense	3/9	-
6-18148082-G-C	TPMT	c.205C>G	p.Leu69Val	Missense	3/9	-
19-41352941-A-G	CYP2A6	c.670T>C	p.Ser224Pro	Missense	5/9	-
1-171077339-G-GT	FMO3	c.604_605insT	p.Glu202Valfs*52	Frameshift	5/9	-
13-95726518-C-G	ABCC4	c.2867G>C	p.Cys956Ser	Missense	23/31	-
8-18258316-G-A	NAT2	c.803G>A	p.Arg268Lys	Missense	2/2	-
7-99365983-A-G	CYP3A4	c.664T>C	p.Ser222Pro	Missense	7/13	-
7-99365983-A-T	CYP3A4	c.664T>A	p.Ser222Thr	Missense	7/13	-
2-234638249-A-G	UGT1A4	c.867+9916A>G	-	IntronicSNV	-	1/4
13-99358401-C-G	SLC15A1	c.1256G>C	p.Gly419Ala	Missense	16/23	-
8-18258316-G-T	NAT2	c.803G>T	p.Arg268Ile	Missense	2/2	-
15-75012979-G-A	CYP1A1	c.1390C>T	p.Arg464Cys	Missense	7/7	-
19-41497295-C-A	CYP2B6	c.85C>A	p.Arg29Ser	Missense	1/9	-
19-41497295-C-T	CYP2B6	c.85C>T	p.Arg29Cys	Missense	1/9	-
2-234591000-G-C	UGT1A7	c.417G>C	p.Glu139Asp	Missense	1/5	-
10-96707539-C-T	CYP2C9	c.485C>T	p.Ser162Leu	Missense	4/9	-
3-121647286-C-T	SLC15A2	c.1225C>T	p.Pro409Ser	Missense	15/22	-
2-169780295-C-T	ABCB11	c.3803G>A	p.Arg1268Gln	Missense	28/28	-
7-75612866-G-C	POR	c.859G>C	p.Ala287Pro	Missense	9/16	-
2-234627508-A-G	UGT1A4	c.42A>G	p.Thr14Thr	Synonymous	1/5	-
10-96740958-T-C	CYP2C9	c.980T>C	p.Ile327Thr	Missense	7/9	-
16-16177275-G-A	ABCC1	c.2168G>A	p.Arg723Gln	Missense	17/31	-
15-75013804-C-T	CYP1A1	c.993G>A	p.Met331Ile	Missense	4/7	-
4-70361348-G-T	UGT2B4	c.232C>A	p.Pro78Thr	Missense	1/6	-
2-234627937-T-G	UGT1A4	c.471T>G	p.Cys157Trp	Missense	1/5	-
6-160575837-G-C	SLC22A1	c.1393G>C	p.Gly465Arg	Missense	9/11	-
6-160575837-G-A	SLC22A1	c.1393G>A	p.Gly465Arg	Missense	9/11	-
2-234665782-G-A	UGT1A4	c.868-9898G>A	-	IntronicSNV	-	1/4
16-16130340-G-A	ABCC1	c.689G>A	p.Arg230Gln	Missense	7/31	-
16-16130340-G-C	ABCC1	c.689G>C	p.Arg230Pro	Missense	7/31	-
22-42525781-A-G	CYP2D6	c.311T>C	p.Val104Ala	Missense	2/9	-
22-42525781-A-T	CYP2D6	c.311T>A	p.Val104Glu	Missense	2/9	-
2-108910712-A-G	SULT1C2	c.179A>G	p.Asp60Gly	Missense	3/9	-
9-107558403-G-A	ABCA1	c.5313C>T	p.Thr1771Thr	Synonymous	39/50	-
12-21331625-C-T	SLCO1B1	c.597C>T	p.Phe199Phe	Synonymous	6/15	-
1-171076936-G-T	FMO3	c.442G>T	p.Gly148*	Nonsense	4/9	-
15-75012894-G-C	CYP1A1	c.1475C>G	p.Pro492Arg	Missense	7/7	-
11-62749434-A-G	SLC22A6	c.677T>C	p.Ile226Thr	Missense	4/10	-
4-69972949-C-G	UGT2B7	c.1059C>G	p.Leu353Leu	Synonymous	4/6	-
2-234637905-C-T	UGT1A3	c.133C>T	p.Arg45Trp	Missense	1/5	-
11-62763607-A-C	SLC22A8	c.779T>G	p.Ile260Arg	Missense	6/11	-
16-28603655-T-G	SULT1A2	c.704A>C	p.Asn235Thr	Missense	7/8	-
19-41497346-A-T	CYP2B6	c.136A>T	p.Met46Leu	Missense	1/9	-
4-89034649-C-A	ABCG2	c.1000G>T	p.Glu334*	Nonsense	9/16	-
14-70245977-A-G	SLC10A1	c.668T>C	p.Ile223Thr	Missense	3/5	-
12-21036418-G-A	SLCO1B3	c.1564G>A	p.Gly522Ser	Missense	13/16	-
6-160668283-G-C	SLC22A2	c.890C>G	p.Ala297Gly	Missense	5/11	-
3-38317479-C-T	SLC22A13	c.1129C>T	p.Arg377Cys	Missense	7/10	-
12-21036418-G-T	SLCO1B3	c.1564G>T	p.Gly522Cys	Missense	13/16	-
7-99366081-A-G	CYP3A4	c.566T>C	p.Phe189Ser	Missense	7/13	-
2-234622359-G-C	UGT1A10	c.856-53321G>C	-	IntronicSNV	-	1/4
3-38357961-C-T	SLC22A14	c.1679C>T	p.Pro560Leu	Missense	9/10	-
22-44248504-G-A	SULT4A1	c.169+9590C>T	-	IntronicSNV	-	1/6
2-234590616-C-T	UGT1A10	c.855+44593C>T	-	IntronicSNV	-	1/4
3-121615316-C-T	SLC15A2	c.169C>T	p.Arg57Cys	Missense	2/22	-
11-74907582-C-T	SLCO2B1	c.1457C>T	p.Ser486Phe	Missense	10/14	-
1-98039499-C-A	DPYD	c.1156G>T	p.Glu386*	Nonsense	11/23	-
22-51063758-C-T	ARSA	c.1345G>A	p.Gly449Arg	Missense	8/8	-
10-101604163-C-T	ABCC2	c.3928C>T	p.Arg1310*	Nonsense	28/32	-
7-99381661-A-G	CYP3A4	c.44T>C	p.Leu15Pro	Missense	1/13	-
2-234526668-G-A	UGT1A8	c.315G>A	p.Leu105Leu	Synonymous	1/5	-
7-75615301-T-C	POR	c.1730T>C	p.Leu577Pro	Missense	14/16	-
4-69692163-C-A	UGT2B10	c.1035C>A	p.Ala345Ala	Synonymous	4/6	-
19-41354629-C-T	CYP2A6	c.383G>A	p.Arg128Gln	Missense	3/9	-
2-234526666-T-A	UGT1A8	c.313T>A	p.Leu105Met	Missense	1/5	-
4-69692163-C-G	UGT2B10	c.1035C>G	p.Ala345Ala	Synonymous	4/6	-
12-21459854-T-A	SLCO1A2	c.404A>T	p.Asn135Ile	Missense	4/14	-
19-41512841-G-A	CYP2B6	c.516G>A	p.Gln172Gln	Synonymous	4/9	-
2-234545773-C-T	UGT1A10	c.605C>T	p.Thr202Ile	Missense	1/5	-
2-234545928-C-T	UGT1A10	c.760C>T	p.Arg254*	Nonsense	1/5	-
4-69962452-C-T	UGT2B7	c.214C>T	p.Leu72Phe	Missense	1/6	-
10-96602710-G-A	CYP2C19	c.1078G>A	p.Asp360Asn	Missense	7/9	-
10-96602710-G-C	CYP2C19	c.1078G>C	p.Asp360His	Missense	7/9	-
2-234527183-G-A	UGT1A8	c.830G>A	p.Cys277Tyr	Missense	1/5	-
7-87230193-A-G	ABCB1	c.-129T>C	-	5_prime_UTR_variant	2/29	-
7-75615301-T-G	POR	c.1730T>G	p.Leu577Arg	Missense	14/16	-
16-16165572-G-A	ABCC1	c.1898G>A	p.Arg633Gln	Missense	14/31	-
1-97544543-G-C	DPYD	c.3067C>G	p.Pro1023Ala	Missense	23/23	-
1-97544543-G-A	DPYD	c.3067C>T	p.Pro1023Ser	Missense	23/23	-
4-69962452-C-G	UGT2B7	c.214C>G	p.Leu72Val	Missense	1/6	-
10-96602710-G-T	CYP2C19	c.1078G>T	p.Asp360Tyr	Missense	7/9	-
12-21325668-C-T	SLCO1B1	c.169C>T	p.Arg57Trp	Missense	3/15	-
10-96805708-C-A	CYP2C8	c.820G>T	p.Glu274*	Nonsense	6/9	-
7-75615006-C-T	POR	c.1508C>T	p.Ala503Val	Missense	13/16	-
3-119526203-G-A	NR1I2	c.106G>A	p.Gly36Arg	Missense	2/9	-
2-234545932-C-T	UGT1A10	c.764C>T	p.Thr255Met	Missense	1/5	-
15-75012985-T-C	CYP1A1	c.1384A>G	p.Ile462Val	Missense	7/7	-
15-75012985-T-A	CYP1A1	c.1384A>T	p.Ile462Phe	Missense	7/7	-
15-75012985-T-G	CYP1A1	c.1384A>C	p.Ile462Leu	Missense	7/7	-
2-234602191-A-G	UGT1A10	c.855+56168A>G	-	IntronicSNV	-	1/4
22-42523858-T-G	CYP2D6	c.971A>C	p.His324Pro	Missense	6/9	-
2-234622067-A-G	UGT1A10	c.856-53613A>G	-	IntronicSNV	-	1/4
2-234526827-C-T	UGT1A8	c.474C>T	p.Ala158Ala	Synonymous	1/5	-
1-97981421-C-T	DPYD	c.1601G>A	p.Ser534Asn	Missense	13/23	-
19-41384786-G-C	CYP2A7	c.557C>G	p.Ala186Gly	Missense	4/8	-
12-21329817-A-G	SLCO1B1	c.467A>G	p.Glu156Gly	Missense	5/15	-
2-169783827-G-C	ABCB11	c.3457C>G	p.Arg1153Gly	Missense	26/28	-
2-234545476-A-G	UGT1A10	c.308A>G	p.Gln103Arg	Missense	1/5	-
2-234681059-T-C	UGT1A1	c.1456T>C	p.Tyr486His	Missense	5/5	-
9-107589255-C-T	ABCA1	c.2311G>A	p.Val771Met	Missense	16/50	-
2-169828550-T-C	ABCB11	c.1445A>G	p.Asp482Gly	Missense	14/28	-
15-75042581-G-C	CYP1A2	c.502G>C	p.Glu168Gln	Missense	2/7	-
10-96745830-A-C	CYP2C9	c.1190A>C	p.Asp397Ala	Missense	8/9	-
9-107589255-C-G	ABCA1	c.2311G>C	p.Val771Leu	Missense	16/50	-
8-18080001-G-A	NAT1	c.445G>A	p.Val149Ile	Missense	3/3	-
19-41350582-C-G	CYP2A6	c.1257G>C	p.Glu419Asp	Missense	8/9	-
4-69973936-C-T	UGT2B7	c.1206C>T	p.Asn402Asn	Synonymous	5/6	-
19-41497293-A-G	CYP2B6	c.83A>G	p.Asp28Gly	Missense	1/9	-
15-75012837-C-A	CYP1A1	c.1532G>T	p.Arg511Leu	Missense	7/7	-
3-119500035-C-T	NR1I2	c.-1135C>T	-	5_prime_UTR_variant	1/9	-
2-234621850-A-G	UGT1A10	c.856-53830A>G	-	IntronicSNV	-	1/4
8-143994266-A-C	CYP11B2	c.1157T>G	p.Val386Gly	Missense	7/9	-
7-75609780-G-T	POR	c.490G>T	p.Val164Leu	Missense	5/16	-
4-70346564-G-C	UGT2B4	c.1375C>G	p.Arg459Gly	Missense	6/6	-
4-69978370-A-G	UGT2B7	c.1506A>G	p.Ala502Ala	Synonymous	6/6	-
2-234637912-T-C	UGT1A4	c.867+9579T>C	-	IntronicSNV	-	1/4
12-21457434-T-G	SLCO1A2	c.516A>C	p.Glu172Asp	Missense	5/14	-
6-160575907-G-T	SLC22A1	c.1463G>T	p.Arg488Met	Missense	9/11	-
6-160575907-G-C	SLC22A1	c.1463G>C	p.Arg488Thr	Missense	9/11	-
2-234527064-A-G	UGT1A8	c.711A>G	p.Thr237Thr	Synonymous	1/5	-
10-96709037-A-G	CYP2C9	c.815A>G	p.Glu272Gly	Missense	5/9	-
15-75012837-C-T	CYP1A1	c.1532G>A	p.Arg511His	Missense	7/7	-
11-62767307-G-T	SLC22A8	c.445C>A	p.Arg149Ser	Missense	4/11	-
11-62767307-G-A	SLC22A8	c.445C>T	p.Arg149Cys	Missense	4/11	-
8-143994266-A-G	CYP11B2	c.1157T>C	p.Val386Ala	Missense	7/9	-
6-18139920-C-T	TPMT	c.395G>A	p.Cys132Tyr	Missense	5/9	-
12-21331599-T-C	SLCO1B1	c.571T>C	p.Leu191Leu	Synonymous	6/15	-
4-70346564-G-T	UGT2B4	c.1375C>A	p.Arg459Arg	Synonymous	6/6	-
17-19451364-C-T	SLC47A1	c.373C>T	p.Leu125Phe	Missense	4/17	-
4-70146719-G-A	UGT2B28	c.501G>A	p.Pro167Pro	Synonymous	1/6	-
4-70146719-G-T	UGT2B28	c.501G>T	p.Pro167Pro	Synonymous	1/6	-
4-70146719-G-C	UGT2B28	c.501G>C	p.Pro167Pro	Synonymous	1/6	-
22-42523843-C-G	CYP2D6	c.985+1G>C	-	IntronicSNV	-	6/8
3-119530497-G-A	NR1I2	c.443G>A	p.Arg148Gln	Missense	4/9	-
22-42523843-C-T	CYP2D6	c.985+1G>A	-	IntronicSNV	-	6/8
2-234527001-A-C	UGT1A8	c.648A>C	p.Glu216Asp	Missense	1/5	-
10-101595975-G-A	ABCC2	c.3542G>A	p.Arg1181Gln	Missense	25/32	-
2-234527001-A-G	UGT1A8	c.648A>G	p.Glu216Glu	Synonymous	1/5	-
4-70359452-C-A	UGT2B4	c.829G>T	p.Val277Phe	Missense	2/6	-
4-70359452-C-T	UGT2B4	c.829G>A	p.Val277Ile	Missense	2/6	-
4-70359452-C-G	UGT2B4	c.829G>C	p.Val277Leu	Missense	2/6	-
10-101591541-G-C	ABCC2	c.3057G>C	p.Gln1019His	Missense	22/32	-
10-101591541-G-A	ABCC2	c.3057G>A	p.Gln1019Gln	Synonymous	22/32	-
2-234681059-T-G	UGT1A3	c.1459T>G	p.Tyr487Asp	Missense	5/5	-
2-234681059-T-A	UGT1A1	c.1456T>A	p.Tyr486Asn	Missense	5/5	-
15-75045575-G-A	CYP1A2	c.1217G>A	p.Cys406Tyr	Missense	6/7	-
19-41354621-A-C	CYP2A6	c.391T>G	p.Ser131Ala	Missense	3/9	-
8-18257583-T-A	NAT2	c.70T>A	p.Leu24Ile	Missense	2/2	-
1-171083479-G-A	FMO3	c.1160G>A	p.Arg387His	Missense	7/9	-
2-234580805-G-A	UGT1A10	c.855+34782G>A	-	IntronicSNV	-	1/4
6-18149357-A-C	TPMT	c.2T>G	p.Met1Arg	Missense	2/9	-
6-18149357-A-G	TPMT	c.2T>C	p.Met1Thr	Missense	2/9	-
2-234676573-G-A	UGT1A1	c.1075G>A	p.Asp359Asn	Missense	3/5	-
22-42523855-G-A	CYP2D6	c.974C>T	p.Pro325Leu	Missense	6/9	-
8-18080440-A-C	NAT1	c.*11A>C	-	3-UTRSNV	3/3	-
19-48377980-T-G	SULT2A1	c.679A>C	p.Lys227Gln	Missense	5/6	-
2-234591114-T-A	UGT1A7	c.531T>A	p.Leu177Leu	Synonymous	1/5	-
8-18079577-T-G	NAT1	c.21T>G	p.Leu7Leu	Synonymous	3/3	-
2-234590970-T-A	UGT1A7	c.387T>A	p.Asn129Lys	Missense	1/5	-
22-42522916-C-G	CYP2D6	c.1252G>C	p.Glu418Gln	Missense	8/9	-
2-234527157-T-C	UGT1A8	c.804T>C	p.Asn268Asn	Synonymous	1/5	-
2-234545225-C-T	UGT1A10	c.57C>T	p.Thr19Thr	Synonymous	1/5	-
3-119530542-A-G	NR1I2	c.488A>G	p.Asp163Gly	Missense	4/9	-
2-234527071-A-G	UGT1A8	c.718A>G	p.Thr240Ala	Missense	1/5	-
22-42525089-G-C	CYP2D6	c.451C>G	p.Gln151Glu	Missense	3/9	-
2-234590751-C-T	UGT1A10	c.855+44728C>T	-	IntronicSNV	-	1/4
1-171086490-G-A	FMO3	c.1507G>A	p.Gly503Arg	Missense	9/9	-
2-234676965-G-C	UGT1A7	c.1175G>C	p.Gly392Ala	Missense	4/5	-
2-234545517-C-A	UGT1A10	c.349C>A	p.Leu117Ile	Missense	1/5	-
22-42522613-G-C	CYP2D6	c.1457C>G	p.Thr486Ser	Missense	9/9	-
2-234675806-C-T	UGT1A1	c.991C>T	p.Gln331*	Nonsense	2/5	-
2-234526719-G-T	UGT1A8	c.366G>T	p.Ser122Ser	Synonymous	1/5	-
1-98058782-G-C	DPYD	c.1120C>G	p.Pro374Ala	Missense	10/23	-
6-160679655-G-GT	SLC22A2	c.134_135insA	p.Phe45Leufs*4	Frameshift	1/11	-
7-75610420-G-A	POR	c.571G>A	p.Val191Met	Missense	6/16	-
7-75610420-G-C	POR	c.571G>C	p.Val191Leu	Missense	6/16	-
4-70160342-T-C	UGT2B28	c.1405T>C	p.Cys469Arg	Missense	6/6	-
6-18139201-G-T	TPMT	c.487C>A	p.Arg163Ser	Missense	6/9	-
19-41497346-A-G	CYP2B6	c.136A>G	p.Met46Val	Missense	1/9	-
4-69536084-A-C	UGT2B15	c.253T>G	p.Tyr85Asp	Missense	1/6	-
15-45554267-C-A	SLC28A2	c.225C>A	p.Ser75Arg	Missense	4/18	-
15-75042142-C-G	CYP1A2	c.63C>G	p.Phe21Leu	Missense	2/7	-
6-160543090-C-T	SLC22A1	c.123C>T	p.Phe41Phe	Synonymous	1/11	-
19-41352912-T-C	CYP2A6	c.699A>G	p.Pro233Pro	Synonymous	5/9	-
10-96535296-G-A	CYP2C19	c.481G>A	p.Ala161Thr	Missense	3/9	-
10-96535296-G-C	CYP2C19	c.481G>C	p.Ala161Pro	Missense	3/9	-
12-21392011-A-G	SLCO1B1	c.1964A>G	p.Asp655Gly	Missense	15/15	-
10-101578683-T-C	ABCC2	c.2408T>C	p.Val803Ala	Missense	18/32	-
2-234627861-T-C	UGT1A4	c.395T>C	p.Leu132Pro	Missense	1/5	-
6-18139201-G-A	TPMT	c.487C>T	p.Arg163Cys	Missense	6/9	-
2-219674482-G-A	CYP27A1	c.438G>A	p.Pro146Pro	Synonymous	2/9	-
10-96702011-C-T	CYP2C9	c.394C>T	p.Arg132Trp	Missense	3/9	-
2-234545928-C-A	UGT1A10	c.760C>A	p.Arg254Arg	Synonymous	1/5	-
15-75013094-A-AA	CYP1A1	c.1275_1275dup	p.Glu426*fs*1	Nonsense	7/7	-
10-101563815-G-A	ABCC2	c.1249G>A	p.Val417Ile	Missense	10/32	-
10-96702006-C-A	CYP2C9	c.389C>A	p.Thr130Lys	Missense	3/9	-
4-100260789-T-A	ADH1C	c.1048A>T	p.Ile350Phe	Missense	8/9	-
10-96702006-C-T	CYP2C9	c.389C>T	p.Thr130Met	Missense	3/9	-
4-100260789-T-C	ADH1C	c.1048A>G	p.Ile350Val	Missense	8/9	-
2-234627914-T-C	UGT1A4	c.448T>C	p.Leu150Leu	Synonymous	1/5	-
11-62782278-C-T	SLC22A8	c.153G>A	p.Pro51Pro	Synonymous	2/11	-
2-234527064-A-C	UGT1A8	c.711A>C	p.Thr237Thr	Synonymous	1/5	-
2-234638580-A-G	UGT1A4	c.867+10247A>G	-	IntronicSNV	-	1/4
12-21329802-A-G	SLCO1B1	c.452A>G	p.Asn151Ser	Missense	5/15	-
4-69535828-A-G	UGT2B15	c.509T>C	p.Leu170Pro	Missense	1/6	-
10-101578577-C-T	ABCC2	c.2302C>T	p.Arg768Trp	Missense	18/32	-
10-101578577-C-A	ABCC2	c.2302C>A	p.Arg768Arg	Synonymous	18/32	-
22-42525821-G-T	CYP2D6	c.271C>A	p.Leu91Met	Missense	2/9	-
15-75044578-A-G	CYP1A2	c.1156A>G	p.Ile386Val	Missense	5/7	-
10-96612671-A-T	CYP2C19	c.1473A>T	-	Missense	9/9	-
2-234590751-C-G	UGT1A10	c.855+44728C>G	-	IntronicSNV	-	1/4
22-42525838-G-A	CYP2D6	c.254C>T	p.Ala85Val	Missense	2/9	-
19-41510282-A-G	CYP2B6	c.415A>G	p.Lys139Glu	Missense	3/9	-
4-70723268-G-A	SULT1E1	c.95C>T	p.Ala32Val	Missense	2/8	-
12-21450445-A-G	SLCO1A2	c.968T>C	p.Leu323Pro	Missense	8/14	-
5-131647954-A-G	SLC22A4	c.494A>G	p.Asp165Gly	Missense	2/10	-
19-41381683-G-T	CYP2A7	c.1247C>A	p.Ser416*	Nonsense	8/8	-
4-70361342-A-G	UGT2B4	c.238T>C	p.Ser80Pro	Missense	1/6	-
2-234627483-A-G	UGT1A4	c.17A>G	p.Gln6Arg	Missense	1/5	-