PMID: 29714060

A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors.

ACS chemical neuroscience
MD Ericson, C Haskell-Luevano
2018-06-20

81 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
16-67516648-T-C AGRP c.290A>G p.Gln97Arg Missense 4/4 -
16-67516583-A-G AGRP c.355T>C p.Cys119Arg Missense 4/4 -
7-24325002-A-T NPY c.143A>T p.Tyr48Phe Missense 2/4 -
7-24324992-A-G NPY c.133A>G p.Met45Val Missense 2/4 -
16-67516580-G-A AGRP c.358C>T p.Arg120Cys Missense 4/4 -
16-67517232-C-A AGRP c.70G>T p.Gly24Cys Missense 2/4 -
16-67516592-A-G AGRP c.346T>C p.Phe116Leu Missense 4/4 -
17-40336354-C-G HCRT c.214G>C p.Gly72Arg Missense 2/2 -
17-40336354-C-T HCRT c.214G>A p.Gly72Arg Missense 2/2 -
16-67516645-T-C AGRP c.293A>G p.Gln98Arg Missense 4/4 -
17-40336399-C-A HCRT c.169G>T p.Gly57Cys Missense 2/2 -
17-40336456-C-T HCRT c.112G>A p.Asp38Asn Missense 2/2 -
17-40336281-G-A HCRT c.287C>T p.Thr96Ile Missense 2/2 -
16-67516607-G-A AGRP c.331C>T p.Arg111Cys Missense 4/4 -
16-67516665-A-C AGRP c.273T>G p.His91Gln Missense 4/4 -
16-67516652-C-T AGRP c.286G>A p.Gly96Arg Missense 4/4 -
17-40336348-G-T HCRT c.220C>A p.Pro74Thr Missense 2/2 -
16-67516590-G-T AGRP c.348C>A p.Phe116Leu Missense 4/4 -
16-67516587-G-C AGRP c.351C>G p.Cys117Trp Missense 4/4 -
16-67516945-C-T AGRP c.199G>A p.Ala67Thr Missense 3/4 -
12-102590453-A-C PMCH c.475T>G p.Tyr159Asp Missense 3/3 -
17-40336284-A-G HCRT c.284T>C p.Leu95Pro Missense 2/2 -
16-67516606-C-T AGRP c.332G>A p.Arg111His Missense 4/4 -
16-67516561-A-G AGRP c.377T>C p.Met126Thr Missense 4/4 -
17-40336335-C-G HCRT c.233G>C p.Gly78Ala Missense 2/2 -
17-40336405-C-T HCRT c.163G>A p.Gly55Ser Missense 2/2 -
16-67516603-A-T AGRP c.335T>A p.Phe112Tyr Missense 4/4 -
12-102590470-C-A PMCH c.458G>T p.Cys153Phe Missense 3/3 -
12-102590470-C-T PMCH c.458G>A p.Cys153Tyr Missense 3/3 -
17-40336459-G-C HCRT c.109C>G p.Pro37Ala Missense 2/2 -
17-40336350-G-A HCRT c.218C>T p.Pro73Leu Missense 2/2 -
7-24324879-T-C NPY c.20T>C p.Leu7Pro Missense 2/4 -
7-24329120-A-T NPY c.191A>T p.Tyr64Phe Missense 3/4 -
16-67516561-A-T AGRP c.377T>A p.Met126Lys Missense 4/4 -
7-24329133-C-T NPY c.204C>T p.Ser68Ser Synonymous 3/4 -
7-24324980-C-T NPY c.121C>T p.Pro41Ser Missense 2/4 -
16-67516681-C-T AGRP c.257G>A p.Arg86His Missense 4/4 -
16-67516553-A-T AGRP c.385T>A p.Cys129Ser Missense 4/4 -
7-24324965-C-A NPY c.106C>A p.Pro36Thr Missense 2/4 -
7-24324965-C-G NPY c.106C>G p.Pro36Ala Missense 2/4 -
16-67517055-G-A AGRP c.131-42C>T - IntronicSNV - 2/3
17-40336454-G-C HCRT c.114C>G p.Asp38Glu Missense 2/2 -
16-67516547-G-A AGRP c.391C>T p.Arg131Cys Missense 4/4 -
12-102590473-C-A PMCH c.455G>T p.Arg152Ile Missense 3/3 -
16-67516590-G-C AGRP c.348C>G p.Phe116Leu Missense 4/4 -
16-67516587-G-A AGRP c.351C>T p.Cys117Cys Synonymous 4/4 -
17-40336372-G-T HCRT c.196C>A p.Leu66Met Missense 2/2 -
17-40336372-G-A HCRT c.196C>T p.Leu66Leu Synonymous 2/2 -
17-40336410-A-C HCRT c.158T>G p.Leu53Arg Missense 2/2 -
7-24329837-T-C NPY c.269+639T>C - IntronicSNV - 3/3
16-67516672-C-G AGRP c.266G>C p.Arg89Thr Missense 4/4 -
16-67516685-G-A AGRP c.253C>T p.Arg85Cys Missense 4/4 -
16-67516665-A-T AGRP c.273T>A p.His91Gln Missense 4/4 -
17-40336335-C-T HCRT c.233G>A p.Gly78Asp Missense 2/2 -
17-40336278-A-G HCRT c.290T>C p.Met97Thr Missense 2/2 -
17-40336277-C-T HCRT c.291G>A p.Met97Ile Missense 2/2 -
7-24329837-T-A NPY c.269+639T>A - IntronicSNV - 3/3
17-40336351-G-A HCRT c.217C>T p.Pro73Ser Missense 2/2 -
17-40336351-G-C HCRT c.217C>G p.Pro73Ala Missense 2/2 -
16-67516615-C-T AGRP c.323G>A p.Cys108Tyr Missense 4/4 -
17-40336360-T-A HCRT c.208A>T p.Arg70Trp Missense 2/2 -
7-24324608-G-A NPY c.1-252G>A - IntronicSNV - 1/3
7-24324992-A-C NPY c.133A>C p.Met45Leu Missense 2/4 -
16-67516681-C-G AGRP c.257G>C p.Arg86Pro Missense 4/4 -
16-67516682-G-A AGRP c.256C>T p.Arg86Cys Missense 4/4 -
7-24324956-C-G NPY c.97C>G p.Pro33Ala Missense 2/4 -
17-40336347-G-A HCRT c.221C>T p.Pro74Leu Missense 2/2 -
17-40336279-T-C HCRT c.289A>G p.Met97Val Missense 2/2 -
12-102590458-C-T PMCH c.470G>A p.Arg157Lys Missense 3/3 -
7-24329186-T-A NPY c.257T>A p.Val86Asp Missense 3/4 -
16-67516570-C-T AGRP c.368G>A p.Gly123Asp Missense 4/4 -
16-67516666-T-C AGRP c.272A>G p.His91Arg Missense 4/4 -
7-24327920-A-G NPY c.189-1198A>G - IntronicSNV - 2/3
7-24327920-A-T NPY c.189-1198A>T - IntronicSNV - 2/3
17-40336335-C-A HCRT c.233G>T p.Gly78Val Missense 2/2 -
16-67516666-T-G AGRP c.272A>C p.His91Pro Missense 4/4 -
16-67516595-C-T AGRP c.343G>A p.Ala115Thr Missense 4/4 -
16-67516586-A-G AGRP c.352T>C p.Tyr118His Missense 4/4 -
16-67516594-G-A AGRP c.344C>T p.Ala115Val Missense 4/4 -
7-24324879-T-A NPY c.20T>A p.Leu7Gln Missense 2/4 -
17-40336380-A-C HCRT c.188T>G p.Ile63Ser Missense 2/2 -