PMID: 31935908

Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases-Current State of the Art.

Cells
K Smorodinsky-Atias, N Soudah, D Engelberg
2020-01-06

349 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
16-30129461-C-G MAPK3 c.567G>C p.Arg189Arg Synonymous 4/7 -
16-30129461-C-T MAPK3 c.567G>A p.Arg189Arg Synonymous 4/7 -
16-30134374-A-G MAPK3 c.157T>C p.Tyr53His Missense 1/7 -
16-30133247-C-T MAPK3 c.251G>A p.Arg84His Missense 2/7 -
7-140534475-CCG-AGC BRAF c.436_438delCGGinsAGC p.Arg146Ser Missense 3/18 -
7-140549989-AA-AG BRAF c.161_162delTTinsAG p.Ile54Lys Missense 2/18 -
16-30128550-G-A MAPK3 c.832C>T p.Arg278* Nonsense 6/7 -
16-30134451-T-C MAPK3 c.80A>G p.Glu27Gly Missense 1/7 -
16-30133195-GAT-TGG MAPK3 c.301_303delATCinsTGG p.Ile101Trp Missense 2/7 -
22-22160142-G-T MAPK1 c.489C>A p.Leu163Leu Synonymous 3/9 -
22-22160142-G-C MAPK1 c.489C>G p.Leu163Leu Synonymous 3/9 -
22-22160142-G-A MAPK1 c.489C>T p.Leu163Leu Synonymous 3/9 -
16-30133307-C-A MAPK3 c.191G>T p.Arg64Leu Missense 2/7 -
7-140500179-G-A BRAF c.963C>T p.Pro321Pro Synonymous 7/18 -
16-30134370-C-G MAPK3 c.161G>C p.Gly54Ala Missense 1/7 -
16-30129787-A-G MAPK3 c.426T>C p.His142His Synonymous 3/7 -
16-30133187-C-T MAPK3 c.311G>A p.Arg104Gln Missense 2/7 -
22-22153375-C-T MAPK1 c.535G>A p.Asp179Asn Missense 4/9 -
5-172195801-G-A DUSP1 c.1068C>T p.Tyr356Tyr Synonymous 4/4 -
22-22162026-G-T MAPK1 c.229C>A p.Arg77Ser Missense 2/9 -
16-30133211-C-T MAPK3 c.287G>A p.Arg96His Missense 2/7 -
16-30129411-G-A MAPK3 c.617C>T p.Ala206Val Missense 4/7 -
16-30134484-C-A MAPK3 c.47G>T p.Arg16Ile Missense 1/7 -
7-140549990-AT-CA BRAF c.160_161delATinsCA p.Ile54His Missense 2/18 -
7-140549990-AT-CC BRAF c.160_161delATinsCC p.Ile54Pro Missense 2/18 -
16-30129372-G-A MAPK3 c.656C>T p.Ser219Phe Missense 4/7 -
8-57026354-A-G MOS c.188T>C p.Leu63Pro Missense 1/1 -
16-30129733-G-C MAPK3 c.480C>G p.Ala160Ala Synonymous 3/7 -
5-172195803-A-C DUSP1 c.1066T>G p.Tyr356Asp Missense 4/4 -
16-30129380-C-T MAPK3 c.648G>A p.Met216Ile Missense 4/7 -
16-30133195-GAT-CAA MAPK3 c.301_303delATCinsCAA p.Ile101Gln Missense 2/7 -
16-30133176-G-A MAPK3 c.322C>T p.Arg108Trp Missense 2/7 -
16-30129451-G-T MAPK3 c.577C>A p.Pro193Thr Missense 4/7 -
5-172195834-G-C DUSP1 c.1035C>G p.Ile345Met Missense 4/4 -
16-30133243-C-A MAPK3 c.255G>T p.Thr85Thr Synonymous 2/7 -
16-30133243-C-G MAPK3 c.255G>C p.Thr85Thr Synonymous 2/7 -
16-30128576-A-G MAPK3 c.806T>C p.Leu269Pro Missense 6/7 -
16-30133243-C-T MAPK3 c.255G>A p.Thr85Thr Synonymous 2/7 -
22-22160310-G-A MAPK1 c.321C>T p.Leu107Leu Synonymous 3/9 -
16-30129434-G-T MAPK3 c.594C>A p.Thr198Thr Synonymous 4/7 -
16-30129434-G-C MAPK3 c.594C>G p.Thr198Thr Synonymous 4/7 -
16-30129008-T-G MAPK3 c.758A>C p.Gln253Pro Missense 5/7 -
16-30133241-A-G MAPK3 c.257T>C p.Leu86Pro Missense 2/7 -
16-30133311-C-T MAPK3 c.187G>A p.Val63Met Missense 2/7 -
16-30129013-C-G MAPK3 c.753G>C p.Leu251Leu Synonymous 5/7 -
16-30129013-C-T MAPK3 c.753G>A p.Leu251Leu Synonymous 5/7 -
16-30129013-C-A MAPK3 c.753G>T p.Leu251Leu Synonymous 5/7 -
16-30133280-A-C MAPK3 c.218T>G p.Ile73Ser Missense 2/7 -
22-22123532-A-G MAPK1 c.1044T>C p.Phe348Phe Synonymous 8/9 -
16-30129733-G-A MAPK3 c.480C>T p.Ala160Ala Synonymous 3/7 -
22-22160166-C-G MAPK1 c.465G>C p.Leu155Leu Synonymous 3/9 -
22-22160166-C-A MAPK1 c.465G>T p.Leu155Leu Synonymous 3/9 -
22-22160166-C-T MAPK1 c.465G>A p.Leu155Leu Synonymous 3/9 -
16-30129752-AG-GG MAPK3 c.460_461delCTinsGG p.Leu154Gly Missense 3/7 -
7-140549990-A-C BRAF c.161T>G p.Ile54Ser Missense 2/18 -
16-30134462-C-T MAPK3 c.69G>A p.Gly23Gly Synonymous 1/7 -
16-30129463-G-A MAPK3 c.565C>T p.Arg189Trp Missense 4/7 -
16-30128216-T-A MAPK3 c.1016A>T p.Glu339Val Missense 7/7 -
16-30129451-G-A MAPK3 c.577C>T p.Pro193Ser Missense 4/7 -
8-57026370-C-G MOS c.172G>C p.Glu58Gln Missense 1/1 -
16-30129754-G-A MAPK3 c.459C>T p.Gly153Gly Synonymous 3/7 -
16-30129475-A-T MAPK3 c.553T>A p.Phe185Ile Missense 4/7 -
16-30128324-G-A MAPK3 c.908C>T p.Ala303Val Missense 7/7 -
16-30129472-C-G MAPK3 c.556G>C p.Gly186Arg Missense 4/7 -
16-30129754-G-C MAPK3 c.459C>G p.Gly153Gly Synonymous 3/7 -
16-30129754-G-T MAPK3 c.459C>A p.Gly153Gly Synonymous 3/7 -
22-22221703-C-G MAPK1 c.28G>C p.Gly10Arg Missense 1/9 -
16-30129683-G-A MAPK3 c.530C>T p.Thr177Ile Missense 3/7 -
16-30133296-C-A MAPK3 c.202G>T p.Val68Leu Missense 2/7 -
16-30133173-C-G MAPK3 c.325G>C p.Ala109Pro Missense 2/7 -
10-49618090-T-G MAPK8 c.329T>G p.Leu110Arg Missense 5/12 -
16-30133308-G-A MAPK3 c.190C>T p.Arg64Cys Missense 2/7 -
16-30129719-C-A MAPK3 c.494G>T p.Arg165Leu Missense 3/7 -
22-22162004-AT-GC MAPK1 c.250_251delATinsGC p.Ile84Ala Missense 2/9 -
22-22160168-G-A MAPK1 c.463C>T p.Leu155Leu Synonymous 3/9 -
10-49617953-A-G MAPK8 c.284A>G p.Gln95Arg Missense 4/12 -
16-30129002-T-C MAPK3 c.764A>G p.Asn255Ser Missense 5/7 -
7-140500179-G-T BRAF c.963C>A p.Pro321Pro Synonymous 7/18 -
8-57026398-GCG-TGA MOS c.142_144delCGCinsTGA p.Arg48* Nonsense 1/1 -
7-140500179-G-C BRAF c.963C>G p.Pro321Pro Synonymous 7/18 -
10-49609806-GG-AC MAPK8 c.103_104delGGinsAC p.Gly35Thr Missense 2/12 -
16-30133218-G-A MAPK3 c.280C>T p.Arg94Cys Missense 2/7 -
10-49609806-GGA-AAC MAPK8 c.103_105delGGAinsAAC p.Gly35Asn Missense 2/12 -
5-172195915-CG-GT DUSP1 c.953_954delCGinsGT p.Ser318Cys Missense 4/4 -
7-140549990-AT-GG BRAF c.160_161delATinsGG p.Ile54Gly Missense 2/18 -
16-30133229-T-C MAPK3 c.269A>G p.Gln90Arg Missense 2/7 -
16-30128541-G-T MAPK3 c.841C>A p.Leu281Ile Missense 6/7 -
5-172195835-AT-TA DUSP1 c.1033_1034delATinsTA p.Ile345Tyr Missense 4/4 -
5-172195910-T-G DUSP1 c.959A>C p.Glu320Ala Missense 4/4 -
16-30129841-C-A MAPK3 c.372G>T p.Leu124Leu Synonymous 3/7 -
16-30129841-C-G MAPK3 c.372G>C p.Leu124Leu Synonymous 3/7 -
16-30129841-C-T MAPK3 c.372G>A p.Leu124Leu Synonymous 3/7 -
7-140534460-TGA-GAC BRAF c.451_453delTCAinsGAC p.Ser151Asp Missense 3/18 -
16-30133263-G-A MAPK3 c.235C>T p.Gln79* Nonsense 2/7 -
16-30129801-G-A MAPK3 c.412C>T p.Leu138Leu Synonymous 3/7 -
16-30133210-G-A MAPK3 c.288C>T p.Arg96Arg Synonymous 2/7 -
8-57025751-G-A MOS c.791C>T p.Ser264Phe Missense 1/1 -
16-30134388-A-T MAPK3 c.143T>A p.Ile48Asn Missense 1/7 -
16-30128278-C-G MAPK3 c.954G>C p.Arg318Arg Synonymous 7/7 -
16-30133210-G-T MAPK3 c.288C>A p.Arg96Arg Synonymous 2/7 -
16-30128278-C-A MAPK3 c.954G>T p.Arg318Arg Synonymous 7/7 -
5-172195910-T-A DUSP1 c.959A>T p.Glu320Val Missense 4/4 -
16-30129736-G-T MAPK3 c.477C>A p.Ser159Ser Synonymous 3/7 -
22-22162109-AC-CA MAPK1 c.145_146delGTinsCA p.Val49His Missense 2/9 -
5-172195835-AT-CA DUSP1 c.1033_1034delATinsCA p.Ile345His Missense 4/4 -
16-30129473-G-A MAPK3 c.555C>T p.Phe185Phe Synonymous 4/7 -
16-30128217-C-T MAPK3 c.1015G>A p.Glu339Lys Missense 7/7 -
16-30133206-C-T MAPK3 c.292G>A p.Glu98Lys Missense 2/7 -
16-30129459-A-G MAPK3 c.569T>C p.Ile190Thr Missense 4/7 -
16-30129837-C-A MAPK3 c.376G>T p.Glu126* Nonsense 3/7 -
16-30129434-G-A MAPK3 c.594C>T p.Thr198Thr Synonymous 4/7 -
16-30129707-G-A MAPK3 c.506C>T p.Pro169Leu Missense 3/7 -
16-30129483-A-T MAPK3 c.545T>A p.Ile182Asn Missense 4/7 -
7-140549990-AT-TA BRAF c.160_161delATinsTA p.Ile54Tyr Missense 2/18 -
16-30128236-C-A MAPK3 c.996G>T p.Gln332His Missense 7/7 -
8-57026128-G-T MOS c.414C>A p.Ile138Ile Synonymous 1/1 -
10-49609806-GGA-AGC MAPK8 c.103_105delGGAinsAGC p.Gly35Ser Missense 2/12 -
16-30133301-G-T MAPK3 c.197C>A p.Thr66Asn Missense 2/7 -
10-49628330-G-T MAPK8 c.583G>T p.Glu195* Nonsense 6/12 -
8-57026128-G-A MOS c.414C>T p.Ile138Ile Synonymous 1/1 -
16-30128280-G-A MAPK3 c.952C>T p.Arg318Trp Missense 7/7 -
16-30128280-G-T MAPK3 c.952C>A p.Arg318Arg Synonymous 7/7 -
16-30134461-C-A MAPK3 c.70G>T p.Val24Phe Missense 1/7 -
22-22142608-A-G MAPK1 c.794T>C p.Leu265Pro Missense 6/9 -
16-30128270-AC-TG MAPK3 c.961_962delGTinsTG p.Val321Trp Missense 7/7 -
16-30133304-T-C MAPK3 c.194A>G p.Lys65Arg Missense 2/7 -
7-140550011-A-G BRAF c.140T>C p.Val47Ala Missense 2/18 -
16-30129752-AG-AA MAPK3 c.460_461delCTinsAA p.Leu154Asn Missense 3/7 -
5-172195834-GAT-TGG DUSP1 c.1033_1035delATCinsTGG p.Ile345Trp Missense 4/4 -
16-30129681-A-G MAPK3 c.532T>C p.Cys178Arg Missense 3/7 -
16-30133239-G-A MAPK3 c.259C>T p.Arg87Trp Missense 2/7 -
22-22123499-TCT-TGG MAPK1 c.1075_1077delAGAinsTGG p.Arg359Trp Missense 8/9 -
10-49628294-AC-GA MAPK8 c.547_548delACinsGA p.Thr183Glu Missense 6/12 -
16-30134460-AC-AG MAPK3 c.70_71delGTinsAG p.Val24Ser Missense 1/7 -
16-30134371-C-T MAPK3 c.160G>A p.Gly54Ser Missense 1/7 -
16-30134371-C-A MAPK3 c.160G>T p.Gly54Cys Missense 1/7 -
5-172195911-C-A DUSP1 c.958G>T p.Glu320* Nonsense 4/4 -
7-140624406-GC-AA BRAF c.97_98delGCinsAA p.Ala33Asn Missense 1/18 -
22-22162108-AAC-AAG MAPK1 c.145_147delGTTinsAAG p.Val49Lys Missense 2/9 -
16-30129450-G-T MAPK3 c.578C>A p.Pro193His Missense 4/7 -
7-140534476-C-A BRAF c.437G>T p.Arg146Leu Missense 3/18 -
16-30133204-C-A MAPK3 c.294G>T p.Glu98Asp Missense 2/7 -
16-30129733-G-T MAPK3 c.480C>A p.Ala160Ala Synonymous 3/7 -
16-30128603-AT-CA MAPK3 c.778_779delATinsCA p.Ile260His Missense 6/7 -
16-30129679-G-A MAPK3 c.534C>T p.Cys178Cys Synonymous 3/7 -
10-49609806-GG-AA MAPK8 c.103_104delGGinsAA p.Gly35Lys Missense 2/12 -
7-140500180-G-A BRAF c.962C>T p.Pro321Leu Missense 7/18 -
16-30133273-G-A MAPK3 c.225C>T p.Pro75Pro Synonymous 2/7 -
16-30128221-C-T MAPK3 c.1011G>A p.Thr337Thr Synonymous 7/7 -
16-30128236-C-G MAPK3 c.996G>C p.Gln332His Missense 7/7 -
16-30128221-C-G MAPK3 c.1011G>C p.Thr337Thr Synonymous 7/7 -
16-30128221-C-A MAPK3 c.1011G>T p.Thr337Thr Synonymous 7/7 -
5-172197173-G-A DUSP1 c.504C>T p.Leu168Leu Synonymous 2/4 -
16-30129805-C-A MAPK3 c.408G>T p.Gln136His Missense 3/7 -
16-30129805-C-G MAPK3 c.408G>C p.Gln136His Missense 3/7 -
5-172197173-G-C DUSP1 c.504C>G p.Leu168Leu Synonymous 2/4 -
5-172197173-G-T DUSP1 c.504C>A p.Leu168Leu Synonymous 2/4 -
16-30133300-AG-TG MAPK3 c.197_198delCTinsTG p.Thr66Met Missense 2/7 -
7-140500181-G-A BRAF c.961C>T p.Pro321Ser Missense 7/18 -
16-30129421-C-T MAPK3 c.607G>A p.Glu203Lys Missense 4/7 -
16-30133193-C-T MAPK3 c.305G>A p.Gly102Asp Missense 2/7 -
16-30133278-T-C MAPK3 c.220A>G p.Ser74Gly Missense 2/7 -
16-30129432-C-T MAPK3 c.596G>A p.Gly199Asp Missense 4/7 -
16-30133195-G-A MAPK3 c.303C>T p.Ile101Ile Synonymous 2/7 -
16-30133195-G-T MAPK3 c.303C>A p.Ile101Ile Synonymous 2/7 -
16-30129771-A-G MAPK3 c.442T>C p.Tyr148His Missense 3/7 -
5-172196791-G-T DUSP1 c.520C>A p.Pro174Thr Missense 3/4 -
16-30129702-T-C MAPK3 c.511A>G p.Asn171Asp Missense 3/7 -
16-30133261-C-G MAPK3 c.237G>C p.Gln79His Missense 2/7 -
16-30133261-C-A MAPK3 c.237G>T p.Gln79His Missense 2/7 -
16-30128225-G-T MAPK3 c.1007C>A p.Pro336Gln Missense 7/7 -
16-30129423-G-A MAPK3 c.605C>T p.Thr202Met Missense 4/7 -
5-172197187-A-G DUSP1 c.490T>C p.Cys164Arg Missense 2/4 -
5-172195836-T-A DUSP1 c.1033A>T p.Ile345Phe Missense 4/4 -
16-30129848-TG-AT MAPK3 c.364_365delCAinsAT p.Gln122Met Missense 3/7 -
16-30133274-G-A MAPK3 c.224C>T p.Pro75Leu Missense 2/7 -
10-49609806-GG-CC MAPK8 c.103_104delGGinsCC p.Gly35Pro Missense 2/12 -
10-49609806-GGA-TGT MAPK8 c.103_105delGGAinsTGT p.Gly35Cys Missense 2/12 -
8-57026304-G-T MOS c.238C>A p.Arg80Ser Missense 1/1 -
22-22162024-GCG-AAG MAPK1 c.229_231delCGCinsAAG p.Arg77Lys Missense 2/9 -
5-172196791-G-A DUSP1 c.520C>T p.Pro174Ser Missense 3/4 -
16-30133319-T-C MAPK3 c.179A>G p.Tyr60Cys Missense 2/7 -
16-30133300-A-C MAPK3 c.198T>G p.Thr66Thr Synonymous 2/7 -
16-30133300-A-G MAPK3 c.198T>C p.Thr66Thr Synonymous 2/7 -
8-57026348-C-T MOS c.194G>A p.Arg65Lys Missense 1/1 -
16-30129047-G-C MAPK3 c.719C>G p.Ser240Cys Missense 5/7 -
16-30133302-T-G MAPK3 c.196A>C p.Thr66Pro Missense 2/7 -
16-30129759-G-A MAPK3 c.454C>T p.Arg152Trp Missense 3/7 -
16-30133240-G-C MAPK3 c.258C>G p.Leu86Leu Synonymous 2/7 -
16-30133240-G-T MAPK3 c.258C>A p.Leu86Leu Synonymous 2/7 -
16-30129461-C-A MAPK3 c.567G>T p.Arg189Arg Synonymous 4/7 -
16-30129756-C-T MAPK3 c.457G>A p.Gly153Ser Missense 3/7 -
7-140534475-CCG-TGT BRAF c.436_438delCGGinsTGT p.Arg146Cys Missense 3/18 -
7-140500278-C-T BRAF c.864G>A p.Leu288Leu Synonymous 7/18 -
16-30129040-C-A MAPK3 c.726G>T p.Arg242Arg Synonymous 5/7 -
5-172195909-CTC-AAC DUSP1 c.958_960delGAGinsAAC p.Glu320Asn Missense 4/4 -
22-22162086-T-C MAPK1 c.169A>G p.Ser57Gly Missense 2/9 -
22-22221688-G-C MAPK1 c.43C>G p.Arg15Gly Missense 1/9 -
16-30129407-C-G MAPK3 c.621G>C p.Thr207Thr Synonymous 4/7 -
16-30129461-CC-AT MAPK3 c.566_567delGGinsAT p.Arg189His Missense 4/7 -
16-30129380-C-A MAPK3 c.648G>T p.Met216Ile Missense 4/7 -
16-30129015-G-A MAPK3 c.751C>T p.Leu251Leu Synonymous 5/7 -
16-30129740-T-A MAPK3 c.473A>T p.His158Leu Missense 3/7 -
22-22162101-C-G MAPK1 c.154G>C p.Ala52Pro Missense 2/9 -
16-30133301-GT-GA MAPK3 c.196_197delACinsGA p.Thr66Asp Missense 2/7 -
22-22221726-CGCC-C MAPK1 c.20_22delCGG p.Ala7delAla InFrameDeletion 1/9 -
16-30129471-C-T MAPK3 c.557G>A p.Gly186Asp Missense 4/7 -
16-30129735-C-T MAPK3 c.478G>A p.Ala160Thr Missense 3/7 -
22-22160323-AT-GC MAPK1 c.307_308delATinsGC p.Ile103Ala Missense 3/9 -
16-30129407-C-A MAPK3 c.621G>T p.Thr207Thr Synonymous 4/7 -
16-30133253-C-T MAPK3 c.245G>A p.Cys82Tyr Missense 2/7 -
16-30128586-G-A MAPK3 c.796C>T p.Gln266* Nonsense 6/7 -
16-30128278-C-T MAPK3 c.954G>A p.Arg318Arg Synonymous 7/7 -
7-140549989-AAT-GAG BRAF c.160_162delATTinsGAG p.Ile54Glu Missense 2/18 -
16-30128513-A-G MAPK3 c.869T>C p.Val290Ala Missense 6/7 -
16-30129818-AA-CC MAPK3 c.394_395delTTinsCC p.Leu132Pro Missense 3/7 -
16-30133300-AGT-CAA MAPK3 c.196_198delACTinsCAA p.Thr66Gln Missense 2/7 -
16-30129778-G-C MAPK3 c.435C>G p.Tyr145* Nonsense 3/7 -
16-30129778-G-T MAPK3 c.435C>A p.Tyr145* Nonsense 3/7 -
16-30134496-C-T MAPK3 c.35G>A p.Gly12Glu Missense 1/7 -
16-30129799-C-G MAPK3 c.414G>C p.Leu138Leu Synonymous 3/7 -
22-22221637-C-A MAPK1 c.94G>T p.Gly32Cys Missense 1/9 -
16-30134471-G-C MAPK3 c.60C>G p.Val20Val Synonymous 1/7 -
16-30134471-G-A MAPK3 c.60C>T p.Val20Val Synonymous 1/7 -
16-30129799-C-A MAPK3 c.414G>T p.Leu138Leu Synonymous 3/7 -
16-30129799-C-T MAPK3 c.414G>A p.Leu138Leu Synonymous 3/7 -
16-30129040-C-G MAPK3 c.726G>C p.Arg242Arg Synonymous 5/7 -
16-30134441-C-T MAPK3 c.90G>A p.Met30Ile Missense 1/7 -
16-30128290-G-A MAPK3 c.942C>T p.Asn314Asn Synonymous 7/7 -
16-30129396-C-G MAPK3 c.632G>C p.Arg211Pro Missense 4/7 -
16-30134393-C-G MAPK3 c.138G>C p.Gln46His Missense 1/7 -
16-30128314-C-T MAPK3 c.918G>A p.Leu306Leu Synonymous 7/7 -
16-30128314-C-A MAPK3 c.918G>T p.Leu306Leu Synonymous 7/7 -
16-30128314-C-G MAPK3 c.918G>C p.Leu306Leu Synonymous 7/7 -
16-30134393-C-A MAPK3 c.138G>T p.Gln46His Missense 1/7 -
16-30134380-C-T MAPK3 c.151G>A p.Gly51Ser Missense 1/7 -
16-30129060-C-T MAPK3 c.706G>A p.Ala236Thr Missense 5/7 -
5-172197826-C-A DUSP1 c.130G>T p.Val44Phe Missense 1/4 -
16-30128291-T-A MAPK3 c.941A>T p.Asn314Ile Missense 7/7 -
16-30128300-AA-CC MAPK3 c.931_932delTTinsCC p.Leu311Pro Missense 7/7 -
5-172195881-C-T DUSP1 c.988G>A p.Asp330Asn Missense 4/4 -
16-30133315-G-C MAPK3 c.183C>G p.Asp61Glu Missense 2/7 -
16-30134499-C-A MAPK3 c.32G>T p.Gly11Val Missense 1/7 -
16-30129407-C-T MAPK3 c.621G>A p.Thr207Thr Synonymous 4/7 -
16-30133315-G-T MAPK3 c.183C>A p.Asp61Glu Missense 2/7 -
16-30134479-C-G MAPK3 c.52G>C p.Glu18Gln Missense 1/7 -
16-30128239-C-T MAPK3 c.993G>A p.Glu331Glu Synonymous 7/7 -
16-30128997-T-C MAPK3 c.769A>G p.Ile257Val Missense 5/7 -
22-22153380-T-C MAPK1 c.530A>G p.Asp177Gly Missense 4/9 -
16-30133282-C-G MAPK3 c.216G>C p.Lys72Asn Missense 2/7 -
16-30134494-C-A MAPK3 c.37G>T p.Glu13* Nonsense 1/7 -
16-30128316-G-A MAPK3 c.916C>T p.Leu306Leu Synonymous 7/7 -
16-30129736-G-A MAPK3 c.477C>T p.Ser159Ser Synonymous 3/7 -
16-30129736-G-C MAPK3 c.477C>G p.Ser159Ser Synonymous 3/7 -
22-22123500-CT-CA MAPK1 c.1075_1076delAGinsCA p.Arg359Gln Missense 8/9 -
16-30129396-C-T MAPK3 c.632G>A p.Arg211Gln Missense 4/7 -
16-30128321-A-G MAPK3 c.911T>C p.Leu304Pro Missense 7/7 -
22-22127240-G-A MAPK1 c.888C>T p.Phe296Phe Synonymous 7/9 -
16-30128297-G-C MAPK3 c.935C>G p.Thr312Ser Missense 7/7 -
16-30133300-A-T MAPK3 c.198T>A p.Thr66Thr Synonymous 2/7 -
16-30134458-G-A MAPK3 c.73C>T p.Pro25Ser Missense 1/7 -
16-30129380-C-G MAPK3 c.648G>C p.Met216Ile Missense 4/7 -
16-30133283-T-C MAPK3 c.215A>G p.Lys72Arg Missense 2/7 -
10-49609807-G-C MAPK8 c.104G>C p.Gly35Ala Missense 2/12 -
16-30133296-C-G MAPK3 c.202G>C p.Val68Leu Missense 2/7 -
5-172197258-G-A DUSP1 c.419C>T p.Ser140Leu Missense 2/4 -
16-30129075-C-G MAPK3 c.691G>C p.Val231Leu Missense 5/7 -
16-30129075-C-A MAPK3 c.691G>T p.Val231Leu Missense 5/7 -
16-30134428-G-A MAPK3 c.103C>T p.Pro35Ser Missense 1/7 -
16-30133241-A-C MAPK3 c.257T>G p.Leu86Arg Missense 2/7 -
16-30129374-G-A MAPK3 c.654C>T p.Asn218Asn Synonymous 4/7 -
16-30133301-G-A MAPK3 c.197C>T p.Thr66Ile Missense 2/7 -
16-30129386-C-G MAPK3 c.642G>C p.Glu214Asp Missense 4/7 -
16-30129386-C-A MAPK3 c.642G>T p.Glu214Asp Missense 4/7 -
5-172195836-T-G DUSP1 c.1033A>C p.Ile345Leu Missense 4/4 -
16-30128229-C-T MAPK3 c.1003G>A p.Asp335Asn Missense 7/7 -
16-30128482-G-C MAPK3 c.900C>G p.Asp300Glu Missense 6/7 -
22-22221636-C-T MAPK1 c.95G>A p.Gly32Asp Missense 1/9 -
16-30133195-GA-GG MAPK3 c.302_303delTCinsGG p.Ile101Arg Missense 2/7 -
5-172196717-C-A DUSP1 c.594G>T p.Leu198Phe Missense 3/4 -
5-172196717-C-G DUSP1 c.594G>C p.Leu198Phe Missense 3/4 -
16-30128482-G-T MAPK3 c.900C>A p.Asp300Glu Missense 6/7 -
22-22123589-G-A MAPK1 c.987C>T p.Phe329Phe Synonymous 8/9 -
16-30133301-GT-CA MAPK3 c.196_197delACinsCA p.Thr66His Missense 2/7 -
16-30133301-GT-CT MAPK3 c.196_197delACinsCT p.Thr66Leu Missense 2/7 -
16-30133325-G-A MAPK3 c.173C>T p.Ser58Leu Missense 2/7 -
16-30134434-C-A MAPK3 c.97G>T p.Gly33Trp Missense 1/7 -
22-22160310-G-T MAPK1 c.321C>A p.Leu107Leu Synonymous 3/9 -
22-22160310-G-C MAPK1 c.321C>G p.Leu107Leu Synonymous 3/9 -
16-30133273-G-T MAPK3 c.225C>A p.Pro75Pro Synonymous 2/7 -
16-30133273-G-C MAPK3 c.225C>G p.Pro75Pro Synonymous 2/7 -
16-30133275-G-A MAPK3 c.223C>T p.Pro75Ser Missense 2/7 -
16-30129843-G-A MAPK3 c.370C>T p.Leu124Leu Synonymous 3/7 -
16-30133267-T-C MAPK3 c.231A>G p.Glu77Glu Synonymous 2/7 -
16-30129042-G-T MAPK3 c.724C>A p.Arg242Arg Synonymous 5/7 -
22-22123590-A-T MAPK1 c.986T>A p.Phe329Tyr Missense 8/9 -
16-30129680-C-T MAPK3 c.533G>A p.Cys178Tyr Missense 3/7 -
22-22162054-TCT-TGT MAPK1 c.199_201delAGAinsTGT p.Arg67Cys Missense 2/9 -
16-30134494-C-T MAPK3 c.37G>A p.Glu13Lys Missense 1/7 -
16-30129461-CCG-TGT MAPK3 c.565_567delCGGinsTGT p.Arg189Cys Missense 4/7 -
16-30133301-GT-TA MAPK3 c.196_197delACinsTA p.Thr66Tyr Missense 2/7 -
5-172195911-C-T DUSP1 c.958G>A p.Glu320Lys Missense 4/4 -
7-140549989-AAT-CAA BRAF c.160_162delATTinsCAA p.Ile54Gln Missense 2/18 -
10-49609807-GA-AC MAPK8 c.104_105delGAinsAC p.Gly35Asp Missense 2/12 -
16-30134420-G-A MAPK3 c.111C>T p.Asp37Asp Synonymous 1/7 -
16-30133282-C-A MAPK3 c.216G>T p.Lys72Asn Missense 2/7 -
16-30129809-C-T MAPK3 c.404G>A p.Ser135Asn Missense 3/7 -
16-30133196-AT-TA MAPK3 c.301_302delATinsTA p.Ile101Tyr Missense 2/7 -
16-30129448-C-G MAPK3 c.580G>C p.Glu194Gln Missense 4/7 -
16-30128298-T-A MAPK3 c.934A>T p.Thr312Ser Missense 7/7 -
7-140534475-CC-AT BRAF c.437_438delGGinsAT p.Arg146His Missense 3/18 -
16-30133212-G-A MAPK3 c.286C>T p.Arg96Cys Missense 2/7 -
16-30134471-G-T MAPK3 c.60C>A p.Val20Val Synonymous 1/7 -
16-30129462-C-T MAPK3 c.566G>A p.Arg189Gln Missense 4/7 -
16-30133301-GT-TT MAPK3 c.196_197delACinsTT p.Thr66Phe Missense 2/7 -
16-30133240-G-A MAPK3 c.258C>T p.Leu86Leu Synonymous 2/7 -
7-140549990-AT-GA BRAF c.160_161delATinsGA p.Ile54Asp Missense 2/18 -
16-30128563-G-C MAPK3 c.819C>G p.Ile273Met Missense 6/7 -
16-30128220-C-T MAPK3 c.1012G>A p.Asp338Asn Missense 7/7 -
16-30129770-T-C MAPK3 c.443A>G p.Tyr148Cys Missense 3/7 -
16-30129373-A-G MAPK3 c.655T>C p.Ser219Pro Missense 4/7 -
16-30129463-G-T MAPK3 c.565C>A p.Arg189Arg Synonymous 4/7 -
22-22143082-T-C MAPK1 c.625A>G p.Ile209Val Missense 5/9 -
16-30133248-G-T MAPK3 c.250C>A p.Arg84Ser Missense 2/7 -
7-140500280-A-G BRAF c.862T>C p.Leu288Leu Synonymous 7/18 -
16-30129040-C-T MAPK3 c.726G>A p.Arg242Arg Synonymous 5/7 -
16-30133279-G-C MAPK3 c.219C>G p.Ile73Met Missense 2/7 -
16-30134462-C-G MAPK3 c.69G>C p.Gly23Gly Synonymous 1/7 -
16-30134462-C-A MAPK3 c.69G>T p.Gly23Gly Synonymous 1/7 -
16-30134441-C-G MAPK3 c.90G>C p.Met30Ile Missense 1/7 -
16-30134441-C-A MAPK3 c.90G>T p.Met30Ile Missense 1/7 -
8-57026347-CC-TC MOS c.194_195delGGinsTC p.Arg65Ile Missense 1/1 -
16-30133210-G-C MAPK3 c.288C>G p.Arg96Arg Synonymous 2/7 -
8-57025792-G-T MOS c.750C>A p.Leu250Leu Synonymous 1/1 -
16-30133256-T-C MAPK3 c.242A>G p.Tyr81Cys Missense 2/7 -
8-57025792-G-C MOS c.750C>G p.Leu250Leu Synonymous 1/1 -
8-57025792-G-A MOS c.750C>T p.Leu250Leu Synonymous 1/1 -
16-30129087-C-T MAPK3 c.679G>A p.Asp227Asn Missense 5/7 -
16-30129758-C-A MAPK3 c.455G>T p.Arg152Leu Missense 3/7 -
16-30134372-G-A MAPK3 c.159C>T p.Tyr53Tyr Synonymous 1/7 -
16-30129807-G-A MAPK3 c.406C>T p.Gln136* Nonsense 3/7 -
16-30129397-G-A MAPK3 c.631C>T p.Arg211Trp Missense 4/7 -
22-22123593-G-A MAPK1 c.983C>T p.Pro328Leu Missense 8/9 -
16-30134373-T-C MAPK3 c.158A>G p.Tyr53Cys Missense 1/7 -
16-30128288-G-T MAPK3 c.944C>A p.Pro315His Missense 7/7 -
16-30133204-C-G MAPK3 c.294G>C p.Glu98Asp Missense 2/7 -
8-57026347-C-A MOS c.195G>T p.Arg65Ser Missense 1/1 -
8-57026347-C-G MOS c.195G>C p.Arg65Ser Missense 1/1 -
16-30133207-A-G MAPK3 c.291T>C p.His97His Synonymous 2/7 -