PMID: 32457649

A Bitter Taste in Your Heart.

Frontiers in physiology
CJ Bloxham, SR Foster, WG Thomas
2020

214 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
7-141490238-G-T TAS2R5 c.77G>T p.Ser26Ile Missense 1/1 -
12-11286422-A-G TAS2R30 c.422T>C p.Val141Ala Missense 1/1 -
7-141464171-C-G TAS2R3 c.213C>G p.Phe71Leu Missense 1/1 -
12-11183406-C-T TAS2R31 c.529G>A p.Ala177Thr Missense 1/1 -
12-11243929-C-T TAS2R43 c.900G>A p.Trp300* Nonsense 1/1 -
12-11183052-G-A TAS2R31 c.883C>T p.Arg295Trp Missense 1/1 -
12-11183255-G-A TAS2R31 c.680C>T p.Ala227Val Missense 1/1 -
12-11244603-T-A TAS2R43 c.226A>T p.Asn76Tyr Missense 1/1 -
12-10961978-C-T TAS2R9 c.697G>A p.Ala233Thr Missense 1/1 -
12-11243960-A-T TAS2R43 c.869T>A p.Phe290Tyr Missense 1/1 -
12-11243960-A-G TAS2R43 c.869T>C p.Phe290Ser Missense 1/1 -
7-141478574-G-C TAS2R4 c.286G>C p.Val96Leu Missense 1/1 -
12-11174286-C-T TAS2R19 c.885G>A p.Trp295* Nonsense 1/1 -
12-11183142-T-G TAS2R31 c.793A>C p.Lys265Gln Missense 1/1 -
12-11214437-T-C TAS2R46 c.457A>G p.Ile153Val Missense 1/1 -
12-11183178-C-T TAS2R31 c.757G>A p.Gly253Arg Missense 1/1 -
12-11183178-C-G TAS2R31 c.757G>C p.Gly253Arg Missense 1/1 -
12-10961765-G-A TAS2R9 c.910C>T p.Leu304Phe Missense 1/1 -
12-11183066-A-T TAS2R31 c.869T>A p.Phe290Tyr Missense 1/1 -
12-11174286-C-A TAS2R19 c.885G>T p.Trp295Cys Missense 1/1 -
12-11244017-T-C TAS2R43 c.812A>G p.Tyr271Cys Missense 1/1 -
12-11286214-C-G TAS2R30 c.630G>C p.Gln210His Missense 1/1 -
12-11244321-T-G TAS2R43 c.508A>C p.Ser170Arg Missense 1/1 -
12-11286314-A-G TAS2R30 c.530T>C p.Met177Thr Missense 1/1 -
12-11338750-T-G TAS2R42 c.794A>C p.Tyr265Ser Missense 1/1 -
12-11338750-T-C TAS2R42 c.794A>G p.Tyr265Cys Missense 1/1 -
12-11244725-C-G TAS2R43 c.104G>C p.Trp35Ser Missense 1/1 -
7-122635183-T-C TAS2R16 c.506A>G p.Lys169Arg Missense 1/1 -
12-11183697-C-A TAS2R31 c.238G>T p.Val80Leu Missense 1/1 -
12-11244687-G-A TAS2R43 c.142C>T p.Leu48Phe Missense 1/1 -
12-11244554-T-C TAS2R43 c.275A>G p.Asn92Ser Missense 1/1 -
12-11244199-C-G TAS2R43 c.630G>C p.Gln210His Missense 1/1 -
12-11244015-G-A TAS2R43 c.814C>T p.Pro272Ser Missense 1/1 -
12-11244117-A-C TAS2R43 c.712T>G p.Cys238Gly Missense 1/1 -
12-11243947-A-C TAS2R43 c.882T>G p.Phe294Leu Missense 1/1 -
12-11243947-A-T TAS2R43 c.882T>A p.Phe294Leu Missense 1/1 -
12-11183506-T-G TAS2R31 c.429A>C p.Gln143His Missense 1/1 -
12-11150054-C-T TAS2R20 c.421G>A p.Val141Ile Missense 1/1 -
12-11174498-T-C TAS2R19 c.673A>G p.Ile225Val Missense 1/1 -
7-141464501-C-G TAS2R3 c.543C>G p.Ile181Met Missense 1/1 -
12-11244234-T-C TAS2R43 c.595A>G p.Ile199Val Missense 1/1 -
12-11244234-T-G TAS2R43 c.595A>C p.Ile199Leu Missense 1/1 -
12-11244230-C-A TAS2R43 c.599G>T p.Cys200Phe Missense 1/1 -
12-11244027-T-A TAS2R43 c.802A>T p.Arg268* Nonsense 1/1 -
12-11244027-T-C TAS2R43 c.802A>G p.Arg268Gly Missense 1/1 -
12-11174397-T-A TAS2R19 c.774A>T p.Lys258Asn Missense 1/1 -
12-11183300-T-C TAS2R31 c.635A>G p.His212Arg Missense 1/1 -
12-11214472-A-G TAS2R46 c.422T>C p.Val141Ala Missense 1/1 -
12-11183286-G-C TAS2R31 c.649C>G p.Gln217Glu Missense 1/1 -
12-11244009-T-C TAS2R43 c.820A>G p.Ile274Val Missense 1/1 -
12-11214145-C-T TAS2R46 c.749G>A p.Trp250* Nonsense 1/1 -
12-11244378-C-T TAS2R43 c.451G>A p.Glu151Lys Missense 1/1 -
7-141464718-TCA-AAC TAS2R3 c.760_762delTCAinsAAC p.Ser254Asn Missense 1/1 -
12-11183832-G-A TAS2R31 c.103C>T p.Arg35Trp Missense 1/1 -
12-11174282-T-C TAS2R19 c.889A>G p.Met297Val Missense 1/1 -
7-80103570-A-G GNAT3 c.587T>C p.Phe196Ser Missense 5/8 -
12-11244591-C-T TAS2R43 c.238G>A p.Val80Ile Missense 1/1 -
12-11244687-G-C TAS2R43 c.142C>G p.Leu48Val Missense 1/1 -
12-11244243-T-G TAS2R43 c.586A>C p.Met196Leu Missense 1/1 -
12-11244369-G-T TAS2R43 c.460C>A p.Arg154Arg Synonymous 1/1 -
7-80117928-T-A GNAT3 c.226A>T p.Asn76Tyr Missense 3/8 -
7-141464847-G-A TAS2R3 c.889G>A p.Val297Met Missense 1/1 -
12-11183753-A-C TAS2R31 c.182T>G p.Val61Gly Missense 1/1 -
12-11214498-T-C TAS2R46 c.396A>G p.Ile132Met Missense 1/1 -
12-11183475-G-C TAS2R31 c.460C>G p.Arg154Gly Missense 1/1 -
12-11183475-G-A TAS2R31 c.460C>T p.Arg154Trp Missense 1/1 -
12-11183123-T-C TAS2R31 c.812A>G p.Tyr271Cys Missense 1/1 -
12-11183114-A-G TAS2R31 c.821T>C p.Ile274Thr Missense 1/1 -
12-10962115-A-G TAS2R9 c.560T>C p.Val187Ala Missense 1/1 -
12-11244285-C-G TAS2R43 c.544G>C p.Val182Leu Missense 1/1 -
7-141478392-G-C TAS2R4 c.104G>C p.Trp35Ser Missense 1/1 -
12-11175077-C-T TAS2R19 c.94G>A p.Val32Ile Missense 1/1 -
12-11214386-T-G TAS2R46 c.508A>C p.Ser170Arg Missense 1/1 -
12-11214386-T-C TAS2R46 c.508A>G p.Ser170Gly Missense 1/1 -
12-11183485-T-G TAS2R31 c.450A>C p.Lys150Asn Missense 1/1 -
12-11183485-T-A TAS2R31 c.450A>T p.Lys150Asn Missense 1/1 -
12-11183232-G-A TAS2R31 c.703C>T p.Leu235Phe Missense 1/1 -
12-11138852-C-T TAS2R50 c.608G>A p.Cys203Tyr Missense 1/1 -
12-11244557-A-G TAS2R43 c.272T>C p.Ile91Thr Missense 1/1 -
7-141478832-G-C TAS2R4 c.544G>C p.Val182Leu Missense 1/1 -
12-11150046-G-T TAS2R20 c.429C>A p.His143Gln Missense 1/1 -
12-11286088-A-C TAS2R30 c.756T>G p.Phe252Leu Missense 1/1 -
7-141479082-G-A TAS2R4 c.794G>A p.Cys265Tyr Missense 1/1 -
12-11244126-G-A TAS2R43 c.703C>T p.Leu235Phe Missense 1/1 -
12-11214634-A-C TAS2R46 c.260T>G p.Val87Gly Missense 1/1 -
7-141464667-C-T TAS2R3 c.709C>T p.Leu237Phe Missense 1/1 -
12-11244591-C-A TAS2R43 c.238G>T p.Val80Leu Missense 1/1 -
12-11244378-C-G TAS2R43 c.451G>C p.Glu151Gln Missense 1/1 -
12-11183046-C-A TAS2R31 c.889G>T p.Val297Leu Missense 1/1 -
12-11183046-C-T TAS2R31 c.889G>A p.Val297Met Missense 1/1 -
12-11244303-T-C TAS2R43 c.526A>G p.Asn176Asp Missense 1/1 -
12-11183576-T-C TAS2R31 c.359A>G p.His120Arg Missense 1/1 -
7-141464616-A-C TAS2R3 c.658A>C p.Ser220Arg Missense 1/1 -
12-11183541-T-C TAS2R31 c.394A>G p.Met132Val Missense 1/1 -
12-11183336-C-A TAS2R31 c.599G>T p.Cys200Phe Missense 1/1 -
12-11286249-T-C TAS2R30 c.595A>G p.Ile199Val Missense 1/1 -
12-11061122-T-C TAS2R13 c.776A>G p.Asn259Ser Missense 1/1 -
12-11244036-T-G TAS2R43 c.793A>C p.Lys265Gln Missense 1/1 -
12-11244036-T-C TAS2R43 c.793A>G p.Lys265Glu Missense 1/1 -
12-11174276-G-A TAS2R19 c.895C>T p.Arg299Cys Missense 1/1 -
7-141464526-C-G TAS2R3 c.568C>G p.Leu190Val Missense 1/1 -
12-11214212-A-T TAS2R46 c.682T>A p.Leu228Met Missense 1/1 -
7-141478800-G-A TAS2R4 c.512G>A p.Ser171Asn Missense 1/1 -
12-11183115-T-C TAS2R31 c.820A>G p.Ile274Val Missense 1/1 -
12-11214212-A-C TAS2R46 c.682T>G p.Leu228Val Missense 1/1 -
12-11183035-C-T TAS2R31 c.900G>A p.Trp300* Nonsense 1/1 -
12-11286184-G-A TAS2R30 c.660C>T p.Ser220Ser Synonymous 1/1 -
12-11286184-G-T TAS2R30 c.660C>A p.Ser220Arg Missense 1/1 -
12-11286569-T-C TAS2R30 c.275A>G p.Asn92Ser Missense 1/1 -
12-11183427-T-G TAS2R31 c.508A>C p.Ser170Arg Missense 1/1 -
12-10978402-G-A TAS2R10 c.467C>T p.Thr156Met Missense 1/1 -
12-11091432-C-T TAS2R14 c.375G>A p.Arg125Arg Synonymous 1/1 -
12-11244017-T-G TAS2R43 c.812A>C p.Tyr271Ser Missense 1/1 -
12-11183223-A-G TAS2R31 c.712T>C p.Cys238Arg Missense 1/1 -
12-11183451-A-C TAS2R31 c.484T>G p.Leu162Val Missense 1/1 -
12-11183177-C-T TAS2R31 c.758G>A p.Gly253Glu Missense 1/1 -
12-11183451-A-T TAS2R31 c.484T>A p.Leu162Met Missense 1/1 -
12-11244319-A-T TAS2R43 c.510T>A p.Ser170Arg Missense 1/1 -
12-11338614-A-T TAS2R42 c.930T>A p.Asn310Lys Missense 1/1 -
12-11149711-C-A TAS2R20 c.764G>T p.Arg255Leu Missense 1/1 -
12-11149720-A-G TAS2R20 c.755T>C p.Phe252Ser Missense 1/1 -
19-49671525-A-G TRPM4 c.457A>G p.Ile153Val Missense 5/25 -
12-11174372-C-G TAS2R19 c.799G>C p.Val267Leu Missense 1/1 -
7-122635024-C-T TAS2R16 c.665G>A p.Arg222His Missense 1/1 -
12-11338614-A-G TAS2R42 c.930T>C p.Asn310Asn Synonymous 1/1 -
12-11244369-G-A TAS2R43 c.460C>T p.Arg154Trp Missense 1/1 -
12-11183708-T-C TAS2R31 c.227A>G p.Tyr76Cys Missense 1/1 -
12-11244252-G-A TAS2R43 c.577C>T p.Leu193Leu Synonymous 1/1 -
12-11091551-T-C TAS2R14 c.256A>G p.Thr86Ala Missense 1/1 -
12-11214847-G-A TAS2R46 c.47C>T p.Thr16Ile Missense 1/1 -
12-11150033-G-T TAS2R20 c.442C>A p.His148Asn Missense 1/1 -
7-141478430-C-G TAS2R4 c.142C>G p.Leu48Val Missense 1/1 -
12-11174302-A-G TAS2R19 c.869T>C p.Phe290Ser Missense 1/1 -
12-11286318-T-C TAS2R30 c.526A>G p.Asn176Asp Missense 1/1 -
12-11174795-T-G TAS2R19 c.376A>C p.Lys126Gln Missense 1/1 -
12-11183506-T-A TAS2R31 c.429A>T p.Gln143His Missense 1/1 -
12-11214351-G-C TAS2R46 c.543C>G p.Ile181Met Missense 1/1 -
7-122635173-A-C TAS2R16 c.516T>G p.Asn172Lys Missense 1/1 -
12-11338957-A-G TAS2R42 c.587T>C p.Phe196Ser Missense 1/1 -
12-11183837-A-G TAS2R31 c.98T>C p.Ile33Thr Missense 1/1 -
12-11090910-CCT-TGT TAS2R14 c.895_897delAGGinsTGT p.Arg299Cys Missense 1/1 -
12-11214455-T-C TAS2R46 c.439A>G p.Ile147Val Missense 1/1 -
7-141464618-C-G TAS2R3 c.660C>G p.Ser220Arg Missense 1/1 -
12-11174715-T-A TAS2R19 c.456A>T p.Arg152Ser Missense 1/1 -
12-11183327-C-T TAS2R31 c.608G>A p.Cys203Tyr Missense 1/1 -
12-11150240-T-C TAS2R20 c.235A>G p.Lys79Glu Missense 1/1 -
12-11183253-A-T TAS2R31 c.682T>A p.Leu228Met Missense 1/1 -
12-11183036-C-T TAS2R31 c.899G>A p.Trp300* Nonsense 1/1 -
7-141478308-T-C TAS2R4 c.20T>C p.Phe7Ser Missense 1/1 -
12-11244071-C-T TAS2R43 c.758G>A p.Gly253Glu Missense 1/1 -
12-11338613-C-G TAS2R42 c.931G>C p.Ala311Pro Missense 1/1 -
12-11244309-A-G TAS2R43 c.520T>C p.Phe174Leu Missense 1/1 -
12-11244261-G-C TAS2R43 c.568C>G p.Leu190Val Missense 1/1 -
12-11091432-C-A TAS2R14 c.375G>T p.Arg125Ser Missense 1/1 -
12-11244390-T-C TAS2R43 c.439A>G p.Ile147Val Missense 1/1 -
12-11183642-A-G TAS2R31 c.293T>C p.Leu98Pro Missense 1/1 -
12-11183217-C-T TAS2R31 c.718G>A p.Val240Ile Missense 1/1 -
12-11091206-G-A TAS2R14 c.601C>T p.Leu201Phe Missense 1/1 -
12-11183092-C-A TAS2R31 c.843G>T p.Trp281Cys Missense 1/1 -
12-11244483-A-G TAS2R43 c.346T>C p.Phe116Leu Missense 1/1 -
12-11174327-C-T TAS2R19 c.844G>A p.Gly282Arg Missense 1/1 -
12-11183496-T-C TAS2R31 c.439A>G p.Ile147Val Missense 1/1 -
12-11149769-T-C TAS2R20 c.706A>G p.Ile236Val Missense 1/1 -
12-11244323-T-C TAS2R43 c.506A>G p.Lys169Arg Missense 1/1 -
12-11244323-T-A TAS2R43 c.506A>T p.Lys169Met Missense 1/1 -
7-141464169-T-C TAS2R3 c.211T>C p.Phe71Leu Missense 1/1 -
7-141464535-T-A TAS2R3 c.577T>A p.Leu193Ile Missense 1/1 -
12-11244470-T-C TAS2R43 c.359A>G p.His120Arg Missense 1/1 -
12-11244117-A-G TAS2R43 c.712T>C p.Cys238Arg Missense 1/1 -
12-11244435-T-C TAS2R43 c.394A>G p.Met132Val Missense 1/1 -
12-11174380-C-T TAS2R19 c.791G>A p.Cys264Tyr Missense 1/1 -
12-11183108-G-C TAS2R31 c.827C>G p.Pro276Arg Missense 1/1 -
7-141464171-C-A TAS2R3 c.213C>A p.Phe71Leu Missense 1/1 -
12-11183421-C-T TAS2R31 c.514G>A p.Val172Met Missense 1/1 -
12-11183185-C-T TAS2R31 c.750G>A p.Trp250* Nonsense 1/1 -
12-11286448-T-C TAS2R30 c.396A>G p.Ile132Met Missense 1/1 -
12-11183186-C-T TAS2R31 c.749G>A p.Trp250* Nonsense 1/1 -
12-11244072-C-T TAS2R43 c.757G>A p.Gly253Arg Missense 1/1 -
12-11244072-C-G TAS2R43 c.757G>C p.Gly253Arg Missense 1/1 -
12-11244008-A-G TAS2R43 c.821T>C p.Ile274Thr Missense 1/1 -
12-11244194-T-C TAS2R43 c.635A>G p.His212Arg Missense 1/1 -
7-141464618-C-A TAS2R3 c.660C>A p.Ser220Arg Missense 1/1 -
12-11183484-C-T TAS2R31 c.451G>A p.Glu151Lys Missense 1/1 -
7-141464217-G-A TAS2R3 c.259G>A p.Val87Ile Missense 1/1 -
12-11183484-C-G TAS2R31 c.451G>C p.Glu151Gln Missense 1/1 -
12-11183676-C-T TAS2R31 c.259G>A p.Val87Ile Missense 1/1 -
12-11183793-G-A TAS2R31 c.142C>T p.Leu48Phe Missense 1/1 -
12-11183793-G-C TAS2R31 c.142C>G p.Leu48Val Missense 1/1 -
12-11339020-T-A TAS2R42 c.524A>T p.Tyr175Phe Missense 1/1 -
12-11339020-T-C TAS2R42 c.524A>G p.Tyr175Cys Missense 1/1 -
12-11183133-T-C TAS2R31 c.802A>G p.Arg268Gly Missense 1/1 -
12-11244299-A-G TAS2R43 c.530T>C p.Met177Thr Missense 1/1 -
12-11338669-C-T TAS2R42 c.875G>A p.Arg292Gln Missense 1/1 -
12-11338669-C-A TAS2R42 c.875G>T p.Arg292Leu Missense 1/1 -
7-141464409-G-C TAS2R3 c.451G>C p.Glu151Gln Missense 1/1 -
12-11338613-C-T TAS2R42 c.931G>A p.Ala311Thr Missense 1/1 -
12-11174845-T-G TAS2R19 c.326A>C p.Lys109Thr Missense 1/1 -
12-11214326-G-A TAS2R46 c.568C>T p.Leu190Leu Synonymous 1/1 -
12-11214326-G-C TAS2R46 c.568C>G p.Leu190Val Missense 1/1 -
12-11214368-T-C TAS2R46 c.526A>G p.Asn176Asp Missense 1/1 -
12-11214368-T-G TAS2R46 c.526A>C p.Asn176His Missense 1/1 -
12-11338781-C-A TAS2R42 c.763G>T p.Gly255Trp Missense 1/1 -
12-11183224-T-A TAS2R31 c.711A>T p.Leu237Phe Missense 1/1 -
12-11183121-G-A TAS2R31 c.814C>T p.Pro272Ser Missense 1/1 -
12-11174271-T-C TAS2R19 c.900A>G - Missense 1/1 -
12-11244319-A-C TAS2R43 c.510T>G p.Ser170Arg Missense 1/1 -
12-11244149-G-A TAS2R43 c.680C>T p.Ala227Val Missense 1/1 -
12-11183722-A-C TAS2R31 c.213T>G p.Phe71Leu Missense 1/1 -
12-11174390-G-A TAS2R19 c.781C>T p.Leu261Phe Missense 1/1 -
12-11244068-C-T TAS2R43 c.761G>A p.Ser254Asn Missense 1/1 -
12-11244068-C-A TAS2R43 c.761G>T p.Ser254Ile Missense 1/1 -
12-11244252-G-T TAS2R43 c.577C>A p.Leu193Ile Missense 1/1 -
12-11244319-A-G TAS2R43 c.510T>C p.Ser170Ser Synonymous 1/1 -
12-11244369-G-C TAS2R43 c.460C>G p.Arg154Gly Missense 1/1 -