PMID: 32457649

A Bitter Taste in Your Heart.

Frontiers in physiology
CJ Bloxham, SR Foster, WG Thomas
2020

214 variants were identified in this publication


Variant ID Gene cDNA Protein Consequence Exon Intron
12-11174282-T-C TAS2R19 c.889A>G p.Met297Val Missense 1/1 -
7-80103570-A-G GNAT3 c.587T>C p.Phe196Ser Missense 5/8 -
12-11244591-C-T TAS2R43 c.238G>A p.Val80Ile Missense 1/1 -
12-11244687-G-C TAS2R43 c.142C>G p.Leu48Val Missense 1/1 -
12-11183832-G-A TAS2R31 c.103C>T p.Arg35Trp Missense 1/1 -
12-11244243-T-G TAS2R43 c.586A>C p.Met196Leu Missense 1/1 -
12-11244369-G-T TAS2R43 c.460C>A p.Arg154Arg Synonymous 1/1 -
7-80117928-T-A GNAT3 c.226A>T p.Asn76Tyr Missense 3/8 -
12-11183485-T-G TAS2R31 c.450A>C p.Lys150Asn Missense 1/1 -
12-11183753-A-C TAS2R31 c.182T>G p.Val61Gly Missense 1/1 -
12-11214498-T-C TAS2R46 c.396A>G p.Ile132Met Missense 1/1 -
12-11183475-G-C TAS2R31 c.460C>G p.Arg154Gly Missense 1/1 -
12-11183475-G-A TAS2R31 c.460C>T p.Arg154Trp Missense 1/1 -
12-11214386-T-G TAS2R46 c.508A>C p.Ser170Arg Missense 1/1 -
12-11214386-T-C TAS2R46 c.508A>G p.Ser170Gly Missense 1/1 -
12-11183123-T-C TAS2R31 c.812A>G p.Tyr271Cys Missense 1/1 -
12-11183485-T-A TAS2R31 c.450A>T p.Lys150Asn Missense 1/1 -
7-141478832-G-C TAS2R4 c.544G>C p.Val182Leu Missense 1/1 -
12-11183232-G-A TAS2R31 c.703C>T p.Leu235Phe Missense 1/1 -
12-11138852-C-T TAS2R50 c.608G>A p.Cys203Tyr Missense 1/1 -
12-11183114-A-G TAS2R31 c.821T>C p.Ile274Thr Missense 1/1 -
12-10962115-A-G TAS2R9 c.560T>C p.Val187Ala Missense 1/1 -
12-11244285-C-G TAS2R43 c.544G>C p.Val182Leu Missense 1/1 -
12-11175077-C-T TAS2R19 c.94G>A p.Val32Ile Missense 1/1 -
7-141464847-G-A TAS2R3 c.889G>A p.Val297Met Missense 1/1 -
12-11150046-G-T TAS2R20 c.429C>A p.His143Gln Missense 1/1 -
12-11244557-A-G TAS2R43 c.272T>C p.Ile91Thr Missense 1/1 -
7-141478392-G-C TAS2R4 c.104G>C p.Trp35Ser Missense 1/1 -
7-141479082-G-A TAS2R4 c.794G>A p.Cys265Tyr Missense 1/1 -
12-11244126-G-A TAS2R43 c.703C>T p.Leu235Phe Missense 1/1 -
7-141464616-A-C TAS2R3 c.658A>C p.Ser220Arg Missense 1/1 -
12-11183336-C-A TAS2R31 c.599G>T p.Cys200Phe Missense 1/1 -
12-11183541-T-C TAS2R31 c.394A>G p.Met132Val Missense 1/1 -
12-11214634-A-C TAS2R46 c.260T>G p.Val87Gly Missense 1/1 -
12-11214212-A-T TAS2R46 c.682T>A p.Leu228Met Missense 1/1 -
7-141464667-C-T TAS2R3 c.709C>T p.Leu237Phe Missense 1/1 -
12-11244591-C-A TAS2R43 c.238G>T p.Val80Leu Missense 1/1 -
12-11286249-T-C TAS2R30 c.595A>G p.Ile199Val Missense 1/1 -
12-11244378-C-G TAS2R43 c.451G>C p.Glu151Gln Missense 1/1 -
12-11183046-C-A TAS2R31 c.889G>T p.Val297Leu Missense 1/1 -
12-11183046-C-T TAS2R31 c.889G>A p.Val297Met Missense 1/1 -
12-11244303-T-C TAS2R43 c.526A>G p.Asn176Asp Missense 1/1 -
12-11244036-T-G TAS2R43 c.793A>C p.Lys265Gln Missense 1/1 -
12-11244036-T-C TAS2R43 c.793A>G p.Lys265Glu Missense 1/1 -
12-11061122-T-C TAS2R13 c.776A>G p.Asn259Ser Missense 1/1 -
12-11183576-T-C TAS2R31 c.359A>G p.His120Arg Missense 1/1 -
12-11286088-A-C TAS2R30 c.756T>G p.Phe252Leu Missense 1/1 -
7-141464526-C-G TAS2R3 c.568C>G p.Leu190Val Missense 1/1 -
12-11183115-T-C TAS2R31 c.820A>G p.Ile274Val Missense 1/1 -
12-11174276-G-A TAS2R19 c.895C>T p.Arg299Cys Missense 1/1 -
12-11183035-C-T TAS2R31 c.900G>A p.Trp300* Nonsense 1/1 -
7-141478800-G-A TAS2R4 c.512G>A p.Ser171Asn Missense 1/1 -
12-11244319-A-T TAS2R43 c.510T>A p.Ser170Arg Missense 1/1 -
12-11214212-A-C TAS2R46 c.682T>G p.Leu228Val Missense 1/1 -
12-11286184-G-A TAS2R30 c.660C>T p.Ser220Ser Synonymous 1/1 -
12-11286569-T-C TAS2R30 c.275A>G p.Asn92Ser Missense 1/1 -
12-11091432-C-T TAS2R14 c.375G>A p.Arg125Arg Synonymous 1/1 -
12-11183223-A-G TAS2R31 c.712T>C p.Cys238Arg Missense 1/1 -
12-10978402-G-A TAS2R10 c.467C>T p.Thr156Met Missense 1/1 -
12-11183451-A-T TAS2R31 c.484T>A p.Leu162Met Missense 1/1 -
12-11183177-C-T TAS2R31 c.758G>A p.Gly253Glu Missense 1/1 -
12-11286184-G-T TAS2R30 c.660C>A p.Ser220Arg Missense 1/1 -
12-11183427-T-G TAS2R31 c.508A>C p.Ser170Arg Missense 1/1 -
12-11244017-T-G TAS2R43 c.812A>C p.Tyr271Ser Missense 1/1 -
12-11183451-A-C TAS2R31 c.484T>G p.Leu162Val Missense 1/1 -
12-11174372-C-G TAS2R19 c.799G>C p.Val267Leu Missense 1/1 -
12-11149711-C-A TAS2R20 c.764G>T p.Arg255Leu Missense 1/1 -
12-11149720-A-G TAS2R20 c.755T>C p.Phe252Ser Missense 1/1 -
19-49671525-A-G TRPM4 c.457A>G p.Ile153Val Missense 5/25 -
12-11338614-A-G TAS2R42 c.930T>C p.Asn310Asn Synonymous 1/1 -
7-122635024-C-T TAS2R16 c.665G>A p.Arg222His Missense 1/1 -
12-11338614-A-T TAS2R42 c.930T>A p.Asn310Lys Missense 1/1 -
12-11183708-T-C TAS2R31 c.227A>G p.Tyr76Cys Missense 1/1 -
12-11244252-G-A TAS2R43 c.577C>T p.Leu193Leu Synonymous 1/1 -
12-11091551-T-C TAS2R14 c.256A>G p.Thr86Ala Missense 1/1 -
12-11214455-T-C TAS2R46 c.439A>G p.Ile147Val Missense 1/1 -
12-11244369-G-A TAS2R43 c.460C>T p.Arg154Trp Missense 1/1 -
12-11214847-G-A TAS2R46 c.47C>T p.Thr16Ile Missense 1/1 -
7-141478430-C-G TAS2R4 c.142C>G p.Leu48Val Missense 1/1 -
12-11286318-T-C TAS2R30 c.526A>G p.Asn176Asp Missense 1/1 -
12-11174795-T-G TAS2R19 c.376A>C p.Lys126Gln Missense 1/1 -
12-11214351-G-C TAS2R46 c.543C>G p.Ile181Met Missense 1/1 -
7-122635173-A-C TAS2R16 c.516T>G p.Asn172Lys Missense 1/1 -
12-11150033-G-T TAS2R20 c.442C>A p.His148Asn Missense 1/1 -
12-11174302-A-G TAS2R19 c.869T>C p.Phe290Ser Missense 1/1 -
12-11183506-T-A TAS2R31 c.429A>T p.Gln143His Missense 1/1 -
12-11183837-A-G TAS2R31 c.98T>C p.Ile33Thr Missense 1/1 -
12-11338957-A-G TAS2R42 c.587T>C p.Phe196Ser Missense 1/1 -
7-141464618-C-G TAS2R3 c.660C>G p.Ser220Arg Missense 1/1 -
12-11090910-CCT-TGT TAS2R14 c.895_897delAGGinsTGT p.Arg299Cys Missense 1/1 -
12-11174715-T-A TAS2R19 c.456A>T p.Arg152Ser Missense 1/1 -
12-11244071-C-T TAS2R43 c.758G>A p.Gly253Glu Missense 1/1 -
7-141478308-T-C TAS2R4 c.20T>C p.Phe7Ser Missense 1/1 -
12-11183327-C-T TAS2R31 c.608G>A p.Cys203Tyr Missense 1/1 -
12-11183253-A-T TAS2R31 c.682T>A p.Leu228Met Missense 1/1 -
12-11150240-T-C TAS2R20 c.235A>G p.Lys79Glu Missense 1/1 -
12-11183036-C-T TAS2R31 c.899G>A p.Trp300* Nonsense 1/1 -
12-11338613-C-G TAS2R42 c.931G>C p.Ala311Pro Missense 1/1 -
12-11244309-A-G TAS2R43 c.520T>C p.Phe174Leu Missense 1/1 -
12-11244261-G-C TAS2R43 c.568C>G p.Leu190Val Missense 1/1 -
12-11244323-T-C TAS2R43 c.506A>G p.Lys169Arg Missense 1/1 -
12-11244390-T-C TAS2R43 c.439A>G p.Ile147Val Missense 1/1 -
12-11183642-A-G TAS2R31 c.293T>C p.Leu98Pro Missense 1/1 -
12-11174327-C-T TAS2R19 c.844G>A p.Gly282Arg Missense 1/1 -
12-11244117-A-G TAS2R43 c.712T>C p.Cys238Arg Missense 1/1 -
12-11183217-C-T TAS2R31 c.718G>A p.Val240Ile Missense 1/1 -
12-11091206-G-A TAS2R14 c.601C>T p.Leu201Phe Missense 1/1 -
12-11183092-C-A TAS2R31 c.843G>T p.Trp281Cys Missense 1/1 -
7-141464169-T-C TAS2R3 c.211T>C p.Phe71Leu Missense 1/1 -
12-11244483-A-G TAS2R43 c.346T>C p.Phe116Leu Missense 1/1 -
12-11183496-T-C TAS2R31 c.439A>G p.Ile147Val Missense 1/1 -
7-141464535-T-A TAS2R3 c.577T>A p.Leu193Ile Missense 1/1 -
12-11244470-T-C TAS2R43 c.359A>G p.His120Arg Missense 1/1 -
12-11149769-T-C TAS2R20 c.706A>G p.Ile236Val Missense 1/1 -
12-11244323-T-A TAS2R43 c.506A>T p.Lys169Met Missense 1/1 -
12-11091432-C-A TAS2R14 c.375G>T p.Arg125Ser Missense 1/1 -
12-11174380-C-T TAS2R19 c.791G>A p.Cys264Tyr Missense 1/1 -
12-11244435-T-C TAS2R43 c.394A>G p.Met132Val Missense 1/1 -
12-11183421-C-T TAS2R31 c.514G>A p.Val172Met Missense 1/1 -
7-141464171-C-A TAS2R3 c.213C>A p.Phe71Leu Missense 1/1 -
12-11183186-C-T TAS2R31 c.749G>A p.Trp250* Nonsense 1/1 -
12-11183185-C-T TAS2R31 c.750G>A p.Trp250* Nonsense 1/1 -
12-11244194-T-C TAS2R43 c.635A>G p.His212Arg Missense 1/1 -
7-141464618-C-A TAS2R3 c.660C>A p.Ser220Arg Missense 1/1 -
12-11286448-T-C TAS2R30 c.396A>G p.Ile132Met Missense 1/1 -
12-11183108-G-C TAS2R31 c.827C>G p.Pro276Arg Missense 1/1 -
12-11244072-C-T TAS2R43 c.757G>A p.Gly253Arg Missense 1/1 -
12-11244072-C-G TAS2R43 c.757G>C p.Gly253Arg Missense 1/1 -
12-11244008-A-G TAS2R43 c.821T>C p.Ile274Thr Missense 1/1 -
12-11183484-C-T TAS2R31 c.451G>A p.Glu151Lys Missense 1/1 -
7-141464217-G-A TAS2R3 c.259G>A p.Val87Ile Missense 1/1 -
12-11183484-C-G TAS2R31 c.451G>C p.Glu151Gln Missense 1/1 -
12-11244319-A-C TAS2R43 c.510T>G p.Ser170Arg Missense 1/1 -
12-11339020-T-A TAS2R42 c.524A>T p.Tyr175Phe Missense 1/1 -
12-11339020-T-C TAS2R42 c.524A>G p.Tyr175Cys Missense 1/1 -
12-11183133-T-C TAS2R31 c.802A>G p.Arg268Gly Missense 1/1 -
7-141464409-G-C TAS2R3 c.451G>C p.Glu151Gln Missense 1/1 -
12-11174845-T-G TAS2R19 c.326A>C p.Lys109Thr Missense 1/1 -
12-11214368-T-G TAS2R46 c.526A>C p.Asn176His Missense 1/1 -
12-11183224-T-A TAS2R31 c.711A>T p.Leu237Phe Missense 1/1 -
12-11338781-C-A TAS2R42 c.763G>T p.Gly255Trp Missense 1/1 -
12-11174271-T-C TAS2R19 c.900A>G - Missense 1/1 -
12-11244299-A-G TAS2R43 c.530T>C p.Met177Thr Missense 1/1 -
12-11183793-G-A TAS2R31 c.142C>T p.Leu48Phe Missense 1/1 -
12-11183793-G-C TAS2R31 c.142C>G p.Leu48Val Missense 1/1 -
12-11183676-C-T TAS2R31 c.259G>A p.Val87Ile Missense 1/1 -
12-11338669-C-T TAS2R42 c.875G>A p.Arg292Gln Missense 1/1 -
12-11338669-C-A TAS2R42 c.875G>T p.Arg292Leu Missense 1/1 -
12-11338613-C-T TAS2R42 c.931G>A p.Ala311Thr Missense 1/1 -
12-11214326-G-A TAS2R46 c.568C>T p.Leu190Leu Synonymous 1/1 -
12-11214326-G-C TAS2R46 c.568C>G p.Leu190Val Missense 1/1 -
12-11214368-T-C TAS2R46 c.526A>G p.Asn176Asp Missense 1/1 -
12-11183722-A-C TAS2R31 c.213T>G p.Phe71Leu Missense 1/1 -
12-11244149-G-A TAS2R43 c.680C>T p.Ala227Val Missense 1/1 -
12-11174390-G-A TAS2R19 c.781C>T p.Leu261Phe Missense 1/1 -
7-141478574-G-C TAS2R4 c.286G>C p.Val96Leu Missense 1/1 -
12-11244319-A-G TAS2R43 c.510T>C p.Ser170Ser Synonymous 1/1 -
12-11183121-G-A TAS2R31 c.814C>T p.Pro272Ser Missense 1/1 -
7-141490238-G-T TAS2R5 c.77G>T p.Ser26Ile Missense 1/1 -
7-141464171-C-G TAS2R3 c.213C>G p.Phe71Leu Missense 1/1 -
12-11183406-C-T TAS2R31 c.529G>A p.Ala177Thr Missense 1/1 -
12-11183052-G-A TAS2R31 c.883C>T p.Arg295Trp Missense 1/1 -
12-11243929-C-T TAS2R43 c.900G>A p.Trp300* Nonsense 1/1 -
12-11244603-T-A TAS2R43 c.226A>T p.Asn76Tyr Missense 1/1 -
12-11243960-A-T TAS2R43 c.869T>A p.Phe290Tyr Missense 1/1 -
12-11243960-A-G TAS2R43 c.869T>C p.Phe290Ser Missense 1/1 -
12-11244369-G-C TAS2R43 c.460C>G p.Arg154Gly Missense 1/1 -
12-11244068-C-T TAS2R43 c.761G>A p.Ser254Asn Missense 1/1 -
12-11244068-C-A TAS2R43 c.761G>T p.Ser254Ile Missense 1/1 -
12-11244252-G-T TAS2R43 c.577C>A p.Leu193Ile Missense 1/1 -
12-11286422-A-G TAS2R30 c.422T>C p.Val141Ala Missense 1/1 -
12-10961978-C-T TAS2R9 c.697G>A p.Ala233Thr Missense 1/1 -
12-11183255-G-A TAS2R31 c.680C>T p.Ala227Val Missense 1/1 -
12-11244321-T-G TAS2R43 c.508A>C p.Ser170Arg Missense 1/1 -
12-11183142-T-G TAS2R31 c.793A>C p.Lys265Gln Missense 1/1 -
12-11244017-T-C TAS2R43 c.812A>G p.Tyr271Cys Missense 1/1 -
12-11286214-C-G TAS2R30 c.630G>C p.Gln210His Missense 1/1 -
12-11286314-A-G TAS2R30 c.530T>C p.Met177Thr Missense 1/1 -
12-11338750-T-G TAS2R42 c.794A>C p.Tyr265Ser Missense 1/1 -
12-11338750-T-C TAS2R42 c.794A>G p.Tyr265Cys Missense 1/1 -
12-11244725-C-G TAS2R43 c.104G>C p.Trp35Ser Missense 1/1 -
12-11214437-T-C TAS2R46 c.457A>G p.Ile153Val Missense 1/1 -
12-11183178-C-T TAS2R31 c.757G>A p.Gly253Arg Missense 1/1 -
12-11183178-C-G TAS2R31 c.757G>C p.Gly253Arg Missense 1/1 -
7-122635183-T-C TAS2R16 c.506A>G p.Lys169Arg Missense 1/1 -
12-10961765-G-A TAS2R9 c.910C>T p.Leu304Phe Missense 1/1 -
12-11174286-C-T TAS2R19 c.885G>A p.Trp295* Nonsense 1/1 -
12-11183066-A-T TAS2R31 c.869T>A p.Phe290Tyr Missense 1/1 -
12-11183697-C-A TAS2R31 c.238G>T p.Val80Leu Missense 1/1 -
12-11174286-C-A TAS2R19 c.885G>T p.Trp295Cys Missense 1/1 -
12-11174397-T-A TAS2R19 c.774A>T p.Lys258Asn Missense 1/1 -
12-11244554-T-C TAS2R43 c.275A>G p.Asn92Ser Missense 1/1 -
12-11244687-G-A TAS2R43 c.142C>T p.Leu48Phe Missense 1/1 -
12-11244015-G-A TAS2R43 c.814C>T p.Pro272Ser Missense 1/1 -
12-11244117-A-C TAS2R43 c.712T>G p.Cys238Gly Missense 1/1 -
7-141464501-C-G TAS2R3 c.543C>G p.Ile181Met Missense 1/1 -
12-11244234-T-C TAS2R43 c.595A>G p.Ile199Val Missense 1/1 -
12-11244234-T-G TAS2R43 c.595A>C p.Ile199Leu Missense 1/1 -
12-11243947-A-C TAS2R43 c.882T>G p.Phe294Leu Missense 1/1 -
12-11243947-A-T TAS2R43 c.882T>A p.Phe294Leu Missense 1/1 -
12-11183506-T-G TAS2R31 c.429A>C p.Gln143His Missense 1/1 -
12-11174498-T-C TAS2R19 c.673A>G p.Ile225Val Missense 1/1 -
12-11244230-C-A TAS2R43 c.599G>T p.Cys200Phe Missense 1/1 -
12-11244027-T-A TAS2R43 c.802A>T p.Arg268* Nonsense 1/1 -
12-11244027-T-C TAS2R43 c.802A>G p.Arg268Gly Missense 1/1 -
12-11244199-C-G TAS2R43 c.630G>C p.Gln210His Missense 1/1 -
12-11150054-C-T TAS2R20 c.421G>A p.Val141Ile Missense 1/1 -
12-11214472-A-G TAS2R46 c.422T>C p.Val141Ala Missense 1/1 -
12-11214145-C-T TAS2R46 c.749G>A p.Trp250* Nonsense 1/1 -
12-11183286-G-C TAS2R31 c.649C>G p.Gln217Glu Missense 1/1 -
12-11244009-T-C TAS2R43 c.820A>G p.Ile274Val Missense 1/1 -
12-11244378-C-T TAS2R43 c.451G>A p.Glu151Lys Missense 1/1 -
12-11183300-T-C TAS2R31 c.635A>G p.His212Arg Missense 1/1 -
7-141464718-TCA-AAC TAS2R3 c.760_762delTCAinsAAC p.Ser254Asn Missense 1/1 -