Publications:

---

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.

Journal Of Experimental & Clinical Cancer Research : Cr

Mlakar, Vid V; Morel, Edouard E; Mlakar, Simona Jurkovic SJ; Ansari, Marc M; Gumy-Pause, Fabienne F

Publication Date: 2021-06-08

Variant appearance in text: NRAS: C181A

PubMed Link: 34103089

Variant Present in the following documents:

• Main text
• 13046_2021_Article_1967.pdf

View BVdb publication page

---

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.

The British Journal Of Dermatology

Polubothu, S S; McGuire, N N; Al-Olabi, L L; Baird, W W; Bulstrode, N N; Chalker, J J; Josifova, D D; Lomas, D D; O'Hara, J J; Ong, J J; Rampling, D D; Stadnik, P P; Thomas, A A; Wedgeworth, E E; Sebire, N J NJ; Kinsler, V A VA

Publication Date: 2020-02

Variant appearance in text: NRAS: C181A

PubMed Link: 31111470

Variant Present in the following documents:

• Main text
• BJD-182-434.pdf

View BVdb publication page

---

Functional annotation of rare gene aberration drivers of pancreatic cancer.

Nature Communications

Tsang, Yiu Huen YH; Dogruluk, Turgut T; Tedeschi, Philip M PM; Wardwell-Ozgo, Joanna J; Lu, Hengyu H; Espitia, Maribel M; Nair, Nikitha N; Minelli, Rosalba R; Chong, Zechen Z; Chen, Fengju F; Chang, Qing Edward QE; Dennison, Jennifer B JB; Dogruluk, Armel A; Li, Min M; Ying, Haoqiang H; Bertino, Joseph R JR; Gingras, Marie-Claude MC; Ittmann, Michael M; Kerrigan, John J; Chen, Ken K; Creighton, Chad J CJ; Eterovic, Karina K; Mills, Gordon B GB; Scott, Kenneth L KL

Publication Date: 2016-01-25

Variant appearance in text: NRAS: C181A

PubMed Link: 26806015

Variant Present in the following documents:

• ncomms10500-s2.xls, sheet 1

View BVdb publication page

---

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Kopetz, Scott S; Desai, Jayesh J; Chan, Emily E; Hecht, Joel Randolph JR; O'Dwyer, Peter J PJ; Maru, Dipen D; Morris, Van V; Janku, Filip F; Dasari, Arvind A; Chung, Woonbook W; Issa, Jean-Pierre J JP; Gibbs, Peter P; James, Brian B; Powis, Garth G; Nolop, Keith B KB; Bhattacharya, Suman S; Saltz, Leonard L

Publication Date: 2015-12-01

Variant appearance in text: NRAS: c181a

PubMed Link: 26460303

Variant Present in the following documents:

• supp_33.34.4032_DS_2015.632497.pdf

View BVdb publication page

---

Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation.

Acs Chemical Biology

Takashima, Asami A; English, Brandon B; Chen, Zhihong Z; Cao, Juxiang J; Cui, Rutao R; Williams, Robert M RM; Faller, Douglas V DV

Publication Date: 2014-04-18

Variant appearance in text: NRAS: C181A

PubMed Link: 24506253

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma.

Clinical & Experimental Metastasis

Birkeland, Einar E; Busch, Christian C; Berge, Elisabet Ognedal EO; Geisler, Jürgen J; Jönsson, Göran G; Lillehaug, Johan Richard JR; Knappskog, Stian S; Lønning, Per Eystein PE

Publication Date: 2013-10

Variant appearance in text: NRAS: C181A

PubMed Link: 23673558

Variant Present in the following documents:

• 10585_2013_9587_MOESM1_ESM.pdf

View BVdb publication page

---

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.

Genes & Development

Vredeveld, Liesbeth C W LC; Possik, Patricia A PA; Smit, Marjon A MA; Meissl, Katrin K; Michaloglou, Chrysiis C; Horlings, Hugo M HM; Ajouaou, Abderrahim A; Kortman, Pim C PC; Dankort, David D; McMahon, Martin M; Mooi, Wolter J WJ; Peeper, Daniel S DS

Publication Date: 2012-05-15

Variant appearance in text: NRAS: C181A

PubMed Link: 22549727

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Kirkwood, John M JM; Bastholt, Lars L; Robert, Caroline C; Sosman, Jeff J; Larkin, James J; Hersey, Peter P; Middleton, Mark M; Cantarini, Mireille M; Zazulina, Victoria V; Kemsley, Karin K; Dummer, Reinhard R

Publication Date: 2012-01-15

Variant appearance in text: NRAS: C181A

PubMed Link: 22048237

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Clinical correlates of NRAS and BRAF mutations in primary human melanoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Ellerhorst, Julie A JA; Greene, Victoria R VR; Ekmekcioglu, Suhendan S; Warneke, Carla L CL; Johnson, Marcella M MM; Cooke, Carolyn P CP; Wang, Li-E LE; Prieto, Victor G VG; Gershenwald, Jeffrey E JE; Wei, Qingyi Q; Grimm, Elizabeth A EA

Publication Date: 2011-01-15

Variant appearance in text: NRAS: C181A

PubMed Link: 20975100

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma.

The Journal Of Investigative Dermatology

Greene, Victoria R VR; Johnson, Marcella M MM; Grimm, Elizabeth A EA; Ellerhorst, Julie A JA

Publication Date: 2009-06

Variant appearance in text: NRAS: C181A

PubMed Link: 19037234

Variant Present in the following documents:

• Main text

View BVdb publication page

---

BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs.

Journal Of Clinical Pathology

Wong, C W CW; Fan, Y S YS; Chan, T L TL; Chan, A S W AS; Ho, L C LC; Ma, T K F TK; Yuen, S T ST; Leung, S Y SY; ,

Publication Date: 2005-06

Variant appearance in text: NRAS: C181A

PubMed Link: 15917418

Variant Present in the following documents:

• Main text

View BVdb publication page

---